The loss of 25 000 staffed hospital beds in the UK since 2010 has created a crisis in urgent and emergency care, a report has warned.The report from the Royal College of Emergency Medicine says that…
Patient characteristics, short-term and long-term outcomes after incident heart failure admissions in a regional Australian setting
Aims This study aims to (1) define the characteristics of patients with a first admission for heart failure (HF), stratified by type (reduced (HFrEF) vs preserved (HFpEF) ejection fraction) in a regional Australian setting; (2) compare the outcomes in terms
Correction: Does reducing the height of the tackle through law change in elite mens rugby union (The Championship, England) reduce the incidence of concussion? A controlled study in 126 games
Stokes KA, Locke D, Roberts S, et al. Does reducing the height of the tackle through law change in elite men’s rugby union (The Championship, England) reduce the incidence of concussion? A controlled study in 126 games. Br J Sports
[Editorial] Cancer, health-care backlogs, and the cost-of-living crisis
As mounting pressures from several fronts—particularly the COVID-19 pandemic, the conflict in Ukraine, and the consequently exacerbated uncertainty around energy supplies—drive the cost-of-living crisis to alarming new heights, both in the UK and internationally, households are coming under increasing financial
[Editorial] Sickle cell disease: a year in review
June 19 is World Sickle Cell Day, a UN-recognised day dedicated to raising global awareness of sickle cell disease. Although the largest affected populations occur in sub-Saharan Africa, the Middle East, and India, recent migration patterns and its status as
A molecular map of T cell activation gives insights into immune disease
Nature Genetics, Published online: 30 May 2022; doi:10.1038/s41588-022-01067-2 A study using single-cell transcriptomics and mapping of expression quantitative trait loci (eQTLs) in a dynamic model of CD4+ T cell activation reveals novel, context-specific eQTLs linked to genes associated with immune
Australian election sparks hope for climate action
Where were you when you realised that covid-19 posed a global threat to health? What was it that broke through your daily routine? For me, it was a 4 am news report that the Italian government had…
Joint British Societies guideline on management of cardiac arrest in the cardiac catheter laboratory
More than 300 000 procedures are performed in cardiac catheter laboratories in the UK each year. The variety and complexity of percutaneous cardiovascular procedures have both increased substantially since the early days of invasive cardiology, when it was largely focused
Stochastic transitions as a major source of cancer heterogeneity
Nature Reviews Genetics, Published online: 27 May 2022; doi:10.1038/s41576-022-00508-2 In this Journal Club, Itay Tirosh highlights a 2011 publication by Gupta et al., which showed that cells undergo frequent stochastic transitions between distinct states in breast cancer cell lines.
Richard Alan Lee
bmj;377/may27_10/o1251/FAF1faAfter boarding school in Taunton, Richard Alan Lee turned down a scholarship to Cambridge, preferring to train at the London Hospital Medical College. At the London, he…
IgG1 pan-neurofascin antibodies define a severe and frequently fatal GBS-like neuropathy which responds to rituximab
Importance Disease modifying treatments in Guillain-Barré syndrome (GBS) are not tailored to the different pathological subtypes. Strategies to prospectively identify sub-sets of patients with specific disease mecha- nisms and inform the use of non-standard therapies may lead to improved outcomes.
Society for Maternal-Fetal Medicine Special Statement: Quality metric for timely postpartum follow-up after severe hypertension
Hypertensive disorders of pregnancy are a leading cause of maternal morbidity and mortality. Because postpartum exacerbation of severe hypertension is common, the American College of Obstetricians and Gynecologists recommends that patients with severe hypertension during the childbirth hospitalization be seen
Chromatin profiling of coronary artery illuminates genetic risk for heart disease
Nature Genetics, Published online: 26 May 2022; doi:10.1038/s41588-022-01029-8 A large-scale single-nucleus chromatin accessibility profiling study in coronary artery samples from patients with coronary artery disease generated a landscape of the regulatory activity during the disease. These data highlight cell type-specific
Sex differences of oestradiol-mediated gene expression
Nature Reviews Genetics, Published online: 26 May 2022; doi:10.1038/s41576-022-00507-3 Gegenhuber et al. now show that, in mice, a neonatal surge in oestradiol activates oestrogen receptor-α to drive a sustained male-typical gene expression programme that determines brain sexual differentiation.
