An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis

While anti-cytokine therapies show promising results in autoimmune diseases, its effects on cardiovascular disease development are not well understood. Fatkhullina and colleagues show that inactivation of IL-23-IL-22 signaling leads to deterioration of the intestinal barrier, expansion of pro-atherogenic bacteria, and

Geographic and Patient Characteristics Associated With Election of Prophylactic Mastectomy in Young Breast Cancer Patients With Early Disease

Objectives: To examine the association between geography and utilization rates of contralateral prophylactic mastectomy (CPM) relative to patient-level factors in patients with early stage breast cancer. Materials and Methods: Using the Truven Health MarketScan Commercial Database, a descriptive analysis of

African genetics for human society

African genetics for human society African genetics for human society, Published online: 26 October 2018; doi:10.1038/s41588-018-0277-7 We are inviting presubmission enquiries for Articles, Perspectives and Analyses on human, animal, plant and microbial genetics and genomics from Africa, by corresponding authors

Spotlight on nucleosomes

Spotlight on nucleosomes Spotlight on nucleosomes, Published online: 26 October 2018; doi:10.1038/s41576-018-0070-6 Two new studies in Nature provide insight into the role of nucleosomes in gene regulation. One describes the genome-wide organization of nucleosomes and the other details how transcription

Acne Vulgaris

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage.

Single-molecule nascent RNA sequencing identifies regulatory domain architecture at promoters and enhancers

Single-molecule nascent RNA sequencing identifies regulatory domain architecture at promoters and enhancers Single-molecule nascent RNA sequencing identifies regulatory domain architecture at promoters and enhancers, Published online: 22 October 2018; doi:10.1038/s41588-018-0234-5 Sequencing nascent RNAs at single-molecule resolution with CoPRO unravels the

Funding of cardiovascular research in the USARobert Califf and Peter Libby – speak about cardiovascular research funding in the United States and what the latest trends are with Mark Nicholls

Funding for cardiovascular research in the United States is undergoing a challenging phase. Political, financial and ethical factors have a growing influence with competition for grants now greater, more sought after, and more strictly-controlled than ever before. This has raised

Characterisation of circulating biomarkers before and after cardiac resynchronisation therapy and their role in predicting CRT response: the COVERT-HF study

Aims Cardiac resynchronisation therapy (CRT) is effective treatment for selected patients with heart failure (HF) but has ~30% non-response rate. We evaluated whether specific biomarkers can predict outcome. Methods A prospective single-centre pilot study of consecutive unselected patients undergoing CRT

Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome

Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome, Published online: 19 October 2018; doi:10.1038/s41588-018-0275-9 Author Correction: Individual variations

Navigating mouse cell types

Navigating mouse cell types Navigating mouse cell types, Published online: 19 October 2018; doi:10.1038/s41576-018-0067-1 A new study reports the ‘Tabula Muris’, an atlas of single-cell RNA sequencing data from >100,000 cells across 20 mouse tissues.

Highlights from this issue

World Cup winners… Hugo Lagercrantz’s editorial (see page 1005) based on the recent Lancet paper by Zylberszteyn examining relative child mortality in Sweden and England reinforces some home truths. Unsurprisingly, as the largest contributor to the numerator, the greatest difference

Hip hip: no hurray

Twenty-first century parents want to be assured that their newborn infant is ‘normal’. But how reliable is the routine newborn examination procedure? Should parents trust us as health professionals when we say, or imply, that they have a normal, healthy

Highlights from this issue

Postnatal steroids for bronchopulmonary dysplasia While there are many strategies for reducing the risk of BPD, the place of corticosteroids remains uncertain in spite of its long history. This month we publish a network meta-analysis by Zhang et al which

Quality assurance for antimicrobial susceptibility testing of Neisseria gonorrhoeae in Latin American and Caribbean countries, 2013-2015

Objectives A Neisseria gonorrhoeae antimicrobial susceptibility quality control comparison programme was re-established in Latin America and the Caribbean to ensure antimicrobial susceptibility data produced from the region are comparable nationally and internationally. Methods Three panels, consisting of N. gonorrhoeae isolates

Effectiveness of exercise interventions in the prevention of excessive gestational weight gain and postpartum weight retention: a systematic review and meta-analysis

Objective Gestational weight gain (GWG) has been identified as a critical modifier of maternal and fetal health. This systematic review and meta-analysis aimed to examine the relationship between prenatal exercise, GWG and postpartum weight retention (PPWR). Design Systematic review with

Prenatal exercise for the prevention of gestational diabetes mellitus and hypertensive disorders of pregnancy: a systematic review and meta-analysis

Objective Gestational diabetes mellitus (GDM), gestational hypertension (GH) and pre-eclampsia (PE) are associated with short and long-term health issues for mother and child; prevention of these complications is critically important. This study aimed to perform a systematic review and meta-analysis

A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila

Scopelliti et al. identified a novel intestinal/neuronal/adipose tissue communication network in Drosophila with implications for endocrine-regulated metabolic homeostasis. In response to nutrients, enteroendocrine cells (EE) secrete the neuroendocrine peptide Bursicon α, which binds to its neuronal receptor DLgr2 to regulate organismal

Acne Vulgaris

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage.

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