Kardiyoloji

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Abstract withdrawn as it was not presented at the Meeting 472 – Non-invasive mapping of electromechanical uncoupling: CMR-ECGI repolarisation abnormalities associate with impaired LV strain Amendments to author list 529 – Barriers and Facilitators to Cardiac Rehabilitation Uptake and Adherence

Background Heart failure (HF) remains associated with high mortality worldwide despite advances in guideline-directed therapy. Aim To characterise the patterns and causes of death among Thai patients with chronic HF enrolled in a nationwide registry and to identify predictors of

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Objective To evaluate trends, early clinical outcomes and surgeon-variation and hospital-variation in trainees performing isolated aortic valve replacement (AVR) and mitral valve (MV) surgery, including replacement (MVR) and MV repair (MVr) in the UK. Methods All adults undergoing elective or

Background and aims Heart failure with preserved ejection fraction (HFpEF) phenotypes have been characterised as static entities in trial populations yet their temporal dynamics remain unexplored in routine clinical practice. We aimed to identify HFpEF phenogroups from real-world electronic health

Background Pregnancy in women with cardiac disease carries substantial maternal risk. The modified WHO classification, Cardiac Disease in Pregnancy Study II (CARPREG II) and Zwangerschap bij Aangeboren HARtAfwijkingen (ZAHARA; Pregnancy in Congenital Heart Disease) are the three principal risk stratification

Introduction The systematic review and meta-analysis recently published in Heart provides the most comprehensive synthesis to date of the survival benefit associated with guideline-directed medical therapy (GDMT) in older patients with heart failure and reduced ejection fraction (HFrEF).1 This meta-analysis

Background Out-of-hospital cardiac arrest (OHCA) treatment often requires multiple defibrillatory shocks due to failed defibrillation or refibrillation. The complete nature of refractory ventricular fibrillation (VF) is unknown, as many studies do not consider shocks delivered by lay rescuers prior to

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Background Evidence regarding optimal haemodynamic parameters and prognostic predictors in right ventricular dysfunction (RVD) remains limited. The aim of this study was to examine the relationship between haemodynamic parameters and cardiac output (CO) in RVD and to identify clinically relevant

Background Fibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that affects medium-sized arteries with multifocal (beaded) or focal stenotic lesions, aneurysms, dissections and tortuosity. The extent of aortic involvement in FMD is uncertain. This study evaluates the prevalence and characteristics

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Objectives This exploratory post hoc secondary analysis of the Colchicine for the Prevention of Perioperative Atrial Fibrillation (COP-AF) randomised controlled trial evaluated the association between coronary artery disease (CAD) and postoperative ischaemic outcomes after non-cardiac thoracic surgery and assessed whether

Objective To examine whether the outputs of machine learning algorithms designed to predict risk of cardiovascular disease (CVD) address known deficiencies of the Framingham Risk Score (FRS) and improve risk estimates. Methods For this critical review, Medline, Embase and IEEE

The situation in the emergency departments (EDs) of the UK remains parlous. There are frequent media reports (both in the medical and in the popular press) showing significant overcrowding with ‘corridor care’ becoming normalised. The situation appears to be progressively

Background Hypertrophic cardiomyopathy (HCM) exhibits complex phenotypic heterogeneity. Left ventricular myocardial strain and atrioventricular coupling hold significant clinical value in cardiovascular diseases; however, the impact of different left ventricular hypertrophy (LVH) distribution patterns on myocardial strain and atrioventricular coupling remains

Aim Low-density lipoprotein cholesterol (LDL-C) goal attainment remains suboptimal among individuals with or at risk for atherosclerotic cardiovascular disease (ASCVD). We evaluated contemporary nationwide real-world LDL-C goal attainment in Denmark and the clinical and economic impact of simulated implementation of

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Background Cardiovascular disease (CVD) and light chain (AL) amyloidosis are important causes of morbidity and mortality in patients with multiple myeloma (MM). Additionally, MM therapies can have cardiovascular effects. However, the extent to which phase III MM trials account for

Rationale Higher blood pressure variability (BPV) has been associated with adverse cardiovascular events in various clinical settings, but its effects during critical illness remain unclear. There have been observed disparities in risk-adjusted mortality between females and males in the intensive

Background The expansion of universal health coverage (UHC) in many low- and middle-income countries (LMICs) has occurred alongside a growing burden of chronic disease and multimorbidity. Heart failure (HF) frequently coexists with multimorbidity, which is associated with worse hospitalisation outcomes.

