Personal perspective: bootless

Nature Genetics, Published online: 30 October 2020; doi:10.1038/s41588-020-00720-y Given an opportunity to chronicle the experience of traversing America as a Black man, I elect to convey a less frequently told vantage point. This is the perspective of the ‘accomplished’ bootless.

Angiographic control versus ischaemia-driven management of patients undergoing percutaneous revascularisation of the unprotected left main coronary artery with second-generation drug-eluting stents: rationale and design of the PULSE trial

Background The role of planned angiographic control (PAC) over a conservative management driven by symptoms and ischaemia following percutaneous coronary intervention (PCI) of the unprotected left main (ULM) with second-generation drug-eluting stents remains controversial. PAC may timely detect intrastent restenosis,


“You are leaving?” she asked. “When will you come again?” “Soon,” I said. “I’ll be back soon, Nanima.” In my heart, I knew it wouldn’t be soon. In truth, I could only bear to visit her once every few months

Nucleic-acid sequencing of proteomes

Nature Reviews Genetics, Published online: 23 October 2020; doi:10.1038/s41576-020-00301-z A recent study re-casts proteomic analyses as a DNA sequencing problem; by fusing in vivo-expressed proteins to their encoding mRNA, molecular interactions can be identified and quantified through high-throughput nucleic-acid sequencing.

Keith Budd

bmj;371/oct23_11/m4073/FAF1faKeith Budd was born to Violet and Hampton in Bournville, Birmingham. He was educated at King’s Norton grammar school before reading medicine at the University of Leeds….

Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial

Background Drug-eluting stent-induced vasospastic angina (DES-VSA) has emerged as a novel complication in the modern era of percutaneous coronary intervention (PCI). Although beta blockers (BBs) are generally recommended for coronary heart disease, they may promote incidence of DES-VSA. This study

Reaching completion for GTEx

Nature Reviews Genetics, Published online: 15 October 2020; doi:10.1038/s41576-020-00296-7 The GTEx consortium reports results from its third and final phase in several new papers. They provide unprecedented detail of human gene expression regulation across tissues.

Effects of adding ivabradine to usual care in patients with angina pectoris: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis

Objective To determine the impact of ivabradine on outcomes important to patients with angina pectoris caused by coronary artery disease. Methods We conducted a systematic review. We included randomised clinical trials comparing ivabradine versus placebo or no intervention for patients

Abuzz with bumblebee genomes

Nature Reviews Genetics, Published online: 09 October 2020; doi:10.1038/s41576-020-00294-9 A study in Molecular Biology and Evolution reports de novo genome sequences for 17 bumblebee species spanning all 15 subgenera. This valuable resource should provide a deeper biological understanding of these

Editing the Mitochondrial Genome

Mitochondrial diseases are a heterogeneous group of disorders with varying clinical features caused by impaired function of the mitochondrial respiratory chain. The underlying cause can be gene mutations affecting either the nuclear DNA or the mitochondrial DNA (mtDNA), both of

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