Objective To explore the characteristics and mechanism of sirtuin 1 (SIRT1) in lipopolysaccharide (LPS)-activated pyroptosis in the renal tissue of children with congenital hydronephrosis (CHn). Methods We detected the expression characteristics and clinical significance of SIRT1 and pyroptosis pathway proteins
Historical shift in pathological type of progressive massive fibrosis among coal miners in the USA
Background Pneumoconiosis among coal miners in the USA has been resurgent over the past two decades, despite modern dust controls and regulatory standards. Previously published studies have suggested that respirable crystalline silica (RCS) is a contributor to this disease resurgence.
Trusts should review policies for handling sexual assault and harassment of staff and patients, NHS England says
NHS trusts and integrated care boards have been told by NHS England to review their policies for handling cases of sexual assault, harassment, and abuse of staff and patients and to consider adopting dedicated policies on sexual safety.The action followed
Overviews of systematic reviews in sports and exercise medicine: what are they and why are they important?
Overview of systematic reviews: not just another review design We live in a new era of information, where the number of academic publications has reached exponential growth without precedent. This may be beneficial to all of us, but excess information
“The Case For Making The First Trimester Anatomical Survey A Standard Of Care Post Dobbs”
Currently, 11-to-14 weeks detailed anatomical surveys are generally reserved for at-risk populations because of the lower incidence of major fetal anomalies in low-risk populations. That standard reflects, in part, the fact that until recently pregnant persons retained the option of
Adjuvant nivolumab shows promise in MCC
Nature Reviews Clinical Oncology, Published online: 28 July 2023; doi:10.1038/s41571-023-00810-w Adjuvant nivolumab shows promise in MCC
Validation of Navigator-Assisted Hypofractionation (NAVAH) Program Survey to Aid American Indian Breast Cancer Patients
No abstract available
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01
Nature Reviews Genetics, Published online: 28 July 2023; doi:10.1038/s41576-023-00641-6 A study in Nature reports a strong association between asymptomatic SARS-CoV-2 infections and the HLA-B*15:01 allele and reveals mechanistic insights into its protective effect.
When I use a word . . . Coroners’ duties: enquiry and prevention
CoronersThe office of coroner in England dates from the end of the 12th century,1 having been established by Richard I in the so-called Articles of Eyre of 1194, an eyre being a court of itinerant justices. Coroners were originally officers
Validity and reliability of the Thai version of the Utrecht Gender Dysphoria Scale-Gender Spectrum (UGDS-GS) in Thai youths and young adults with gender dysphoria
Background Many people who are gender variant have undiagnosed gender dysphoria, resulting in delayed receipt of gender-affirming support and prolonged distress in living with their gender-non-conforming sex. The Utrecht Gender Dysphoria Scale-Gender Spectrum (UGDS-GS) is a newly developed tool that
Rationale and design of the NEO-NORMAL-AF study examination of the usefulness of implantable loop recorder for arrhythmia detection including atrial fibrillation in heart failure with non-reduced ejection fraction cases: a pilot study
Introduction The incidence of arrhythmia in heart failure with non-reduced ejection fraction (HFnon-rEF) in patients who have a history of hospitalisation is unclear. The aim of this study is to investigate the usefulness of an implantable loop recorder (ILR) for
Trajectories of self-reported pain-related health outcomes and longitudinal effects on medication use in rheumatoid arthritis: a prospective cohort analysis using the Australian Rheumatology Association Database (ARAD)
Objective To determine distinct trajectories of self-reported pain-related health status in rheumatoid arthritis (RA), their relationship with sociodemographic factors and medication use. Methods 988 Australian Rheumatology Association Database participants with RA (71% female, mean age 54 years, mean disease duration
Editors commentary
When choosing a restaurant, should we visit an old favourite where we know we shall get a good meal, or try somewhere new, which may be better or worse? This illustrates the ‘explore/exploit trade-off’, a model developed in psychology and
Evaluation of a scoring system for the detection of central sensitization among women with chronic pelvic pain.
Central sensitization is frequently associated with chronic pelvic pain and requires specific management. The pain is described as hypersensitivity to an innocuous stimulus that is both widespread and persistent. However, no study has evaluated if central sensitization can be measured
Identifying critical cell types and gene regulatory pathways for hair and skin disease
Nature Genetics, Published online: 27 July 2023; doi:10.1038/s41588-023-01447-2 Matched single-cell transcriptomic and epigenomic profiles obtained from human scalp reveal gene regulatory maps of diverse cell types in the hair follicle niche. Integrating these data with existing genome-wide association studies enabled
Alu sequences promote long-distance relationships
Nature Reviews Genetics, Published online: 27 July 2023; doi:10.1038/s41576-023-00642-5 Liang et al. report in Nature that complementary Alu sequences allow an enhancer to find its cognate promoter over long distances, potentially through the formation of RNA duplexes.