In the early 2000s, the natural history of heart failure (HF) was vividly illustrated, highlighting a defining feature of HF progression: a prolonged course of fluctuating yet steadily worsening functional status, accelerated by episodes of worsening HF.1 Each episode often

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Introduction The optimal anticoagulation strategy for patients with atrial fibrillation (AF) and prior intracranial haemorrhage (ICH) remains uncertain. Although direct oral anticoagulants (DOACs) have demonstrated a more favourable safety profile than vitamin K antagonists (VKAs) in the general AF population,

Objective This study aimed to evaluate the safety and efficacy of transapical epicardial temporary pacemaker lead implantation compared with the conventional transvenous approach in patients undergoing transapical transcatheter aortic valve implantation (TAVI). Methods In this single-centre retrospective study, 399 patients

Background Diagnosing heart failure with preserved ejection fraction (HFpEF) can be challenging because natriuretic peptide (NP) plasma levels and diastolic function parameters during rest echocardiography may be normal or marginally abnormal in patients displaying exercise-induced symptoms suggestive of HF. In

Background Electrical cardioversion (ECV) is widely used for restoring sinus rhythm in atrial fibrillation (AF). However, population-level trends in use of ECV in individuals with AF remain poorly characterised. Aim We examined nationwide temporal trends in ECV utilisation between 2010

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Acquired valvular heart disease (VHD) is common in the 21st century and its prevalence is increasing, mainly due to increasing longevity associated with the progression of age-related degenerative changes as well as the rising prevalence of rheumatic heart disease.1 Cross-sectional

Background This study aimed to explore the association of long-term left ventricular assist device (LVAD) support with changes in inflammation and cardiac remodelling in subjects with advanced heart failure (HF). Methods A single-centre prospective observational trial was conducted in 16

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Background Black individuals have a lower incidence of atrial fibrillation (AF) than White individuals, despite a higher burden of traditional risk factors. Prior studies have suggested that European genetic ancestry may contribute to this paradox, but findings have been inconsistent.

In this issue of the journal, Shoji et al showed that isolated non-specific ST-segment and T-wave abnormalities (NSSTTAs) are associated with incident heart failure (HF).1 The authors conducted a large prospective general population cohort study of more than 30 000

Background For patients with a high risk of sudden cardiac death, despite the benefits of an implantable cardioverter defibrillator (ICD), some patients are still at high risk of death. Aim The purpose of this study was to develop and validate

Background Clinical benefit of percutaneous coronary intervention (PCI) in chronic coronary syndromes (CCS) remains controversial. Coronary wave intensity analysis (WIA) provides mechanistic insights into cardiac–coronary coupling. Objectives To assess peri-PCI WIA changes at rest and during hyperaemia, and to identify

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Background Australian guidelines recommend the CHA2DS2-VA (congestive heart failure, hypertension, age ≥75 years (double weight), diabetes mellitus, previous stroke (double weight), vascular disease, age 65–74 years) score to identify patients with atrial fibrillation (AF) at low stroke risk who should

Background Differentiating heart failure (HF) with mildly reduced/reduced ejection fraction (HFmr/rEF) from HF with preserved ejection fraction (HFpEF) guides therapy but echocardiography may be delayed or unavailable. We developed and validated machine learning models using routine 12-lead ECG data to

Objectives Elevated resting heart rate (RHR) predicts mortality in middle-aged and older adults, primarily through cardiovascular disease (CVD). Whether RHR predicts mortality in young adults, which causes of death are involved and whether the association replicates are unclear. In young

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Background Postoperative atrial fibrillation (AF) is a common complication after coronary artery bypass grafting (CABG) but is less well characterised after multivessel percutaneous coronary intervention (MV-PCI). With the increasing use of MV-PCI, we compared the incidence and clinical implications of

Infective endocarditis (IE) is a complex and severe disease with in-hospital mortality plateauing at ~20% and 1 year mortality up to 40% in most contemporary cohorts. Although 60–70% of patients with IE present theoretical indication(s) for surgery,1 cohort studies report

Background Extracorporeal membrane oxygenation (ECMO) is increasingly used to treat patients with severe cardiac and pulmonary failure but the complications of acute kidney injury and fluid overload are common. We aimed to determine whether the early initiation of continuous renal

Background Permanent pacemaker implantation (PPI) remains a serious complication following aortic root replacement (ARR) and valve-sparing root replacement (VSRR). This is due to the proximity of the atrioventricular node and the bundle of His to the aortic valve annulus and

