Obesity, Immunity, and Cancer

Obesity, which is increasing to epidemic proportions, is strongly associated with increased susceptibility to a variety of diseases. Diabetes and cardiovascular diseases top the list, but many more have also become apparent. Several different types of cancer, such as thyroid,

Atopic Dermatitis

Atopic dermatitis is one of the most prevalent inflammatory skin diseases. It usually develops in childhood and may persist into adulthood; less frequently, it starts in midlife or late life. The disorder is characterized by recurrent, pruritic, localized eczema, often

Atopic Dermatitis

Atopic dermatitis is one of the most prevalent inflammatory skin diseases. It usually develops in childhood and may persist into adulthood; less frequently, it starts in midlife or late life. The disorder is characterized by recurrent, pruritic, localized eczema, often

Circadian Mechanisms in Medicine

In addition to the sleep–wake cycle and cognitive functions such as learning and memory, intrinsic clocks determine nearly all circadian cycles in physiology, such as daily variation in blood pressure, heart rate, hormone levels, respiratory and exercise capacity, and coagulation.

Clinical cancer genomic profiling

Nature Reviews Genetics, Published online: 24 March 2021; doi:10.1038/s41576-021-00338-8 Profiling tumours by next-generation sequencing can improve diagnostic accuracy, assess for heritable cancer risk and guide treatment selection. The authors review efforts to enhance the clinical utility of cancer genomic profiling

Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel

Cardiac disease is now the leading cause of death in Duchenne muscular dystrophy (DMD). Clinical evaluations over time have demonstrated asymptomatic cardiac troponin elevations and acute elevations are associated with symptoms and cardiac dysfunction in DMD. Clinicians require a better

Circadian Mechanisms in Medicine

In addition to the sleep–wake cycle and cognitive functions such as learning and memory, intrinsic clocks determine nearly all circadian cycles in physiology, such as daily variation in blood pressure, heart rate, hormone levels, respiratory and exercise capacity, and coagulation.

Highlights from this issue

Barriers to saving lives in OOHCA The Editor’s choice this month is a retrospective study assessing the barriers to effective dispatcher-assisted CPR when bystanders called the emergency medical services in China. The study found a median of 30 minutes delay

Evaluation of the prognostic value of GDF-15, ABC-AF-bleeding score and ABC-AF-death score in patients with atrial fibrillation across different geographical areas

Objectives Growth differentiation factor 15 (GDF-15) is a biomarker independently associated with bleeding and death in anticoagulated patients with atrial fibrillation (AF). GDF-15 is also used as one component in the more precise biomarker-based ABC (age, biomarkers, clinical history)-AF-bleeding and

Unexpected finding

Clinical question Herein, we describe an 81-year-old female patient, who presented with pancytopenia and bacteraemia due to Escherichia coli infection. Her pancytopenia continued despite complete response of the bacteraemia. The patient underwent a bone marrow biopsy as well as agastroscopy

Incidence and predictors of prosthesis-patient mismatch after TAVI using SAPIEN 3 in Asian: differences between the newer and older balloon-expandable valve

Background The balloon-expandable SAPIEN 3 (S3) is superior to the older-generation balloon-expandable SAPIEN XT (XT) in a lower incidence of paravalvular aortic regurgitation, lower complication rates and better survival in transcatheter aortic valve implantation (TAVI). However, prosthesis–patient mismatch (PPM) more

My Intern

“Bobby hasn’t come in yet today,” one of my chief residents told me. “He isn’t picking up his phone or answering his pager. Could you go and check on him?” I was in my final year of my internal medicine

Sulfonamide Crystals

Fatigue and decreased urinary output developed in a 42-year-old man who had been admitted to the hospital for treatment of Pneumocystis jirovecii pneumonia. He had a history of infection with the human immunodeficiency virus (HIV). The CD4+ T-cell count was

My Intern

“Bobby hasn’t come in yet today,” one of my chief residents told me. “He isn’t picking up his phone or answering his pager. Could you go and check on him?” I was in my final year of my internal medicine

Circadian Mechanisms in Medicine

In addition to the sleep–wake cycle and cognitive functions such as learning and memory, intrinsic clocks determine nearly all circadian cycles in physiology, such as daily variation in blood pressure, heart rate, hormone levels, respiratory and exercise capacity, and coagulation.

Circadian Mechanisms in Medicine

In addition to the sleep–wake cycle and cognitive functions such as learning and memory, intrinsic clocks determine nearly all circadian cycles in physiology, such as daily variation in blood pressure, heart rate, hormone levels, respiratory and exercise capacity, and coagulation.

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