[Editorial] A broader vision for women’s health
At the 2023 Women Deliver Conference on July 17, an event that seeks to champion gender equality, the UN Women Executive Director, Sima Bahous, said “Our hopes and aspirations for a brighter, more sustainable, more equal, and more peaceful planet
Hospital appointments: Last minute cancellation widens health inequalities, watchdog warns
Repeated or last minute cancellations of planned NHS appointments are having a catastrophic effect on patients’ health and are widening health inequalities, Healthwatch England has warned.1The watchdog said that last minute cancellations can lead to patients getting sicker and can
Heartbeat: diet and primary prevention of cardiovascular disease in women
We all would agree that diet plays a key role in primary prevention of cardiovascular disease (CVD) yet this conclusion is based on clinical studies that mostly included men or did not include sex-specific analyses so that whether this holds
The evolving landscape of salivary gland tumors
Abstract Salivary gland cancers are a rare, histologically diverse group of tumors. They range from indolent to aggressive and can cause significant morbidity and mortality. Surgical resection remains the mainstay of treatment, but radiation and systemic therapy are also critical
Epidermolysis bullosa acquisita involving the vulva
[Editorial] Where are the long COVID trials?
The news in early July, 2023, that STOP-PASC, a clinical trial at Stanford University, CA, USA, testing nirmatrelvir-ritonavir in patients with long COVID, is closing enrolment before the full study size has been reached, is disheartening. STOP-PASC is one of
Parkrun as self-managed cardiac rehabilitation: secondary analysis of a cross-sectional survey of parkrun in the UK
Objectives Cardiac rehabilitation following a cardiovascular disease (CVD)-related illness has been shown to reduce the risk of heart attack and hospital admission. The American College of Sports Medicine recommends 3–5 days per week of moderate to vigorous exercise. Despite this,
Gordon McInnes: professor of clinical pharmacology, past president of the British Hypertension Society, and key figure in cardiovascular research
bmj;382/jul26_17/p1728/FAF1faKnown as “Big Gordon” by colleagues—not least on account of his stature (he was 2 m tall)—Gordon McInnes, who has died suddenly aged 77, was a huge figure in the areas of hypertension, stroke prevention, and clinical pharmacology. At a
BRAF plus MEK inhibition effective in papillary craniopharyngioma
Nature Reviews Clinical Oncology, Published online: 25 July 2023; doi:10.1038/s41571-023-00807-5 BRAF plus MEK inhibition effective in papillary craniopharyngioma
Moderate or intensive management of the active phase of second-stage labor and risk of urinary and anal incontinence: results of the PASST randomized controlled trial
Incontinence occurs frequently in the postpartum period. Several theoretical pathophysiological models may underlie the hypothesis that different types of management of the active phase of the second stage of labor have different effects on pelvic floor muscles and thus perhaps
The chromosome hoarding syndrome of (some) ferns and lycophytes
Nature Reviews Genetics, Published online: 25 July 2023; doi:10.1038/s41576-023-00639-0 Fay-Wei Li recalls a 1966 paper by Klekowski and Baker, who built on their observation that homosporous pteridophytes have many more chromosomes than heterosporous lineages to generate hypotheses on the evolutionary
[Editorial] Gender equality: timely and timeless
With an estimated global population of around 8 billion people, the world’s population continues to grow steadily. Increased life expectancy has resulted in a trend in the distribution of populations worldwide towards older age. For instance, in Japan, nearly 30%
The Vexing Problem of Preterm Birth Prevention
Preterm birth (delivery before 37 weeks of gestation) is a significant risk factor for maternal and perinatal mortality. Despite intensive efforts to develop preventive and treatment interventions intended to delay delivery until term, preterm birth continues to be one of
Don’t assume that cutting back on cancer diagnosis would improve other services
Cancer is the UK’s leading cause of death,1 and, as Mathew notes, the UK’s record compares unfavourably with those of other high income countries.2 Mathew is concerned that thresholds for two week wait referrals in the NHS have evolved without
Enhanced detection of severe aortic stenosis via artificial intelligence: a clinical cohort study
Objective We developed an artificial intelligence decision support algorithm (AI-DSA) that uses routine echocardiographic measurements to identify severe aortic stenosis (AS) phenotypes associated with high mortality. Methods 631 824 individuals with 1.08 million echocardiograms were randomly spilt into two groups.
Towards modulating the gut microbiota to enhance the efficacy of immune-checkpoint inhibitors
Nature Reviews Clinical Oncology, Published online: 24 July 2023; doi:10.1038/s41571-023-00803-9 Advances over the past decade have established a prominent role of the gut microbiota in the modulation of immune homeostasis and function, including in patients with cancer receiving immune-checkpoint inhibitors.
Multidisciplinary management in the treatment of intrahepatic cholangiocarcinoma
CA: A Cancer Journal for Clinicians, Volume 73, Issue 4, Page 346-352, July/August 2023.
