UK general practitioners think that mental health services for children and young people are inadequate, a survey has found.The survey of 1000 UK GPs found that 99% feared that young people may come…
Rationale and design of the Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) diagnostic study: the CorMicA CMR sub-study
Introduction Angina with no obstructive coronary artery disease (ANOCA) is a common syndrome with unmet clinical needs. Microvascular and vasospastic angina are relevant but may not be diagnosed without measuring coronary vascular function. The relationship between cardiovascular magnetic resonance (CMR)-derived
Marion Murray, PhD
Journal of Neurotrauma, Volume 36, Issue 2, Page 189-189, January 15, 2019.
[Editorial] Putting the family at the centre of newborn health
The arrival of a newborn is a highly anticipated occasion. But for families with preterm and ill babies, the associated health challenges and psychological burden can make the occasion a stressful one. Each year in Europe, an estimated 500 000 babies—roughly
Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells
A combination of single-cell and systems biology approaches determines the molecular programs defining the identity and function of human tissue resident type I innate lymphoid cells and natural killer cells.
[Editorial] Dealing with drug pricing: not just one solution
On Dec 11, US Food and Drug Administration Commissioner Scott Gottlieb announced a set of rules that would change the way insulin production is regulated in the USA, potentially leading to increased accessibility and lower prices for the drug. Those
[Editorial] Terrorism and conflict: effects beyond trauma
The 2017 Global Burden of Disease data published in The Lancet show that conflict and terrorism is one of the fastest-growing causes of death globally, having increased by 118% between 2007 and 2017. Although the figures are precise, the language
[Editorial] NHS staff shortages threaten the future of respiratory health
As 2018 draws to a close and the start of a new year beckons, it is time to think of resolutions and optimistic plans for the future. For people living with respiratory diseases in England, and those clinicians treating them,
Johnson & Johnson knew for decades talcum powder contained asbestos, reports allege
Executives at Johnson & Johnson repeatedly discussed their worries about the potential health effects of asbestos contamination of their talcum Baby Powder even as they told regulators and the public…
Evaluation of time to failure of strategy as an alternative surrogate endpoint in patients with lung cancer with EGFR mutations
Background Epidermal growth factor receptor (EGFR) is one of the most common oncogenes in non-small cell lung cancer (NSCLC). EGFR-tyrosine kinase inhibitor (TKI) and platinum-doublet chemotherapy (PT) are effective regimens in patients with NSCLC harbouring EGFR mutations. Among these patients,
New Classification for Myeloproliferative Neoplasms [News in Brief]
Myeloproliferative neoplasms have traditionally been split into three categories, but a new study that analyzed mutations in more than 2,000 patients suggests dividing the illness into eight subtypes. Using statistical models that incorporated clinical and genomic data, researchers accurately predicted
Two steps forward and one step back
Two steps forward and one step back Two steps forward and one step back, Published online: 21 December 2018; doi:10.1038/s41571-018-0154-4 Perioperative chemotherapy is the standard of care for localized gastric cancer (GC). In 2018, additional postoperative radiotherapy was found to
Neoadjuvant Interdigitated Chemoradiotherapy Using Mesna, Doxorubicin, and Ifosfamide for Large, High-grade, Soft Tissue Sarcomas of the Extremity: Improved Efficacy and Reduced Toxicity
Objectives: Patients with large, high-grade extremity soft tissue sarcoma (STS) are at high risk for both local and distant recurrence. RTOG 95-14, using a regimen of neoadjuvant interdigitated chemoradiotherapy with mesna, doxorubicin, ifosfamide, and dacarbazine followed by surgery and 3
Retraction Notice to: Protein Kinase A Determines Timing of Early Differentiation through Epigenetic Regulation with G9a
(Cell Stem Cell 10, 759–770; June 14, 2012)
Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression
Larson et al. show that H3.3 K27M cooperates with active PDGFRα mutant and loss of p53 to induce brainstem gliomas molecularly resembling human DIPG in mice. These tumors show global H3K27 modification but restricted gene expression changes, including upregulation of genes
[Editorial] E-cigarettes—new product, old tricks
Tobacco smoking cessation represents one of the most successful public health initiatives in the world, with smoking prevalence at its lowest during the past decade according to recent WHO estimates. However, since the introduction of e-cigarettes in 2003, marketed as
[Editorial] The humanitarian cost of Yemen’s crumbling health system
While there is always an element of uncertainty weaved into the 9-month journey of ultrasounds, blood tests, and physical checkups, ultimately, in the delivery room, excitement and joy are typically the overwhelming emotion for expectant mothers. This situation, however, is
Global patterns in excess body weight and the associated cancer burden
Abstract The prevalence of excess body weight and the associated cancer burden have been rising over the past several decades globally. Between 1975 and 2016, the prevalence of excess body weight in adults—defined as a body mass index (BMI) ≥
Computerized analysis of cardiotocograms and ST signals is associated with significant reductions in hypoxic-ischemic encephalopathy and cesarean delivery: an observational study in 38 466 deliveries
