Warm-Up As we slowly emerge from the pandemic, the world is finding its new normal and we are beginning to quantify the ramifications of COVID-19 and what it means to physical activity, sport and health. With lockdowns, restrictions and fear
What should a health and social care workforce strategy look like?
This week’s cross-party parliamentary report on the NHS and social care workforce paints a bleak picture. Highlighting Nuffield Trust estimates, the committee points out that the NHS has struggled with 12 000 hospital doctor vacancies and more than 50 000
Transient activated fibroblasts contribute to zebrafish heart regeneration
Nature Genetics, Published online: 28 July 2022; doi:10.1038/s41588-022-01130-y In the zebrafish heart, several transient fibroblast types appear after injury. High-throughput lineage tracing revealed that injury-responsive fibroblasts are derived from two distinct lineage origins: the epicardium and the endocardium. Targeted cell-type-specific
[Editorial] Monkeypox: a global wake-up call
WHO’s declaration on July 23 that the current monkeypox outbreak constitutes a Public Health Emergency of International Concern (PHEIC) was unprecedented. It is the seventh such declaration, but the first made against the advice of a majority of the emergency
Forecasting the mental health harms of overturning Roe v Wade
The US Supreme Court’s decision to eliminate the federal right to abortion means that around half of reproductive age women in the US will soon be living in states without access to abortion, with restrictions disproportionately affecting people of colour1
Defining clinically important overall survival thresholds: lessons from quality of life
Nature Reviews Clinical Oncology, Published online: 27 July 2022; doi:10.1038/s41571-022-00667-5 In randomized controlled trials in oncology, changes in quality of life are usually reported together with a description of the differences considered a priori to be clinically important, but overall
Junior doctors still await rotas just days before changeover
Wednesday 3 August marks the changeover date for foundation trainees, yet with less than a week to go some junior doctors have told The BMJ that they remain in limbo without a rota for their next placement.Junior doctors are contractually
Correction: Gender differences in use of invasive diagnostic and therapeutic procedures for acute ischaemic heart disease in Chinese adults
Levy M, Chen Y, Clarke R, et al. Gender differences in use of invasive diagnostic and therapeutic procedures for acute ischaemic heart disease in Chinese adults. Heart 2022;108:292–299. This article has been corrected since it was first published. In Figure
Craniospinal irradiation improves leptomeningeal metastasis control
Nature Reviews Clinical Oncology, Published online: 26 July 2022; doi:10.1038/s41571-022-00669-3 Craniospinal irradiation improves leptomeningeal metastasis control
Health insurance status and cancer stage at diagnosis and survival in the United States
Abstract Previous studies using data from the early 2000s demonstrated that patients who were uninsured were more likely to present with late-stage disease and had worse short-term survival after cancer diagnosis in the United States. In this report, the authors
[Editorial] Anything but pro-life
Sexual and reproductive health and rights are essential to the fight against HIV. And for many people, abortion care and other sexual and reproductive health contacts provide important entry points into HIV prevention and treatment. Therefore, the decision by the
Treatment of Retinopathy of Prematurity
Retinopathy of prematurity (ROP) is a major cause of blindness among children worldwide. This disorder was first described as “retrolental fibroplasia” in the 1940s, and the role of unrestricted oxygen in the development of ROP was demonstrated in randomized clinical
[Editorial] COVID-19 pandemic disturbs respiratory virus dynamics
The winter months normally bring a higher number of respiratory viruses as people spend more time indoors together and the cold, dry air allows viruses to survive, and infect people, more easily. The last two winters, however, have been very
Concurrent surgery across two parallel operating theatres carries risks, say researchers
Researchers have warned of the risks of having a single surgeon work across two parallel operating theatres and cast doubt on the method as a means of treating more patients to cut NHS waiting lists.They say there is no evidence
The Brown University Oncology Group Experience With FOLFOX + Nab-paclitaxel [FOLFOX-A] for Metastatic and Locally Advanced Pancreatic, BrUOG-292 and BrUOG-318
Objectives: To evaluate response rate, toxicity, and efficacy of the novel combination of nab-paclitaxel, oxaliplatin, 5-fluorouracil, and leucovorin [FOLFOX-A] in patients with advanced pancreatic ductal adenocarcinoma [PDAC]. Methods: BrUOG-292 and BrUOG-318 were two concurrently run, prospective, single-arm phase II studies
[Editorial] Progress on tobacco control and e-cigarettes
In an Editorial in October, 2019, against a backdrop of increasing e-cigarette use and reports of vaping-related lung illness, we called for swift action to “ensure we do not blunder in to another long-running unhealthy, life shortening, odyssey of replacing
[Editorial] Thrombosis and mental health
The ongoing COVID-19 pandemic has highlighted the importance of mental health alongside physical health. Physicians who specialise in the treatment of venous thromboembolism might not consider mental health sequela as within their primary remit; however, there is an increasing body
Health insurance status and cancer stage at diagnosis and survival in the United States
