Lake and Chaidarun provide images of spade phalanx signs typical of acromegaly.1 In the text accompanying these images, they elaborate on acromegalic arthropathy and claim that carpal tunnel syndrome…
Progress in refining the clinical management of cancer of unknown primary in the molecular era
Nature Reviews Clinical Oncology, Published online: 29 April 2020; doi:10.1038/s41571-020-0359-1 Despite improvements in diagnostic strategies, cancer of unknown primary — metastatic cancer in patients in whom the primary tumour remains undetected — continues to account for around 1–2% of all
[Editorial] The resurgence of convalescent plasma therapy
The global pandemic of severe acute respiratory coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), continues to spread around the world, having infected more than 1·8 million people and causing over 100 000 deaths as of April 13, 2020. High-quality
Covid-19 in Immune-Mediated Inflammatory Diseases — Case Series from New York
To the Editor: Data on Covid-19 in patients with immune-mediated inflammatory disease who have received anticytokine biologics, other immunomodulatory therapies, or both on a long-term basis are scarce. Trials to assess the efficacy of antirheumatic therapies such as hydroxychloroquine and…
Covid-19 in Immune-Mediated Inflammatory Diseases — Case Series from New York
To the Editor: Data on Covid-19 in patients with immune-mediated inflammatory disease who have received anticytokine biologics, other immunomodulatory therapies, or both on a long-term basis are scarce. Trials to assess the efficacy of antirheumatic therapies such as hydroxychloroquine and…
Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy
To the Editor: Despite the risk of rapid respiratory failure and cardiac complications due to Covid-19, it is unclear whether there is an association between Covid-19 and out-of-hospital cardiac arrest. The Lombardy region of Italy was among the first areas
Covid-19 in Immune-Mediated Inflammatory Diseases — Case Series from New York
To the Editor: Data on Covid-19 in patients with immune-mediated inflammatory disease who have received anticytokine biologics, other immunomodulatory therapies, or both on a long-term basis are scarce. Trials to assess the efficacy of antirheumatic therapies such as hydroxychloroquine and…
A National Medical Response to Crisis — The Legacy of World War II
This August marks the 75th anniversary of the conclusion of World War II. In history’s largest, most destructive war, an estimated 80 million people, or roughly 3% of the world population, died. Nearly 420,000 Americans were killed, and 670,000 were
[Editorial] COVID-19: endgames
As of April 14, 2020, coronavirus disease 2019 (COVID-19) has killed more than 120 000 people and led to nearly 2 million confirmed infections worldwide. At least a third of the global population is in some form of lockdown, treading the
Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations
Covid-19 in Immune-Mediated Inflammatory Diseases — Case Series from New York
To the Editor: Data on Covid-19 in patients with immune-mediated inflammatory disease who have received anticytokine biologics, other immunomodulatory therapies, or both on a long-term basis are scarce. Trials to assess the efficacy of antirheumatic therapies such as hydroxychloroquine and…
Covid-19: Antibody test that claims to be 99% accurate is certified by EU
An antibody blood test for covid-19, which the manufacturer Abbott claims is 99% accurate, has been certified for use by the European Union.The test—which has received its CE mark, meaning that it…
Cancer Management in India during Covid-19
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. The Covid-19 pandemic has
Society for Maternal-Fetal Medicine (SMFM) Consult Series #51: Thromboembolism Prophylaxis for Cesarean Delivery
Venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality. The risk of VTE is particularly elevated during the postpartum period and especially following cesarean delivery. There is considerable variation in the approach to VTE prophylaxis in pregnancy,
Chromosome structure at micro-scale
Nature Reviews Genetics, Published online: 28 April 2020; doi:10.1038/s41576-020-0243-y Two studies in Molecular Cell report fine-scale structural profiles of mammalian genomes using Micro-C, indicating that fine chromosomal structure is regulated by diverse transcription-related features.
Reduced Rate of Hospital Admissions for ACS during Covid-19 Outbreak in Northern Italy
To the Editor: To address the coronavirus (Covid-19) pandemic, strict social containment measures have been adopted worldwide, and health care systems have been reorganized to cope with the enormous increase in the numbers of acutely ill patients. During this same
Cancer Management in India during Covid-19
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. The Covid-19 pandemic has
Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations
Head Injury Deaths on the Rise
Fall-related head injury deaths in the United States increased by 17% from 2008 to 2017, according to a CDC report.
Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations
Physical Therapy before the Needle for Osteoarthritis of the Knee
Clinical guidelines for the treatment of osteoarthritis of the knee emphasize education, exercise, and (if appropriate) weight loss, rather than the use of drugs or surgery. However, a survey conducted in four European countries showed that these treatments were recommended
William Frankland: the “grandfather of allergy”
bmj;369/apr28_16/m1717/FAF1faPhoto credit: Imperial College LondonWilliam Frankland (“Bill”), the British clinical allergist who transformed global understanding of allergies, has died aged 108. He…
Cancer and COVID-19 — potentially deleterious effects of delaying radiotherapy
Nature Reviews Clinical Oncology, Published online: 27 April 2020; doi:10.1038/s41571-020-0375-1 Radiotherapy can be safely delivered during the coronavirus disease 2019 (COVID-19) pandemic, often through use of hypofractionated regimens, which minimize the number of visits to treatment centres while also avoiding
Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations
Reply to Letter to the Editor regarding “Midtrimester amniotic fluid from healthy pregnancies has no microorganisms using multiple methods of microbiologic inquiry”
Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
Nature Genetics, Published online: 27 April 2020; doi:10.1038/s41588-020-0629-y Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
Utility of balloon aortic valvuloplasty in the transcatheter aortic valve implantation era
Background Balloon aortic valvuloplasty (BAV) has seen renewed interest since the advent of transcatheter aortic valve implantation (TAVI). The study aimed to characterise a contemporary BAV cohort and determinants of clinical outcomes. Methods Patients undergoing BAV at a single tertiary
[Editorial] Isolation and inclusion
The COVID-19 crisis will touch the life of everyone in some way. While viral transmission, incubation times, and care of severely affected patients rightly dominate the news, it is heartening that mental health is given plenty of airtime. Symptoms of
Covid-19: protecting patients in hospital for neurorehabilitation and their therapists
One of the unforeseen challenges for NHS hospitals during the covid-19 epidemic1 is ensuring the safety of patients who would normally be residing in the hospital at this time of year, such as those…
Fetal Interventions in the Setting of COVID-19 Pandemic: Statement from the North American Fetal Therapy Network (NAFTNet)
Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility
The first reported case of coronavirus disease 2019 (Covid-19) in the United States was diagnosed in a resident of Snohomish County, Washington, on January 20, 2020. In late February, an outbreak was identified in a skilled nursing facility in neighboring
Microbial invasion of amniotic cavity:What is the early sign detected by mid-pregnancy genetic amniocentesis?
