The aetiology of death for marathon runner Phidippides?Endurance training and myocardial infarction with non-obstructive coronary artery disease may have been the cause of death of Phidippides, from present day evidence of an athlete who survived, and is discussed

Phidippides was a legendary Greek runner who ran from Marathon to Athens in 490 BC to announce the victory of the Greeks over the Persians. After running about 40 km to the Acropolis in Athens, he promptly collapsed and died.

Assessment of clinical and occupational cardiovascular riskThis second article in the occupational cardiology series discusses risk for the individual worker, the remainder of the workforce and the public in high-hazard occupations

Physicians assessing cardiovascular risk in a high-hazard workforce face a complex problem. A cardiovascular event in routine operations performed by high-hazard workers may result in widespread loss of life or extensive environmental damage. Using cheap, reliable, and reproducible screening tools,

Factors influencing long-term heart failure mortality in patients with obstructive hypertrophic cardiomyopathy in Western Sweden: probable dose-related protection from beta-blocker therapy

Objective In order to avoid effects of referral bias, we assessed risk factors for disease-related mortality in a geographical cohort of patients with hypertrophic obstructive cardiomyopathy (HOCM), and any therapy effect on survival. Methods Diagnostic databases in 10 hospitals in

Correction: 23 Long term lead survival in adult congenital heart disease patients: a retrospective analysis using clinical correspondence data mining

Stokes A, Brigante O, Rohan K, et al 23 Long term lead survival in adult congenital heart disease patients: a retrospective analysis using clinical correspondence data mining. Heart 2018;104:A22–3. doi: 10.1136/heartjnl-2018-BCS.23. In this article the author Ozhin Brigante should have been listed as

Cardiovascular outcomes of early versus delayed coronary intervention in low to intermediate-risk patients with STEMI in Thailand: a randomised trial

Background The benefit of an early coronary intervention after streptokinase (SK) therapy in low to intermediate-risk patients with ST-elevation myocardial infarction (STEMI) still remains uncertain. The current study aimed to evaluate the cardiovascular outcomes of early versus delayed coronary intervention

The UK National Amyloidosis CentreThe National Amyloidosis Centre at the Royal Free Hospital and University College London is the world’s largest amyloidosis centre with almost 1500 patient referrals annually

The National Amyloidosis Centre (NAC) is a wholly integrated clinic and research facility located in the Royal Free Hospital and University College London (UCL). The NAC has been at the cutting edge of research and treatment into all aspects of

High-sensitive cardiac troponin T as a predictor of efficacy and safety after pulmonary vein isolation using focal radiofrequency, multielectrode radiofrequency and cryoballoon ablation catheter

Introduction Myocardial injury markers such as high-sensitive cardiac troponin T (hs-cTnT) and creatine kinase MB (CK-MB) reflects the amount of myocardial injury with ablation. The aim of the study was to identify the value of myocardial injury markers to predict

Exercise-based cardiac rehabilitation for patients following open surgical aortic valve replacement and transcatheter aortic valve implant: a systematic review and meta-analysis

Objectives Exercise-based cardiac rehabilitation (CR) may be beneficial to patients following transcatheter aortic valve implantation (TAVI) and open surgical aortic valve replacement (SAVR). We aimed to undertake a systematic review and meta-analysis to evaluate the efficacy, safety and costs of

Mechanical performance and healing patterns of the novel sirolimus-eluting bioresorbable Fantom scaffold: 6-month and 9-month follow-up by optical coherence tomography in the FANTOM II study

Objectives We aimed to evaluate the mechanical properties and healing patterns 6 and 9 months after implantation of the sirolimus-eluting Fantom bioresorbable scaffold (BRS). Background The Fantom BRS (Reva Medical, San Diego, USA) has differentiating properties including radiopacity, strut thickness

Pharmacological interventions for the prevention of contrast-induced acute kidney injury in high-risk adult patients undergoing coronary angiography: a systematic review and meta-analysis of randomised controlled trials

Objective Quantify the efficacy of strategies to prevent contrast-induced acute kidney injury (CI-AKI) in high-risk patients undergoing coronary angiography (CAG) with or without percutaneous coronary intervention (PCI). Background CI-AKI remains a common problem. The renoprotective efficacy of existing pharmacological agents

Rationale and design of the Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) diagnostic study: the CorMicA CMR sub-study

Introduction Angina with no obstructive coronary artery disease (ANOCA) is a common syndrome with unmet clinical needs. Microvascular and vasospastic angina are relevant but may not be diagnosed without measuring coronary vascular function. The relationship between cardiovascular magnetic resonance (CMR)-derived

Risk classification in primary prevention of CVD according to QRISK2 and JBS3 ‘heart age, and prevalence of elevated high-sensitivity C reactive protein in the UK cohort of the EURIKA study

Objectives This study assessed cardiovascular disease (CVD) risk classification according to QRISK2, JBS3 ‘heart age’ and the prevalence of elevated high-sensitivity C reactive protein (hsCRP) in UK primary prevention patients. Method The European Study on Cardiovascular Prevention and Management in

Funding of cardiovascular research in the USARobert Califf and Peter Libby – speak about cardiovascular research funding in the United States and what the latest trends are with Mark Nicholls

Funding for cardiovascular research in the United States is undergoing a challenging phase. Political, financial and ethical factors have a growing influence with competition for grants now greater, more sought after, and more strictly-controlled than ever before. This has raised

Characterisation of circulating biomarkers before and after cardiac resynchronisation therapy and their role in predicting CRT response: the COVERT-HF study

Aims Cardiac resynchronisation therapy (CRT) is effective treatment for selected patients with heart failure (HF) but has ~30% non-response rate. We evaluated whether specific biomarkers can predict outcome. Methods A prospective single-centre pilot study of consecutive unselected patients undergoing CRT

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