Abstract Previous studies using data from the early 2000s demonstrated that patients who were uninsured were more likely to present with late-stage disease and had worse short-term survival after cancer diagnosis in the United States. In this report, the authors
Author Correction: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
Nature Genetics, Published online: 25 July 2022; doi:10.1038/s41588-022-01164-2 Author Correction: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
Old buildings and out of date facilities are costing the NHS dear
“We operate 21st century healthcare from 19th century buildings. It is increasingly unsustainable.” So said one NHS leader responding to NHS Providers’ survey of trusts included in the government’s flagship New Hospital Programme (NHP), underpinned by its manifesto commitment to
Different drugs, different sides: injection use of opioids alone, and not stimulants alone, predisposes to right-sided endocarditis
Objectives Many studies suggest that infective endocarditis (IE) in people who inject drugs is predominantly right sided, while other studies suggest left sided disease; few have differentiated by class of drug used. We hypothesised that based on differing physiological mechanisms,
Correction: BTS clinical statement for the assessment and management of respiratory problems in athletic individuals
Hull JH, Burns P, Carre J, et al. BTS clinical statement for the assessment and management of respiratory problems in athletic individuals. Thorax 2022;77:540–551. doi: 10.1136/thoraxjnl-2021-217904 The affiliation for author JC is incorrect and should have been listed as SportPark,
Increased risk of subsequent chlamydia infection among women not tested at the anorectal anatomical location
Background Universal anorectal testing for Chlamydia trachomatis (chlamydia) among women is not recommended in many countries, while anorectal chlamydia infections are common. Missed anorectal infections might cause sequelae at the genital site if autoinoculation from the anorectum is possible, but
Tasadenoturev active in DIPG
Nature Reviews Clinical Oncology, Published online: 22 July 2022; doi:10.1038/s41571-022-00666-6 Tasadenoturev active in DIPG
Author Correction: From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill
Nature Genetics, Published online: 22 July 2022; doi:10.1038/s41588-022-01160-6 Author Correction: From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill
Global cooperation for a global pandemic
Nature Reviews Genetics, Published online: 22 July 2022; doi:10.1038/s41576-022-00522-4 The COVID-19 pandemic has highlighted the challenges and opportunities of our inter-connected world in responding to global crises.
How can we optimise learning from trials in child and adolescent mental health?
Improving child and adolescent mental health requires the careful development and rigorous testing of interventions and delivery methods. This includes universal school-based mindfulness training, evaluated in the My Resilience in Adolescence (MYRIAD) trial reported in this special edition. While discovering
Knowing who to trust: women and public health
In this issue of the JME, age-old questions around how to balance the interests of mother and fetus are revisited in two separate contexts: alcohol consumption during pregnancy, and maternal request caesarean sections. Both have been the subject of recent
Arun Raha
bmj;378/jul22_10/o1807/FAF1faArun Raha worked in India for a couple of years before coming to the UK in 1967. After a few years of working as a trainee in general medicine, he went on to work in general practice in 1971. He
Future of mental health in the metaverse
The metaverse and non-fungible tokens (NFTs) were some of the hottest tech terms in 2021, according to a Google Trends search. Our review aims to describe the metaverse and NFTs in the context of their potential application in the treatment
Long-term childhood outcomes for babies born at term who were exposed to antenatal corticosteroids
Antenatal corticosteroids (ACS) improve neonatal outcomes when administered to infants who are at risk of preterm delivery. Many women who receive ACS for threatened preterm labor go on to deliver at term. Thus, long-term outcomes should be evaluated for term-born
Endogenous retroviruses steer transcriptional condensates away from pluripotency
Nature Genetics, Published online: 21 July 2022; doi:10.1038/s41588-022-01111-1 The impact of endogenous retrovirus silencing during mammalian development is poorly understood. A new study shows that their abnormal reactivation in pluripotent cells dismantles key gene regulatory networks by perturbing transcriptional condensates
The integral partnership of biology and technology
Technology is a powerful partner in biology and biomedicine, allowing for the exploration of frontiers previously beyond our physical and conceptual reach. Transformative discoveries have often come together with the development and clever deployment of a new method, tool, or
[Editorial] Viral hepatitis elimination: a challenge, but within reach
July 28 marks World Hepatitis Day. Hepatitis B and C are the two major forms of viral hepatitis, causing inflammation, damage to the liver, and sometimes cancer. Their burden is huge—more men acquired hepatitis B (890 000 cases) in 2019–20 than
Governance and injury prevention
Urban governance implies that state authorities and other actors (including private and social sectors) work together with authentic community participation as needed to meet the challenges to achieve urban health. In this context, addressing the problem of injury is critical.