Audio Interview: Approaches to Covid-19 Vaccines and Antivirals
The rapid spread of SARS-CoV-2, a novel coronavirus that emerged in late 2019, and the resulting Covid-19 disease has been labeled a Public Health Emergency of International Concern by the World Health Organization. What physicians need to know about transmission,
Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility
The first reported case of coronavirus disease 2019 (Covid-19) in the United States was diagnosed in a resident of Snohomish County, Washington, on January 20, 2020. In late February, an outbreak was identified in a skilled nursing facility in neighboring
Mild or Moderate Covid-19
This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors’ clinical recommendations. A 73-year-old
Covid-19 and Kidney Transplantation
To the Editor: Kidney-transplant recipients appear to be at particularly high risk for critical Covid-19 illness due to chronic immunosuppression and coexisting conditions. At Montefiore Medical Center, we identified 36 consecutive adult kidney-transplant recipients who tested positive for Covid-19…
Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee
Osteoarthritis of the knee is a leading cause of disability. Current management is typically limited to the treatment of symptoms until late stages of arthritis lead to knee replacement. Intraarticular glucocorticoid injections are commonly used as a primary treatment for
Capecitabine, Oxaliplatin, Irinotecan, and Bevacizumab Combination Followed by Pazopanib Plus Capecitabine Maintenance for High-Grade Gastrointestinal Neuroendocrine Carcinomas
Objectives: Gastrointestinal neuroendocrine carcinoma (NEC) is a lethal, uncommon, and understudied neoplasm. We present the efficacy and safety of first-line capecitabine (CP), oxaliplatin, irinotecan, and bevacizumab (CAPOXIRI-BEV) combination followed by pazopanib plus CP maintenance therapy in patients with advanced high-grade
Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer
Venous thromboembolism is a common cause of death and complications in patients with cancer. The high risk of recurrent thromboembolism and bleeding in patients with cancer makes anticoagulant treatment challenging, so specific studies involving these patients are necessary. Major guidelines…
Teasing the Immune System to Repair the Heart
Heart failure is a pandemic disease that affects nearly 6 million persons in the United States and 26 million persons worldwide. Despite the development of new drugs and devices for the treatment of heart failure, the outlook for patients with
Effective study design for comparative functional genomics
Nature Reviews Genetics, Published online: 24 April 2020; doi:10.1038/s41576-020-0242-z Comparative studies struggle to balance technical properties with the need to obtain samples from multiple species. The authors argue for extensive record keeping and reporting of metadata to minimize the effect
Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19
The renin–angiotensin–aldosterone system (RAAS) is an elegant cascade of vasoactive peptides that orchestrate key processes in human physiology. Severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and SARS-CoV-2, which have been responsible for the SARS epidemic in 2002 to 2004 and
Asymptomatic Transmission, the Achilles’ Heel of Current Strategies to Control Covid-19
Traditional infection-control and public health strategies rely heavily on early detection of disease to contain spread. When Covid-19 burst onto the global scene, public health officials initially deployed interventions that were used to control severe acute respiratory syndrome (SARS) in
Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility
The first reported case of coronavirus disease 2019 (Covid-19) in the United States was diagnosed in a resident of Snohomish County, Washington, on January 20, 2020. In late February, an outbreak was identified in a skilled nursing facility in neighboring
Rural Matters — Coronavirus and the Navajo Nation
I stand in the parking lot of our emergency department and watch three men on horseback trot up the shoulder of the highway. They wear bandanas over their faces, a traditional accessory here in northwest New Mexico, where spring is
Cerebral Metastases
Figure 1.
[Editorial] India under COVID-19 lockdown
The largest COVID-19 national lockdown in the world has been extended to May 3. As of April 22, India has reported 18 985 confirmed cases and 603 deaths from COVID-19 in 31 states and union territories since its first case on
Transforming ORs into ICUs
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. Treating patients in New
Elizabeth Rang
bmj;369/apr24_10/m1650/FAF1faElizabeth Rang (née Clapham) was born in Oxford where her father, botanist Arthur Roy Clapham FRS, had a teaching post at the university. After the onset of war in 1940,…
Paired maternal and fetal cardiac functional measurements in women with gestational diabetes mellitus at 35-36 weeks’ gestation.
Gestational diabetes mellitus (GDM) is associated with early onset cardiovascular disease and increased incidence of adverse cardiovascular outcomes in mothers and their offspring. Few studies in a limited number of patients have reported subclinical cardiac functional changes in the context
Evaluation and Care of Patients with Diabetic Retinopathy
Vascular complications of diabetes mellitus, including the evolution of the retinal damage known as diabetic retinopathy, have been recognized for centuries. Over the past decade, advances in technology such as retinal imaging and the development of new therapies have dramatically
Infectious Proctitis
Figure 1.
Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19
The renin–angiotensin–aldosterone system (RAAS) is an elegant cascade of vasoactive peptides that orchestrate key processes in human physiology. Severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and SARS-CoV-2, which have been responsible for the SARS epidemic in 2002 to 2004 and
Ten Weeks to Crush the Curve
The President says we are at war with the coronavirus. It’s a war we should fight to win. The economy is in the tank, and anywhere from thousands to more than a million American lives are in jeopardy. Most analyses
Management of Coronary Disease in Patients with Advanced Kidney Disease
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease. The presence of kidney disease has been associated with an increased risk of procedural complications (including renal injury) from coronary angiography and revascularization, and it is
Late-Onset Neonatal Sepsis in a Patient with Covid-19
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations
Hospitalizations and Deaths Associated with EVALI
E-cigarette, or vaping, products were introduced into the U.S. market in 2007, and after their introduction, sales rose rapidly. The aerosols generated by these products typically contain nicotine, flavorings, and additives and can deliver other substances, such as tetrahydrocannabinol (THC),
Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations
Cornelia de Lange syndrome: from molecular diagnosis to therapeutic approach
Cornelia de Lange syndrome (CdLS) is a severe genetic disorder characterised by multisystemic malformations. CdLS is due to pathogenetic variants in NIPBL, SMC1A, SMC3, RAD21 and HDAC8 genes which belong to the cohesin pathway. Cohesin plays a pivotal role in
Covid-19: Doctors should be alert for signs of myocardial injury, says NICE
Doctors treating patients with known or suspected covid-19 should be vigilant for signs of acute myocardial injury, a new rapid guideline from the National Institute for Health and Care Excellence…
Heartbeat: bathing daily is associated with a lower cardiovascular risk
Lifestyle behaviours such as smoking, exercise and diet have received consideration attention as risk factors for cardiovascular disease (CVD) with lifestyle modification now serving as the foundation for primary prevention. Tub bathing is a potentially beneficial behaviour that has received
Highlights from this issue
Good luck everyone As we write this edition of Airwaves we are bracing for the Global COVID-19 Pandemic. Normally we choose a theme with humorous undertones to highlight some of the excellent content that we publish in each monthly edition
Covid-19 and mental health: a transformational opportunity to apply an evidence-based approach to clinical practice and research
Covid-19 was first recognised in December 2019 and is now posing critical challenges for public health, clinical research and medical care worldwide.1 The covid-19 outbreak has rapidly evolved into a fast-moving global pandemic, with world updates produced on a daily
Finally, a Successful Randomized Trial for GVHD
For the past half century, we have been attempting to understand graft-versus-host disease (GVHD), at times randomly and more recently in a methodical manner. It became clear early on that GVHD, especially acute GVHD (which occurs primarily in the first
Innovations in research and clinical care using patient‐generated health data
Abstract Patient‐generated health data (PGHD), or health‐related data gathered from patients to help address a health concern, are used increasingly in oncology to make regulatory decisions and evaluate quality of care. PGHD include self‐reported health and treatment histories, patient‐reported outcomes
COVID-19 in Pregnancy: Consider Thromboembolic Disorders and Thromboprophylaxis
Secondary prevention and outcomes in outpatients with coronary artery disease, atrial fibrillation or heart failure: a focus on disease overlap
Objective To assess secondary prevention and outcomes in patients with chronic coronary artery disease (CAD), atrial fibrillation (AF) and heart failure (HF), focusing on disease overlap. Methods We analysed the data of 10 517 outpatients with a diagnosis of CAD,
French Pandemic Resistance
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. “It is as if
[Editorial] Obesity-related stigma—hiding in plain sight
The fact that viruses do not discriminate, people do, has become crystal clear during the coronavirus disease 2019 (COVID-19) pandemic. Health-associated stigma, or the negative association between a person or group of people who share certain characteristics and a specific
“Starry Sky” Appearance from Multiple Biliary Hamartomas
Figure 1.
Managing Stable Ischemic Heart Disease
The preferred contemporary approach to the management of stable ischemic heart disease, also referred to as chronic coronary syndrome, is not well defined. Two strategies are commonly used. The conservative strategy uses guideline-based medical therapy, including antianginal drugs as well
Flipping the Switch: Homeostatic Tuning of Chandelier Synapses Follows Developmental Changes in GABA Polarity
Homeostatic plasticity rules are well described for glutamatergic synapses but less clear for GABAergic synapses. In this issue of Neuron, Pan-Vazquez et al. (2020) leverage the precise targeting of chandelier-to-pyramidal cell connectivity to understand how homeostatic plasticity regulates GABAergic synapses, showing
[Editorial] The fight against stroke must go on
Rio de Janeiro, Brazil, recently hosted what will probably be one of the last in-person neurology conferences for some time. The first Global Stroke Alliance meeting, held on March 11–13, 2020, ended a day early because of the COVID-19 pandemic,
Guillain–Barré Syndrome Associated with SARS-CoV-2
To the Editor: From February 28 through March 21, 2020, in three hospitals in northern Italy, we examined five patients who had Guillain–Barré syndrome after the onset of coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome
[Editorial] Pandemic school closures: risks and opportunities
The novel coronavirus disease 2019 (COVID-19) has swept across 210 countries and territories with over 1·2 million cases and 67 594 deaths reported by April 6, 2020. Most countries have implemented social distancing measures to curb the spread of infection and
Promising Evidence of Antipsychotic Efficacy without Dopamine D2-Receptor Binding
A French surgeon, Henri Laborit, discovered the first antipsychotic drug, chlorpromazine (Thorazine), in 1952 while experimenting with compounds to enhance anesthesia. Since then, antipsychotic drugs have helped transform the lives of people with schizophrenia, allowing most to live in the…
French Pandemic Resistance
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. “It is as if
Physical Therapy before the Needle for Osteoarthritis of the Knee
Clinical guidelines for the treatment of osteoarthritis of the knee emphasize education, exercise, and (if appropriate) weight loss, rather than the use of drugs or surgery. However, a survey conducted in four European countries showed that these treatments were recommended
Maternity care inquiry expands to almost 1200 cases
An inquiry into childbirth cases of “serious and potentially serious concern” at Shrewsbury and Telford Hospitals NHS Trust has expanded to 1170 cases, putting it on course to be one of the biggest…
From barefoot hunter gathering to shod pavement pounding. Where to from here? A narrative review
Understanding the current prevalence and incidence of running injury from an evolutionary perspective has sparked great debate. Proponents of the evolutionary approach to understanding running injury suggest that humans ran using less injurious biomechanics prior to the invention of cushioned
KTE-X19 active in MCL
Nature Reviews Clinical Oncology, Published online: 21 April 2020; doi:10.1038/s41571-020-0373-3 KTE-X19 active in MCL
A framework for an evidence-based gene list relevant to autism spectrum disorder
Nature Reviews Genetics, Published online: 21 April 2020; doi:10.1038/s41576-020-0231-2 A curated list of genes that are relevant to autism spectrum disorder (ASD) would greatly benefit clinical genetic testing. This Roadmap discusses the need for an evidence-based framework for gene curation
Specialist valve clinic in a cardiac centre: 10-year experience
Aims Guidelines recommend specialist valve clinics as best practice for the assessment and conservative management of patients with heart valve disease. However, there is little guidance on how to set up and organise a clinic. The aim of this study
Norman K. Hollenberg, MD PhD (1936–2020)A world leader in hypertension and nephrology has been lost to research in January 2020
End Obesity Stigma, International Panel Urges
To bridge the gap between damaging beliefs about obesity and the condition’s scientific underpinnings, an international panel of experts has issued a consensus statement condemning weight stigma.