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Aims Cardiopulmonary exercise testing (CPET) parameters are used for heart failure (HF) prognostication. While the ventilation to carbon dioxide production (VE/VCO2) slope ≥34 identifies high risk, patients with intermediate values remain heterogeneous. The VE/VCO2 Y-intercept, reflecting dead space ventilation at

Background Socioeconomic deprivation has been associated with adverse outcomes after aortic surgery, although evidence remains inconsistent. We assessed its impact on postoperative and long-term outcomes after major aortic surgery. Methods We included consecutive patients who underwent type A acute aortic

Cardiac implantable electronic devices (CIEDs), such as pacemakers and implantable cardioverter-defibrillators, are increasingly common in patients with cardiovascular disease. CIEDs contain detailed records of cardiac rhythm and device function that can provide additional information on the final moments before death.

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Aim This study investigated the influence of depression status on lipid lowering therapy (LLT) prescribing and achievement of guideline targets for low density lipoprotein cholesterol (LDL-C) levels in patients after first documentation of a high risk of developing atherosclerotic cardiovascular

Background Congenital aortic stenosis (ConAoS) accounts for approximately 4%–8% of all congenital heart diseases. Chronic pressure overload may result in myocardial stiffening, leading to impaired cardiac filling, reduced contractility and ultimately contributing to the onset of symptomatic heart failure. Shear

Background Premature ventricular complexes (PVCs) are common and can cause concerns in both patients and their caregivers. In patients with structural heart disease, PVCs are associated with worse clinical outcomes. However, in patients without such disease, the prognostic implications of

Background Systolic murmurs are common in adults without significant valvular heart disease (VHD) and are more prevalent in women than in men, but the determinants of murmur audibility remain unclear. We aimed to identify the physiological determinants of innocent murmurs

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Shimamoto K, Ohno S, Kato K, et al. Impact of cascade screening for catecholaminergic polymorphic ventricular tachycardia type 1. Heart 2022;108:840-7. ­ This article was previously published with an error. In Results section ‘AAs 3378–4201’ should read ‘AAs 3778–4201’. The

Background Racial disparities in valvular heart disease are well-documented, yet evidence specific to mitral regurgitation (MR) remains fragmented. This study examined racial differences in mortality and treatment access among patients with moderate-severe MR within a universal healthcare system. Methods This

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Background The Forrester classification remains a cornerstone for assessing haemodynamic status in heart failure, yet its clinical application is restricted by the invasiveness of right heart catheterisation. This study aimed to develop a novel, non-invasive and reproducible alternative by integrating

Objective To develop and interpret an explainable machine learning (ML) model integrating inflammatory biomarkers and traditional risk factors for the diagnosis of coronary artery disease (CAD). Methods We retrospectively analysed 4656 patients undergoing coronary angiography for suspected CAD. Demographic, clinical,

Background Approximately one million individuals live with heart failure in the UK, and clinicians diagnose around 200 000 new cases each year. Although lifesaving treatments such as heart transplantation (HTx) and left ventricular assist device (LVAD) therapy exist, healthcare providers

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Background Chronic total occlusion (CTO) often triggers collateral coronary development, yet the relationship between angiographically graded collaterals and myocardial viability remains incompletely understood. We evaluated whether Rentrop collateral grading predicts tissue-level viability using contemporary quantitative cardiac magnetic resonance (CMR). Methods

In the healthcare field, we treat disease. When high blood pressure was first recognised by insurance actuaries as an adverse mortality risk, we adopted the term ‘hypertension’ as a disease in fitting with that approach. Adverse lipid profiles were added

Background Congenital heart disease surgery includes intricate structures that are perhaps hard to completely understand by traditional two-dimensional shapes. Individualised, centre-based three-dimensional (3D) heart models may enhance structural imaging and surgical preparation, while data on their medical effect continue to

Background Atrioventricular block (AVB) in Takotsubo cardiomyopathy (TCM) is a rarely reported complication. Due to its low incidence and lack of randomised trials, there remain significant gaps in the evidence regarding its underlying mechanisms, the probability of conduction recovery and

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Background Mineralocorticoid receptor antagonists (MRAs) are core therapy in chronic heart failure (HF) and reduce all-cause mortality and sudden cardiac death. However, direct comparisons of spironolactone and eplerenone in the context of ventricular arrhythmia recurrence are lacking. This study aims

