Göz Hastalıkları

Teprotumumab reduces extraocular muscle and orbital fat volume in thyroid eye disease (see page 165) Teprotumumab reduces orbital muscle and fat volumes, which correlates to its clinical effect of proptosis and diplopia reduction in patients with active thyroid eye disease.

Objective To compare the two surgical techniques in terms of efficacy, safety, and postoperative management over 36 months of follow-up. Methods This retrospective clinical cohort study compared the outcome of trabeculectomy surgery and Xen gel implant in patients having uncontrolled

Objective To demonstrate the spectrum of autoimmune retinopathy (AIR) associated with immunotherapy for advanced cutaneous melanoma. Methods and analysis Retrospective chart review on patients with advanced cutaneous melanoma who developed AIR after initiating immunotherapy. Complete ophthalmic examination and relevant ancillary

Loss of endothelial cells in viral DNA-positive grafts after keratoplasty: a two-year follow-up study (see page 26) Recipients of viral DNA-positive grafts in keratoplasty are at risk of decompensation of donor endothelium. Over a 2-year post-transplant follow-up, we observed rapid

Association between atopic keratoconjunctivitis and the risk of corneal ulcer (see page 1632) Our population-based cohort study supports an association between corneal ulcer and atopic keratoconjunctivitis. It suggests that all patients with atopic keratoconjunctivitis should be advised of the risk

Long-term outcome of transcanalicular microdrill dacryoplasty—a minimally invasive alternative to dacryocystorhinostomy (see page 1480) In contrast to dacryocystorhinostomy, transcanalicular microdrill dacryoplasty is an anatomy preserving, microendoscopic lacrimal duct surgery technique, which is suitable for management of nasolacrimal duct obstruction in

A case series of shrinking hydroxyapatite orbital implants (see page 1338) Bone-derived hydroxyapatite orbital implants can reduce in size by osteoclastic activity in as little time as four years, requiring further intervention to maintain orbital volume. Nationwide trends in the

Prevalence, incidence and risk factors of strabismus in a Chinese population-based cohort of pre-school children: the Nanjing eye study (see page 1203) The prevalence of strabismus at baseline (3 years old) was 2.48% and the annual incidence of strabismus during

Can we eradicate trachoma? A survey of stakeholders (see page 1059) We surveyed trachoma stakeholders to assess beliefs related to feasibility of trachoma eradication as an end goal for trachoma programs. Most experts reported that eradication was possible, although major

Characteristics of endothelial corneal transplant rejection following immunisation with SARS-CoV-2 messenger RNA vaccine (see page 893) Acute DMEK allograft rejection was found in two patients at one and three weeks following SARS-CoV-2 mRNA vaccination. Rejection signs responded to intensive topical

Impact of eyeglasses wear on uncorrected visual acuity among urban migrant primary school children in China: a cluster-randomised clinical trial (see page 761) This cluster-randomised clinical trial of 94 schools and 4376 participants showed that providing free eyeglasses slowed slightly

Long-term follow-up of cystinosis patients treated with 0.55% cysteamine hydrochloride (see page 608) Results from the French ATU cohort to confirm the safety, efficacy and tolerability in real-world clinical practice of a 0.55% cysteamine hydrochloride ophthalmic solution for cystinosis are

Myopia in school-aged children with preterm birth: the roles of time spent outdoors and serum vitamin D (see page 468) In school-age preterm children, myopia is associated with the severity of retinopathy of prematurity and less time spent outdoors but

Background/Aims The classification of retinal detachment is currently still based on many objective criteria such as duration of symptoms and funduscopic macular status, which leaves some important questions unanswered. The most important factor is the macular status, which is determined

Using incognito standardised patients to evaluate quality of eye care in China (see page 311) Employing incognito standardised patients to evaluate refractionists at 133 randomly-selected optical facilities in western China revealed inaccurate refraction (>= 1.0 diopter of inaccuracy in 25.6%)

Objective Meibomian gland dysfunction (MGD) is a primary cause of dry eye disease. Analysis of MGD, its severity, shapes and variation in the acini of the meibomian glands (MGs) is receiving much attention in ophthalmology clinics. Existing methods for diagnosing,

