Economic evaluation of a novel dual-energy, large focal lattice-tip catheter versus conventional contact-force sensing radiofrequency catheter, for persistent atrial fibrillation ablation, from the English National Health Service perspective

Introduction Persistent atrial fibrillation (PersAF) presents a significant clinical and economic burden and is associated with poorer outcomes after catheter ablation compared with paroxysmal atrial fibrillation (AF). Pulsed field ablation (PFA) has emerged as a new form of energy modality

Frederick Edwin Willmott

bmj;392/jan29_12/s188/FAF1faFred was born in Beeston, Nottingham, and attended Henry Mellish grammar school before training at Guy’s Hospital, qualifying in 1964. Following posts in Nottingham he joined the Royal Navy and had several postings, including to Singapore. On discharge from the

At a glance

Corneal multifocality after penetrating keratoplasty or deep anterior lamellar keratoplasty is associated with intraocular lens power calculation error (see page 133) This study evaluated IOL calculation accuracy in eyes after PK or DALK and found that discrepancies between subjective and

Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction

Nature Genetics, Published online: 21 January 2026; doi:10.1038/s41588-025-02470-1 Multi-trait genome-wide analyses identify variants associated with comorbid lung diseases. Polygenic scores leveraging shared components of heritable risk improve prediction of asthma, chronic obstructive pulmonary disease and lung cancer in a multi-ancestry

How epistemic trust, mistrust and credulity relate to mental health, personality pathology, treatment engagement and relationship in psychotherapeutic and psychiatric settings

Background Epistemic trust describes the capacity to appropriately identify others as reliable and relevant sources of information, an ability closely linked to attachment and social learning. Epistemic disruption can manifest as heightened suspicion (mistrust) or excessive reliance (credulity) vis-à-vis others,

Atoms

Sucrose in spoonfuls October 1949. Year 8 redbrick classroom: late afternoon, mid England. ‘Adams, that’s extra lines in detention’ shrieked the head of year, perspiration gleaming on his pate, his quivering, now quite ample paunch failing to disguise the decline

Development and external validation of machine learning approaches for risk prediction of cardiovascular disease in individuals with schizophrenia: a nationwide Swedish and Danish study

Background Currently available cardiovascular disease (CVD) risk prediction tools may underestimate the risk in individuals with schizophrenia. Objective To develop and externally validate 5-year CVD risk prediction models for people with schizophrenia using large-scale register data in Sweden and Denmark

Probiotics for the treatment of vulvovaginal candidiasis in non-pregnant women: A systematic review and meta-analysis of randomized controlled trials

Vulvovaginal candidiasis and recurrent vulvovaginal candidiasis significantly impair women’s quality of life and psychological well-being. Although numerous randomized controlled trials have explored probiotics as alternative or adjunctive therapies, their clinical efficacy remains inconclusive. This meta-analysis systematically assessed the therapeutic value

Journeys of hope

Nature Genetics, Published online: 12 January 2026; doi:10.1038/s41588-025-02466-x Inequities in access to cancer diagnostics and care are a reality for millions globally. Despite rapid advances in personalized medicine, these will not benefit most patients in the global south if we

Correction: Response to: Correspondence on ‘Estimated sodium intake and premature ventricular complexes: data from the population-based Swedish CArdioPulmonary bioImage study by Campbell

Johnson LS, Economou Lundeberg J, Wuopio J, et al. Response to: Correspondence on ‘Estimated sodium intake and premature ventricular complexes: data from the population-based Swedish CArdioPulmonary bioImage study’ by Campbell. Heart 2025;111:741–43. This letter was updated post-publication in response to

A trunkload of ancient RNA

Ancient DNA has become a workhorse for evolutionary biologists. In contrast, ancient RNA studies have been rare and often methodologically controversial. Mármol-Sánchez et al. provide compelling evidence that aRNA survived up to ca. 50,000 years in permafrost-preserved mammoth (Mammuthus primigenius)