Background Aortic stenosis (AS) leads to left ventricular (LV) remodelling and fibrosis. Myocardial fibrosis can be focal and irreversible, associated with poor prognosis, or diffuse and potentially reversible after surgery. Cardiac magnetic resonance imaging (CMR) shows promise in quantifying diffuse

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On behalf of the President, Board, Executive and Programme Committee of the British Cardiovascular Society (BCS), we are delighted to welcome colleagues to Manchester Central from 1 June to 3 June 2026 for the BCS Annual Conference. This year’s theme,

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Background and aims The Heavy, Hypertensive, Atrial fibrillation, Pulmonary hypertension, Elder, Filling pressure (H2FPEF) score is a widely used diagnostic tool for heart failure with preserved ejection fraction (HFpEF). Angina symptoms are common in patients with HFpEF but are not

Objective To quantify ethnic disparities in mortality after acute coronary syndrome (ACS) by comparing outcomes in Black, Asian and hite population groups. Methods We conducted a systematic review and meta-analysis of observational studies reporting mortality after ACS by ethnicity. Embase,

Background Conduction system pacing (CSP) has emerged as an alternative to right ventricular pacing (RVP) for atrioventricular block (AVB) aiming to avoid ventricular dyssynchrony and adverse heart failure outcomes yet clinical adoption remains limited due to insufficient randomised evidence. Objectives

Background Despite growing interest in male–female differences in cardiovascular disease, evidence in infective endocarditis (IE) is limited and contradictory. Methods This prospective study included all patients with definite or possible valvular IE discussed by the endocarditis team from 2016 to

‘War does not determine who is right, only who is left.’ Bertrand Russell Many of us have ‘left-right’ fatigue when it comes to news and politics, but for those who care for people with congenital heart disease, the question of

Objective Syndromic conditions are frequently associated with congenital heart disease (CHD). Their distribution, recognition and prognostic impact in adults with CHD (ACHD) remain poorly characterised due to limited assessment beyond childhood. Methods We retrospectively analysed 9826 patients with ACHD from

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Background Native aortic valve endocarditis continues to present significant operative challenges, often complicated by heart failure, peri-annular extension and conduction disturbances. This study aimed to evaluate temporal trends, outcomes and predictors of mortality following surgery within a nationwide cohort. Methods

Background Cancer survivors often face the risk of developing heart failure (HF) as a result of their previous cancer therapy. However, the availability of early predictors for such complications remains limited. Recent studies have highlighted the potential link between chronic

Background Patients with coexisting heart failure (HF) and diabetes mellitus are often prescribed complex treatment regimens, which can contribute to adverse clinical outcomes. However, the impact of such therapeutic complexity may be shaped by social determinants of health, particularly educational

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Objective To investigate whether aligning exercise timing with chronotype enhances cardiometabolic and sleep-related benefits in sedentary adults with cardiovascular risk factors. Methods In this 12-week randomised controlled trial conducted in Lahore, Pakistan (January–June 2025), 150 sedentary adults (aged 40–60) with

Advances in congenital and acquired heart disease management have allowed more women than ever to reach reproductive age and pursue pregnancy. Yet, as maternal cardiology evolves, new stressors emerge that challenge conventional risk stratification.1 Among them, twin pregnancy represents a

Introduction Control of blood pressure (BP) continues to be a challenge globally. Clinical trials have shown home BP monitoring and text-message interventions to lower BP. Integrating these to personalise supportive messaging in response to changing BP and activity through leveraging

Background Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of sudden cardiac death (SCD), and myocardial fibrosis plays a central role in the pathophysiology process. Radiolabelled fibroblast activation protein inhibitor (FAPI) positron emission tomography computed tomography (PET) imaging enables

Cardiovascular disease remains the primary cause of mortality among women worldwide.1 Nevertheless, sex-specific evidence still lags compared with that for men only. The majority of our current practice rests on a ‘one-size-fits-all’ approach, developed from studies involving predominantly male cohorts,

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 For the podcast associated with this article, please visit https://academic.oup.com/eurheartj/pages/Podcasts.

 For the podcast associated with this article, please visit https://academic.oup.com/eurheartj/pages/Podcasts.

Background Preprocedural risk prediction of 30-day all-cause mortality after percutaneous coronary intervention (PCI) aids in clinical decision-making and benchmarking hospital performance. This study aimed to identify preprocedural factors to predict the risk of 30-day all-cause mortality post-PCI using machine learning

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Introduction The PRECISE study demonstrated that the Prospective multicentre imaging study for evaluation of chest pain (PROMISE) Minimal risk score (PMRS) can identify patients with recent onset stable chest pain who could safely be reassured and discharged without further testing.