Morphological change and recovery of corneal endothelial cells after rho-associated protein kinase inhibitor eye-drop (ripasudil 0.4%) instillation (see page 169) In glaucoma patients treated with ROCK-inhibitor eye-drops, corneal-endothelial-cell density (CECD) number calculated by automated non-contact-specular-microscopy software appeared to show a

Objective To report the results of a global survey on cataract practice patterns related to preoperative, intraoperative and postoperative care, surgical setting and personnel allocation. Methods and analysis An online 28 questions survey was sent to 240 ophthalmologists asking to

Objective To study the effectiveness of amblyopia screening at ages 3–4. Methods and Analysis From a population with no previous screening, a cohort of 2300 children with 3–4 years old attending school (91% of children this age attend school in

Indications and prognosis for keratoplasty in eyes with severe visual impairment and blindness due to corneal disease in India (see page 17) In this hospital-based study of 28 824 patients with severe visual impairment or blindness due to corneal disease,

Tackling HTLV-1 infection in ophthalmology: a nationwide survey of ophthalmic care in an endemic country, Japan (see page 1647) In a nationwide survey in Japan, most ophthalmic facilities examined for HTLV-1 infection when considering he differential diagnoses for uveitis. Providing

Glaucoma in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA): cohort profile, prevalence, awareness and associations (see page 1492) The crude prevalence of glaucoma in Northern Ireland of 2.83% (95% CI 2.31%, 3.46%) is comparable to other

Thirty-five years trend in the prevalence of refractive error in Austrian conscripts based on 1.5 million participants (see page 1338) In Austrian conscripts, the prevalence of myopia almost doubled between 1983 and 2017. It was constantly lower yet increased more

Core outcomes for geographic atrophy trials (see page 1196) Core outcomes for geographic atrophy trials were identified that are relevant to patients, clinicians and researchers: functional outcomes (reading speed, near, distance and low luminance visual acuity), a patient-reported outcome measure,

Biologic therapy for Behcet’s uveitis: a systematic review (see page 1045) Of trials retrieved on six biologics used in Behcet’s uveitis, daclizumab, secukinumab and gevokizumab failed. Adalimumab was not evaluated for Behcet’s uveitis. Interferon alpha 2a and rituximab showed promise

Smoking and treatment outcomes of neovascular age-related macular degeneration over 12 months (see page 893) In this cohort of neovascular age-related macular degeneration (AMD) patients, current smoking was associated with a younger age of AMD onset and key treatment outcomes

Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease (see page 748) RNA for the severe acute respiratory syndrome coronavirus 2 was detected in the conjunctival swab specimen 13 days after illness, with a brief presence and

Longitudinal changes in axial length in high myopia: 4-year prospective study (see page 600) A persistent increase in axial length was observed over 4 years in adult myopic patients, which correlated with initial axial axial length. Longitudinal changes in the

Altered ellipsoid zone reflectivity and deep capillary plexus rarefaction correlate with progression in best disease (see page 461) Patients in the vitelliform stage of Best disease show significant ellipsoid zone and vascular alterations at deep capillary plexus. The severity of

Implementation of a cloud-based referral platform in ophthalmology: making telemedicine services a reality in eye care (see page 312) After implementation of a cloud-based referral platform, the data flow between optometrists and ophthalmologists has improved. More than half of the

Objective To assess the impact of a 5 min interactive online survey on raising awareness about cornea donation and willingness to become a donor. Methods An interactive online questionnaire was used to collect information regarding awareness, perceptions and attitudes towards

Optical coherence tomography angiography in preclinical Alzheimer’s disease (see page 157) In this study, an increased retinal vessel density was observed in cognitively normal individuals positive for cortical amyloid-beta on positron emission tomography. This suggests that vessel density might be

Topic This paper reviews the ocular side effects of medications used in the treatment of rheumatological conditions. Clinical relevance Rheumatic diseases are inflammatory conditions that may affect the skin, blood vessels, joints, muscles and internal organs. Immunosuppressive agents are often