[Editorial] Explaining the unexplained hepatitis in children
As The Lancet Infectious Diseases went to press, more than 300 probable cases of acute hepatitis in previously healthy children were being investigated around the world. The majority of cases have been reported from the UK (163 as of May
Viruses to the rescue—Use of bacteriophage to treat resistant pulmonary infections
People with cystic fibrosis (CF) are commonly infected with difficult to treat organisms, including non-tuberculous mycobacteria. Bacteriophage are viruses that lyse specific bacteria. Nick and colleagues describe the first successful treatment of a Mycobacterium abscessus lung infection with bacteriophage in
[Editorial] A hunger for action
The basic nutritional needs of children are at grave risk. Worldwide, more than 13·6 million children under 5 years have severe acute malnutrition, a serious wasting condition associated with poverty and prolonged insufficient access to food. Severe acute malnutrition weakens
Parametric mapping CMR for the measurement of inflammatory reactions of the pericardium
Objectives Although cardiovascular magnetic resonance (CMR) is increasingly used to diagnose pericardial inflammation, imaging can still be challenging using conventional CMR techniques. Parametric mapping (T1/T2 mapping) techniques have emerged as novel methods to quantify focal and global changes of the
Tom Nolan’s research reviews—26 May 2022
The world of prediabetes, where no one can hear you screenI remember those joyous early years after it was announced that HbA1c could be used instead of a fasting glucose to diagnose diabetes. People…
Advancing therapy for neuroblastoma
Nature Reviews Clinical Oncology, Published online: 25 May 2022; doi:10.1038/s41571-022-00643-z Neuroblastomas are tumours of sympathetic origins typically seen in infants (≤5 years of age). In this Review, the authors describe progress in the treatment of patients with neuroblastoma, which has
Doctors express “grave concerns” at GMC action after GP is suspended over laptop claim
A GP has been suspended for a month after it was ruled that she had exaggerated what she had been told by a senior doctor when making a request for a laptop and that this amounted to dishonesty.1The…
Thromboembolic events in left ventricular non-compaction: comparison between children and adults – a systematic review and meta-analysis
Objective Left ventricular non-compaction (LVNC) is morphologically characterised by excessive trabeculations and deep recesses in the ventricular wall. The risk of thromboembolic disease in the paediatric patients with LVNC has not been clearly established. We conducted this systematic review to
Correlation between preseason body composition and sports injury in an English Premier League professional football team
Objectives To identify the correlation between preseason body composition and incidence coupled with injury burden throughout the season in adult male professional football players. Methods A retrospective case series was performed for linear regression analysis of preseason body composition variables
Boy with abdominal distension and hyperamylasaemia
Clinical introduction A 14-year-old boy was admitted for the abrupt onset of non-bilious vomiting and inability to tolerate oral intake. He had a Pallister-Killian syndrome with severe cognitive impairment, inability to walk and mild scoliosis. On physical examination, he presented
Joint British Societies guideline on management of cardiac arrest in the cardiac catheter laboratory
More than 300 000 procedures are performed in cardiac catheter laboratories in the UK each year. The variety and complexity of percutaneous cardiovascular procedures have both increased substantially since the early days of invasive cardiology, when it was largely focused
Collaborator Name Misspelled
In the Original Investigation titled “Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial,” published in the February 1, 2022, issue of JAMA, a collaborator’s
The NHS in England should use horizontal networks rather than vertical structures to improve health and care
The NHS passed a landmark on 19 May 2022 when its national leaders in England announced a reduction from a level 4 (national) incident to a level 3 (regional) incident in the covid-19 response.1840…
Impact of dapagliflozin treatment on renal function and diuretics use in acute heart failure: a pilot study
Objective To determine the impact of sodium-dependent glucose type 2 cotransporter inhibitors on the renal function in acute heart failure. Methods In a single-centre, controlled, randomised study, patients were prescribed dapagliflozin in addition to standard therapy, or were in receipt
Combination improves salvage outcomes
Nature Reviews Clinical Oncology, Published online: 23 May 2022; doi:10.1038/s41571-022-00651-z Combination improves salvage outcomes
Mechanical regulation of chromatin and transcription
Nature Reviews Genetics, Published online: 23 May 2022; doi:10.1038/s41576-022-00493-6 Dupont and Wickström review the current understanding of how mechanical forces regulate chromatin state and gene expression and discuss the importance of this mechanosensitive gene regulation to physiology and disease.