Objective To develop diagnostic models to predict initial heart failure (HF) hospitalisation in patients with unstable angina (UA) and prognostic models to predict rehospitalisation for recurrent or new-onset HF after discharge, aiming to enhance early identification and patient care strategies.

Background Cardiovascular disease (CVD) is the leading cause of mortality worldwide, while depression is highly prevalent in this patient population and has long been regarded as an independent risk factor for increased mortality. However, recent evidence suggests that this association

Background Patients with heart failure (HF) frequently suffer from undetected declines in cardiorespiratory fitness (CRF), which significantly increases their risk of poor outcomes. However, current clinical practice lacks effective tools for early CRF risk stratification. Methods We conducted an artificial

Background Estimates of long-term atrial fibrillation (AF) incidence in individuals with sinus rhythm are limited. This study investigated age-stratified and sex-stratified long-term incidence of AF in individuals with baseline sinus rhythm and no history of AF, and examined associations between

Background Worse prognosis in cardiac sarcoidosis (CS) is likely associated with diagnostic delay and cardiac involvement as first sarcoidosis (de novo) presentation, but data are limited. Methods We retrospectively investigated 95 patients with CS diagnosed 2003–2024. Using electronic health records,

Background Invasive coronary function testing (CFT) is indicated in patients with refractory angina with non-obstructed coronary arteries (ANOCA). Despite this, questions remain regarding patient selection for testing, safety and integration of CFT within clinical pathways and the impact that endotyping

The integration of artificial intelligence (AI) and machine learning (ML) into cardiology represents one of the most profound opportunities to transform patient care. Automated diagnostics, predictive analytics and prescriptive treatment recommendations promise to reshape workflows, improve efficiency and get us

Background Delays in performing urgent coronary artery bypass graft (CABG) surgery are increasing across the UK, with national wait times now exceeding guideline targets. Prolonged preoperative admissions contribute to hospital bed pressures, increased costs and negative psychosocial effects for patients.

Background Anticoagulation non-adherence is attributed to myriad factors in patient populations across the world. While direct oral anticoagulants (DOACs) have demonstrated several clinical advantages over other anticoagulant classes, non-adherence persists and the underlying contributors vary by geography. Objective Outline patient

Background Although exercise stress testing (EST) is commonly used for risk stratification in coronary artery disease (CAD), it yields inconclusive results in up to 20% of patients. Stress perfusion cardiac magnetic resonance (CMR) is a comprehensive and accurate tool for

The following abstracts have been corrected since publication: 2-032 – The author list has been updated to list ‘Prasanth Giri Neelam Naganathan’ as the first author. 2-036 – The author list has been updated to add missing authors and correct the order.

Background Plasma concentrations of procollagen type-I C-terminal pro-peptide (PICP) and collagen type-I C-terminal telopeptide (CITP) may reflect collagen turnover and systemic fibrosis. We investigated the effect of pirfenidone, an anti-fibrotic agent, on PICP and CITP, and their association with myocardial

Background Previous studies have suggested an adverse role of epicardial adipose tissue (EAT) in aortic stenosis (AS), potentially mediated by direct effects on the myocardium. This study aimed to assess whether EAT volume and density are associated with cardiac remodelling

Aims Heart failure (HF) often coexists with chronic kidney disease (CKD), impacting prognosis. This study aims to evaluate renal function trajectories and their impact on major clinical outcomes in a cohort of patients hospitalised for ‘de novo’ HF with reduced

Background Persistent atrial fibrillation (AF) remains challenging to treat with catheter ablation. The left atrial posterior wall (PW) may represent an important non-pulmonary vein (PV) substrate; however, randomised trials have not demonstrated improved outcomes with adjunctive PW isolation (PWI), potentially

Background International guidelines recommend percutaneous coronary intervention within 120 min for high-risk acute coronary syndrome. In Indonesia, a sprawling archipelago with a rising cardiovascular burden, the ministry of health is expanding catheterisation laboratory (cath lab) infrastructure. This study aims to

Background Early graft failure within 90 postoperative days is the leading cause of mortality after heart transplantation. Existing risk scores, based on linear regression, often struggle to capture the complex, multifactorial biological interactions necessary for personalised donor–recipient matching. This study