Practice guidelines for BRCA1/2 tumour testing in ovarian cancer
The purpose of this document is to provide pre-analytical, analytical and post-analytical considerations and recommendations to Canadian clinical laboratories developing, validating and offering next-generation sequencing (NGS)-based BRCA1 and BRCA2 (BRCA1/2) tumour testing in ovarian cancers. This document was drafted by
Applied sports science and sports medicine in womens rugby: systematic scoping review and Delphi study to establish future research priorities
Objectives In part 1, the objective was to undertake a systematic scoping review of applied sports science and sports medicine in women’s rugby, and in part 2 to develop a consensus statement on future research priorities. Design In part 1,
Improving the quality of publications on structural racism in healthcare
In 2021 the US Centers for Disease Control and Prevention (CDC) announced that structural racism was a public health threat.1 In January 2022 The BMJ considered how to solve a problem as entrenched as racism in health research.23Unfortunately, there are
Highlights from this issue
Silicone oil versus gas tamponade for primary rhegmatogenous retinal detachment treated successfully with a propensity score analysis: Japan retinal detachment registry (see page 1044) Propensity score analysis of eyes with rhegmatogenous retinal detachment showed that postoperative vision was worse in
First trimester nuchal translucency measurements: using a transverse or sagittal plane？
The emerging landscape of spatial profiling technologies
Nature Reviews Genetics, Published online: 20 July 2022; doi:10.1038/s41576-022-00515-3 Spatial omics methods enable the charting of cellular heterogeneity, complex tissue architectures and dynamic changes during development and disease. The authors review the developing landscape of in situ spatial transcriptome, genome
[Editorial] Reaching the vulnerable without stigma
As of June 30, there have been 5323 cases of monkeypox outside of endemic regions (west and central Africa). The cases have largely been centred in the USA and western Europe and most have been reported in men who have
Evolution gone wrong: Enteric serotonergic neurons and colorectal cancer
Serotonin is a multifunctional signaling molecule. In this issue of Neuron, Zhu et al. (2022) demonstrate, surprisingly, that despite the diminutive size of the enteric serotonin neuronal pool, it is serotonin from these neurons that drives proliferation of colorectal cancer stem
UK heatwave piles further pressure on stretched NHS services
NHS leaders have urged the government to provide resources to improve buildings and infrastructure after many trusts were forced to cancel appointments and change their working patterns in response to the heatwave that has gripped the UK this week.NHS Providers,
Update on the management of diabetes in long-term care facilities
The number of patients with diabetes is increasing among older adults in the USA, and it is expected to reach 26.7 million by 2050. In parallel, the percentage of older patients with diabetes in long-term care facilities (LTCFs) will also
Multispecialty multidisciplinary input into comorbidities along with treatment optimisation in heart failure reduces hospitalisation and clinic attendance
Aims Heart failure (HF) is associated with comorbidities which independently influence treatment response and outcomes. This retrospective observational study (January 2020–June 2021) analysed the impact of monthly HF multispecialty multidisciplinary team (MDT) meetings to address management of HF comorbidities and
Highlights from this issue
The COVID-19 oximetry at home programme This months Editors Choice is an analysis of the CO@h programme. In November 2020, NHS England recommended that patients with symptomatic confirmed COVID-19 who were over 65 years or clinically vulnerable be provided with
Non-invasive prediction models of intraamniotic infection in women with preterm labor
Among women with preterm labor, those with intra-amniotic infection present the highest risk of early delivery and the most adverse outcomes. Identification of intra-amniotic infection requires amniocentesis, perceived as too invasive by women and physicians. Non-invasive methods for identifying intra-amniotic
[Editorial] What’s preventing us from curbing the obesity crisis?