A cautionary tale for potentially dishonest doctors
There is a scene in episode three of the BBC series “This is Going to Hurt” where the central character, a junior doctor called Adam, is walking briskly in an underground station. As he is about to…
Peak troponin T in STEMI: a predictor of all-cause mortality and left ventricular function
Background The clinical significance of peak troponin levels following ST-elevation myocardial infarction (STEMI) has not been definitively established. The purpose of this study was to examine the relationship between peak high-sensitivity cardiac troponin T (hs-cTnT) and all-cause mortality at 30
Legitimising values
While apparently helpful concepts such as “best interests” appear to have the virtue of simplicity, they are really place holders for the communication, time and listening that’s required to understand what truly matters to patients and others involved in healthcare.
Improving Primary Care Follow-up for Gynecologic Patients with Hypertension: An Implementation Science Pilot Study
Maternal pregnancy outcomes in women with cardiomyopathy: A systematic review and meta-analysis
To systematically assess the impact of cardiomyopathy on maternal pregnancy outcomes.
Ensuring completeness and timeliness of cancer treatment guidelines
Nature Reviews Clinical Oncology, Published online: 20 May 2022; doi:10.1038/s41571-022-00646-w Timely and comprehensive updating of treatment guidelines remains a challenge and necessity in medical oncology. Herein we discuss our assessment of how trial results with four off-patent drugs have been
The magic and meaning of Mendel’s miracle
Nature Reviews Genetics, Published online: 20 May 2022; doi:10.1038/s41576-022-00497-2 Commemorating the 200th birthday of Gregor Mendel, Kim Nasmyth reflects on Mendel’s life and legacy and how his work has shaped and defined the field of modern genetics.
Pandemic treaty: a chance to level up on equity
The Intergovernmental Negotiating Body (INB) is in the midst of developing a blueprint for the proposed pandemic instrument: a political framework to prevent, detect, and respond to emerging…
Traffic safety lessons ignored in confronting COVID-19
Traffic safety policy in the USA has been a catastrophic failure because it rejects science.1–3 This notwithstanding, some successful US traffic safety measures provide lessons that were ignored in confronting the COVID-19 pandemic. After safety belts were installed in vehicles,
Highlights from this issue
Improvement of asymmetric thyroid eye disease with teprotumumab (see page 755) Teprotumumab, a novel IGF-1R antibody, differentially reduces proptosis in patients with asymmetric thyroid eye disease. Anterior segment optical coherence tomography and ultrasound biomicroscopy for measuring thickness of corneal and
Patient-derived cellular models of primary ciliopathies
Primary ciliopathies are rare inherited disorders caused by structural or functional defects in the primary cilium, a subcellular organelle present on the surface of most cells. Primary ciliopathies show considerable clinical and genetic heterogeneity, with disruption of over 100 genes
ACR-ACNM-ASTRO-SNMMI Practice Parameter for Lutetium-177 (Lu-177) DOTATATE Therapy
Objectives: This practice parameter (PP) for Lutetium-177 (Lu-177) DOTATATE peptide receptor radionuclide therapy (PRRT) aims to guide authorized users in selection of appropriate adult candidates with gastroeneropancreatic neuroendocrine tumors (GEP-NETs) from foregut, midgut, and hindgut. The essential selection criteria include
Navigating financial toxicity in patients with cancer: A multidisciplinary management approach
Abstract Approximately one-half of individuals with cancer face personal economic burdens associated with the disease and its treatment, a problem known as financial toxicity (FT). FT more frequently affects socioeconomically vulnerable individuals and leads to subsequent adverse economic and health
Severity of Intrapartum Fever and Neonatal Outcomes
The few studies that have addressed the relationship between severity of intrapartum fever and neonatal and maternal morbidity have mixed results. The impact of the duration between maximum intrapartum temperature and delivery on neonatal outcomes remains unknown.