What will we learn from covid-19? That we live in an uncertain world
Salisbury asks what we might learn from the covid-19 pandemic.1 At times like this, we have to make it up as we go along. There isn’t time to go through the hoops of obtaining official permission to…
Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD
Nature Reviews Clinical Oncology, Published online: 20 April 2020; doi:10.1038/s41571-020-0356-4 Haematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for several haematological malignancies. Improvements in HSCT methodologies have considerably reduced treatment-related morbidity and mortality, thus broadening eligibility and placing
Liability threshold modeling of case–control status and family history of disease increases association power
Nature Genetics, Published online: 20 April 2020; doi:10.1038/s41588-020-0613-6 A new association method using both case–control status and family history (LT-FH) greatly increases association power in analyses of 12 diseases from the UK Biobank.
The Untold Toll — The Pandemic’s Effects on Patients without Covid-19
In late March, Zoran Lasic, an interventional cardiologist at Jamaica Hospital Medical Center and Lenox Hill Hospital in New York, was finishing afternoon clinic when he was approached by a nurse colleague seeking his advice. Her husband — a 56-year-old
Covid-19: We need to be open about rationing ventilators
Why aren’t we being more explicit about the ever changing problems around ventilators?1234 The Italians warned us.5 The New England Journal of Medicine said that volunteers should “shoulder the…
Highlights from this issue
Longitudinal changes in axial length in high myopia: 4-year prospective study (see page 600) A persistent increase in axial length was observed over 4 years in adult myopic patients, which correlated with initial axial axial length. Longitudinal changes in the
Autopsy in suspected COVID-19 cases
The severe acute respiratory syndrome (SARS)-coronavirus-2 (CoV-2) outbreak in Wuhan, China has now spread to many countries across the world including the UK with an increasing death toll. This will inevitably lead to an increase in the number of suspected
It is all about the knee! A focus on sportswomen and sports physiotherapy at #sportfisio2020 in Bern
The Swiss Sports Physiotherapy Association (SSPA) will hold its 18th annual conference on November 13th, 2020 in Bern, capital of Switzerland and home of this event since 2005. The goal of SSPA has always been to organise a high-quality scientific
How to calculate the risk of preeclampsia in women with a history of positive screening
Sweet’s Syndrome
Figure 1.
The Untold Toll — The Pandemic’s Effects on Patients without Covid-19
In late March, Zoran Lasic, an interventional cardiologist at Jamaica Hospital Medical Center and Lenox Hill Hospital in New York, was finishing afternoon clinic when he was approached by a nurse colleague seeking his advice. Her husband — a 56-year-old
Clinical Characteristics of Covid-19 in New York City
To the Editor: The world is in the midst of the coronavirus disease 2019 (Covid-19) pandemic, and New York City has emerged as an epicenter. Here, we characterize the first 393 consecutive patients with Covid-19 who were admitted to two
Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee
Osteoarthritis of the knee is a leading cause of disability. Current management is typically limited to the treatment of symptoms until late stages of arthritis lead to knee replacement. Intraarticular glucocorticoid injections are commonly used as a primary treatment for
Soft‐tissue sarcoma in adults: An update on the current state of histiotype‐specific management in an era of personalized medicine
Abstract Soft‐tissue sarcomas (STS) are rare tumors that account for 1% of all adult malignancies, with over 100 different histologic subtypes occurring predominately in the trunk, extremity, and retroperitoneum. This low incidence is further complicated by their variable presentation, behavior,
Reply to Li re: caution on bias
ST-Segment Elevation in Patients with Covid-19 — A Case Series
To the Editor: Myocardial injury with ST-segment elevation has been observed in patients with coronavirus disease 2019 (Covid-19). Here, we describe our experience in the initial month of the Covid-19 outbreak in New York City. Patients with confirmed Covid-19 who
Covid-19 and Immunity in Aging Populations — A New Research Agenda
The race is on throughout the world to develop Covid-19 vaccines and therapeutics and end a pandemic that threatens to infect a substantial portion of the planet’s population and perhaps kill millions of people, especially older adults. As billions of
Case 11-2020: A 37-Year-Old Man with Facial Droop, Dysarthria, and Kidney Failure
Presentation of Case. Dr. Sarimer Sanchez (Medicine): A 37-year-old man was admitted to this hospital because of a facial droop, dysarthria, and kidney failure. The patient had been well until 1 week before admission, when weakness of the right arm
Guillain–Barré Syndrome Associated with SARS-CoV-2
To the Editor: From February 28 through March 21, 2020, in three hospitals in northern Italy, we examined five patients who had Guillain–Barré syndrome after the onset of coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome
A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia
Antipsychotic drugs have produced clinical benefit in patients with psychosis presumably through antagonist or partial agonist effects at postsynaptic dopamine D2 receptors. The efficacy of D2-receptor–binding antipsychotics is often limited in the treatment of negative symptoms (e.g. blunted…
Roles and mechanisms of alternative splicing in cancer — implications for care
Nature Reviews Clinical Oncology, Published online: 17 April 2020; doi:10.1038/s41571-020-0350-x Alternative splicing enables the regulated generation of multiple mRNA and protein products from a single gene. This Review outlines the splicing process and its alterations in cancer before highlighting related
The Untold Toll — The Pandemic’s Effects on Patients without Covid-19
In late March, Zoran Lasic, an interventional cardiologist at Jamaica Hospital Medical Center and Lenox Hill Hospital in New York, was finishing afternoon clinic when he was approached by a nurse colleague seeking his advice. Her husband — a 56-year-old
Soft‐tissue sarcoma in adults: An update on the current state of histiotype‐specific management in an era of personalized medicine
Abstract Soft‐tissue sarcomas (STS) are rare tumors that account for 1% of all adult malignancies, with over 100 different histologic subtypes occurring predominately in the trunk, extremity, and retroperitoneum. This low incidence is further complicated by their variable presentation, behavior,
Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China
To the Editor: Despite the large and rapidly rising number of cases of coronavirus disease 2019 (Covid-19) and resulting deaths, there are limited data about the clinical characteristics of pregnant women with the disease. We extracted information regarding epidemiologic, clinical,
COVID19 during pregnancy: a systematic review of reported cases.