A guide to cancer screening

Nature Reviews Clinical Oncology, Published online: 07 January 2026; doi:10.1038/s41571-025-01112-z Cancer screening aims to identify either pre-malignant conditions or earlier-stage disease in non-symptomatic individuals. The authors of this Review recapitulate the general principles of cancer screening, discussing the current screening

Gut microbiome in biliary atresia

Biliary atresia (BA) is a progressive cholangiopathy of infancy and the leading cause of pediatric liver transplantation. Despite surgical intervention with the Kasai portoenterostomy, long-term outcomes remain poor, with many patients progressing to cirrhosis. Emerging evidence implicates the gut microbiota—a

Prevalence and anatomical distribution of MRI lesions in axSpA and differences between patients with and without peripheral involvement: results from the ASAS classification cohort

Objective To evaluate the prevalence and anatomical distribution of inflammatory and structural MRI lesions in axial spondyloarthritis (axSpA) and compare these between patients with isolated axial involvement and those with peripheral manifestations. Methods Data from the Assessment of SpondyloArthritis International

A genomic and epigenomic view of human centromeres

Nature Reviews Genetics, Published online: 06 January 2026; doi:10.1038/s41576-025-00923-1 The complex and repetitive nature of centromeres has historically posed challenges to their genomic assembly and functional understanding, which are now being overcome with long-read sequencing. This Review discusses recent genomic

Change to Open Access

For the Original Investigation titled “Once-Weekly Navepegritide in Children With Achondroplasia: the APPROACH Randomized Clinical Trial,” published on November 17, 2025, the publication status was changed to open access (CC-BY-NC-ND). This article was corrected online.

Mapping the disease interactome

Nature Reviews Genetics, Published online: 05 January 2026; doi:10.1038/s41576-025-00922-2 In this Journal Club, Valborg Gudmundsdottir recalls a study by Menche et al., who used a network-based approach to systematically identify clusters of connections between disease-related proteins and elucidate the molecular

[Editorial] No health without peace

What will be the most pressing health challenge of 2026? Climate change? Artificial intelligence? Pandemics? Non-communicable diseases? These issues will continue to shape health and medicine. Yet across much of the world, conflict is a fundamental determinant of people’s health

Artificial intelligence-based assessment of central aortic haemodynamics using non-invasive pulse wave analysis in constrictive pericarditis

Background Constrictive pericarditis (CP) is a rare but significant pericardial disease resulting in impaired ventricular filling and heart failure symptoms, often following cardiac surgery. Its clinical presentation complicates diagnosis, mimicking other causes of heart failure. Recent technological advances, including artificial

Changes in myocardial blood flow and microvascular resistance in patients with coronary artery disease undergoing transcatheter aortic valve implantation

Background Severe aortic stenosis (AS) causes a pathophysiological cascade, which impairs myocardial blood flow. This effect is exacerbated in the presence of coronary disease (CAD). Treatment with transcatheter aortic valve implantation (TAVI) may promote reversal of these pathophysiological conditions. Methods

When cardiology forgets to ask why

Contemporary cardiology faces a paradox: unprecedented technological capability coincides with declining scientific curiosity and clinical judgement. This manuscript examines the shift from question-driven, physiologic medicine to an approach dominated by procedural feasibility, commercial influence and algorithmic decision-making. Advances such as

Introducing myself

‘The path from novice to expert is surprisingly short’. These words came from June Edhouse, my educational supervisor during my very first job as a Senior House Officer in Emergency Medicine, back in 2001. June was explaining how publishing a

Isolated Severe Systolic Hypertension With Diastolic <110 mmHg During Delivery Admission and Maternal Outcomes: A Secondary Analysis of the APEX Cohort

Systolic hypertension has emerged as a predictor of maternal morbidity, with current guidelines recommending treatment of systolic blood pressure ≥160 mmHg regardless of diastolic values. However, evidence supporting the independent prognostic significance of elevated systolic pressure in pregnancy remains limited,

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