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk
Nature Genetics, Published online: 19 May 2022; doi:10.1038/s41588-022-01069-0 Single-nucleus ATAC-seq characterization of chromatin accessibility in human coronary artery disease samples identifies cell-type- and state-specific regulatory mechanisms underlying disease risk, highlighting the roles of TBX2 and PRDM16.
The GLUE that holds omics layers together
Nature Reviews Genetics, Published online: 19 May 2022; doi:10.1038/s41576-022-00505-5 A new study presents GLUE (graph-linked unified embedding), a generalizable computational framework for integrating unpaired single-cell multi-omics data and for inferring regulatory interactions.
[Editorial] Assistive technologies: time for a shift in thinking
Sustainable Development Goal 3—to ensure healthy lives and promote wellbeing for all at all ages—is a far-off wish for 2·5 billion people. So suggests the first Global Report on Assistive Technology released this week by WHO and UNICEF. The report
Covid-19: Second boosters may benefit at-risk groups but have “minimal” impact for others, says WHO
Short term benefits are seen after a second covid-19 vaccine booster—normally a fourth vaccine dose—in health workers, over 60s, and people with immunocompromising conditions, the World Health…
Gene of the month: NKX3.1
NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced
Highlights from this issue
Taking a second lookWarmia, Poland 1530s An extraordinary polymath called Nicolaus Copernicus is completing his work on heliocentricity, challenging (with support from both academic and theological colleagues) the ‘earth at the centre of the universe’ assumption Soho, London 1850s A
Role of neoadjuvant chemoimmunotherapy for resectable NSCLC
Nature Reviews Clinical Oncology, Published online: 18 May 2022; doi:10.1038/s41571-022-00647-9 Immune-checkpoint inhibitors have revolutionized the treatment of patients with non-small-cell lung cancer (NSCLC). Recently, indications for immune-checkpoint inhibitors have expanded from advanced-stage NSCLC to adjuvant, and now neoadjuvant, therapy for
Racism and Perinatal Health Inequities Research: Where we have been and where we should go
For over a century, substantial racial and ethnic inequities in perinatal health outcomes have persisted despite technical clinical advances and changes in public health practice that lowered the overall incidence of morbidity. Race is a social construct and not an
[Editorial] Menopause: a turning point for women’s health
Rising demand for menopausal hormone therapy (MHT) in the UK has resulted in shortages of some products, as suppliers struggle to keep up with demand. A consequence of increasing awareness of menopause symptoms and treatment options among women, prescriptions for
The (ultra)sound of neurons firing
Functional ultrasound (fUS) is an emerging technique that measures blood flow to report brain activity. In this issue of Neuron, Nunez-Elizalde et al. (2022) use simultaneous electrophysiological and fUS measurements to quantify the relationship between firing and fUS signals in awake
Highlights from this issue
There are just a few heroes and many villains on the UK and international scene at present. With a nod to wider geopolitical events (and many works of fiction), this month’s Airwaves presents you with the heroes and villains of
Rising cost of living is damaging people’s health, says royal college
Over half of UK people in a survey commissioned by the Royal College of Physicians have reported that their health has been negatively affected by the rising cost of living.The poll by YouGov was…
Neonatal pneumothorax in congenital diaphragmatic hernia: Be wary of high ventilatory pressures
Background Patients with congenital diaphragmatic hernia (CDH) require invasive respiratory support and higher ventilator pressures may be associated with barotrauma. We sought to evaluate the risk factors associated with pneumothorax in CDH neonates prior to repair. Methods We retrospectively reviewed
Opportunities and challenges for the use of common controls in sequencing studies
Nature Reviews Genetics, Published online: 17 May 2022; doi:10.1038/s41576-022-00487-4 Publicly available sequencing data can be used as external common controls for rare variant analyses but cautious sample ascertainment and processing is needed to avoid bias and confounding. The authors review
Ancient Myth and 21st-Century Psychedelic Medicine
This Arts and Medicine essay reviews how 21st-century evidence-based approaches to the use of psychedelic medicine replicate the ancient practices of Asclepian medicine.