In early June, 2022, when the SURMOUNT-1 trial reported over a 20% weight loss with tirzepatide an explosion of social media posts labelled the results as “unprecedented”, “phenomenal”, and “game-changing”. As obesity rates continue to rise worldwide and the burden
Highlights from this issue
Despite wide ranging advances in neurological therapeutics for many neurological conditions, there are frustratingly few interventions that can reverse a neurological deficit or prevent deterioration. Patients are faced with the consequences—some of which we can help. One such is loss
Omecamtiv Mecarbil as a Therapy for Heart Failure With Low Ejection Fraction
Omecamtiv mecarbil is an oral selective myosin activator being tested as a therapy for patients with chronic heart failure and low left ventricular ejection fraction (LVEF). Its novel mechanism of action, direct activation of myosin, contrasts with that of currently
Time to disrupt health care or is that impossible?
Strain in the NHSListening to the radio while eating my porridge, I hear stories of ambulances waiting 11 hours outside NHS hospitals to be able to transfer patients to accident and emergency departments. Whole shifts of the ambulance crews are
Nearly half of patients with chronic tendinopathy may have a neuropathic pain component, with significant differences seen between different tendon sites: a prospective cohort of more than 300 patients
Objectives Identifying the prevalence of neuropathic pain components in patients with chronic tendinopathy conditions using the Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) questionnaire. Methods Patients with chronic tendinopathy and ‘tendon-like’ conditions treated within a single hospital outpatient
Highlights from this issue
Rumours of the demise of the observational study have been grossly exaggerated So, maybe I’ve taken some artistic licence with Mark Twain’s original version, but this methodological ‘family’ deserved a fair backing. Take the cohort design: this may have had
Clinical utility of pathology data
The practice of pathology is constantly evolving, and much of what we do is data-driven. Precision medicine requires precision pathology. This encompasses a wide remit of modalities that have diagnostic, therapeutic and prognostic ramifications. This has necessitated a greater depth
New genetic loci associated with the risk of clonal hematopoiesis
Nature Genetics, Published online: 18 July 2022; doi:10.1038/s41588-022-01125-9 Genetic and phenotypic analyses of data from over 400,000 participants in the UK Biobank identified 10 new loci associated with the development of clonal hematopoiesis and implicated DNA damage, oncogene signaling, telomere
The impact of insurance mandates on donor oocyte utilization: an analysis of 39,338 donor oocyte cycles from the Society for Assisted Reproductive Technology registry.
Nineteen states passed legislation mandating insurance coverage of assisted reproductive technology (ART), and out-of-pocket costs associated with in vitro fertilization (IVF) vary significantly depending on the region. Consequently, it has been observed that ART utilization differs regionally and is associated
Defining an Approach to Monitoring Brain Health in Individuals Exposed to Repetitive Head Impacts: Lessons Learned from Radiation Safety
Journal of Neurotrauma, Volume 39, Issue 13-14, Page 897-901, July 2022.
The medical expert: time for a re-think?
Medical expert opinion continues to play a critical role in a range of criminal, civil, coronial, and regulatory processes. Such opinion can determine, for example, whether or not the Crown Prosecution Service pursues a conviction for gross negligence manslaughter following
Society for Maternal-Fetal Medicine Consult Series #63: Cesarean scar ectopic pregnancy
Cesarean scar ectopic pregnancy is a complication in which an early pregnancy implants in the scar from a previous cesarean delivery. This condition presents a substantial risk for severe maternal morbidity and mortality because of challenges in securing a prompt
Characterizing cis-regulatory elements using single-cell epigenomics
Nature Reviews Genetics, Published online: 15 July 2022; doi:10.1038/s41576-022-00509-1 In this Review, Preissl, Gaulton and Ren discuss single-cell epigenomic methods and data analysis tools, their readiness for profiling cis-regulatory elements in human tissues and the insight they can provide into
Pregnancy at Age 35 Years or Older
Centers for Disease Control and Prevention data from 2020 demonstrate the continued upward trend in the mean age of pregnant individuals in the United States. Observational studies demonstrate that pregnancy in older individuals is associated with increased risks of adverse
[Editorial] Prevention is better than cure
Attributed to the Dutch humanist scholar, Desiderius Erasmus, the concept of proactive awareness and preventative interventions being more effective than later remedial action has never been more relevant in mental health. Initiatives such as the WHO Mental Health Gap Action
Cardiopulmonary exercise testing for cardiovascular risk assessment in patients undergoing gastric and oesophageal cancer surgery: results from a prospective interventional cohort study
Background Cardiopulmonary exercise testing (CPET) has shown to be useful for preoperative risk stratification in various types of intra-abdominal and thoracic surgery. However, data about the predictive value of CPET for cardiovascular outcome after gastric or oesophageal cancer surgery are
More to Illich than overtreatment: his work is relevant as we reflect on pandemic management
Abbasi repeats Ivan Illich’s quote from the 1970s: “The medical establishment has become a major threat to health.”1 The revival of interest in Illich’s work is welcome, but there is a danger that only the parts endorsed by the medical
Show courage!
