Atrial Fibrillation

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors’ clinical recommendations. Stage.

Leveraging a health information exchange to examine the accuracy of self-report emergency department utilization data among hospitalized injury survivors

Background Accurate acute care medical utilization history is an important outcome for clinicians and investigators concerned with improving trauma center care. The objective of this study was to examine the accuracy of self-report emergency department (ED) utilization compared with utilization

Addressing admixture with Tractor

Nature Reviews Genetics, Published online: 27 January 2021; doi:10.1038/s41576-021-00333-z In this paper in Nature Genetics, Atkinson et al. describe Tractor, a statistical framework and software package that enables admixed populations to be included in large-scale genomics studies.

One of Us

Dr. Susan Moore was one of us. She immigrated to the United States from Jamaica as a child and earned a medical degree from the University of Michigan. She was a family physician in Indianapolis who found herself hospitalized with

A new view of genome organization

Nature Reviews Genetics, Published online: 22 January 2021; doi:10.1038/s41576-021-00330-2 A report in Science describes in situ genome sequencing (IGS), a method that enables genomes to be simultaneously sequenced and imaged in intact samples, including early mouse embryos. IGS will facilitate

Editorial: JMG in 2021

The need for precision in scientific communication is long established. In genetics, one area in which it is particularly important that information be communicated accurately is the reporting of DNA variants. Over the past 2 years, a working group convened

What happens next

The election of Joe Biden as the next president of the United States is a cause for celebration for many scientists. Not only has Biden historically championed science, but the immediacy of the COVID-19 public health crisis led him to

Highlights from this issue

Morphological change and recovery of corneal endothelial cells after rho-associated protein kinase inhibitor eye-drop (ripasudil 0.4%) instillation (see page 169) In glaucoma patients treated with ROCK-inhibitor eye-drops, corneal-endothelial-cell density (CECD) number calculated by automated non-contact-specular-microscopy software appeared to show a

Design of the Association of Uterine Perforation and Expulsion of IUD (APEX-IUD) Study: A Multisite Retrospective Cohort Study

Intrauterine devices (IUDs) are effective and safe, long-acting reversible contraceptives, but risk of uterine perforation occurs with an estimated incidence of 1-2 per 1,000 insertions. EURAS-IUD, a European prospective observational study that enrolled 61,448 participants (2006-2012), found that women breastfeeding

Ewing’s Sarcoma

In 1920, during a meeting of the New York Pathological Society, James Ewing described an unusual tumor in a 14-year-old girl as a “diffuse endothelioma of bone.” The tumor had initially been diagnosed as an osteosarcoma, but its architecture, the

Same genomes, but different

Nature Reviews Genetics, Published online: 13 January 2021; doi:10.1038/s41576-021-00328-w A study in Nature Genetics applies whole-genome sequencing to monozygotic twins, their parents, partners and offspring to identify and characterize early developmental mutations, as well as the fate of mutated cells.

Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: retrospective analysis in a multiethnic Asian population

Objective ST segment elevation myocardial infarction (STEMI) is associated with significant mortality leading to loss of productive life years, especially in younger patients. This study aims to compare the characteristics and outcomes of young versus older patients with STEMI undergoing

Breathing for Two

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows.

Fixing an ageing mutation

Nature Reviews Genetics, Published online: 12 January 2021; doi:10.1038/s41576-021-00327-x A study in Nature reports that adenine base editors can correct the mutation that causes Hutchinson–Gilford progeria syndrome in a mouse model of this disease, extending lifespan.

Hydroxychloroquine shortages among patients with systemic lupus erythematosus during the COVID-19 pandemic: experience of the Systemic Lupus International Collaborating Clinics

Early scientific and public enthusiasm for hydroxychloroquine (HCQ) as a potential therapy for COVID-19 has prompted over 100 registered trials to date, although its efficacy remains to be demonstrated.1 Unfortunately, accelerated demand for HCQ has the potential to diminish supplies

Left Ventricular Rupture

A 72-year-old woman with hypertension presented to a local hospital with a 5-day history of nausea, sharp epigastric pain, shortness of breath, and malaise. Electrocardiography revealed anterolateral ST-segment elevations, which prompted her transfer to a tertiary care facility for primary…

Left Ventricular Rupture

A 72-year-old woman with hypertension presented to a local hospital with a 5-day history of nausea, sharp epigastric pain, shortness of breath, and malaise. Electrocardiography revealed anterolateral ST-segment elevations, which prompted her transfer to a tertiary care facility for primary…

Left Ventricular Rupture

A 72-year-old woman with hypertension presented to a local hospital with a 5-day history of nausea, sharp epigastric pain, shortness of breath, and malaise. Electrocardiography revealed anterolateral ST-segment elevations, which prompted her transfer to a tertiary care facility for primary…

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