Management of asymptomatic severe aortic stenosis: a systematic review and meta-analysis
Objectives The management of severe aortic stenosis mandates consideration of aortic valve intervention for symptomatic patients. However, for asymptomatic patients with severe aortic stenosis, recent randomised trials supported earlier intervention. We conducted a systematic review and meta-analysis to evaluate all
Seven monkeypox cases are confirmed in England
Seven cases of monkeypox, a viral infection that can cause a rash similar to chickenpox or syphilis, have been confirmed in England, the UK Health Security Agency (UKHSA) has said.The update adds…
Highlights from this issue
To make a decision is to answer a question. Clinical neurology involves a sequence of questions relevant to most patients—what is the clinical syndrome? what investigations are needed? what is the probable diagnosis? what is the best treatment? what is
Lessons learned from the Tokyo games isolation hotel experience
Despite the SARS-CoV-2 pandemic, the Tokyo2020 Organizing Committee (TOGOC), IOC, International Paralympic Committee (IPC) and National Olympic and Paralympic Committees (NOC/NPCs) delivered events across 42 venues for over 15 000 athletes from over 200 countries. Athletes lived in congregate housing
Correction: From late Sunday evening meetings to the formation of a special interest group for racially minoritised populations
Hunt D, Nwaosu U. From late Sunday evening meetings to the formation of a special interest group for racially minoritised populations. Sex Transm Infect 2022;98:75–6. doi:10.1136/sextrans-2021-055373 This article has been corrected since it was first published. The title has been
Genomic outbreak surveillance in resource-poor settings
Nature Reviews Genetics, Published online: 16 May 2022; doi:10.1038/s41576-022-00500-w Lillian Musila highlights a paper by Quick et al., which reported the use of portable nanopore sequencing for on-site, real-time genomic surveillance during the 2014–2016 Ebola virus epidemic.
Visualising harms: barely scratching the surface
Good visuals and graphs can quickly convey substance in a way that words cannot. Graphics make a lasting impression, are easy to digest, but hard to make. Far from being just an additional…
Outcomes of biliary atresia splenic malformation (BASM) syndrome following Kasai operation: a systematic review and meta-analysis
Inconsistency between overall and subgroup analyses
Suppose we have a sample of subjects in two treatment groups. To study the difference of the treatment effects, we can analyse the data using all subjects (overall analysis). We may also divide the subjects into several subgroups based on
Error in the dosage of Methotrexate in the EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis
The EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis (AAV)1 are a pillar in the treatment of patients with these diseases worldwide. Hence, it is of the utmost importance that information, especially dosing be correct and therefore reliable. More than
Effect of long-duration oxygen vs room air during labor on umbilical cord venous partial pressure of oxygen: a randomized controlled trial
Prolonged oxygen exposure was not associated with higher fetal oxygen content but was associated with a trend of fetal acidosis.
Cell-free DNA analysis for noninvasive examination of trisomy: comparing two targeted methods
Calling time on the use of war metaphors in covid-19
In 2020, as cases rose, health systems scrambled to adapt, and the economy was shut down—our entire world changed to flatten the curve. During these early days, the language used to describe the…
Levonorgestrel 52 mg intrauterine system efficacy and safety through 8 years of use
Extending hormonal intrauterine system (IUS) duration will allow users to have less need for procedures to provide long-term contraception.