to conduct a systematic review of the outcomes reported for pregnant patients with COVID 19.
ST-Segment Elevation in Patients with Covid-19 — A Case Series
To the Editor: Myocardial injury with ST-segment elevation has been observed in patients with coronavirus disease 2019 (Covid-19). Here, we describe our experience in the initial month of the Covid-19 outbreak in New York City. Patients with confirmed Covid-19 who
Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol
The binding of proprotein convertase subtilisin–kexin type 9 (PCSK9) in the circulation by monoclonal antibodies reduces both low-density lipoprotein (LDL) cholesterol levels and the incidence of cardiovascular events. Inclisiran, a small interfering RNA (siRNA) therapeutic agent, reduces hepatic…
“Starry Sky” Appearance from Multiple Biliary Hamartomas
Figure 1.
In Pursuit of PPE
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. As a chief physician
ST-Segment Elevation in Patients with Covid-19 — A Case Series
To the Editor: Myocardial injury with ST-segment elevation has been observed in patients with coronavirus disease 2019 (Covid-19). Here, we describe our experience in the initial month of the Covid-19 outbreak in New York City. Patients with confirmed Covid-19 who
Guillain–Barré Syndrome Associated with SARS-CoV-2
To the Editor: From February 28 through March 21, 2020, in three hospitals in northern Italy, we examined five patients who had Guillain–Barré syndrome after the onset of coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome
Covid-19: Government cannot say whether NHS will run out of protective gowns this weekend
NHS staff may not have enough protective gowns this weekend because of a severe shortage in supplies, the health secretary has admitted.Matt Hancock told MPs on the health select committee on 17…
Highlights from this issue
Sepia In the pre-internet era, in the days of non-digital photography, most families owned and treasured their albums of pictures. Often arranged chronologically by year, each series of collections defined lives. Unlike today’s ubiquitous smart phone compilations hung out to
Highlights from this issue
Perinatal care for extremely preterm infants As I write, at the end of March, we are in lockdown. Deaths due to Covid-19 are rising at the rate predicted by epidemiological modelling, and there is enormous tension about whether intensive care
Presidents musings
Sometimes we need reminding who we are and what our objectives are. BASHH—The British Association for Sexual Health and HIV—is the biggest organisation of its kind worldwide. Its objectives are To promote, encourage and improve the study and practice of
Meeting the mark by 2020: country progress toward FP2020 and UNAIDS HIV targets
Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-901 targets aim to ensure that 90% of people are tested for HIV, and that 90% of those testing positive for HIV receive antiretroviral therapy (ART) and achieve viral suppression by 2020. Those
Benefit from pemigatinib in cholangiocarcinoma
Nature Reviews Clinical Oncology, Published online: 16 April 2020; doi:10.1038/s41571-020-0369-z Benefit from pemigatinib in cholangiocarcinoma
Epidemiologic and Survival Trends in Amyloidosis, 1987–2019
To the Editor: Amyloidosis is a group of rare disorders caused by deposition of misfolded proteins as insoluble fibrils, which leads to progressive multiorgan failure and death. The past 30 years have seen remarkable advances in diagnostic imaging, more accurate
An Uncomplicated Delivery in a Patient with Covid-19 in the United States
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations
Management of early pregnancy loss with mifepristone and misoprostol: clinical predictors of success from a randomized trial
Early pregnancy loss (EPL) is a common event in the first trimester, occurring in 15-20% of recognized pregnancies. A common evidence-based medical regimen for EPL management uses the prostaglandin E1 analogue misoprostol 800 mcg self-administered vaginally. The clinical utility of
Epidemiologic and Survival Trends in Amyloidosis, 1987–2019
To the Editor: Amyloidosis is a group of rare disorders caused by deposition of misfolded proteins as insoluble fibrils, which leads to progressive multiorgan failure and death. The past 30 years have seen remarkable advances in diagnostic imaging, more accurate
Harnessing genomics to fast-track genetic improvement in aquaculture
Nature Reviews Genetics, Published online: 16 April 2020; doi:10.1038/s41576-020-0227-y Genetic improvement of production traits in aquaculture has great potential to help meet the rising seafood demands driven by human population growth. The authors review how genomics is being applied to
Immune Thrombocytopenic Purpura in a Patient with Covid-19
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations
Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol
The binding of proprotein convertase subtilisin–kexin type 9 (PCSK9) in the circulation by monoclonal antibodies reduces both low-density lipoprotein (LDL) cholesterol levels and the incidence of cardiovascular events. Inclisiran, a small interfering RNA (siRNA) therapeutic agent, reduces hepatic…
Sweet’s Syndrome
Figure 1.