Intrapartum cardiotocography (CTG) is widely used in high-resource countries and remains at the centre of fetal monitoring and the decision to intervene, but there is ample evidence of poor reliability in visual interpretation, as well as limited accuracy in identifying
Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta
Dermal immature adipocytes fight against Staphylococcus aureus infection by secreting antimicrobial peptides during adipogenesis. Zhang et al. demonstrate that activation of the TGF-β pathway suppresses the adipogenic potential of dermal fibroblasts and therefore leads to an age-dependent loss of antimicrobial protection
Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial
Wedell-Neergaard et al. show that in abdominally obese people, exercise-mediated loss of visceral adipose tissue mass requires IL-6 receptor signaling. Given that abdominal fat is metabolically harmful to health, this study raises a potentially important side effect of IL-6 receptor antibodies,
[Editorial] Type 1 diabetes research: poised for progress
Since type 1 diabetes was first proposed to be an autoimmune disease in the 1970s, the search has been on to identify the key pathogenic determinants and immune cell types involved. The Immunology of Diabetes Society Congress in October, 2018
[Editorial] Ironing out unmet need in genetic haemochromatosis
Nearly a third of patients with genetic haemochromatosis (iron overload) in the UK are not offered recommended liver function tests on diagnosis, and more than 40% of patients do not receive the simple blood test required to monitor their disease.
[Editorial] HIV in Europe: a long road still lies ahead
In the run up to World AIDS Day on Dec 1 the usual flurry of publications surfaced. One example was the joint report from European Centre for Disease Prevention and Control (ECDC) and WHO entitled HIV/AIDS Surveillance in Europe 2018.
[Editorial] Children affected by HIV need a holistic approach to care
Despite the global target to achieve an AIDS-free generation by 2015 through eliminating mother-to-child transmission (MTCT), around 180 000 children continue to be infected with HIV each year. To mark World AIDS Day, we dedicate our December issue to examining strategies
Harnessing Genetic Complexity to Enhance Translatability of Alzheimer’s Disease Mouse Models: A Path toward Precision Medicine
Neuner et al. describe the generation and validation of the AD-BXDs, the first reproducible set of AD mouse models incorporating genetic diversity. These models recapitulate aspects of human AD and provide a new resource to identify genes and pathways associated with
[Editorial] The data to put neurology on top of the public-health agenda
Every January issue of The Lancet Neurology includes a special Round Up section. Its pages are a celebration of research achievements over the previous year. Our 2018 Round Up reveals a booming specialty, in which the pace of discovery is
Best supportive care in advanced lung cancer—more than a label?
Cancer multidisciplinary team meetings are standard clinical practice in the UK and seek to confirm diagnoses and propose appropriate treatment plans through expert consensus. Patients who are too…
The role of sex in the genomics of human complex traits
The role of sex in the genomics of human complex traits The role of sex in the genomics of human complex traits, Published online: 23 December 2018; doi:10.1038/s41576-018-0083-1 Understanding the fundamental impact of sex and gender on human health and disease is
Editorial
Dear Forensic Scientists,We are here with the last issue of the Bulletin of Forensic Medicine in 2018. May 2019 bring health, happiness and success to all colleagues working at the field forensics. We are happy and proud with the fact
The Evaluation of Deterrence in University Students with Regards to Substance Use
Objective:One of the most important components in the fight against crime is penal policies. The aim of this research is to determine the meaning of penal sanctions with regards to substance use and reveal the influence of punishment in individuals
Deaths Among Homeless in Ankara
Objective: Homeless people are a national problem for Turkey as well as in other countries. The higher death rates of homeless people than general population makes important to determine causes of preventable deaths and to inform the social institutions and the
Evaluation of Cases Belonging to Youths Autopsied in Muğla
Objective:The objective of this study was to evaluate the cases belonging to youths autopsied in Muğlaand to reveal regional profile of deaths in forensic cases to make suggestions by evaluating these cases. Materials and Method:We retrospectively evaluated the autopsy reports
Risk Factors Predicting Juvenile Recidivism
Objective: The identification of risk factors for juvenile recidivism is crucial to prevent recurrent juvenile delinquency. The aim of the present study is to determine the variables that predict juvenile recidivism. In this regard, it is aimed to reveal predictive
Use of HINTS in the acute vestibular syndrome. An Overview
Following the initial description of HINTS to diagnose acute vestibular syndrome (AVS) in 2009, there has been significant interest in the systematic evaluation of HINTs to diagnose stroke and other less common central causes of AVS. This trend increased with
Shifting Hepatitis A Epidemiology
Large outbreaks of acute hepatitis A in California, Kentucky, Michigan, and Utah that predominantly affected individuals who were homeless or reported using drugs signal a shift in the epidemiology of US hepatitis A outbreaks, according to a CDC report.