Genomic analyses reveal domestication history and transgenic insertions in papaya
Nature Genetics, Published online: 12 May 2022; doi:10.1038/s41588-022-01030-1 The genome of the SunUp transgenic papaya cultivar includes a complex 1.64-Mb insertion that contains 3 transgenic fragments integrated with 61 nuclear genome fragments from the progenitor Sunset cultivar and 13 organelle
Precision medicine requires understanding how both sex and gender influence health
Progress in studying sex as a biological variable (SABV) is slow, and the influence of gendered effects of the social environment on biology is largely unknown. Yet incorporating these concepts into basic science research will enhance our understanding human health
[Editorial] Why Roe v. Wade must be defended
“Abortion presents a profound moral issue on which Americans hold sharply conflicting views.” So begins a draft opinion by Associate Justice Samuel Alito, leaked from the US Supreme Court on May 2, 2022. If confirmed, this judgement would overrule the
[Editorial] Intimate partner violence and trauma
In this issue, a Commission on intimate partner violence and mental health, led by Sian Oram, Helen Fisher, and Louise Howard, summarises current knowledge on this crucial topic and lays out a roadmap of recommendations to reduce incidence and aid
A call for de-implementation research and clinical practice in Chinese healthcare
Medical overuse in China and de-implementationIn recent years, The BMJ has published a series of articles highlighting medical overuse in China.12345 Overdiagnosis and overtreatment increases the…
Gender differences in authorship prior to and during the COVID-19 pandemic in research submissions to Occupational and Environmental Medicine (2017-2021)
Objective To explore whether the COVID-19 pandemic has impacted productivity of female academics in the field of occupational and environmental health, by examining trends in male and female authorship of submissions during and prior to the COVID-19 pandemic in Occupational
Getting the best from the Heart Team: guidance for cardiac multidisciplinary meetings
The purpose of this document is to update the existing joint British Societies recommendations on multidisciplinary meetings (MDMs) published in 2015 to reflect changes in practice. We aim to provide guidance on the structure and function of MDMs which should
COVID-19 vaccination in pregnancy
Despite recent endorsement from official and professional bodies, unequivocally recommending COVID-19 vaccination, hesitancy among pregnant persons remains high. The accumulated evidence clearly demonstrates that pregnant persons are a special risk group for COVID-19, with increased risk of intensive care unit
[Editorial] No area of stroke research should be left behind
More than 12 million incident cases of stroke are thought to have occurred in 2019, when stroke was also the second-leading cause of death and the third-leading cause of death and disability combined. Thanks to the efforts of stroke researchers
NHS data breaches: a further erosion of trust
The BMJ has uncovered failures by NHS data users to comply with the terms of their agreements for managing and using data they received from NHS Digital.1 The audits did not uncover evidence of…
Mindfulness-based intervention in patients with persistent pain in chest (MIPIC) of non-cardiac cause: a feasibility randomised control study
Objective The study evaluated the feasibility of mindfulness-based cognitive therapy (MBCT) in patients with non-cardiac chest pain by assessing their willingness to participate and adhere to the programme, and for these data to help further refine the content of MBCT
Validating a calculator without race and ethnicity to predict vaginal birth after cesarean delivery
KIRs mark killers suppressing autoimmunity
Identification of regulatory CD8+ T cells that suppress pathological immune responses is an importunate pursuit. In a recent issue of Science, Li et al. demonstrated that human KIR+CD8+ T cells suppress autoimmunity by eliminating pathogenic CD4+ T cells.
Variability exposes hidden buffering in the network specifying intestinal cell fate
Nature Reviews Genetics, Published online: 10 May 2022; doi:10.1038/s41576-022-00496-3 Elizabeth Mason recalls a seminal study by Raj et al., who used single-molecule approaches to expose principles governing how genes in a network cooperate to buffer perturbation while maintaining essential cellular
[Editorial] Youth STIs: an epidemic fuelled by shame
Sexually transmitted infections (STIs) are blighting the USA. Despite pandemic restrictions and limited testing capacity leading to a reduction in recorded STIs in early 2020, rates resurged once restrictions were lifted, and 2·4 million new cases were registered by the
New Brain Charts Could Become Clinical Benchmarks
Physicians may one day be able to track brain development across the human lifespan much as they do height and weight in children. Preliminary brain charts based on magnetic resonance imaging (MRI) scans are now available online.