An Uncomplicated Delivery in a Patient with Covid-19 in the United States
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations
Cochlear Implantation in Adults
Hearing loss is one of the most prevalent and undertreated disabilities worldwide. Often simply considered one of the stigmata of senescence, hearing loss has become increasingly recognized as an important health issue that may lead to increased risks of social
Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1
To the Editor: A novel human coronavirus that is now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (formerly called HCoV-19) emerged in Wuhan, China, in late 2019 and is now causing a pandemic. We analyzed the aerosol and surface
Promising Evidence of Antipsychotic Efficacy without Dopamine D2-Receptor Binding
A French surgeon, Henri Laborit, discovered the first antipsychotic drug, chlorpromazine (Thorazine), in 1952 while experimenting with compounds to enhance anesthesia. Since then, antipsychotic drugs have helped transform the lives of people with schizophrenia, allowing most to live in the…
COVID-19: Navigating Uncertainties Together
The COVID-19 outbreak, caused by the newly described viral pathogen SARS-CoV-2, is having a devastating effect on the scientific community. China has been battling the virus for months and provides a bellwether for the impact we are starting to experience
[Editorial] COVID-19 in the USA: a question of time
With more than 600 000 confirmed cases and close to 27 000 deaths, the USA has become the current centre of the global coronavirus disease 2019 (COVID-19) pandemic. Fewer than 3 months have elapsed since the first severe acute respiratory syndrome coronavirus
Promising Evidence of Antipsychotic Efficacy without Dopamine D2-Receptor Binding
A French surgeon, Henri Laborit, discovered the first antipsychotic drug, chlorpromazine (Thorazine), in 1952 while experimenting with compounds to enhance anesthesia. Since then, antipsychotic drugs have helped transform the lives of people with schizophrenia, allowing most to live in the…
Covid-19: Coronavirus was first described in The BMJ in 1965
The first description of human coronavirus—a family of viruses that now includes SARS-CoV-2, the cause of the current covid-19 pandemic—was published in The BMJ in 1965.The research, led by…
Inflammatory and non-inflammatory triggers of acute coronary syndromes
Inflammation plays an important role in the pathogenesis of acute coronary syndromes (ACS).1 However, ACS include different clinical conditions that can present as an acute cardiac event, and it may also be seen in various clinical settings independent of underlying
Provision of cancer care during the COVID-19 pandemic
Nature Reviews Clinical Oncology, Published online: 15 April 2020; doi:10.1038/s41571-020-0370-6 Health-care services are rapidly transforming their organization and workforce in response to the coronavirus disease 2019 (COVID-19) pandemic. These changes, and a desire to mitigate infection risk, are having profound
Immune Thrombocytopenic Purpura in a Patient with Covid-19
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations
Pregnant versus non-pregnant SARS-CoV-2 and COVID-19 Hospital Admissions: The first 4 weeks in New York
Better together
Nature Reviews Genetics, Published online: 15 April 2020; doi:10.1038/s41576-020-0238-8 Just as humans thrive from being part of a community, genetics and genomics benefit from interdisciplinary collaboration and knowledge integration.
Neurologic Features in Severe SARS-CoV-2 Infection
To the Editor: We report the neurologic features in an observational series of 58 of 64 consecutive patients admitted to the hospital because of acute respiratory distress syndrome (ARDS) due to Covid-19. The patients received similar evaluations by intensivists in
Droplets and Aerosols in the Transmission of SARS-CoV-2
To the Editor: Anfinrud et al. now illustrate in the Journal how liquid droplets exhaled during speech can linger in the air. The large particles to which they refer remain airborne only briefly before settling because of gravity; these particles
Neurologic Features in Severe SARS-CoV-2 Infection
To the Editor: We report the neurologic features in an observational series of 58 of 64 consecutive patients admitted to the hospital because of acute respiratory distress syndrome (ARDS) due to Covid-19. The patients received similar evaluations by intensivists in
Neurologic Features in Severe SARS-CoV-2 Infection
To the Editor: We report the neurologic features in an observational series of 58 of 64 consecutive patients admitted to the hospital because of acute respiratory distress syndrome (ARDS) due to Covid-19. The patients received similar evaluations by intensivists in
Neurologic Features in Severe SARS-CoV-2 Infection
To the Editor: We report the neurologic features in an observational series of 58 of 64 consecutive patients admitted to the hospital because of acute respiratory distress syndrome (ARDS) due to Covid-19. The patients received similar evaluations by intensivists in
Covid-19: UK government is urged to publish daily care home deaths as it promises more testing
The UK government’s pledge to boost covid-19 testing for staff in care homes must be delivered as quickly as possible and be matched with greater transparency over the number of residents dying from…
Identifying patterns of cognitive deficits: the path to better outcomes after stroke
Today cognitive models are bound to impact on neurorehabilitation and define patient profiles, which respond to specific therapeutic interventions The seminal paper by Tatemichi and colleagues1 sets a cornerstone for the diagnosis of poststroke cognitive impairment. The authors documented the
The COVID-19 pandemic: major risks to healthcare and other workers on the front line
Since the first cluster of cases of coronavirus disease 2019 (COVID-19) infection was reported in Wuhan, China at the end of December 2019, reporting of cases has spread widely over the past 3 months to become a pandemic of crisis
Tummy Time for ILC2
Little is known about host-microbiota interactions regulating anti-microbial immunity in the stomach. In this issue, Satoh-Takayama et al. describe an additional immune mechanism involving innate lymphoid cells type 2 (ILC2), which controls infection with Helicobacter pylori, a bacterium associated with inflammation
Early chromatin dynamics
Nature Reviews Genetics, Published online: 14 April 2020; doi:10.1038/s41576-020-0237-9 A study in Nature provides new insights into chromatin dynamics and allele-specific gene expression regulation during early mouse embryogenesis.
The Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Germany
During the last 10 years, Hannover has evolved as a hotspot on the map of non-coding RNAs (ncRNAs) in cardiovascular research when considering Germany, Europe, and even the global view. This is mainly due to a unit of the Hannover Medical
AI for the Eye — Automated Assistance for Clinicians Screening for Papilledema
Accurate assessment of the optic-nerve head, the optic disk, by funduscopy is an important, cost-effective, and noninvasive diagnostic tool for a variety of ocular, neurologic, and inflammatory conditions. Unfortunately, reliable funduscopic assessment is challenging for clinicians working with…
Not Dying Alone — Modern Compassionate Care in the Covid-19 Pandemic
Dr. Wakam: I’m 5 hours into my ICU shift at a community hospital in Detroit when the results of another arterial blood gas return. My patient has been hospitalized for 3 days and is Covid-19–positive. Over the past 12 hours,
Not Dying Alone — Modern Compassionate Care in the Covid-19 Pandemic
Dr. Wakam: I’m 5 hours into my ICU shift at a community hospital in Detroit when the results of another arterial blood gas return. My patient has been hospitalized for 3 days and is Covid-19–positive. Over the past 12 hours,
Self-Reported Cognitive Function and Mental Health Diagnoses among Former Professional American-Style Football Players
Journal of Neurotrauma, Volume 37, Issue 8, Page 1021-1028, April 15, 2020.
