More than a quarter of GP and practice nurse posts in England could be vacant in the next decade unless the government takes urgent action, a new analysis has warned.1The Health Foundation says that…
Progress over 30 years should not mean principles have to change: a Society of Sports Therapists perspective
The development of Sports Therapy principles When The Society of Sports Therapists was formed in 1990, the Sport and Exercise Medicine (SEM) landscape, especially in the UK, was significantly different to how it is today, even though the overriding principles
Cancer treatment and survivorship statistics, 2022
Abstract The number of cancer survivors continues to increase in the United States due to the growth and aging of the population as well as advances in early detection and treatment. To assist the public health community in better serving
Association of life-course reproductive duration with mortality: a population-based twin cohort study
Although age at menopause has been linked to mortality, the association between the entire reproductive lifespan and mortality remains unclear.
Publisher Correction: A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex
Nature Genetics, Published online: 29 June 2022; doi:10.1038/s41588-022-01145-5 Publisher Correction: A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex
The fall of Roe v Wade: the fight for abortion rights is universal
On the 24 June 2022, the Supreme Court of the United States overturned Roe v Wade, the landmark 1973 decision to legalise abortion in the US, which for half a century has guaranteed that women had…
Active expectancy as alternative to treatment for cervical intraepithelial neoplasia grade 2 in women aged 25 – 30 years: ExCIN2, a prospective clinical multicenter cohort study
Women aged 25-30 years with fully visible SCJ and CIN2, but without HPV16, have a high rate of regression within 15 months and should not be treated immediately.
Copy-number classifiers for cancer
Nature Reviews Genetics, Published online: 28 June 2022; doi:10.1038/s41576-022-00516-2 Two new papers in Nature report copy-number-based classification systems across cancer types that provide routes for personalized therapy.
[Editorial] Equitable access to long-acting PrEP on the way?
In May, ViiV Healthcare announced that it was negotiating with the Medicines Patent Pool (MPP) for the voluntary licencing of injectable long-acting cabotegravir (CAB-LA) as pre-exposure prophylaxis (PrEP). This development will potentially allow manufacture of generic versions of CAB-LA in
[Editorial] The hidden costs of big tobacco
The devastating effects of tobacco on the health of users are well known, as are the associated economic costs, including lost productivity due to smoking-related illness, which equate to approximately US$1·4 trillion per year. However, the environmental impact of the
JAMA ’s The Arts and Medicine Section at 5 Years: Progress and Opportunities
In this essay, the Arts and Medicine editor reviews features in the section over the past 5 years, covering visual arts, culture, design, performance, history, and more, and offers welcome to future contributions.
Children call for root and branch reform of air pollution
bmj;377/jun28_14/o1576/FAF1faRichard H SmithChildren and teenagers at King’s College Hospital in London marked this year’s Clean Air Day by writing messages to help improve their air quality, on…
A case of antipsychotic-induced psychomotor seizure
A seizure is one of the most uncommon severe adverse side effects of antipsychotics. Clinical recognition rates for it are low, especially for psychomotor seizures. The authors present a case of psychomotor seizure caused by amisulpride to treat schizophrenia. A
Sacituzumab Govitecan-hziy in Breast Cancer
Trophoblast cell-surface antigen-2 (Trop-2) is a transmembrane calcium signal transducer and its overexpression is common in many types of malignant epithelial tumors, including breast cancer (BC). Sacituzumab govitecan-hziy (SG), the anti-Trop-2 antibody-drug conjugate, resulted in a significant survival benefit over
[Editorial] Awareness campaigns and cancer screening
Dame Deborah James, a former deputy head teacher in the UK, raised more than £6·5 million in just over a month for the Cancer Research UK Bowelbabe Fund. Unfortunately, at just 40 years of age, James has also announced that
[Editorial] The dystopia of enforced childbirth
In May, 2022, a controversial draft opinion from the US Supreme Court surfaced publicly, revealing the court plans to overturn Roe v. Wade, which grants abortion rights in the country. If enacted, it is expected that 13 of 50 states
Genome-scale single-cell CRISPR screens
Nature Reviews Genetics, Published online: 27 June 2022; doi:10.1038/s41576-022-00517-1 A report in Cell takes single-cell CRISPR screens to genome scale and demonstrates how the transcriptional phenotypes can be used to resolve gene functions.