Association between espresso coffee and serum total cholesterol: the Tromso Study 2015-2016
Background Coffee raises serum cholesterol because of its diterpenes, cafestol and kahweol, and the effect varies by brewing method. Population-based research on espresso coffee’s impact on serum cholesterol is scarce. Our aim was to examine how various brewing methods, in
Sexual violence as a weapon of war in Ukraine
The atrocities unfolding in Ukraine are shocking to watch. After the destruction of cities and the flight of Ukrainians turned refugees, we saw the images of murdered civilians in Bucha and received…
Ivosidenib combination improves OS
Nature Reviews Clinical Oncology, Published online: 09 May 2022; doi:10.1038/s41571-022-00644-y Ivosidenib combination improves OS
Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition
The stimulator of interferon genes (STING) is a critical signaling transducer of cytosolic DNA sensing, eliciting IRF3- and NFκB-dependent transcription of type I IFNs and pro-inflammatory cytokines. The importance of tumor-localized STING activation in priming endogenous antitumor immunity is well
The incidence of wound complications following primary repair of Obstetric Anal Sphincter Injuries (OASIs): A systematic review and meta-analysis
To systematically determine the incidence of wound infection and wound dehiscence following primary obstetric anal sphincter injury (OASI) repair.
Author Correction: Indirect paths from genetics to education
Nature Genetics, Published online: 09 May 2022; doi:10.1038/s41588-022-01092-1 Author Correction: Indirect paths from genetics to education
Traversing industry and academia in biomedicine: the best of both worlds?
Nature Reviews Genetics, Published online: 09 May 2022; doi:10.1038/s41576-022-00486-5 Traversing industry and academia in biomedicine: the best of both worlds?
[Editorial] The problem of antimicrobial resistance in chronic liver disease
In 2019, an estimated 1·27 million individuals died due to bacterial antimicrobial resistance (AMR). Beyond the obvious threat to global public health, AMR also threatens global development—even the most optimistic scenario modelled by the World Bank in 2017 estimates that
Clinical virology in the pandemic response—a missed opportunity
Doctors and scientists advising the UK government on covid-19 during the past two years have become household names. They are often mathematical modellers, statisticians, or epidemiologists. The…
Genesis of improved quality in imaging through a national Australian echocardiography registry
Background Despite rapid technological advances and growth, quality in imaging has not received the focus seen elsewhere in cardiovascular medicine, resulting in significant gaps between guidelines and practice. Contemporary echocardiography practice requires comprehensive real-time data collection to allow dynamic auditing
Reasons why people may refuse COVID‐19 vaccination (and what can be done about it)
World Psychiatry, Volume 21, Issue 2, Page 217-218, June 2022.
Reply to “Does Cesarean Delivery on Maternal Request Cause Adverse Outcomes?”
Christine Anne Abercrombie
bmj;377/may06_10/o1129/FAF1faChristine Anne Abercrombie qualified at the young age of 22 and while working as a junior doctor in Stoke was encouraged to train in anaesthetics. During her anaesthetic…
Death by differentiation: CD4+ T cells kick out suspicious stem cells
Antigen presentation is typically regarded as the domain of immune cells such as dendritic cells and B cells. Hernandez-Malmierca et al. (2022) upend this notion by observing that hematopoietic stem and progenitor cells process and present antigen via major histocompatibility class
Nutrition and Physical Activity Guideline for Cancer Survivors
CA: A Cancer Journal for Clinicians, Volume 72, Issue 3, Page 263-265, May/June 2022.
Polygenic risk scores for CARDINAL study
Nature Genetics, Published online: 05 May 2022; doi:10.1038/s41588-022-01074-3 The Cardiometabolic Disorders in African-Ancestry Populations (CARDINAL) study site is a well-powered, first-of-its-kind resource for developing, refining and validating methods for research into polygenic risk scores that accounts for local ancestry, to
[Editorial] COVID-19: the next phase and beyond
After living for more than 2 years with COVID-19—with over 6·2 million confirmed deaths (but probably many more, with an estimated 20 million excess deaths) and over 510 million confirmed cases—the world is at a critical point. The omicron wave,
Heatwaves in India and Pakistan are lasting longer than previously seen
India and Pakistan have been in the grip of a series of intense and prolonged heatwaves since March, with temperatures reaching 43-46°C in north and central India on 28 April, the Indian Meteorology…
Relative risk rather than absolute risk reduction should be preferred to sensitise the public to preventive actions
We thank Lawrence and colleagues1 for their interest in our work,2 about which they raised some comments as the need of expressing results in absolute rather than relative risks. As they appropriately mentioned in their correspondence, absolute risk is an
Gregor Mendel and the concepts of dominance and recessiveness
Nature Reviews Genetics, Published online: 04 May 2022; doi:10.1038/s41576-022-00495-4 On the occasion of Gregor Mendel’s bicentenary, the authors reflect on the history of the terms dominant and recessive, and their current use in medical genetics.
