Mechanical performance and healing patterns of the novel sirolimus-eluting bioresorbable Fantom scaffold: 6-month and 9-month follow-up by optical coherence tomography in the FANTOM II study

Objectives We aimed to evaluate the mechanical properties and healing patterns 6 and 9 months after implantation of the sirolimus-eluting Fantom bioresorbable scaffold (BRS). Background The Fantom BRS (Reva Medical, San Diego, USA) has differentiating properties including radiopacity, strut thickness

Development of sodium fluoride PET response criteria for solid tumours (NAFCIST) in a clinical trial of radium-223 in osteosarcoma: from RECIST to PERCIST to NAFCIST

Purpose The development of osteosarcoma therapeutics has been challenging, in part because of the lack of appropriate criteria to evaluate responses. We developed a novel criteria in a clinical trial of radium-223 dichloride (223RaCl2) for response assessment in osteosarcoma, NAFCIST

Author Correction: Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes

Author Correction: Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes Author Correction: Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes, Published online: 27 February 2019; doi:10.1038/s41588-019-0377-z

Highlights from this issue

All you need is nitrous We are privileged to publish a wonderful randomised controlled trial this month. Seiler et al randomised children undergoing painful procedures under sedation with 70% nitrous oxide to receive additional intranasal fentanyl or a placebo. They

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations, Published online: 25 February 2019; doi:10.1038/s41588-018-0342-2 Genome-wide analysis of chronic obstructive pulmonary disease identifies

Publisher Correction: An evolutionary framework for measuring epigenomic information and estimating cell-type-specific fitness consequences

Publisher Correction: An evolutionary framework for measuring epigenomic information and estimating cell-type-specific fitness consequences Publisher Correction: An evolutionary framework for measuring epigenomic information and estimating cell-type-specific fitness consequences, Published online: 20 February 2019; doi:10.1038/s41588-019-0369-z Publisher Correction: An evolutionary framework for

Getting the drop on chromatin interaction

Getting the drop on chromatin interaction Getting the drop on chromatin interaction, Published online: 19 February 2019; doi:10.1038/s41576-019-0103-9 A new technique named ChIA-Drop combines chromatin interaction analysis (ChIA) with droplet-based and barcode-linked high-throughput sequencing to capture multiplex chromatin interactions at

Somatostatin-Expressing Interneurons Enable and Maintain Learning-Dependent Sequential Activation of Pyramidal Neurons

Adler et al. reveal mechanisms underlying learning-dependent sequential activation of pyramidal neurons in the primary motor cortex. SST-expressing interneurons and CaMKII-dependent synaptic plasticity control the establishment of sequential activity during motor training and prevent the interference from new learning.

The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock

ABCF1 has been associated with immune signaling and various autoimmune disorders. Arora and colleagues demonstrate that ABCF1 is an E2 ubiquitin-conjugating enzyme that regulates various innate immune responses in macrophages, including potentiation of TLR4 endocytosis and M2 polarization, and promotes

The Devil Is in the Details

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows.

Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration, Published online: 11 February 2019; doi:10.1038/s41588-019-0351-9 The authors transcriptionally profiled postmortem retinas from 453 age-related macular

Plant-derived polyunsaturated fatty acids and markers of glucose metabolism and insulin resistance: a meta-analysis of randomized controlled feeding trials

The objective of this meta-analysis was to investigate the effects of plant-derived polyunsaturated fatty acids (PUFAs) on glucose metabolism and insulin resistance. Scopus and PubMed databases were searched until January 2018. Eligible studies were randomized controlled feeding trials that investigated

Society for Maternal-Fetal Medicine (SMFM) Consult Series #48: Immediate postpartum long-acting reversible contraception for women at high-risk for medical complications

Reproductive planning is important for all women but essential for those with complex health conditions or at high-risk for complications. Pregnancy planning can allow these high-risk women the opportunity to receive preconception counseling, medication adjustment, and risk assessment related to

Rehabbed to Death

Ms. P. was an 87-year-old woman with moderate dementia who lived alone in an apartment before being admitted to the hospital with pneumonia. During her hospitalization, she became deconditioned and could no longer walk without assistance. Friends and family were

Bridging the Gap

A 21-year-old man was found unresponsive in a park, with a 1-gallon container of green liquid, approximately half of it gone, nearby. The label was not legible, but the liquid was presumed to be antifreeze. The man was brought to

Rehabbed to Death

Ms. P. was an 87-year-old woman with moderate dementia who lived alone in an apartment before being admitted to the hospital with pneumonia. During her hospitalization, she became deconditioned and could no longer walk without assistance. Friends and family were

De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma

Self-renewal and differentiation programs are critical determinants of tissue homeostasis and tumor growth. Sastre-Perona et al. identify a cancer-specific PITX1-, SOX2-, and TRP63-dependent transcriptional feed-forward circuit that governs self-renewal and squamous cell carcinoma growth as it inhibits KLF4-dependent differentiation.

Genomics and our future food security

Genomics and our future food security Genomics and our future food security, Published online: 31 January 2019; doi:10.1038/s41588-019-0352-8 Ensuring that agricultural production meets the goal of feeding a world experiencing continued human population growth and increasingly severe effects from climate

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