To Scar or Not to Scar

Most human skin wounds heal with scarring; some heal with hypertrophic scarring (Fig. 1A), and a small number heal with keloids from fibroblast hyperplasia (Fig. 1B). Scars — especially those resulting from thermal and chemical burns — can lead to

Real-world Patterns of Adjuvant Chemotherapy Following Neoadjuvant Chemoradiation for Patients With Resected Rectal Adenocarcinoma

Objective: The objective of this study was to analyze patterns of adjuvant chemotherapy among patients with resected rectal adenocarcinomas following neoadjuvant chemoradiation and surgical resection. Methods: Alberta Cancer Registry and other provincial electronic medical registries (2004 to 2018) identified patients

Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells

Nature Genetics, Published online: 22 July 2021; doi:10.1038/s41588-021-00897-w The oncohistone H3.3-K27M decreases chromatin accessibility and H3K27ac at some active enhancers and downregulates nearby neurodevelopmental genes, while increasing transcriptional repression of a subset of PRC2-bound neurodevelopment genes.

IF

When we took the editorship of Evidence-Based Mental Health (EBMH) at the end of 2013, we set two main objectives: to promote and embed an evidence-based medicine (EBM) approach into daily mental health clinical practice, and to get an impact

Effectiveness of high-intensity interval training for weight loss in adults with obesity: a randomised controlled non-inferiority trial

Introduction Obesity treatment guidelines suggest moderate-intensity continuous training (MICT), but the patient’s compliance to this indication remains low. High-intensity interval training (HIIT) is a time sparing training mode whose metabolic effects are not clear. This study aimed to determine whether

Freedom of Speech

Of the many functions delegated to the human nervous system, perhaps none is more essentially human than the ability to express one’s thoughts. For persons with severe speech and motor impairments, restoration of the ability to communicate even simple needs

Freedom of Speech

Of the many functions delegated to the human nervous system, perhaps none is more essentially human than the ability to express one’s thoughts. For persons with severe speech and motor impairments, restoration of the ability to communicate even simple needs

Associations between physical activity, sedentary behaviour and left ventricular structure and function from the Echocardiographic Study of Latinos (ECHO-SOL)

Objective The cross-sectional association between accelerometer-measured physical activity (PA), sedentary behaviour (SB) and cardiac structure and function is less well described. This study’s primary aim was to compare echocardiographic measures of cardiac structure and function with accelerometer measured PA and

Hematuria in Adults

Visible (macroscopic) hematuria, documented since ancient times, is striking, particularly when there is no prior event, such as trauma, dysuria due to cystitis, or flank pain with passage of a kidney stone, to provide a clear explanation. In contrast, nonvisible

Understanding the diverse sexual repertoires of men who have sex with men, trans and gender-diverse groups is important for sexually transmitted infection prevention

The sexual repertoires of men who have sex with men (MSM), transgender (trans) and gender-diverse groups are poorly understood despite their disproportionate rates of sexually transmitted infections (STIs). The interrelated landscapes and syndemics of the social and sexual behaviour of

Correction: Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial–mesenchymaltransition

Zhu W, Cai M, Tong Z, et al. Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial—mesenchymaltransition. Gut 2012;61:562–75. doi:10.1136/gutjnl-2011-300207 The representative images of SW116-EIF5A2-sic-myc cells in Migration assay of Figure 6C lower

Oncogenesis by phase separation

Nature Reviews Genetics, Published online: 09 July 2021; doi:10.1038/s41576-021-00396-y A new study by Ahn et al. shows that chimeric proteins containing intrinsically disordered regions mediate oncogenesis by inducing liquid–liquid phase separation and thereby affecting chromatin conformation and transcription.

Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease

Nature Genetics, Published online: 08 July 2021; doi:10.1038/s41588-021-00894-z An integrative analysis of single-nucleus assay for transposase-accessible chromatin with sequencing and RNA sequencing in normal and Alzheimer’s disease brain tissue identifies cell-type-specific cis-regulatory elements and candidate target genes at disease-associated loci.

ESCRTs got your Bac!

ESCRT-III proteins, which form filaments that deform, bud, and sever membranes, are found in eukaryotes and some archaea. Three studies in this issue of Cell reveal that PspA and Vipp1 are bacterial and cyanobacterial members of the ESCRT-III superfamily, indicating

Effect of oral and transdermal oestrogen therapy on bone mineral density in functional hypothalamic amenorrhoea: a systematic review and meta-analysis

Background Female athletes might develop reduced bone mineral density (BMD) and amenorrhoea due to low energy intake. Objective To systematically review the literature of randomised controlled trials (RCTs) assessing the effect of oestrogen oral contraceptives (OCP), conjugated oestrogens (CE) and

Cost Effectiveness of Behavioral and Pelvic Floor Muscle Therapy Combined With Midurethral Sling Surgery vs Surgery Alone Among Women With Mixed Urinary Incontinence: Results of the ESTEEM Randomized Trial

Urinary incontinence is prevalent among women, and it has a significant economic impact. Mixed urinary incontinence, with both stress and urgency urinary incontinence, has a greater adverse impact on quality of life and is more complex to treat compared to

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