Safety and effectiveness of non-vitamin K oral anticoagulants versus warfarin in real-world patients with non-valvular atrial fibrillation: a retrospective analysis of contemporary Japanese administrative claims data

Objective To assess the safety (ie, risk of bleeding) and effectiveness (ie, risk of stroke/systemic embolism (SE)) separately for four non-vitamin K oral anticoagulants (NOACs; apixaban, dabigatran, edoxaban and rivaroxaban) versus warfarin in Japanese patients with non-valvular atrial fibrillation (NVAF),

GRACE score and cardiovascular outcomes prediction among the delayed coronary intervention after post-fibrinolytic STEMI patients in a limited PCI-capable hospital

Background In Thailand, due to limited availability of percutaneous coronary intervention (PCI)-capable hospitals, a number of patients with ST-elevation myocardial infarction (STEMI) after fibrinolytic therapy underwent the delayed coronary intervention (24 hours to 2 weeks). Existing tool such as the

Association of left anterior descending artery involvement on clinical outcomes among patients with STEMI presenting with and without out-of-hospital cardiac arrest

Background ST-segment elevation myocardial infarction (STEMI) outcomes are influenced by the location of the culprit vessel with worse outcomes portended with a left anterior descending (LAD) culprit lesion. However, relatively little is known about the independent association of LAD involvement

Under Our Very Eyes

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows.

Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: the Nordic-Baltic Bifurcation Study IV

Background It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to

Correction: 8 A prospective longitudinal follow up study using T1 and T2 mapping sequences and twelve-segment myocardial assessment to identify and monitor myocardial inflammation in myositis

Bromage D, Nabeebaccus A, O’gallagher K, et al. 8 A prospective longitudinal follow up study using T1 and T2 mapping sequences and twelve-segment myocardial assessment to identify and monitor myocardial inflammation in myositis. Heart 2019;105:A7–8. doi: 10.1136/heartjnl-2019-BSCMR.8. In this abstract, the

The Key Laboratory of Pulmonary Vascular Medicine, Chinese Academy of Medical Sciences (KLPVM-CAMS)A medical centre focusing on clinical, translational and basic research, whose mission is to improve the outcome of patients with pulmonary vascular disease: Over 1800 patient referrals during 2018

For over 20 years, the Key Laboratory of Pulmonary Vascular Medicine, under the leadership of Dr Zhi-Cheng Jing together with his multidisciplinary team have studied pulmonary vascular science in China. The major research performed, and internationally recognized findings are as follows.

When the CAR Targets Scar

Deposition of extracellular matrix in disease-stressed tissue occurs in diverse organs and disease contexts. The resulting fibrosis may have short-term adaptive features, but it impairs tissue function over time. In the heart, fibrosis is commonly divided into two types: reactive

Effects of oral sildenafil on exercise capacity in children with pulmonary arterial hypertension: a randomised trial

Objective The 16-week, randomised, double-blind Sildenafil in Treatment-Naïve Children, Aged1–17 years, with Pulmonary Arterial Hypertension (STARTS-1) study assessed the effect of sildenafil on cardiopulmonary exercise testing (CPET) in treatment-naïve paediatric patients with pulmonary arterial hypertension (PAH) and included a long-term

Acute Severe Hypertension

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage.

Effect of procedural refinement of transfemoral transcatheter aortic valve implantation on outcomes and costs: a single-centre retrospective study

Objectives To determine the effect of introducing several procedural refinements of transfemoral transcatheter aortic valve implantation (TAVI) on clinical outcomes and costs. Design Retrospective analysis comparing two consecutive 1-year periods, before and after the introduction of procedural refinements. Setting Tertiary

Mobile Devices and Health

Mobile health — the application of sensors, mobile apps, social media, and location-tracking technology to obtain data pertinent to wellness and disease diagnosis, prevention, and management — makes it theoretically possible to monitor and intervene whenever and wherever acute and

The aetiology of death for marathon runner Phidippides?Endurance training and myocardial infarction with non-obstructive coronary artery disease may have been the cause of death of Phidippides, from present day evidence of an athlete who survived, and is discussed

Phidippides was a legendary Greek runner who ran from Marathon to Athens in 490 BC to announce the victory of the Greeks over the Persians. After running about 40 km to the Acropolis in Athens, he promptly collapsed and died.

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