AI for the Eye — Automated Assistance for Clinicians Screening for Papilledema
Accurate assessment of the optic-nerve head, the optic disk, by funduscopy is an important, cost-effective, and noninvasive diagnostic tool for a variety of ocular, neurologic, and inflammatory conditions. Unfortunately, reliable funduscopic assessment is challenging for clinicians working with…
US-Acquired Chagas Disease Case Found After Blood Donation
A Missouri woman whose Chagas disease was diagnosed through screening when she donated blood is likely the state’s first autochthonous case, according to a CDC report.
Mental Health and the Covid-19 Pandemic
Uncertain prognoses, looming severe shortages of resources for testing and treatment and for protecting responders and health care providers from infection, imposition of unfamiliar public health measures that infringe on personal freedoms, large and growing financial losses, and conflicting…
Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs
Examination of the optic nerves is a fundamental component of the clinical examination, but direct ophthalmoscopy is usually avoided or poorly performed by general physicians and nonophthalmic specialists. Detection of papilledema, defined as optic-nerve edema from intracranial hypertension, and…
Physical Therapy before the Needle for Osteoarthritis of the Knee
Clinical guidelines for the treatment of osteoarthritis of the knee emphasize education, exercise, and (if appropriate) weight loss, rather than the use of drugs or surgery. However, a survey conducted in four European countries showed that these treatments were recommended
Covid-19: Third of surgeons do not have adequate PPE, royal college warns
Over half of surgeons and trainees in the UK have experienced shortages of personal protective equipment (PPE) in the past month, the Royal College of Surgeons of England has found.Meanwhile, the BMA…
Heartbeat: smartwatch devices for detection of atrial fibrillation
Smartwatch-based devices for monitoring heart rate and rhythm are increasingly popular with patients but many physicians are concerned about accuracy for detection of atrial fibrillation (AF). In a prospective multi-centre study, Rajakariar and colleagues1 compared automated smartwatch diagnosis of AF
Changing for a Better Future
Since its inception in 2002, Cancer Cell has established itself as a destination for the most important cancer research. I am honored to be given the responsibility to take the helm and steer it to an even brighter future. As
Universal Screening for SARS-CoV-2 in Women Admitted for Delivery
To the Editor: In recent weeks, Covid-19 has rapidly spread throughout New York City. The obstetrical population presents a unique challenge during this pandemic, since these patients have multiple interactions with the health care system and eventually most are admitted
Cutaneous T-cell lymphoma of the vulva
Identifying genetic variants underlying phenotypic variation in plants without complete genomes
Nature Genetics, Published online: 13 April 2020; doi:10.1038/s41588-020-0612-7 Application of a new k-mer-based genome-wide association approach to 2,000 phenotypes in Arabidopsis thaliana, tomato and maize detects new associations with structural variants and with regions missing from reference genomes.
Selumetinib in Children with Inoperable Plexiform Neurofibromas
Neurofibromatosis type 1, an autosomal dominant genetic disorder characterized by multiple progressive tumor and nontumor manifestations, has limited treatment options. In patients with the disorder, dysfunction of the guanosine triphosphatase–activating protein neurofibromin leads to…
Managing Stable Ischemic Heart Disease
The preferred contemporary approach to the management of stable ischemic heart disease, also referred to as chronic coronary syndrome, is not well defined. Two strategies are commonly used. The conservative strategy uses guideline-based medical therapy, including antianginal drugs as well
They Call Us and We Go
Do you remember a time before PPE and ventilator shortages; virtual grand rounds and telemedicine “exams”; elbow bumps and then the avoidance, even, of elbows? A scene that keeps coming back to me during these sleepless nights occurred the first
Alpha1-Antitrypsin Deficiency
Alpha1-antitrypsin (AAT) deficiency is one of the most common genetic diseases. Most persons carry two copies of the wild-type M allele of SERPINA1, which encodes AAT, and have normal circulating levels of the protein. Ninety-five percent of severe cases of
Case 11-2020: A 37-Year-Old Man with Facial Droop, Dysarthria, and Kidney Failure
Presentation of Case. Dr. Sarimer Sanchez (Medicine): A 37-year-old man was admitted to this hospital because of a facial droop, dysarthria, and kidney failure. The patient had been well until 1 week before admission, when weakness of the right arm
Soft‐tissue sarcoma in adults: An update on the current state of histiotype‐specific management in an era of personalized medicine
Abstract Soft‐tissue sarcomas (STS) are rare tumors that account for 1% of all adult malignancies, with over 100 different histologic subtypes occurring predominately in the trunk, extremity, and retroperitoneum. This low incidence is further complicated by their variable presentation, behavior,
A genome-wide association study of polycystic ovary syndrome identified from electronic health records
Polycystic ovary syndrome is the most common endocrine disorder affecting women of reproductive age. A number of criteria have been developed for clinical diagnosis of polycystic ovary syndrome, with the Rotterdam criteria being the most inclusive. Evidence suggests that polycystic
Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee
Osteoarthritis of the knee is a leading cause of disability. Current management is typically limited to the treatment of symptoms until late stages of arthritis lead to knee replacement. Intraarticular glucocorticoid injections are commonly used as a primary treatment for
Sociodemographic Characteristics of Early Marriage Cases According to The Civil Code: A Single Center Study
Objective: According to the Turkish Civil Code, men and women cannot marry unless they are 17 years old. However, the judge may allow the marriage of men or women who have reached the age of 16 for extraordinary and so
Postmortem Heart School
Introduction: Autopsy is the first and only choice in determining cause of death in sudden cardiac death. An updated guideline has been published by the AssociationforEuropean Cardiovascular Pathology for describing sudden death/ sudden cardiac death, autopsy procedure and laboratory tests
Sociodemographic and Clinical Features of Children Dragged To Crime in Sivas Province