Outcome of peripheral iridotomy in subjects with uveitis (see page 8) The peripheral iridotomy (PI) survival time was 70 days for YAG PI and 11 years for surgical PI in uveitic patients. Younger age and iris bombe were associated with

BTNL2 gene polymorphism and sarcoid uveitis (see page 1690) The butyrophilin-like 2 G16071A gene polymorphism seems to predispose for sarcoidosis; however, it does not seem to predispose for all subtypes of sarcoid uveitis. Retinal vessel oxygen saturation is affected in

A universal artificial intelligence platform for collaborative management of cataracts (see page 1553) Universal AI-based multilevel platforms have the potential to make accurate cataract diagnoses and detect referral cases after evaluation of severity. The novel tertiary referral pattern achieved the

Incidence of exudative age-related macular degeneration and treatment load under the Korean National health insurance system in 2010–15 (see page 1361) This population-based cohort study investigated the incidence of exudative age-related macular degeneration and associated use of ranibizumab and aflibercept

Outer retinal layer thickness in glaucoma patients with horizontal hemifield visual field defects (see page 1217) In glaucoma patients with horizontal hemifield defects, the authors observed a significant horizontal asymmetry in inner retinal layer thickness but, not in outer layer

Altered retinoid metabolism gene expression in chronic Stevens-Johnson’s syndrome (see page 1015) Altered vitamin A metabolism in chronic ocular sequelae of SJS. Photophobia and sensations of dryness in migraine patients occur independent of baseline tear volume and improve following botulinum

Prevalence and causes of vision loss in North Africa and Middle East in 2015: Magnitude, temporal trends, and projections (see page 863) The age-standardised prevalence of vision impairment for all ages and genders decreased from 1990 to 2015 in NAME.

Objective To determine the common indications for, and outcomes of pars plana vitrectomy surgery among black Africans in a low-resource setting. Methods and Analysis A retrospective, non-comparative case review was undertaken. Data from 1000 consecutive eyes of 1000 patients in

Astigmatism and its components in 12-year-old Chinese children: the Anyang Childhood Eye Study (see page 768) In Chinese children (mostly 12-year-olds) with high a prevalence of astigmatism, refractive (RA) and corneal (CA) astigmatism were mainly “with-the-rule” and increased with the

Prior non-irradiative focal therapies do not compromise the efficacy of delayed episcleral plaque brachytherapy in retinoblastoma (see page 699) In a retrospective study of 50 patients, the lack of prior diode or green laser therapy was predictive of an increased

Background/aims To monitor treatment-naïve patients with wet age-related macular degeneration (wet AMD) receiving intravitreal aflibercept (IVT-AFL) in France. Methods RAINBOW (Real life use of intravitreal Aflibercept In FraNce – oBservatiOnal study in Wet age-related macular degeneration) is an ongoing, observational,

Choriocapillaris and retinal vascular plexus density of diabetic eyes using Split-spectrum Amplitude-Decorrelation spectral domain optical coherence tomography angiography (see page 452) Capillary perfusion density in Choriocapillaris and retinal vascular plexuses in diabetic patients were observed in association with worsening retinopathy

Objective Explore relationships between systemic exposure to intravitreal aflibercept injection (IAI) and systemic pharmacodynamic effects via post hoc analyses of clinical trials of IAI for neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME). Methods and analysis Adults from

In vivo confocal microscopy indicates an inverse relationship between the subbasal corneal plexus and the conjunctivalization in patients with limbal stem cell deficiency (see page 327) In this study the authors observed an inverse relationsip between sub-basal corneal nerve plexus

Micro-interventional endocapsular nucleus disassembly: novel technique and results of first-in-human randomized controlled study (see page 176) In a prospective, masked, multi-surgeon randomised clinical trail, the authors observed that microinterventional cataract fragmentation and endocapsular nucleus disassembly prior to conventional phacoemulsification safely

Background/Aims Optical coherence tomography (OCT) has become standard of care in the diagnosis and management of a myriad of retinal and optic nerve pathology. Access to diagnostic equipment and skilled imaging personnel in the after-hours setting is often limited. We