We are proud to present to you the annual Norwegian Sports and Exercise Medicine Society’s issue of BJSM. MOT means courage in Norwegian. MOT is also the name of the organisation and life skill programme established 25 years ago after
Health insurance status and cancer stage at diagnosis and survival in the United States
Abstract Previous studies using data from the early 2000s demonstrated that patients who were uninsured were more likely to present with late-stage disease and had worse short-term survival after cancer diagnosis in the United States. In this report, the authors
Vasa Previa: Avoiding Incising The Membranes At Cesarean Delivery
Vasa previa (VP) refers to unprotected fetal vessels running through the membranes over the cervix. Rupture of these vessels frequently leads to fetal death. Prenatal diagnosis with ultrasound and scheduled cesarean delivery at about 35-36 weeks is the only effective
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways
Nature Genetics, Published online: 14 July 2022; doi:10.1038/s41588-022-01124-w Genome-wide association meta-analysis of insomnia in 593,724 cases and 1,771,286 controls identifies 554 risk loci and implicates specific biological pathways through gene prioritization.
[Editorial] WHO launches its Global Action Plan for brain health
On May 27, the 75th World Health Assembly adopted the Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders 2022–2031 (IGAP). By launching the IGAP, WHO is now committed to prioritise brain health over the next decade. This action
[Editorial] Measuring the future of humanity for health
Estimating the future is fraught with uncertainty. Time makes fools of all prophets. But the broad contours of humanity’s destiny can be sketched, at least tentatively. The latest World Population Prospects 2022, published by the UN, provides provocative insights into
Correction: Integrating vocational rehabilitation and mental healthcare to improve the return-to-work process for people on sick leave with depression or anxiety: results from a three-arm, parallel randomised trial
Hoff A, Poulsen RM, Fisker J, et al. Integrating vocational rehabilitation and mental healthcare to improve the return-to-work process for people on sick leave with depression or anxiety: results from a three-arm, parallel randomised trial. Occup Environ Med 2022;79:134–42. The
Sixty seconds on . . . the end of hangovers?
The dream is finally hereA new pill touted as the end of hangovers sold out less than 24 hours after it was released. De Faire Medical, the Swedish probiotics firm behind Myrkl, claims its product is…
Shortening of leucocyte telomere length is independently correlated with high body mass index and subcutaneous obesity (predominantly truncal), in Asian Indian women with abnormal fasting glycemia
Introduction Leucocyte telomere length (LTL) is linked to accelerate aging and premature mortality. In this research, we aimed to explore the relations between biochemical and anthropometry markers and LTL in Asian Indian women with abnormal fasting glycemia (impaired fasting glucose).