Corrigendum to ‘Levonorgestrel 52 mg intrauterine system efficacy and safety through 8 years of use’ [American Journal of Obstetrics and Gynecology 2022;227:871.e1-871.e7]
The authors regret an error in the text of the manuscript. In the Results section, in reference to adverse events and reactions, urinary tract infection rates were reported but not also present in Table 3. The events listed in the table
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions
Nature Genetics, Published online: 24 July 2023; doi:10.1038/s41588-023-01450-7 CRISPRi-based screen identifies enhancers that nonlinearly regulate lineage-specifying transcription factors during definitive endoderm differentiation. A new CTCF-loop-constrained Interaction Activity (CIA) model is better at predicting functional enhancers than previous Hi-C-based enhancer–promoter contact
Use and misuse of research: Canada’s response to covid-19 and its health inequalities
Canada had one of the lowest rates of covid-19 cases and deaths per population than most in the G10 group of industrialised countries.1 But overall rates ignore underlying health inequalities—a consistent feature of the covid-19 pandemic across countries, within and
Danish study of Non-Invasive Testing in Coronary Artery Disease 3 (Dan-NICAD 3): study design of a controlled study on optimal diagnostic strategy
Introduction Current guideline recommend functional imaging for myocardial ischaemia if coronary CT angiography (CTA) has shown coronary artery disease (CAD) of uncertain functional significance. However, diagnostic accuracy of selective myocardial perfusion imaging after coronary CTA is currently unclear. The Danish
Primary survey: highlights from this issue
Not just a minor injury The term minor in the vernacular of emergency medicine is relative, often a misnomer can serve to downplay and underestimate the complexity of some injuries and the potential adverse ramifications and outcomes for patients with
Care not criminalisation: reform of British abortion law is long overdue
Megan1 is a young teenage patient who suffered a stillbirth at 28 weeks, leading to a year long police investigation dropped only after postmortem tests found that her pregnancy was lost due to natural causes. The stress of the investigation
Multidisciplinary management in the treatment of intrahepatic cholangiocarcinoma
CA: A Cancer Journal for Clinicians, Volume 73, Issue 4, Page 346-352, July/August 2023.
Adverse pregnancy outcomes and risk of type 2 diabetes in postmenopausal women
Although gestational diabetes and delivering high-birth-weight infants are known to predict a higher risk of future type 2 diabetes, the association of hypertensive disorders of pregnancy and other adverse pregnancy outcomes with type 2 diabetes is not well-established.
Combining Early Pregnancy Bleeding with Ultrasound Measurements to Assess Spontaneous Abortion Risk Among Infertile Patients
Approximately 15% of all clinically recognized pregnancies in infertile patients result in spontaneous abortion. However, despite its potential to have a profound and lasting impact on physical and emotional wellbeing, the natural history of spontaneous abortion in women with infertility
Platinum-ineligible: atezolizumab preferable
Nature Reviews Clinical Oncology, Published online: 21 July 2023; doi:10.1038/s41571-023-00806-6 Platinum-ineligible: atezolizumab preferable
A model for the return and referral of all clinically significant secondary findings of genomic sequencing
Secondary findings (SFs) identified through genomic sequencing (GS) can offer a wide range of health benefits to patients. Resource and capacity constraints pose a challenge to their clinical management; therefore, clinical workflows are needed to optimise the health benefits of
Strike action: Doctors’ leader tells consultants “we will win this fight”
On the first day of their two day strike on 20 and 21 July, consultants in England put the blame for the crisis in the profession and the NHS squarely at the door of the government.The failure of senior doctors’
Real-time ultrasound demonstration of uterine isthmus contractions during pregnancy
Isthmic contractions are a frequent physiological phenomenon in pregnancy, sometimes triggered by bladder voiding. They can interfere with proper cervical length assessment and may lead to false images of placenta previa. However, there is limited research on the prevalence and
Regulation of transposable elements and stem cell fate by crosstalk between RNA and DNA methylation
Nature Genetics, Published online: 20 July 2023; doi:10.1038/s41588-023-01453-4 How the chromatin states of transposable elements (TEs) are controlled in development and disease is unclear. We present CARGO-BioID, a CRISPR-based proteomic approach to identify TE-associated proteins, and reveal an interplay between
Respiratory syncytial virus Prefusion F vaccine
Respiratory syncytial virus (RSV) is the most common cause of serious respiratory infection in infants. Reinfections occur commonly, including in older adults. For six decades, effective vaccines remained elusive. Stabilization of the prefusion conformation of the RSV glycoprotein F was
[Editorial] Genomic newborn screening: current concerns and challenges
60 years ago, the first newborn screening test for phenylketonuria, a rare inherited metabolic disease, was developed. The heel prick test, devised by Robert Guthrie, enabled babies with the condition to be identified soon after birth and begin a diet
Further 100 000 appointments cancelled during latest strike action by ȷunior doctors
There were 101 977 acute inpatient and outpatient appointments cancelled during the latest round of strike action by junior doctors in England, NHS data1 show.Overall, more than three quarters of a million (754 555) appointments across acute, mental health, ambulance,
Hearts, knees and reducing disease through exercise – what is happening this year in the world of sport and exercise medicine in Australasia?
