Prime Time for Genome Editing?

In 1902, Garrod discovered that a difference in human metabolism (alkaptonuria) can be transmitted through the germline in accordance with Mendel’s first law. A half century later, Ingram discovered the molecular basis for such transmission in human disease — specifically,

A means to an end for transcription?

Nature Reviews Genetics, Published online: 29 January 2020; doi:10.1038/s41576-020-0213-4 Two new studies in Molecular Cell report a role for antisense oligonucleotides in inducing transcriptional termination, with important implications for the interpretation of functional studies of long non-coding RNAs.

Highlights from this issue

Optical coherence tomography angiography in preclinical Alzheimer’s disease (see page 157) In this study, an increased retinal vessel density was observed in cognitively normal individuals positive for cortical amyloid-beta on positron emission tomography. This suggests that vessel density might be

Exploratory analysis of front-line therapies in REVEL: a randomised phase 3 study of ramucirumab plus docetaxel versus docetaxel for the treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy

Introduction Non-small-cell lung cancer (NSCLC) is a heterogeneous disease. Front-line therapy may affect responses to subsequent treatment regimens, thus influencing second-line therapy decision making. In the randomised phase 3 REVEL study, second-line ramucirumab plus docetaxel (ram+doc) versus docetaxel (doc) improved

Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: the Nordic-Baltic Bifurcation Study IV

Background It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to

Suicide

Throughout the world, approximately 800,000 people die by suicide every year, accounting for 1.5% of all deaths. Suicide is the 10th leading cause of death in North America and the foremost cause of death worldwide among persons 15 to 24

Suicide

Throughout the world, approximately 800,000 people die by suicide every year, accounting for 1.5% of all deaths. Suicide is the 10th leading cause of death in North America and the foremost cause of death worldwide among persons 15 to 24

Familial adenomatosis polyposis-related desmoid tumours treated with low-dose chemotherapy: results from an international, multi-institutional, retrospective analysis

Introduction Desmoid tumour (DT) is a locally aggressive fibroblastic proliferative disease representing the most common extraintestinal manifestation of familial adenomatosis polyposis (FAP). As data on the activity of chemotherapy in these patients are limited, we examined the outcomes of patients

Baroreflex Dysfunction

The autonomic nervous system innervates all body organs, including the cardiovascular system. Smooth muscle in arteries, arterioles, and veins and pericytes in capillaries receive autonomic innervation, which modulates vascular smooth-muscle tone and vessel diameter. Afferent sensory neurons with…

Eva Raik

bmj;368/jan10_10/m91/FAF1faBorn in Prague, Eva Raik graduated from the Medical School of Sydney University in 1959. She completed a postgraduate medical course at Hammersmith Hospital, London, in…

Defeating Schistosomiasis

Schistosomiasis is an ancient, neglected parasitic disease caused by blood flukes (trematode worms) of the genus schistosoma. Affecting an estimated 200 million persons in 78 countries, the disease is intimately associated with poverty and is grossly debilitating, leading to chronic

WhatsApp WhatsApp'tan Bize Yazın