Longest and largest cohort study of delirium to date reinforces association while causation remains elusive
The authors of this large cohort study show that one-third of older people with delirium in hospital will develop dementia within 5 years. In the longest and largest cohort study of delirium patients to date Leighton et al1 report that
Change of the residual myometrial thickness during pregnancy after laparoscopic niche resection in comparison to controls without niche surgery; a prospective comparative cohort study
Reduced residual myometrial thickness before and during pregnancy is associated with uterine rupture or dehiscence after vaginal birth after caesarean section. Laparoscopic niche resection performed in case of gynecological symptoms has shown to increase residual myometrial thickness six months after
Generating specificity in genome regulation through transcription factor sensitivity to chromatin
Nature Reviews Genetics, Published online: 12 July 2022; doi:10.1038/s41576-022-00512-6 In this Review, Isbel et al. describe our current understanding of how transcription factors navigate features of chromatin — particularly DNA methylation and nucleosomes — and how this contributes to specificity
[Editorial] No child health without planetary health
Our planet is in crisis. Climate change is affecting every person on earth, with rising temperatures and sea levels, increased water and air pollution, and extreme weather events having an impact on our health, wellbeing, and stability. Children, in particular,
Pay gap: Women in healthcare sector earn 24% less than men, international report finds
Women working in healthcare earn on average 24% less than their male peers and face a larger gender pay gap than in other economic sectors, a joint report by the International Labour Organization and…
VEXAS syndrome extends the neurological complications of haemopathies
VEXAS is a complex acronym for a probably frequent disease neurologist should suggest in various neurological situations. Bert-Marcaz et al report the first case of a CIDP (Chronic Inflammatory Demyelinating Polyneuropathy) revealing in fact a vacuole, E1 enzyme, X-linked, autoinflammatory,
Correction: Joint British Societies guideline on management of cardiac arrest in the cardiac catheter laboratory
Dunning J, Archbold A, de Bono JP, et al. Joint British Societies’ guideline on management of cardiac arrest in the cardiac catheter laboratory. Heart 2022;108:e3. doi:10.1136/heartjnl-2021-320588 This article has been corrected since it was first published to correct a typo
Overall survival as a primary end point in multiple myeloma trials
Nature Reviews Clinical Oncology, Published online: 12 July 2022; doi:10.1038/s41571-022-00665-7 Median overall survival for patients with newly diagnosed multiple myeloma may surpass ten years. Nonetheless, many patients face considerable treatment-related morbidity and relapsed disease. Owing to this typically long overall
Description of the ascertainment of the quality of studies by Fejzo et al. in “Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis”
Alternative splicing as a source of phenotypic diversity
Nature Reviews Genetics, Published online: 12 July 2022; doi:10.1038/s41576-022-00514-4 In this Perspective, the authors discuss how regulated alternative splicing can generate phenotypic diversity and outline emerging evidence that alternative splicing contributes to adaptation and species divergence.
Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells
Two studies published in Immunity propose the existence of distinct functional subpopulations of Kupffer cells in mouse liver, termed KC1 and KC2, based upon single cell and bulk RNA-seq analysis (Bleriot et al., 2021; De Simone et al., 2021). The minor KC2 population (20–30%
Dual Anti-HIV Antibodies Provide Long-term Viral Suppression
Treatment with 2 monoclonal antibodies completely suppressed HIV for about 40 weeks in patients who participated in a small phase 1 trial. The findings, reported in Nature, suggest that future antibody therapies may offer effective HIV treatment for extended periods
Scottish NHS patients can visit US expert for mesh removal surgery
Women in Scotland who suffered life changing side effects from transvaginal mesh implant surgery have been told that they can travel to the United States to have the mesh removed, with all costs met…
Association of hemoglobin A1c time in range with risk for diabetes complications
Introduction We assessed the association between hemoglobin A1c time in range (A1c TIR), based on unique patient-level A1c target ranges, with risks of developing microvascular and macrovascular complications in older adults with diabetes. Research design and methods We used a
COVID-19 in patients with rheumatic diseases: what is the real mortality risk?
We read with great interest the paper published by D’Silva et al1 regarding the main outcomes in rheumatic patients with COVID-19. According to this cohort, there was a mortality rate of 6%, slightly similar to the frequency observed in individuals
A proposed classification for intrauterine device position:the Tal-Reeves classification
Background The lack of a common system for classification of intrauterine device (IUD) position is problematic. In one study, where IUD position was determined by expert opinion alone, increased IUD removal resulted in more pregnancies, while no pregnancies occurred among
Sex and cancer immunotherapy: Current understanding and challenges
Recent evidence highlights patients’ sex relevance in antitumor immune response through a complex interaction—among hormones, genes, behaviors, and the microbiome—that affects both innate and adaptive immune functions, as well as immune evasion mechanisms. These complex interactions ultimately influence the efficacy
Gaps in Evidence Based Medicine: Underrepresented Populations Still Excluded from Research Trials Following 2018 Recommendations from the Health and Human Services Task Force on Research Specific to Pregnant Women and Lactating Women (PRGLAC)
Mapping genetic variants to cellular contexts
Nature Genetics, Published online: 11 July 2022; doi:10.1038/s41588-022-01136-6 Mapping genetic variants to cellular contexts
In-hospital electrical muscle stimulation for patients early after heart failure decompensation: results from a prospective randomised controlled pilot trial
Background Electrical muscle stimulation (EMS) is being evaluated as a possible alternative to exercise training to improve functional capacity in severely deconditioned patients with heart failure (HF). However, there is insufficient data on delayed effects of EMS starting early after
Covid-19: Hospitals and GP clinics return to universal mask wearing as rates rise
Hospitals and general practices around the country are once more insisting on mask wearing by staff and patients in response to high rates of covid.Responsibility for infection control decisions over…
New studies examine COVID‐19 risks among cancer patients
CA: A Cancer Journal for Clinicians, Volume 72, Issue 4, Page 305-307, July/August 2022.
