Catastrophic health expenditures, insurance churn, and non-employment among gynecologic cancer patients in the United States

In recent years, there has been growing recognition of the financial burden of severe illness, including associations with higher rates of non-employment, uninsurance and catastrophic out-of-pocket health spending. Gynecologic cancer patients often require expensive and prolonged treatments, potentially disrupting employment

Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial

Objective To test the effectiveness of an impedance cardiography (ICG) guided treatment strategy on improving blood pressure (BP) control in real-world clinical practice. Design A single-centre, pragmatic randomised trial. Setting A hypertension clinic of the Peking University People’s Hospital in

Towards individualised contraceptive counselling: clinical and reproductive factors associated with self-reported hormonal contraceptive-induced adverse mood symptoms

Objective The study aim was to establish which demographic, clinical, reproductive and psychiatric factors are associated with self-reported hormonal contraceptive (HC)-induced adverse mood symptoms. Study design We compiled baseline data from two Swedish studies: one cross-sectional study on combined oral

Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression

Nature Genetics, Published online: 23 September 2021; doi:10.1038/s41588-021-00925-9 Mice bearing mutations in Flt3-ITD and Npm1c, which are commonly found in acute myeloid leukemia, are used to characterize the cooperative effects of these cancer drivers on the cellular epigenome and three-dimensional

Investigating the efficacy of chest pressure for direct current cardioversion in atrial fibrillation: a randomised control trial protocol (Pressure-AF)

Introduction Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide. Direct current cardioversion is commonly used to restore sinus rhythm in patients with AF. Chest pressure may improve cardioversion success through decreasing transthoracic impedance and increasing cardiac energy delivery.

A new era in functional genomics screens

Nature Reviews Genetics, Published online: 20 September 2021; doi:10.1038/s41576-021-00409-w In this Review, Przybyla and Gilbert describe the latest approaches for CRISPR-based functional genomics screens, including the adoption of single-cell transcriptomic read-outs and applications in characterizing the non-coding genome and mapping

Gene of the month: FH

Fumarate hydratase (FH), encoded by the FH gene, is an enzyme which catalyses the conversion of fumarate to L-malate as part of the tricarboxylic acid cycle. Biallelic germline mutations in FH result in fumaric aciduria, a metabolic disorder resulting in

Epigenome plasticity in plants

Nature Reviews Genetics, Published online: 15 September 2021; doi:10.1038/s41576-021-00407-y The authors review intra-individual and inter-individual plant epigenome variation during development and in response to environmental changes, including stress. They also discuss functions of epigenome plasticity and epigenome editing technologies that

Autoimmune nodopathies: treatable neuropathies beyond traditional classifications

Precise characterisation of the target antigens and autoantibody isotypes improves patient care in inflammatory neuropathies Antibodies targeting all neurofascin isoforms (pan-neurofascin) have been associated with variants of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that include ataxic presentations, cranial nerve involvement, respiratory

CRISPR systems go mini

Nature Reviews Genetics, Published online: 14 September 2021; doi:10.1038/s41576-021-00419-8 Three recent studies report the generation of miniature CRISPR systems based on compact Cas effector proteins, showing high efficiency of genome editing or transcriptional regulation in mammalian cells.

Correction: 61 The inconsistent choices of inotropic and vasopressors at the front door in patients with ischaemic cardiogenic shock and its impact on in-hospital mortality

Shabana A, Dholoo F, Tran P, et al. 61 The inconsistent choices of inotropic and vasopressors at the front door in patients with ischaemic cardiogenic shock and its impact on in-hospital mortality. Heart 2021;107:A51–52. doi:10.1136/heartjnl-2021-BCS.61 This Abstract has been corrected since

Testing the super-enhancer concept

Nature Reviews Genetics, Published online: 03 September 2021; doi:10.1038/s41576-021-00398-w In this Viewpoint, five experts discuss our biological understanding of super-enhancers, how we can responsibly study their functions, and their opinions on whether names for enhancer clusters are an informative reflection

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