Use of HINTS in the acute vestibular syndrome. An Overview
Following the initial description of HINTS to diagnose acute vestibular syndrome (AVS) in 2009, there has been significant interest in the systematic evaluation of HINTs to diagnose stroke and other less common central causes of AVS. This trend increased with
Modelling human cardiac diseases with 3D organoid
The development of 3D cultures to resemble cardiac function and physiology in vitro
The copy number variation landscape of congenital anomalies of the kidney and urinary tract
The copy number variation landscape of congenital anomalies of the kidney and urinary tract The copy number variation landscape of congenital anomalies of the kidney and urinary tract, Published online: 21 December 2018; doi:10.1038/s41588-018-0281-y Genome-wide analysis of copy number variants
Genome editing for disease locus dissection
Genome editing for disease locus dissection Genome editing for disease locus dissection, Published online: 21 December 2018; doi:10.1038/s41576-018-0091-1 A new study uses haplotype editing to dissect the functions of a major genetic risk locus for cardiovascular disease.
GMC and Bawa-Garba agree six months’ more suspension owing to personal circumstances
The General Medical Council has suspended Hadiza Bawa-Garba for a further six months after she told the regulator that personal circumstances meant that she needed more time before facing a public…
GMC and Bawa-Garba agree six months’ more suspension owing to personal circumstances
The General Medical Council has suspended Hadiza Bawa-Garba for a further six months after she told the regulator that personal circumstances meant that she needed more time before facing a public…
Mechanisms regulating zygotic genome activation
Mechanisms regulating zygotic genome activation Mechanisms regulating zygotic genome activation, Published online: 20 December 2018; doi:10.1038/s41576-018-0087-x The maternal-to-zygotic transition (MZT) is the process by which the transcriptionally silent embryonic genome is gradually activated. The mechanisms underlying the MZT are not
Effect of ranolazine on glycaemia in adults with and without diabetes: a meta-analysis of randomised controlled trials
Background Ranolazine is an antianginal drug reported to have hypoglycaemic effects. Objectives To assess the effect of ranolazine versus placebo on glycaemic control for adults with and without diabetes. Methods A systematic search of seven databases was conducted to identify
Breast implants linked to rare cancer are removed from European market
One of the world’s best selling types of silicone breast implants, which have been linked to a rare form of atypical lymphoma (BIA-ALCL), have been removed from the market across Europe.The recall of…
Junior doctors could be stopped from working in UK under new immigration rules, health leaders warn
Junior doctors and other healthcare staff from the European Union could be blocked from taking up valuable posts in the NHS under new UK immigration rules, healthcare leaders have warned.The warning…
Junior doctors could be stopped from working in UK under new immigration rules, health leaders warn
Junior doctors and other healthcare staff from the European Union could be blocked from taking up valuable posts in the NHS under new UK immigration rules, healthcare leaders have warned.The warning…
Greetings from the editor 2019
First of all, let me wish you a healthy, happy and prosperous New Year—may your personal and professional wishes come true. Second, let me thank you for your continued support of the Annals of the Rheumatic Diseases (ARD)—as readers, as
Global Impact of Air Pollution on Children’s Health
Indoor and outdoor air pollution contributed to respiratory tract infections that in 2016 led to the deaths of 543 000 children younger than 5 years, according to a new report from the World Health Organization (WHO) that emphasizes children’s vulnerability to
Synthetic readers and writers for mammalian chromatin
Synthetic readers and writers for mammalian chromatin Synthetic readers and writers for mammalian chromatin, Published online: 18 December 2018; doi:10.1038/s41576-018-0090-2 A study in Cell reports the development of a synthetic, modular and programmable read–write system that serves as a platform
Treatment resistant depression: what are the options?