Correction: Comparison between non-pulmonary and pulmonary immune responses in a HIV decedent who succumbed to COVID-19
Goh D, Lee JN, Tien T, et al. Comparison between non-pulmonary and pulmonary immune responses in a HIV decedent who succumbed to COVID-19. Gut 2022;71:1231–1234. doi:10.1136/gutjnl-2021-324754 The grant number C21112056 is incorrect and should be C210112056.
Maternal health: “white” medical curriculum needs overhaul to tackle racial inequalities, campaigners say
Tackling the large racial inequalities seen in maternal health will require changes to the education and training that healthcare workers receive so that they reflect the diversity of patients,…
The etiological spectrum of bowel obstruction and early postoperative outcome among neonates at a tertiary hospital in Uganda
Background Bowel obstruction is a common surgical emergency in newborns. One-fourth of neonates with obstruction suffer postoperative complications, with high mortality, especially in low-income countries. Factors attributed to mortality include prematurity, late presentation and associated multiple congenital anomalies. The prevalence
When can we be confident of surgical cure with ctDNA?
Nature Reviews Clinical Oncology, Published online: 07 July 2022; doi:10.1038/s41571-022-00664-8 Tracking circulating tumour DNA (ctDNA) after surgery holds promise for patient management and therapeutic intervention in non-small-cell lung cancer (NSCLC). A study published by Zhang and colleagues tracks ctDNA from
Human Down syndrome microglia are up for a synaptic feast
In this issue of Cell Stem Cell, Jin et al. report that human Down syndrome microglia exhibit enhanced synaptic engulfment and accelerated tau-induced cellular senescence in human-mouse chimeric brains. They show that inhibiting interferon signaling rescues both developmental and tau-associated phenotypes,
Identification of two intrinsic epithelial subtypes of colorectal cancer
Nature Genetics, Published online: 07 July 2022; doi:10.1038/s41588-022-01101-3 By integrating single-cell and bulk transcriptomic analyses, we found that malignant cells belong to two major intrinsic epithelial subtypes. We propose a refined, three-tiered classification of colorectal cancer subtypes based on intrinsic
COVID fog demystified
Acute mild respiratory SARS-CoV-2 infection can lead to a more chronic cognitive syndrome known as “COVID fog.” New findings from Fernández-Castañeda et al. reveal how glial dysregulation and consequent neural circuit dysfunction may contribute to cognitive impairments in long COVID.