Problems with needle-free laparoscopic cervical cerclage
Language matters: representations of ‘heart failure in English discourse–a large-scale linguistic study
Aims Heart failure (HF) has a lower public profile compared with other serious health conditions, notably cancer. This discourse analysis study investigates the extent to which HF is discussed in general contemporary English, UK parliamentary debates and the ways in
Polio’s detection in London is a wake-up call
The UK Health Security Agency (UKHSA) has declared a “national incident” after poliovirus was detected in London sewage.1 Detection of poliovirus in UK sewage is not in itself an unprecedented…
Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer
Most small non-coding RNAs (sncRNAs) with regulatory functions are encoded by majority sequences in the human genome, and the emergence of high-throughput sequencing technology has greatly expanded our understanding of sncRNAs. sncRNAs are composed of a variety of RNAs, including
Endometriosis Causes Cardiovascular Disease
From ASCO 2022
Nature Reviews Clinical Oncology, Published online: 24 June 2022; doi:10.1038/s41571-022-00656-8 From ASCO 2022
Cancer treatment and survivorship statistics, 2022
Abstract The number of cancer survivors continues to increase in the United States due to the growth and aging of the population as well as advances in early detection and treatment. To assist the public health community in better serving
James Irvine Currie
bmj;377/jun24_11/o1522/FAF1faJames Irvine Currie (“Jim”) underperformed at school so needed to take first MB. This was fortunate as it led to his being in the same year group as his future wife,…
Associations between short-term exposure to PM2.5 and cardiomyocyte injury in myocardial infarction survivors in North Carolina
Objective Short-term ambient fine particulate matter (PM2.5) is associated with adverse cardiovascular events including myocardial infarction (MI). However, few studies have examined associations between PM2.5 and subclinical cardiomyocyte damage outside of overt cardiovascular events. Here we evaluate the impact of
To bridge or not to bridge: summary of the new evidence in endovascular stroke treatment
Heartbeat: treatment delays with telephone triage for acute myocardial infarction
Prevention of myocardial damage and optimal outcomes in patients with acute myocardial infarction (MI) are achieved when primary percutaneous coronary intervention (PCI) is performed as soon as possible after symptom onset. Although some patients present directly to the emergency department
Linking genetic variants to kidney disease via the epigenome
Nature Genetics, Published online: 23 June 2022; doi:10.1038/s41588-022-01098-9 The largest GWAS for kidney function so far provided the starting point for integrated multi-stage annotation of genetic loci. Whole kidney and single-cell epigenomic information is crucial for translating GWAS information to
Nano-omics: nanotechnology-based multidimensional harvesting of the blood-circulating cancerome
Nature Reviews Clinical Oncology, Published online: 23 June 2022; doi:10.1038/s41571-022-00645-x Liquid biopsy assays of diverse cancer-associated molecular alterations in blood, including genomic, epigenomic, transcriptomic, proteomic and metabolomics changes, offer considerable opportunities for early detection of cancer as well as improved
APOE told me put my fat in the bag and nobody gets hurt
The ε4 variant in the APOE gene is the strongest genetic risk factor for Alzheimer’s disease. How does this gene impact different cell types in the brain to increase disease risk? In this issue of Cell, TCW and colleagues report
[Editorial] Cancer care: widening the scope of innovation
The keynote address at the 2022 American Society of Clinical Oncology (ASCO) meeting earlier in June was met with great enthusiasm. André Ilbawi, WHO’s Cancer Control Officer, announced the first partnership between ASCO and WHO that, he says, “catalyses meaningful
Looking back and looking forward
This July 2022 issue of the JME contains several articles addressing ethical issues related to COVID-19 as well as reproductive ethics—a timely topic, given the leaked U.S. Supreme Court document, anticipating the overturn of Roe v. Wade. On the COVID-19
Initial health assessments for new migrants: the evidence gap
We welcome the timely article by Knights and colleagues about initial health assessments for new migrants from Afghanistan, though, as the authors point out, this is relevant for any new…
Expectant versus medical management for retained products of conception after medical termination of pregnancy: A randomized controlled study
Despite the rise of medical treatments for the termination of pregnancy, to-date no prospective trial has evaluated the efficacy of misoprostol in treating retained products of conception after induced termination of pregnancy.
[Editorial] Prioritising COVID-19 over everything: the unintended harm
During the past 2 and a half years, countries worldwide saw disruptions in their health-care services as they redirected their efforts and resources to manage the COVID-19 pandemic. At the same time, many people with underlying conditions limited their interactions
[Editorial] Monkeypox: a neglected old foe
Monkeypox is a zoonosis caused by a virus belonging to the genus orthopoxvirus and endemic to western and central Africa. The disease is making headlines worldwide because of a growing number of cases being reported from North America and countries
Manjula Arora case: GMC announces co-chairs and scope of review
The review into the case of Manjula Arora—a GP who was given a one month suspension over her use of the word “promised” when requesting a work laptop—will be co-chaired by Iqbal Singh and Martin…
IGFBP7 as a preoperative predictor of congestive acute kidney injury after cardiac surgery
Objective Congestive acute kidney injury (c-AKI) refers to AKI in the presence of right ventricular failure (RVF) and is a highly morbid complication of cardiac surgery. However, treatment has traditionally been reactive rather than proactive due to limited modalities to
Increased risk of cardiovascular events and death in the initial phase after discontinuation of febuxostat or allopurinol: another story of the CARES trial
Objectives The Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (CARES) trial suggested a higher risk of cardiovascular (CV) death from febuxostat than from allopurinol. However, a significant number of patients died after discontinuation of febuxostat or allopurinol.