Some patients with treatment resistant depression have tried up to 12 antidepressants and waited 10 years before they are seen at specialist centres, a recent press briefing heard. The figures fall…
Treatment resistant depression: what are the options?
Some patients with treatment resistant depression have tried up to 12 antidepressants and waited 10 years before they are seen at specialist centres, a recent press briefing heard. The figures fall…
Single-cell and single-molecule epigenomics to uncover genome regulation at unprecedented resolution
Single-cell and single-molecule epigenomics to uncover genome regulation at unprecedented resolution Single-cell and single-molecule epigenomics to uncover genome regulation at unprecedented resolution, Published online: 17 December 2018; doi:10.1038/s41588-018-0290-x Single-cell and single-molecule epigenomics to uncover genome regulation at unprecedented resolution.
Everyone with type 1 diabetes should have access to a flash glucose device
Would you drive a car without a speedometer? With a fuel gauge visible only infrequently and after it had pricked you? That is what we expect of insulin users who monitor their diabetes with finger…
Predictors of {beta}-blocker adherence in cardiac inherited disease
Objective The cardiac inherited disease (CID) population has suboptimal adherence to long-term β-blocker therapy, which is known to be a risk for sudden cardiac death. This study aimed to identify the clinical and psychosocial variables associated with non-adherence in this
Aripiprazole augmentation in treating comorbid bipolar disorder and obsessive-compulsive disorder
Obsessive-compulsive disorder (OCD) is one of the most difficult additional diagnoses to manage in patients with bipolar disorder (BD) since the gold standard treatment for one disease (antidepressants for OCD) can worsen the other. This case report describes the efficacy
Arterial and pulmonary hypertension: risk assessment and current pharmacological and interventional management
For the podcast associated with this article, please visit https://academic.oup.com/eurheartj/pages/Podcasts.
Differences in inflammatory profiles between ALS and FTD
Neuroinflammation contributes to ALS and FTD pathophysiology The pathophysiological mechanisms underlying the development of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) remain to be fully elucidated, although overlapping biological processes expressed in different proportions in neuronal and non-neuronal cells
Deciphering bacterial epigenomes using modern sequencing technologies
Deciphering bacterial epigenomes using modern sequencing technologies Deciphering bacterial epigenomes using modern sequencing technologies, Published online: 13 December 2018; doi:10.1038/s41576-018-0081-3 DNA methylation is the primary epigenetic modification in bacteria, but a lack of suitable methods has hampered its study. Now,
Grounded ethical analysis
There’s no doubt that medical ethics should be ‘grounded’, in the sense that it aims to make a practical, normative contribution to significant ethical issues in medicine. There are a number of ways in which ethics can do that, two
Apocrine lesions of the breast: part 1 of a two-part review: benign, atypical and in situ apocrine proliferations of the breast
Apocrine morphology is a common phenomenon encountered in everyday breast pathology practice, and is defined as cuboidal or columnar cells exhibiting abundant eosinophilic granular cytoplasm, prominent apical granules, a low nuclear-cytoplasmic ratio, and round nuclei with pale chromatin and prominent
Cardiovascular screening in Olympic athletes: time to achieve a uniform standard
In British Journal of Sports Medicine, Toresdahl et al describe the preparticipation cardiovascular (CV) screening practices implemented for athletes participating in the 2016 Rio Olympic Games.1 This study is of particular importance because it highlights the range of CV screening in the world’s
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
AbstractObjectiveTo determine if using a parachute prevents death or major traumatic injury when jumping from an aircraft.DesignRandomized controlled trial.SettingPrivate or commercial aircraft…
Highlights from this issue
Neuroretinal atrophy following resolution of macular oedema in retinal vein occlusion (see page 36) In this study of patients with retinal vein occlusion treated with ranibizumab, significant neuroretinal thinning was observed after the resolution of macular oedema in 11% of
Highlights from this issue
Recipe for success The editor’s choice this month would make a great choice for your journal club. When you have read it and the accompanying editorial by Lamia Soghier and Billie Lou Short you will want plenty of your colleagues
Highlights from this issue
Parsimony Parsimony, ‘the quality of frugality in the use of resources’, is an unusual term. Unusual in that it has both pejorative (personal—meanness) and complimentary connotations. A parsimonious statistical model, for example, makes fewer assumptions, has fewer variables and has
Highlights from this issue
Standing on the shoulders of giants… In this month’s airwaves, we salute those titans of medicine who have made present day advances in medicine possible. Back to Black Almost 40 years ago, the Black Report demonstrated that health inequalities were
Cancer immunotherapy: challenges and clinical applications
Immunotherapy has emerged as one of the standard treatment modalities against cancer along with surgery, radiotherapy, chemotherapy and targeted therapy. Cancer immunotherapy harnesses the immune system to fight tumours, aiming at mounting effective antitumour immune responses. During the past few
Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study
AbstractObjectiveTo measure the energy content of frequently ordered meals from full service and fast food restaurants in five countries and compare values with US data.DesignCross sectional…
Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study
AbstractObjectiveTo measure the energy content of frequently ordered meals from full service and fast food restaurants in five countries and compare values with US data.DesignCross sectional…
Heartbeat: heart failure induced by cancer therapy
Heart failure (HF) is the most common and serious cardiovascular complication of cancer therapy. As succinctly stated in an editorial by Lyon, ‘Success in the diagnosis and treatment of many cancers has resulted in a growing population of people living either
Bruised apples: violence against women in the education sector
Chen et al1 illuminate the increasing risk of workplace violence to women in the education sector through analysis of lost time claims and emergency department visits in Ontario, Canada. The authors compare workplace violence lost-time injury workers’ compensation claims as
Contractility surrogates derived from three-dimensional lead motion analysis and prediction of acute haemodynamic response to CRT
Background Patient-specific left ventricular (LV) lead optimisation strategies with immediate feedback on cardiac resynchronisation therapy (CRT) effectiveness are needed. The purpose of this study was to compare contractility surrogates derived from biventricular lead motion analysis to the peak positive time
Publisher Correction: Cancer genetics, precision prevention and a call to action
Publisher Correction: Cancer genetics, precision prevention and a call to action Publisher Correction: Cancer genetics, precision prevention and a call to action, Published online: 12 December 2018; doi:10.1038/s41588-018-0326-2 Publisher Correction: Cancer genetics, precision prevention and a call to action
Proximity-CLIP — close encounters of the RNA kind
Proximity-CLIP — close encounters of the RNA kind Proximity-CLIP — close encounters of the RNA kind, Published online: 12 December 2018; doi:10.1038/s41576-018-0086-y Proximity-CLIP, a method that combines proximity-based protein biotinylation and UV crosslinking, profiles the transcriptome and ribonucleoproteins in subcellular
Highlights for December 11, 2018
China harvested organs from political prisoners on substantial scale, says tribunal
Forced harvesting of organs from prisoners of conscience in China has been “substantial,” says an interim judgment of an independent “people’s tribunal” set up to determine whether the country’s…
Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies
Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies, Published online: 10 December 2018; doi:10.1038/s41588-018-0287-5 Activating HER2 mutations are shown to
Annual flu vaccination reduces risk of death in patients with heart failure, study finds
The risk of all-cause and cardiovascular death in patients with heart failure is reduced by almost one fifth in those having annual flu vaccinations compared with non-vaccinated patients, a Danish…
Improving professionalism will increase job satisfaction, says RCP
Helping doctors bridge the gap between their training and the reality of modern practice by improving professionalism could increase job satisfaction, improve patient care, and raise productivity,…
Bariatric surgery among patients with heart failure: a systematic review and meta-analysis
Background Bariatric surgery reduces cardiovascular risk in obese patients. Heart failure (HF) is associated with an increased perioperative risk following bariatric surgery. This systematic review aimed to assemble the evidence on bariatric surgery in patients with known HF and the
Assessing myocardial ischaemia in epicardial coronaries and the microcirculation
Risk loci for ADHD
Risk loci for ADHD Risk loci for ADHD, Published online: 07 December 2018; doi:10.1038/s41576-018-0084-0 A study in Nature Genetics reports the first genome-wide significant loci for attention deficit/hyperactivity disorder and implicates biologically informative genes, such as FOXP2, as contributors to
Many patients in England are waiting more than two weeks to see a GP, figures show
A fifth of patients waited more than two weeks for a general practice appointment in October, show new figures from NHS Digital.1 General practices in England had 27 million appointments in October,…
Many patients in England are waiting more than two weeks to see a GP, figures show
A fifth of patients waited more than two weeks for a general practice appointment in October, show new figures from NHS Digital.1 General practices in England had 27 million appointments in October,…
Highlights from this issue
Upper gastrointestinal bleeding Acute upper gastrointestinal bleeding is one of the most common medical emergencies in the UK (85 000 cases per year, 4000 deaths). It has a significant impact on resources with the need for 24/7 on call bleeding
Obituary: Ian Forgacs 1951-2018 BSG President 2014-16
Prospero: “Be cheerful, sir: our revels now are ended. These our actors as I foretold you, were all spirits and are melted into air: into thin air…” The Tempest Act IV scene i. There are two facets to each of
Sample sizes based on three popular indices of risks
Sample size justification is a very crucial part in the design of clinical trials. In this paper, the authors derive a new formula to calculate the sample size for a binary outcome given one of the three popular indices of
Cast of the Right Bronchial Tree
Figure 1.