Nau mai haere mai to the Australasian College of Sport and Exercise Physicians (ACSEP) edition of the British Journal of Sports Medicine (BJSM). A recent highlight for the ACSEP has been our annual scientific meeting which took place in Adelaide,
At a glance
Ocular morbidity in Marfan syndrome: a nationwide epidemiological study (see page 1051) This nationwide epidemiological study of ocular morbidity in Marfan syndrome demonstrates a profound burden, compared to controls, especially concerning disorders of lens, retinal detachment, and glaucoma, which translates
Prognostic utility of N-terminal pro B-type natriuretic peptide ratio in mixed aortic valve disease
Objective We aimed to assess the incremental prognostic value of N-terminal-pro-B-type natriuretic peptide (Nt-proBNP) for risk stratification in mixed aortic valve disease (MAVD) patients. Methods We included 556 (73±12 years, 37% women) consecutive patients with at least a moderate aortic
Clock cells ticking in summer
In this issue of Neuron, Xie et al. highlight a role of cholecystokinin (CCK) neurons in the suprachiasmatic nucleus (SCN) central clock for tracking the onset of circadian activities, adapting circadian rhythms to long photoperiods, and regulating circadian phase resetting.
[Editorial] Time to get serious about the Global Action Plan on dementia
The slow progress made by WHO and national governments on meeting the key targets of the Global Action Plan on the public health response to dementia is disappointing. The targets—which were published by WHO 6 years ago, in 2017—should have
[Editorial] The how and where of substance use in the USA
Substance use is responsible for 5·5% of the global burden of disease. The prevalence of alcohol and drug use disorders is rising globally but shows considerable regional variation. Public health measures, such as public consumption bans and minimum legal age,
Covid-19: “Panic buying” of PPE led to inadequate checks on private companies, say MPs
The Department of Health and Social Care was guilty of “panic buying” personal protective equipment (PPE) during the covid pandemic, with insufficient checks made on private companies it was handing contracts to, a parliamentary select committee has concluded.The Commons Public
Atoms
OK. I’ll come clean. Occasionally, I procrastinate. Both editorially and clinically if an acute situation doesn’t demand an instant response. There it is, I’ve said it now: out in the open for all to see. This, though, can be advantageous,
Drug-induced hyperammonaemia
Hyperammonaemia (HA) as a consequence of numerous primary or secondary causes, gives rise to clinical manifestations due to its toxic effects on the brain. The neurological consequences broadly reflect the ammonia level, duration and age, with paediatric patients being more
The effect of valacyclovir on secondary prevention of congenital cytomegalovirus infection, following primary maternal infection acquired periconceptionally or in the first trimester of pregnancy. An individual patient data meta-analysis
Recent studies have showed that oral valacyclovir 8g/day reduces significantly the vertical CMV transmission rate in women with primary CMV infection acquired periconceptionally or during the first trimester. The present individual patient data meta-analysis aims to assess the effectiveness and
A focus on single-cell omics
Nature Reviews Genetics, Published online: 18 July 2023; doi:10.1038/s41576-023-00628-3 Single-cell omics approaches are providing unprecedented insights into cellular function and dysfunction. This Editorial highlights the remarkable potential of these technologies and their profound impact on our understanding of biology and
Prognosis of light chain amyloidosis: a multivariable analysis for survival prediction in patients with cardiac involvement proven by endomyocardial biopsy
Background Cardiac involvement is a main determinant of mortality in light chain (AL) amyloidosis but data on survival of patients with cardiac AL amyloidosis proven by endomyocardial biopsy (EMB) are sparse. Methods This study analysed clinical, laboratory, electrocardiography and echocardiographic
Universal Childhood Lipid Screening
Screening for lipid disorders in children and adolescents can identify 2 types of lipid disorders: primary lipid disorders, which typically are monogenic, rare, and severe, and the more common secondary lipid disorders that often result from other disease processes or
[Editorial] Prioritising displaced children in the global refugee agenda
The Third Global Consultation on the Health of Refugees and Migrants kicked off in June, 2023, with the adoption of the Rabat Declaration, an expression of heightened commitment from the UN towards refugees and migrants through more inclusive national health
Retract or be damned: the “bystander effect” is worsening the situation
We agree with Abbasi that this is a “dangerous moment for science,”1 and are worried that a “bystander effect” is worsening research misconduct. The organisations that could help are largely walking by. Publishers expect institutions to prevent poor quality and
Problematic crossovers in cancer drug trials
Nature Reviews Clinical Oncology, Published online: 17 July 2023; doi:10.1038/s41571-023-00805-7 Crossover in a randomized trial can skew the interpretation of the efficacy of a cancer drug. In this Comment, I use examples from clinical trials presented at the 2023 ASCO
Public Perceptions of Abortion Complications
Misinformation contributes to the perception that abortion has substantial health risks, despite the known safety of medication and aspiration abortion. We lack detailed information about which health risks the public believes are most likely.