Objective: In this study, it was aimed to investigate the sociodemographic characteristics, types of crime and intelligence levels of delinquent children and to determine the reasons that push these children into crime. Materials and Methods: The data of 86 cases
Investigation of Sociodemographic Characteristics, Work Life and Mental Health in Mobbing Victims: Case Series
Objective: The aim of this study to evaluate mobbing victims who resorted to outpatient clinics of Department of Forensic Medicine at İstanbul University Faculty of Medicine. 34 workers who were exposed to mobbing were evaluated by clinical interview and social
Forensic Medical Evaluation of the Near Hanging: Case series
Objective: The aim was to discuss the sociodemographic characteristics of the near hanging cases, the complications of hanging, the criteria of life hazard. Materials and Methods: We present 9 cases who survive after suicide attempt by hanging from the Forensic
Care of the Pregnant Woman with COVID-19 in Labor and Delivery: Anesthesia, Emergency cesarean delivery, Differential diagnosis in the acutely ill parturient, Care of the newborn, and Protection of the healthcare personnel
Selumetinib in Children with Inoperable Plexiform Neurofibromas
Neurofibromatosis type 1, an autosomal dominant genetic disorder characterized by multiple progressive tumor and nontumor manifestations, has limited treatment options. In patients with the disorder, dysfunction of the guanosine triphosphatase–activating protein neurofibromin leads to…
Initial Invasive or Conservative Strategy for Stable Coronary Disease
The goals of treating patients with stable coronary disease are to reduce their risk of death and ischemic events and to improve their quality of life. All patients with coronary disease should be treated with guideline-based medical therapy (hereafter, medical
Compassionate Use of Remdesivir for Patients with Severe Covid-19
Since the first cases were reported in December 2019, infection with the severe acute respiratory coronavirus 2 (SARS-CoV-2) has become a worldwide pandemic. Covid-19 — the illness caused by SARS-CoV-2 — is overwhelming health care systems globally. The symptoms of
Compassionate Use of Remdesivir for Patients with Severe Covid-19
Since the first cases were reported in December 2019, infection with the severe acute respiratory coronavirus 2 (SARS-CoV-2) has become a worldwide pandemic. Covid-19 — the illness caused by SARS-CoV-2 — is overwhelming health care systems globally. The symptoms of
Physical Therapy before the Needle for Osteoarthritis of the Knee
Clinical guidelines for the treatment of osteoarthritis of the knee emphasize education, exercise, and (if appropriate) weight loss, rather than the use of drugs or surgery. However, a survey conducted in four European countries showed that these treatments were recommended
Sociodemographic Characteristics of Early Marriage Cases According to The Civil Code: A Single Center Study
Objective: According to the Turkish Civil Code, men and women cannot marry unless they are 17 years old. However, the judge may allow the marriage of men or women who have reached the age of 16 for extraordinary and so
Postmortem Heart School
Introduction: Autopsy is the first and only choice in determining cause of death in sudden cardiac death. An updated guideline has been published by the AssociationforEuropean Cardiovascular Pathology for describing sudden death/ sudden cardiac death, autopsy procedure and laboratory tests
Sociodemographic and Clinical Features of Children Dragged To Crime in Sivas Province
Objective: In this study, it was aimed to investigate the sociodemographic characteristics, types of crime and intelligence levels of delinquent children and to determine the reasons that push these children into crime. Materials and Methods: The data of 86 cases
Investigation of Sociodemographic Characteristics, Work Life and Mental Health in Mobbing Victims: Case Series
Objective: The aim of this study to evaluate mobbing victims who resorted to outpatient clinics of Department of Forensic Medicine at İstanbul University Faculty of Medicine. 34 workers who were exposed to mobbing were evaluated by clinical interview and social
Forensic Medical Evaluation of the Near Hanging: Case series
Objective: The aim was to discuss the sociodemographic characteristics of the near hanging cases, the complications of hanging, the criteria of life hazard. Materials and Methods: We present 9 cases who survive after suicide attempt by hanging from the Forensic
Single-institute comparison of the efficacy of systemic chemotherapy for oesophagogastric junction adenocarcinoma and stomach adenocarscinoma in a metastatic setting
Background Different approaches are used to treat resectable tumours in patients having adenocarcinoma at the oesophagogastrointestinal junction (EGJ) or in the stomach. However, there is limited information about treatment efficacy for patients at metastatic stage. A recent molecular analysis of
Informative censoring — a neglected cause of bias in oncology trials
Nature Reviews Clinical Oncology, Published online: 09 April 2020; doi:10.1038/s41571-020-0368-0 Informative censoring occurs when progression-free survival is the primary end point of a randomized clinical trial and unequal patient dropout is observed between treatment arms owing to poorer tolerance of
Selumetinib in Children with Inoperable Plexiform Neurofibromas
Neurofibromatosis type 1, an autosomal dominant genetic disorder characterized by multiple progressive tumor and nontumor manifestations, has limited treatment options. In patients with the disorder, dysfunction of the guanosine triphosphatase–activating protein neurofibromin leads to…
Hospital Mergers and Conscience-Based Objections — Growing Threats to Access and Quality of Care
Since 2001, the number of Catholic hospitals in the United States has grown by 22%. One in six U.S. hospital beds is now affiliated with a Catholic hospital system. As nonreligiously affiliated rural hospitals merge with Catholic corporations (in some
Balancing the Effect of Leukotrienes in Asthma
Inflammation and its timely resolution represent a vital physiologic response to infection, injury, and “sterile provocation” by endogenous stimuli. There is a growing appreciation that the initiation, progression, and resolution of inflammation and the return of tissue to its original
Frey’s Syndrome
Figure 1.
Case 11-2020: A 37-Year-Old Man with Facial Droop, Dysarthria, and Kidney Failure
Presentation of Case. Dr. Sarimer Sanchez (Medicine): A 37-year-old man was admitted to this hospital because of a facial droop, dysarthria, and kidney failure. The patient had been well until 1 week before admission, when weakness of the right arm
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