“Déjà vu” in an autism gene mouse model modifies social mores
Genetic and environmental factors during development are involved in autism, and in this issue of Neuron Krüttner et al. (2022) find environment may play a more acute role in modulating autism behavior in a Shank3 exon 21 deletion mutant mouse (Shank3ΔC/ΔC).
The pollution of health discourse and the need for effective counter-framing
The UK Health Foundation argues that to better communicate on the social determinants of health, we need to change our framing.1 Framing describes what we say about an issue or concept and how we say…
From AACR 2022
Nature Reviews Clinical Oncology, Published online: 03 May 2022; doi:10.1038/s41571-022-00642-0 From AACR 2022
PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms
Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer’s disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain
A New Score Based on the International Standards for Neurological Classification of Spinal Cord Injury for Integrative Evaluation of Changes in Sensorimotor Functions
Journal of Neurotrauma, Volume 39, Issue 9-10, Page 613-626, May 2022.
Error in Table
The Review article titled “Diagnosis and Treatment of Acute Coronary Syndromes: A Review,” published in the February 15, 2022, issue of JAMA, included an error in Table 3 in which aldosterone, rather than spironolactone, was listed as a mineralocorticoid receptor
No minister, a “protective ring” was not thrown around care homes
Margaret Thatcher famously said “Advisers advise, ministers decide.”1 Yet, throughout the covid-19 pandemic this distinction has often seemed blurred. Ministers justified decisions by claiming they…
Biobanking in Latinos: current status, principles for conduct, and contribution of a new biobank, El Banco por Salud, designed to improve the health of Latino patients of Mexican ancestry with type 2 diabetes
Underserved Latino communities experience a greater burden of type 2 diabetes mellitus (T2DM) than the general population. Predictors of glycemic control are likely to include both biological/genetic and social determinants of health (SDOH). A variety of approaches have been used
Keep moving: overcoming physical, mental and pandemic challenges to stay active
There is little argument against the benefits of physical activity for most cohorts: healthy individuals, patients with non-communicable disease and auto-immune conditions, and patients with cancer – all experience improved health outcomes from regular physical activity. However, the physical activity
A case of prenatal strangulated inguinal hernia
Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies
Nature Genetics, Published online: 02 May 2022; doi:10.1038/s41588-022-01051-w Analyses of cis-genetic regulation of the plasma proteome in European and African American populations lead to the identification of shared and unique cis-protein quantitative trait loci and models for proteome-wide association studies
Making sense of the ageing methylome
Nature Reviews Genetics, Published online: 02 May 2022; doi:10.1038/s41576-022-00477-6 In this Review, the authors give an overview of age-related changes to the methylation landscape and the statistical tools used to quantify them. They also discuss the evidence for longevity strategies
Use of Irradiated Red Blood Cell Blood Transfusions in Newborns to Improve Intracerebral Saturation
Since the 1950s, neonatal intensive care practitioners have worked to preserve brain oxygenation. The physiological rationale that red blood cell (RBC) transfusion improved oxygen carrying capacity was a tantalizing prospect. In this issue of JAMA Pediatrics, Saito-Benz et al renew
Migraine and adverse pregnancy outcomes: the nuMoM2b study
Migraine affects 28% of women in their pregnancy-capable years,1 and is associated with systemic inflammation, endothelial dysfunction, and increased risk of pregnancy-associated thromboembolic events.2, 3 Migraine history has been associated with adverse pregnancy outcomes (APO) of placental origin, including hypertensive
WhatsApp'tan Bize Yazın