Introduction Persistent atrial fibrillation (PersAF) presents a significant clinical and economic burden and is associated with poorer outcomes after catheter ablation compared with paroxysmal atrial fibrillation (AF). Pulsed field ablation (PFA) has emerged as a new form of energy modality

Background There is a lack of contemporary data describing patients with left ventricular (LV) systolic dysfunction post myocardial infarction (MI) in terms of symptom burden and secondary prevention measures. The aim of this study was to describe patients with various

Objectives To evaluate if an intervention to improve health literacy, using the risk communication tool ‘Your Heart Forecast’ and informative e-mails, can lower patients’ blood pressure (BP) and total cholesterol to high-density lipoprotein ratio (TC/HDL). Design A cluster randomised controlled

Background The benefits of minimally invasive mitral valve surgery (MIMVS) compared with conventional approaches (CMVS, conventional mitral valve surgery) remain controversial. We conducted a systematic review and meta-analysis to evaluate the short-term benefits between these approaches. Objective To evaluate the

Despite the widespread implementation of heart failure (HF) management in routine clinical practice, clinicians still face major challenges in achieving precise and cost-effective diagnoses of HF with preserved ejection fraction (HFpEF).1 2 The conventional HFA-PEFF (Heart Failure Association Pre-test assessment,

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Background Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) carries high mortality. Early revascularisation improves survival, but the effect of structured multidisciplinary care on outcomes remains underexplored. Methods and results ACT-SHOCK is a service evaluation at a UK tertiary cardiac

Introduction Inherited cardiac conditions, including dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), may have a monogenic cause identified through genetic testing (GT). Confirmation of pathogenic gene variants can have important implications for the patient and their relatives. The UK National

Background Patients with severe aortic stenosis (AS) are at high risk of mortality, regardless of symptom status. Despite this, aortic valve replacement rates remain low for patients with severe AS due to challenges in identifying clinically significant AS in time.

Background The epidemiology of native valve infective endocarditis (IE) has shifted toward older adults with substantial comorbidity burdens, yet contemporary nationwide data on outcomes and surgical impact remain limited. Methods We conducted an 18-year nationwide cohort study of adults hospitalised

Johnson LS, Economou Lundeberg J, Wuopio J, et al. Response to: Correspondence on ‘Estimated sodium intake and premature ventricular complexes: data from the population-based Swedish CArdioPulmonary bioImage study’ by Campbell. Heart 2025;111:741–43. This letter was updated post-publication in response to

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Background Annually, 4% of the global population undergoes non-cardiac surgery, with 30% of those patients having at least one cardiovascular risk factor. It is estimated that the 30-day mortality is between 0.5% and 2%. The main objective of this study

Background Constrictive pericarditis (CP) is a rare but significant pericardial disease resulting in impaired ventricular filling and heart failure symptoms, often following cardiac surgery. Its clinical presentation complicates diagnosis, mimicking other causes of heart failure. Recent technological advances, including artificial

Background Severe aortic stenosis (AS) causes a pathophysiological cascade, which impairs myocardial blood flow. This effect is exacerbated in the presence of coronary disease (CAD). Treatment with transcatheter aortic valve implantation (TAVI) may promote reversal of these pathophysiological conditions. Methods

Background Although chest X-rays (CXRs) are widely used, diagnosing mitral stenosis (MS) based solely on CXR findings remains challenging in some cases. Objective This study aimed to develop a deep learning-based artificial intelligence (AI) model to detect MS using CXR.

In their interesting paper, Davidson et al1 studied the ability of auscultation to identify heart valve disease. They randomly selected participants in the Tromsø 7 study to undergo both cardiac auscultation (digitally recorded and then evaluated offline by trained general

Contemporary cardiology faces a paradox: unprecedented technological capability coincides with declining scientific curiosity and clinical judgement. This manuscript examines the shift from question-driven, physiologic medicine to an approach dominated by procedural feasibility, commercial influence and algorithmic decision-making. Advances such as

Background Malnutrition influences prognosis in patients with heart failure, but current nutritional evaluation methods are excessively complex for routine clinical use. The role of the serum albumin concentration, a widely used surrogate marker, in acute heart failure remains unclear. We

Introduction and objectives Brugada syndrome (BS) is a channelopathy associated with an increased risk of sudden cardiac death (SCD). Intense physical activity is a recognised trigger of life-threatening arrhythmias in long QT syndrome, catecholaminergic ventricular tachycardia syndrome and arrhythmogenic cardiomyopathy,

Background Predicting progression to aortic valve replacement (AVR) in moderate aortic stenosis (AS) is challenging. This study explored whether haemodynamic parameters from four-dimensional flow MRI (4D flow MRI) are associated with the potential progression to AVR. Methods 15 patients with

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Atrial fibrillation (AF) and premature ventricular complexes (PVCs) are two of the most prevalent arrhythmias in the general population. It is not surprising that their prevalence increases further with longer monitoring durations and among patients with structural heart disease (SHD).