COVID-19 in congenital heart disease (COaCHeD) study
Background COVID-19 has caused significant worldwide morbidity and mortality. Congenital heart disease (CHD) is likely to increase vulnerability and understanding the predictors of adverse outcomes is key to optimising care. Objective Ascertain the impact of COVID-19 on people with CHD
Iranian healthcare caught in political crossfire: a global call to action
Medical impartiality is a well established principle but the impartial practice of medicine has brought clinicians into conflict with the authorities in Iran. The current crisis in Iranian healthcare and protests began in September 2022, following the killing of Mahsa
Race to address sexual health inequalities among people of Black Caribbean heritage: could co-production lead to more culturally appropriate guidance and practice?
People of Black Caribbean heritage in the UK experience a disproportionate burden of STIs. This has persisted for decades. Notably, rates of diagnosed chlamydia and gonorrhoea in England among those of Black Caribbean ethnicity were over five times and nearly
Postpartum long-acting reversible contraceptive use among active-duty, female U.S. Army soldiers
Postpartum utilization of long-acting reversible contraception (LARC) has been found to be effective at increasing inter-pregnancy intervals, reducing unintended pregnancies, and optimizing health outcomes for mothers and babies. Among female active-duty military members, reproductive planning may be particularly important, yet
Trends in utilization of indocyanine green for sentinel lymph node mapping in vulvar cancer
RNA Pol II enters the ring of cohesin-mediated loop extrusion
Nature Genetics, Published online: 14 July 2023; doi:10.1038/s41588-023-01463-2 The three-dimensional organization of mammalian chromosomes can regulate transcription. Whether transcription itself influences genome structure has remained a source of debate. Using sensitive genome-wide readouts, two recent studies describe the involvement of
Maverick — top gun of horizontal gene transfer
Nature Reviews Genetics, Published online: 14 July 2023; doi:10.1038/s41576-023-00635-4 A study in Science identifies Mavericks, a class of ancient, virus-like transposable elements, as a vector for horizontal gene transfer in nematodes.
Thomas Horner
Thomas Horner (“Tom”), born in Belfast, was one of five children. His childhood was shaped by the Great Depression, with his father managing a linen export company and having to move to the nearby Gilnahirk countryside to reduce the family
BASEM: innovation in SEM: female athlete health and physical activity
Welcome to the annual edition of the British Journal of Sports Medicine (BJSM) guest edited by the British Association of Sport and Exercise Medicine (BASEM). Our Sport and Exercise Medicine (SEM) energy in this edition is focused on innovation of
Leveraging family relatedness to detect participation bias in genetic studies
Nature Genetics, Published online: 13 July 2023; doi:10.1038/s41588-023-01440-9 Identifying the ways that a study sample is not representative is essential for maximizing the generalizability of findings to the population. A new method proposes discerning non-representativeness in large-scale genetic studies by
Society for Maternal-Fetal Medicine Special Statement: Checklists for transabdominal cerclage
The recent Society for Maternal-Fetal Medicine Consult Series #65 provides a comprehensive review of transabdominal cervical cerclage. The present article condenses the consult recommendations regarding patient selection, counseling, and management into two simple one-page checklists, one for the primary obstetrical
[Editorial] Clearing the air for a sustainable future
The latest WHO European Region report, published on July 5, estimates that 97% of the region’s population is exposed to air pollution levels exceeding WHO guideline limits. Ambient and household air pollutions were linked to 723 000 premature deaths in 2019
Correspondence on “Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: results from the COVID-19 global rheumatology alliance physician registry”
Sparks et al1 are to be congratulated on an important and timely study. They found that the use of JAKi was associated with worse outcome of COVID-19 infection, and they interpret this as a harmful effect of the treatment in
A commitment to act on data sharing
The argument is simple enough. Ensuring that research is registered in advance, the findings reported quickly, and the data and code shared readily is in the best interests of science and the public good. Ultimately, the public pays for the
Maintenance programmes following pulmonary rehabilitation in idiopathic pulmonary fibrosis: exercise, drugs and rock n roll
The evidence for pulmonary rehabilitation (PR) as a non-pharmacological management strategy for people with idiopathic pulmonary fibrosis (IPF) is consistent and continues to accrue. Meta-analysis has demonstrated that it effectively improves exercise capacity, dyspnoea and health-related quality of life,1 and
Influence of oral tobacco versus smoking on multiple sclerosis disease activity and progression
We aimed to study the influence of smoking habits, exposure to passive smoking and snuff use on disease progression, cognitive performance and quality of life in patients with multiple sclerosis (MS). Method Patients from two population-based case–control studies were categorised
The evolving cancer genome
Nature Genetics, Published online: 12 July 2023; doi:10.1038/s41588-023-01457-0 The evolving cancer genome
[Editorial] Homecare medicines services are failing patients in the UK
On June 6, 2023, the House of Lords Public Services Committee announced the launch of a rapid inquiry to examine widespread reports of unreliable provision of essential medicines by homecare medicines services in England. This follows a commitment for a
Joint British Societies position statement on bullying, harassment and discrimination in cardiology
Inappropriate behaviour is an umbrella term including discrimination, harassment and bullying. This includes both actions and language and can affect any member of the cardiovascular workforce/team. Evidence has suggested that such behaviour is regularly experienced within UK cardiology departments, where
Adult social care: Workforce numbers improve slightly, but health leaders warn of challenges ahead
Health leaders have welcomed a 7% fall in the number of vacant posts for adult social care in the past year in England, but they warned of “profound challenges” still ahead in filling the 152 000 posts currently empty.New figures
Is contragestion the future?