[Editorial] Road safety: more than reducing injuries
The UN High-Level Meeting on global road safety (June 30–July 1) aims to put the issue on the highest political agenda. The need is huge. The global burden of road traffic injuries is estimated at an annual 1·35 million deaths,
Removing special covid leave will only undervalue staff and threaten patient safety
The Office for National Statistics (ONS) estimates that two million people (3% of the population) in the UK currently have long covid. Of those, 1.4 million say the symptoms are adversely affecting…
Cancer treatment and survivorship statistics, 2022
Abstract The number of cancer survivors continues to increase in the United States due to the growth and aging of the population as well as advances in early detection and treatment. To assist the public health community in better serving
[Editorial] Dietary supplements: improving education is not enough
Worldwide demand for dietary supplements skyrocketed at the beginning of the COVID-19 pandemic; some countries reported sales increases of more than 50% in March, 2020, compared with the same period the previous year, and the market continues to grow. Concerns
A GPI-anchored Neurexin 3 proteoform mediates dendritic inhibition
Neuronal wiring is facilitated by diverse synaptic adhesion proteins and their repertoire of alternatively spliced isoforms. In this issue of Neuron, Hauser et al. (2022) uncovered the role of a GPI-anchored neurexin 3 splice variant in inhibitory synapse development and dendritic
Saȷexit: what Saȷid Javid’s tenure as Health Secretary achieved
Although the change of Secretary of State for Health and Social Care usually feels fairly dramatic to avid watchers of NHS politics, Sajid Javid’s second resignation from Boris Johnson’s government…
Workforce attachment after a congenital long QT syndrome diagnosis: a Danish nationwide study
Objective To examine workforce attachment among patients with congenital long QT syndrome (cLQTS) following diagnosis and identify factors associated with workforce attachment. Methods and results In this nationwide cohort study, all patients diagnosed with cLQTS in Denmark between 1996 and
Peter J. Roach (1948–2022)
Peter J. Roach, Indiana University distinguished professor, IUPUI Chancellor’s Professor, and professor of biochemistry and molecular biology at Indiana University School of Medicine, lost his battle to heart failure in Indianapolis on March 11, 2022, 3 months short of his 74th
Errors in Table
In the Original Contribution titled “Association Between Helicopter vs Ground Emergency Medical Services and Survival for Adults With Major Trauma,” published in the April 18, 2012, issue of JAMA, Table 1 has been fixed to include correct data for the
Association of Food and Nonalcoholic Beverage Marketing With Children and Adolescents’ Eating Behaviors and Health
This systematic review and meta-analysis quantifies the association of food and nonalcoholic beverage marketing with behavioral and health outcomes in children and adolescents.
How best to achieve a better and sustainable world?
The world is warming rapidly, and, as the Intergovernmental Panel on Climate Change keeps telling us, we are running out of time to avoid catastrophe and the possible extinction of humans. We seem to…
Making an impact on kidney disease in people with type 2 diabetes: the importance of screening for albuminuria
Albuminuria is useful for early screening and diagnosis of kidney impairment, especially in people with pre-diabetes or type 2 diabetes (T2D), which is the leading cause of chronic kidney disease (CKD) and end-stage kidney disease (ESKD), associated with increased mortality,
Role of artificial intelligence in defibrillators: a narrative review
Automated external defibrillators (AEDs) and implantable cardioverter defibrillators (ICDs) are used to treat life-threatening arrhythmias. AEDs and ICDs use shock advice algorithms to classify ECG tracings as shockable or non-shockable rhythms in clinical practice. Machine learning algorithms have recently been
Maternal morbidity and fetal outcomes among pregnant women at 22 weeks’ gestation or less with complications in two Texas hospitals after legislation on abortion
Decoding the zebrafish genome
Nature Genetics, Published online: 04 July 2022; doi:10.1038/s41588-022-01080-5 A large-scale collaborative effort now provides a comprehensive annotation of functional non-coding elements in the zebrafish genome. This work serves as an essential foundation for future studies to understand how gene regulatory
Specialty training: record number of applicants and posts filled in England, say officials
England saw its highest ever number of doctors applying for specialty training programmes this year and awarded more places than ever before, Health Education England has said, highlighting the stiff…
Low-dose antenatal betamethasone treatment achieves preterm lung maturation equivalent to that of the WHO dexamethasone regimen but with reduced endocrine disruption in a sheep model of pregnancy
This study demonstrates that, in a sheep model of pregnancy, low-dose antenatal steroid treatments (66% reduction in steroid administered) achieve equivalent lung maturation to standard-dose regimens currently in use. The low-dose regimen was predicted to achieve lower peak steroid exposures
T-DXd active in HER2-low disease
Nature Reviews Clinical Oncology, Published online: 01 July 2022; doi:10.1038/s41571-022-00663-9 T-DXd active in HER2-low disease
Digital health and care plan: a compelling and surprisingly realistic vision
This week, Sajid Javid, the Secretary of State for Health and Social Care, published the Digital Health and Care Plan, a document that brings clarity to the myriad digital transformation plans in…
Hypertrophic Plaques on the Vulva
Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
Nature Genetics, Published online: 30 June 2022; doi:10.1038/s41588-022-01100-4 A single-cell transcriptomic analysis of 63 patients with colorectal cancer classifies tumor cells into two epithelial subtypes. An improved tumor classification based on epithelial subtype, microsatellite stability and fibrosis reveals differences in
[Editorial] Ending child marriage: ensuring healthy futures for girls
One in five women are married before the age of 18 years. This fact has serious ramifications for health and wellbeing. Child marriage is associated with pregnancy at a young age, dangerous complications during pregnancy and childbirth, HIV acquisition, and
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