Objective Identify predictors for mortality and clinical short-term outcomes in patients with left-sided infective endocarditis (IE). Methods This study was a retrospective cohort investigating 376 patients who experienced left-sided IE between 1 January 2013 and 31 December 2022, at the

Aim To systematically evaluate whether relationships between cardiac rehabilitation participation and clinical outcomes, return to work, or knowledge about cardiovascular disease vary across socioeconomic indicators. Methods A systematic review was conducted using CENTRAL, CINAHL, Embase and Medline up to 1

Objective To develop and validate a 10-year predictive model for cardiovascular and metabolic disease (CVMD) risk using comprehensive health examination data from nearly 37 701 individuals. Methods This retrospective cohort study used health examination data, including demographic information, clinical measurements,

Diabetes mellitus is highly prevalent in patients with coronary atherosclerosis. As a result of several factors, including a pro-inflammatory state, dyslipidaemia, hyperglycaemia and insulin resistance, coronary artery disease in patients with diabetes is characterised by diffusely diseased vessels with smaller

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Background Nonagenarians and centenarians admitted to intensive care units (ICUs) following in-hospital cardiac arrest (IHCA) represent a growing yet understudied population. Clinicians require accurate prognostic tools to inform early goals of care discussions and resource allocation. This study evaluated the

Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide, and CT imaging plays a crucial role in its diagnosis and management. However, the clinical use of CT is limited by factors, such as suboptimal image quality,

This May, the World Health Assembly (WHA) will vote on re-establishing a mandate for the WHO to address the health consequences of nuclear weapons and war.1 Health professionals and their associations should urge their governments to support such a mandate

Background Guidelines strongly recommend reperfusion therapy, including thrombolysis and percutaneous coronary intervention, for ST-elevation myocardial infarction but contraindicate its use in most non-ST-elevation acute coronary syndromes (ACS). This practice largely stems from the landmark fibrinolytic therapy trialists (FTT) meta-analysis, which

Background Acute kidney injury (AKI) often complicates percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG). However, evidence on the incidence and prognostic impact of AKI after revascularisation for left main coronary artery disease (LMCAD) is scant, especially in

Background Stroke after transcatheter aortic valve implantation (TAVI) is an infrequent but serious complication with important impact on morbidity and mortality. Contemporary real-world evidence on the risk factors of early stroke after TAVI is scarce. We aimed to evaluate the

Abstract Background and aims Strategies of de-escalation of dual antiplatelet therapy (DAPT) improve outcomes after percutaneous coronary intervention compared to standard DAPT. However, the potential impact of sex on the safety and efficacy of these strategies is yet to be

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Background Fabry disease (FD) is an X linked lysosomal disorder with ventricular myocardial involvement that drives morbidity and mortality. Early diagnosis of cardiac involvement can be difficult. This study explored whether abnormal left atrial (LA) strain by cardiovascular magnetic resonance

Background Coronary artery disease (CAD) is one of the biggest causes of mortality worldwide. Risk stratification for early detection is essential for the primary prevention of CAD. QRISK3 is known to overestimate future CAD risk in some populations, resulting in

Legalisation of medical and recreational cannabis commerce is spreading around the world, associated with increased use1 and falling perception of the risk.2 Frequent cannabis use has increased in several countries, and many users believe that it is a safe and

Background Since the 1960s, beta blockers have been used to treat hypertrophic obstructive cardiomyopathy (HOCM), a genetic disorder causing abnormal heart muscle thickening. This systematic review evaluates their efficacy across clinical outcomes. Methods Registered on PROSPERO (CRD42022344255), searches were performed

Background We aimed to estimate mental disorder disparities in cardiovascular disease (CVD) incidence and determine whether these disparities were worsened by the COVID-19 pandemic. Methods For each outcome (myocardial infarction (MI), heart failure and stroke), we created a population-based cohort