Background In the 1980s, the term ‘contragestion’ was coined by French scientists investigating progesterone receptor modulators (PRMs). Contragestion refers to a method that works after ovulation and throughout luteal phase and beyond.1 A contragestive could prevent or disrupt implantation, which
A critical appraisal of the ATLAS trial of maintenance therapy for multiple myeloma: end points, censoring and equipoise
Nature Reviews Clinical Oncology, Published online: 11 July 2023; doi:10.1038/s41571-023-00801-x A recent report from the ATLAS trial comparing different maintenance strategies following haematopoeitic stem cell transplantation for multiple myeloma provides an opportunity to explore various themes of critical appraisal, including
Maternal report of cannabis-screening and recommendations during prenatal care visits in the United States
Genetics of autoinflammation instructs selective IL-1 targeting
Interleukin-1 (IL-1) is a primary pro-inflammatory cytokine requiring tightly controlled negative regulation. In this issue of Immunity, Wang et al.,1 inspired by an IL-1 receptor missense mutation associated with unleashed IL-1-mediated inflammation, design a new drug to selectively inhibit IL-1.
A diverse and inclusive human pangenome
Nature Reviews Genetics, Published online: 11 July 2023; doi:10.1038/s41576-023-00634-5 In five new studies, the Human Pangenome Reference Consortium reports the generation and initial characterization of a draft human pangenome.
Nonalcoholic fatty liver disease mortality may not be decreasing: A need for careful interpretation of GBD 2019 estimates of liver deaths
The Global Burden of Disease (GBD) data provide information on population health; however, careful understanding of the estimation methods and limitations of these data is critical. Herein, Paik et al. discuss the recent study by Chew and colleagues in the context
Impact of concomitant oral glucose-lowering medications on the success of basal insulin titration in insulin-naïve patients with type 2 diabetes: a systematic analysis
Basal insulin treatment for type 2 diabetes is usually initiated on a background of oral glucose-lowering medications (OGLM). We wanted to examine the influence of various OGLMs on fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) values achieved after titration.
Cytisinicline to Speed Smoking Cessation in the United States
In 1984, the US Food and Drug Administration (FDA) approved nicotine gum as the first pharmacotherapy for cigarette smoking cessation. Other types of nicotine replacement therapy have followed (nicotine lozenges, transdermal patches, inhaler, and a nasal spray), and in 1997,
Fibromyalgia and mortality: a systematic review and meta-analysis
Objective To conduct a systematic review of the literature on the association between fibromyalgia and mortality and to pool the results in a meta-analysis. Methods The authors searched the PubMed, Scopus, and Web of Science databases using the key words
Helen Salisbury: Physician associates in general practice
Last week, the tragic and avoidable death of a young woman was discussed in parliament.1 The patient had presented to her general practice with, reportedly, obvious symptoms of a deep vein thrombosis and a pulmonary embolus. This diagnosis was not
Precise patient stratification in esophageal cancer: Biomarkers for immunochemotherapy
Studies have established immunochemotherapy as the first-line treatment for advanced esophageal cancer. Chen et al. and Carrol et al. performed exploratory analysis of the JUPITER-06 and LUD2015-005 trials, respectively and identified biomarkers to predict therapy response based on immunogenomic analysis. These findings
The physiology of Intrapartum fetal head compression
RNA polymerase II dynamics shape enhancer–promoter interactions
Nature Genetics, Published online: 10 July 2023; doi:10.1038/s41588-023-01442-7 Perturbation of RNA polymerase II (Pol II) via chemical inhibition or dTAG-induced degradation and analysis using Micro-C and run-on sequencing show that enhancer–promoter contacts are dependent on transcription and stabilized by paused
WHO fired seven people for sexual misconduct in six months
The World Health Organization has fired seven people, including at director level, for sexual misconduct in six months as the body attempts to reform after a number of scandals.In 2021 an independent commission published its report on WHO’s links to
Incident cardiovascular, renal, metabolic diseases and death in individuals identified for risk-guided atrial fibrillation screening: a nationwide cohort study
Objective Risk-guided atrial fibrillation (AF) screening may be an opportunity to prevent adverse events in addition to stroke. We compared events rates for new diagnoses of cardio-renal-metabolic diseases and death in individuals identified at higher versus lower-predicted AF risk. Methods
Effects of high-intensity interval training on cardiac remodelling, function and coronary microcirculation in de novo heart transplant patients: a substudy of the HITTS randomised controlled trial
Objectives High-intensity interval training (HIT) improves peak oxygen consumption (VO2peak) in de novo heart transplant (HTx) recipients. It remains unclear whether this improvement early after HTx is solely dependent on peripheral adaptations, or due to a linked chain of central
Anticoagulation use is associated with lower fetal fraction and more indeterminate results.