Neuroretinal atrophy following resolution of macular oedema in retinal vein occlusion (see page 36) In this study of patients with retinal vein occlusion treated with ranibizumab, significant neuroretinal thinning was observed after the resolution of macular oedema in 11% of

Acanthamoeba keratitis: confirmation of the UK outbreak and a prospective case–control study identifying contributing risk factors (see page 1621) There has been a threefold increase in Acanthamoeba keratitis among contact lens users in South East England since 2010–2011. Risk factors

Background/aims Teleophthalmology is well positioned to play a key role in screening of major chronic eye diseases. Economic evaluation of cost-effectiveness of teleophthalmology, however, is lacking. This study provides a systematic review of economic studies of teleophthalmology screening for diabetic

Epiblepharon, a common occurrence among children of East Asian descent, is a congenital anomaly whereby a horizontal skin fold across the eyelid (upper or lower) overlaps the eyelid margin resulting in inturning of the eyelashes.1–3 This usually occurs in the

Aim To evaluate glaucoma-associated mortality in a rural cohort in India. Methods The study cohort comprised individuals aged 40 years and above who took part in the Andhra Pradesh Eye Disease Study (APEDS1) during 1996–2000. All participants underwent detailed comprehensive

Background/aims To determine the diagnostic accuracy of trained rural ophthalmologists and non-medical image graders in the assessment of diabetic retinopathy (DR) in rural China. Methods Consecutive patients with diabetes mellitus were examined from January 2014 to December 2015 at 10

Non-incisional eyelid everting suture technique for treating lower lid epiblepharon (see page 1504) Non-incisional eyelid everting sutures can be useful in patients with mild to moderate lower lid epiblepharon and it is important to determine the appropriate indications for this

Objective We investigated the efficacy of additional topical betamethasone in persistent cystoid macular oedema (CMO) after carbonic anhydrase inhibitors (CAIs) therapy. Methods and analysis This retrospective cohort study included 16 eyes of 10 patients with retinitis pigmentosa (RP). All patients

Objective Microbial infection has been reported to cause blepharitis, conjunctivitis and keratitis. We evaluated the safety and efficacy of a foam formulation of 2% 4-terpineol (T4O) against common ocular microorganisms. Material and methods The antimicrobial effect of a 2% T4O

Background/aims To report alterations in visual acuity and visual pathway structure over an interval of 1–3 years in a cohort of children, adolescents and young adults who have Wolfram syndrome (WFS) and to describe the range of disease severity evident

Objective To determine the prevalence of, associations with and diagnoses leading to mild visual impairment or worse (logMAR >0.3) in middle-aged adults in the UK Biobank study. Methods and analysis Prevalence estimates for monocular and binocular visual impairment were determined

Objective To evaluate the success of an intravitreal injection of ocriplasmin to release symptomatic vitreomacular traction (VMT) and close a full-thickness macular hole. Methods and analysis An observational retrospective multicentre study conducted in Italy. Patients with symptomatic distortion and loss

Background Trachoma is the leading infectious cause of blindness. Until recently, reliable data on the global extent of the disease, detailed plans for elimination, and government, donor and partner engagement were all inadequate. Methods The trachoma community undertook a systematic, three-pronged strategy

Purpose To determine the prevalence of refractive errors in Colombia and its relations with demographic and socioeconomic variables. Methods A cross-sectional study performed in 10 Colombian administrative districts (MIOPUR study), including children and adolescents from 8 to 17 years old

Polytetrafluoroethylene (Gore-Tex) suture is preferred for scleral fixation of intraocular lenses or capsular tension devices as it is more resilient to breakage than polypropylene 10–0. However, manipulation of the thick calibre and overcurved configuration of the Gore-Tex needle within the eye

The BJO is primarily a clinical and scientific journal and rarely comments on commercial activities. Nevertheless, the recent developments in the field of glaucoma surgery,1 merit some comment. An area that has traditionally failed to attract significant commercial interest has

Effect of intravitreal triamcinolone acetonide injection at the end of vitrectomy for vitreous hemorrhage related to proliferative diabetic retinopathy (see page 1351) In a prospective multicenter randomised study, intravitreal injection of triamcinolone acetonide at the end of vitrectomy was associated