Prognosis and risk stratification in patients with decompensated heart failure receiving inotropic therapy
Objectives The prognostic significance of transient use of inotropes has been sufficiently studied in recent heart failure (HF) populations. We hypothesised that risk stratification in these patients could contribute to patient selection for advanced therapies. Methods We analysed a prospective
Mental Health Act must be updated to give patients power over care, says review
People detained under the Mental Health Act deserve to be treated with respect and dignity and to have their views properly taken into account, an independent review of the act commissioned by the…
Congenital Pulmonary Lymphangiectasia
A female infant was born at 40 weeks and 3 days of gestation, weighing 2970 g. The Apgar scores were 8, 10, and 10 at 1, 5, and 10 minutes, respectively. Within one hour after birth, severe respiratory distress with
Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
Objective Myocardial early systolic lengthening (ESL) duration is prolonged in patients with coronary artery disease (CAD). However, the relationship between the fractional flow reserve (FFR), the current gold standard for evaluating physiological myocardial ischaemia, and ESL has not been studied.
Integrating behavioural health tracking in human genetics research
Integrating behavioural health tracking in human genetics research Integrating behavioural health tracking in human genetics research, Published online: 06 December 2018; doi:10.1038/s41576-018-0078-y This Comment discusses how data from smartphones or wearables could be used for behavioural phenotyping, knowledge that may
Sachchidanand Sinha
bmj;363/dec05_11/k5121/FAF1faSachchidanand Sinha did a short service commission for the Indian Army in the Royal Army Medical Corps. With postgraduate degrees in general surgery and orthopaedics he…
Reply to ‘Mosaic loss of chromosome Y in leukocytes matters’
Reply to ‘Mosaic loss of chromosome Y in leukocytes matters’ Reply to ‘Mosaic loss of chromosome Y in leukocytes matters’, Published online: 04 December 2018; doi:10.1038/s41588-018-0310-x Reply to ‘Mosaic loss of chromosome Y in leukocytes matters’
Harnessing genomic information for livestock improvement
Harnessing genomic information for livestock improvement Harnessing genomic information for livestock improvement, Published online: 04 December 2018; doi:10.1038/s41576-018-0082-2 Improvements to livestock genetics will be critical to tackling the looming food crisis. Achieving this goal will require implementation of improved genomic
Highlights for December 4, 2018
David Oliver: Preventing a Gosport repeat
In the wake of this June’s inquiry report on the sometimes preventable or needlessly distressing deaths of 451 patients at Gosport War Memorial Hospital in the 1990s,1 a November Commons statement by…
Initially Normal Coronary Arteries and Abnormal Findings on Follow-up Echocardiography in Patients With Kawasaki Disease
This cohort study assesses whether echocardiographic imaging of pediatric patients with Kawasaki diseaes 6 weeks after onset of illness adds value for patients whose earlier examinations showed no coronary artery abnormalities.
Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations
Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations, Published online: 03 December 2018; doi:10.1038/s41588-018-0285-7
John Galvin
bmj;363/dec03_10/k5123/FAF1faJohn Galvin was many things to many people: a devoted husband, a wonderful father, a dutiful son, a beloved granddad, a constant and loyal friend, a teller of awful…
WhatsApp'tan Bize Yazın