Maternal anticoagulation use may increase indeterminate result rates on cell-free DNA (cfDNA) based screening, but existing studies are confounded by inclusion of individuals with autoimmune disease, which alone is associated with indeterminate results. Changes in chromosome level Z-scores are proposed
Correct dosing, adherence and persistence of DOACs in atrial fibrillation and chronic kidney disease: a systematic review and meta-analysis
Background Chronic kidney disease (CKD) and atrial fibrillation (AF) are increasing in prevalence globally and share common risk factors. Our aim was to characterise real-world evidence on direct oral anticoagulant (DOAC) prescribing for people with AF and CKD, in terms
Who do patient representatives represent?
Lynch and Largent discuss the contribution of patients—current and future—to regulatory approvals for promising new medicines, but they overlook a key point: the independence of the patients who represent the consumer voice.1 European drug companies invest heavily in patients’ groups.
Validation of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in an academic tertiary care centre
Objectives To assess the sensitivity and specificity of the 2019 EULAR/American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) in outpatients at an academic tertiary care centre and to compare them to the 1997 ACR and the
Safety of interrupting adjuvant endocrine therapy to conceive: early data are POSITIVE
Nature Reviews Clinical Oncology, Published online: 06 July 2023; doi:10.1038/s41571-023-00797-4 Planning for a pregnancy in patients receiving adjuvant endocrine therapy following a diagnosis of hormone receptor (HR)-positive early stage breast cancer is challenging. Recent data from the POSITIVE trial provide
Regulation of developmental tempo in different vertebrate species
In this issue, Lazaro et al.1 use iPSC-derived presomitic mesoderm cells to analyze the oscillatory expression of somitic clock genes. Comparison of a wide range of species, including mouse, rabbit, cattle, rhinoceros, human, and marmoset, demonstrates an excellent correlation between biochemical
Multidisciplinary management in the treatment of intrahepatic cholangiocarcinoma
CA: A Cancer Journal for Clinicians, Volume 73, Issue 4, Page 346-352, July/August 2023.
Endometrial cancer in asymptomatic postmenopausal women: the importance of a rapid, non-harmful and non-invasive diagnosis.
Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis
Nature Genetics, Published online: 06 July 2023; doi:10.1038/s41588-023-01435-6 Slide-seq profiling of mouse embryos at the onset of organogenesis (embryonic days 8.5–9.5) coupled with a new three-dimensional reconstruction and visualization tool (sc3D) provides high-resolution maps of spatiotemporal gene expression dynamics.
Multi-Center Validation of the McGovern Pediatric Blunt Cerebrovascular Injury Screening Score
Journal of Neurotrauma, Volume 40, Issue 13-14, Page 1451-1458, July 2023.
The scientific director: A complimentary model for academic leadership
The current model for academic leadership places unique demands on scientists with highly active research programs. A complimentary model with a dedicated scientific director could remove this strain and allow a greater institutional investment in the community via a partnership.
[Editorial] Loneliness as a health issue
Loneliness is not new, but it does seem to be gaining attention as a social and health concern. The UK and Japan appointed ministers of loneliness in 2018 and 2021, respectively. The US Surgeon General recently called loneliness a public
Sports and Exercise Therapists – working across the physical activity spectrum
There is a growing recognition of the impact of musculoskeletal (MSK) conditions on people, employers, the health service and the economy. MSK conditions are now recognised as one of six major health disorders contributing to the burden of disease in
England’s new workforce plan is a propaganda masterclass in glossing over the gaps
When the analysis is done on the new workforce plan for England’s NHS, the verdict might not be the rosy one that was presented to the world one week ago. The plan is full of ideas and solutions—more doctors, more
Engineered IFN-{alpha} and anti-PDL1 containing compounds to target the liver and restore antiviral protection for HBV cure
Chronic HBV infection, with hepatic inflammation and viral genome persistence in the hepatocytes either in the form of cccDNA or partially integrated into the host nucleus, is one of the major causes of liver cirrhosis and hepatocellular carcinoma.1 Available therapies
Reticulocyte Hemoglobin Trend in Pregnancy
[Editorial] LGBTQ+: a community united by stigma
In May, President Yoweri Museveni of Uganda signed a bill into law extending the criminalisation of homosexuality in the country. Uganda’s Anti-Homosexuality Act 2023 increases penalties for attempted same-sex conduct to a 10-year sentence and introduces the death penalty for
Tiam1 creates a painful link between dendritic spine remodeling and NMDA receptors
Dendritic spine remodeling in the dorsal horn is associated with many chronic pain models. Li et al. demonstrate that Tiam1 links Rac1-mediated spine changes to NMDA receptor activity to promote behavioral signs of chronic pain in rodents.