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Background Transcatheter aortic valve replacement (TAVR) has emerged as an alternative treatment for aortic regurgitation (AR) in patients at high surgical risk. However, evidence comparing outcomes of different new-generation devices remains limited. Objectives To compare clinical outcomes of on-label, off-label

Introduction Resistant hypertension remains a clinical challenge, often linked to elevated aldosterone levels not fully controlled by mineralocorticoid receptor antagonists. Aldosterone synthase inhibitors (ASIs) directly suppress aldosterone production. We evaluated the efficacy and safety of ASIs for blood pressure (BP)

In his song ‘Envelhecer’ (‘Aging’), Arnaldo Antunes states that “the most modern thing there is in this life is to grow old”.1 In this piece, he reframes aging not only as an inevitable biological process, but also as a privilege.

Background Atrial fibrillation (AF)-induced cardiomyopathy (AIC) is characterised by reversible left ventricular (LV) dysfunction after restoration of sinus rhythm (SR). The need for continued guideline-directed medical therapy (GDMT) for heart failure after LV ejection fraction (LVEF) recovery in AIC after

Background Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial regulator of cholesterol metabolism. Loss-of-function variants in PCSK9 are associated with lower levels of circulating low-density lipoprotein cholesterol (LDL-C) and reduced cardiovascular disease (CVD) risk, while gain-of-function variants correlate

Background Routine invasive management by coronary angiography and revascularisation as appropriate reduces recurrent ischaemic events in non-ST-segment myocardial infarction (NSTEMI), but its mortality benefit is uncertain. Methods Within this state-wide retrospective cohort study, patients with a primary diagnosis of NSTEMI

Background Hospitalisation with acute heart failure (AHF) carries a high risk of death, and those surviving to discharge remain at high risk of death or rehospitalisation with AHF. The impact of outpatient heart failure (HF) specialist care after discharge from

In the context of a steadily ageing population, there is a continuous increase in the prevalence and incidence of all primary chronic conditions.1 Among the chronic conditions, heart failure (HF), together with other cardiovascular conditions (ie, atrial fibrillation), shows increasing

Aim In the UK, pharmacological management of patients with heart failure (HF) occurs predominantly in general practice. Using data from the Clinical Practice Research Datalink, we examined the prevalence and risk factors for medication non-adherence and its association with hospitalisation

Introduction An evidence-based selection between fractional flow reserve (FFR) and optical coherence tomography (OCT) to drive percutaneous coronary intervention is still lacking. Methods Patients enrolled in the Fractional Flow Reserve vs. Optical Coherence Tomography to Guide Revascularization of Intermediate Coronary

Background Those with premature coronary heart disease (pCHD) have a lower 5-year risk of repeat events; however, their lifetime risk is high. The aim of this study was to assess secondary prevention (SP) medical therapy and risk factor (RF) monitoring

Background Though undiagnosed in many patients, especially those with cryptogenic stroke, atrial fibrillation (AF) is a key cause of ischaemic stroke. By allowing extended cardiac monitoring, implantable loop recorders (ILRs) may help enhance AF identification and secondary stroke prevention. Compared

Revascularisation of multivessel coronary artery disease (MVD) can be accomplished by either percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery. An individual-patient-data pooled analysis from eight randomised controlled trials (RCTs) that assigned 7040 patients with MVD (without

Background Acute myocarditis is a potentially life-threatening cardiac condition and immediate assessment of this disease is imminent. While laboratory tests, electrocardiography or transthoracic echocardiography can provide indirect signs for the presence of acute myocarditis, cardiac magnetic resonance (CMR) imaging enables

Background Evidence regarding cardiovascular adaptation to pregnancy in women with pregestational diabetes is limited. Our study aimed to describe left ventricular (LV) remodelling and vascular adaptation to pregnancy in women with type 1 diabetes. Methods In this prospective cohort study,

Background The complication risk of procedures may be influenced by operator and institutional characteristics. Our aim was to assess whether supervising consultant seniority and operative volume, and hospital volume were associated with the risk of reintervention following complex device implantation.

Background Valvular surgery for infective endocarditis (IE) can improve survival but carries substantial risk. Limited data exist on long-term outcomes for patients who survive surgery compared with a background population. We aim to compare long-term mortality and morbidity in patients

Background Truncating variants in the Filamin C (FLNCtv) gene are causative of highly arrhythmogenic cardiomyopathies. Guidelines remain controversial concerning competitive and high-intensity sports for FLNCtv carriers. Indeed, the impact of high-intensity exercise on individuals carrying these variants remains poorly understood.