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial
Objectives To determine how much of the effect of vertebral corner inflammation on development of syndesmophytes is explained by vertebral corner fat deposition. Methods Patients with radiographic axial spondyloarthritis (r-axSpA) from the SIAS (Sensitive Imaging in Ankylosing Spondylitis) cohort and
Differences in psychological readiness for return to sport after anterior cruciate ligament injury is evident in thigh musculature motor unit characteristics
Background Following anterior cruciate ligament (ACL) injury, many athletes that undergo surgery and 6–9 months of rehabilitation struggle to return to sport. Evidence suggests that psychological factors contribute to this failure to return-to-sport. Objective Determine the motor control relationship between
NICE advises GPs to offer home tests to all patients with bowel cancer symptoms to reduce waiting lists
GPs should offer all patients presenting with signs of colorectal cancer a faecal immunochemical test (FIT) to reduce the waiting times for a colonoscopy, the National Institute for Health and Care Excellence (NICE) has recommended in draft guidance.1The current NICE
Multidisciplinary management in the treatment of intrahepatic cholangiocarcinoma
CA: A Cancer Journal for Clinicians, Volume 73, Issue 4, Page 346-352, July/August 2023.
Antibiotic treatment of women with isolated intrapartum fever vs clinical chorioamnionitis: maternal and neonatal outcomes
Clinical chorioamnionitis refers to the presence of maternal fever (≥38°C) and at least 2 clinical signs: (1) maternal tachycardia (>100 bpm), (2) fetal tachycardia (>160 bpm), (3) maternal leukocytosis >15,000/mm2, (4) purulent vaginal discharge, and (5) uterine tenderness. Few data
[Editorial] Managing medical (mis)information
Patients need accurate, evidence-based information to understand a diagnosis, learn about treatment options, and make autonomous and informed decisions about their health care. Doctors are still the preferred and trusted source of medical information for most people, but the internet,
Diabetic retinopathy in African-Americans with end-stage kidney disease: a cross-sectional study on prevalence and impact on quality of life
Introduction The prevalence, severity, and quality of life (QoL) impact of diabetic retinopathy (DR) among African–Americans (AAs) with end-stage kidney disease (ESKD) undergoing dialysis are unknown. Research design and methods A cross-sectional study was conducted on 93 AA adults with
Delivering the NHS workforce plan is a massive organisational challenge
Delivering the NHS workforce plan depends on implementing major reforms which will challenge professional and organisational power.The NHS Long Term Workforce Plan for England1 makes bold assumptions about productivity improvements, moving care out of hospital, getting better at prevention and
[Editorial] Meeting the need for germline testing
Germline genetic testing for pathogenic mutations in people diagnosed with cancer is recommended for several cancer types and has been shown to have a positive effect on survival. The US NCCN guidelines recommend that all, or a high proportion of,
[Editorial] Burnout in the haematological workforce
Burnout has been defined as a syndrome of emotional exhaustion, depersonalisation, and a sense of low personal accomplishment, leading to decreased effectiveness at work. It is an issue which is affecting health-care systems around the world. Burnout in physicians, which
Potent and uniform fetal hemoglobin induction via base editing
Nature Genetics, Published online: 03 July 2023; doi:10.1038/s41588-023-01434-7 A comparison of fetal hemoglobin gene editing strategies using human sickle cell disease donor cells and in vivo transplantation finds that adenine base editing of the –175A>G site in the γ-globin gene
Steering and controlling evolution — from bioengineering to fighting pathogens
Nature Reviews Genetics, Published online: 03 July 2023; doi:10.1038/s41576-023-00623-8 Control can be applied to alter the ecological or evolutionary trajectory of a target system towards a predefined objective. In this Review, the authors discuss the aims, applications, mechanisms and dynamics
JAMA Pediatrics
Vision: JAMA Pediatrics will be the most respected source of information for investigators, providers, and policy makers seeking the highest quality evidence to guide decision-making.
Audio Highlights
Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
Reversing the urgent and emergency care spiral of decline
NHS urgent and emergency care is under intolerable strain. This strain is increasingly causing harm to patients.1 Timely and high quality patient care is often not being delivered due to overcrowding driven by workforce and capacity constraints.23 While the covid-19
Timing of antenatal corticosteroids and survival without neurological disabilities at 5½ years in children born before 35 weeks of gestation
The efficacy of antenatal corticosteroids on neonatal preterm complications wanes beyond 7 days after treatment. The neurodevelopmental effects of longer treatment-to-birth intervals have not been adequately evaluated.