Perceived stigma and quality of life in Parkinsons disease with additional health conditions
Background Parkinson’s disease (PD) is associated with perceived stigma and affects quality of life (QoL). Additional health conditions may influence these consequences of PD. Aims This study assessed the impact of health conditions on perceived stigma and QoL in persons
Highlights from this issue
Much of what emergency physicians do is assess risk. Sometimes it’s the likelihood of a diagnosis – does this chest pain represent ischaemic heart disease? And sometimes we know the diagnosis but not how likely the patient is to suffer
Highlights from this issue
Eye health indicators for universal health coverage: results of a global expert prioritisation process (see page 893) An online prioritisation process among 72 eye health experts from all global regions produced a menu of 22 indicators which can inform new
Mortality Risk After Pediatric Tonsillectomy
Pediatric tonsillectomy is the first-line surgical treatment for children with obstructive sleep-disordered breathing or recurrent throat infections. Weighted survey data from 2009 to 2010 suggest that an estimated 340 000 ambulatory and 10 000 inpatient tonsillectomies are performed per year,
Minimum alcohol prices in Europe could significantly reduce health harms, says WHO
European countries could significantly reduce the health harms caused by alcohol consumption by introducing minimum pricing for alcoholic beverages, the World Health Organization has said.1The No…
Early versus delayed complete revascularisation in patients presenting with ST-segment elevation myocardial infarction and multivessel disease: a systematic review and meta-analysis of randomised controlled trials
Background Several studies have demonstrated that complete revascularisation improves clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary disease. However, the optimal timing of non-culprit lesion revascularisation remains controversial. Objective The aim of this systematic review
Radiotheranostics in oncology: current challenges and emerging opportunities
Nature Reviews Clinical Oncology, Published online: 20 June 2022; doi:10.1038/s41571-022-00652-y Radiotheranostics enables the clinician to image and then target lesions using the same probe. Despite this appealing potential, interest in the field of radiotheranostics has long been constrained by a
Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
Nature Genetics, Published online: 20 June 2022; doi:10.1038/s41588-022-01126-8 Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
Incorrect news on a good old trial
As a former member of The BMJ’s editorial board, I am a big fan of its focus on sharing knowledge and expertise to improve healthcare outcomes and have contributed to this on several occasions. But I…
Highlights from this issue
Moving forward post pandemic – BSG Live 2022 Please read and enjoy this special edition of Frontline Gastroenterology put together to celebrate BSG live 2022 with the overarching theme – Moving forward post pandemic. The content reflects the breadth and
Examining the interrelationships between mindfulness‐based interventions, depression, inflammation, and cancer survival
Abstract Depression is highly prevalent in those diagnosed with cancer and is also associated with poorer prognostic outcomes. Mindfulness-based interventions are effective in reducing depressive symptoms and improving quality of life in patients with cancer. The objective of this review
Measuring biological age using omics data
Nature Reviews Genetics, Published online: 17 June 2022; doi:10.1038/s41576-022-00511-7 Molecular measures of biological ageing based on high-throughput omics technologies are enabling the quantitative characterization of ageing. The authors review how epigenomic, transcriptomic, proteomic, metabolomic and other omics data can be
Tranexamic Acid for the Prevention of Blood Loss after Cesarean Among Women With Twins. A Secondary Analysis of the TRAAP2 Randomized Clinical Trial
Although prophylactic tranexamic acid administration at cesarean delivery resulted in a lower incidence of calculated estimated blood loss > 1000 mL or red-cell transfusion by day 2, its failure to reduce the incidence of hemorrhage-related secondary clinical outcomes (TRAAP2 trial)
Adrenal insufficiency: a commentary
Adrenal insufficiency (AI) due to corticosteroid administration occurs frequently in those on higher prolonged steroid doses; however, an exact threshold other than high clinical suspicion remains unknown.1 Outside of tertiary AI, adrenal failure is rare and for primary adrenal insufficiency
Covid-19: Long covid risk is lower with omicron than delta, researchers find
The risk of developing long covid is lower among people with the omicron variant of SARS-CoV-2 than with delta, shows an analysis of self reported data to the UK ZOE covid app.1Researchers from…
Highlights from this issue
Probiotics and the microbiome Paul Fleming addresses the question of whether it is time for neonatal units to provide probiotics routinely in the care of preterm infants. This editorial was commissioned in relation to a single centre report of outcomes
Highlights from this issue
The view from here… On the edge of Islamabad, close to the start of the Karakoram highway and the Punjab- Khyber-Pakhtunkhwa border lies a semicircular range of mountains, the Margalla Hills. Densely forested and often engulfed in low cloud, which
Trends in public- and industry-funded uterine cancer clinical trials to disability-adjusted life years from 2007 to 2019
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
Nature Genetics, Published online: 16 June 2022; doi:10.1038/s41588-022-01097-w Genome-wide analyses identify hundreds of loci associated with kidney function. Integrated analyses of expression, methylation and single-cell open chromatin and expression data derived from human kidney samples prioritize genes and mechanisms underlying
[Editorial] Attitudes towards menopause: time for change
In this week’s issue of The Lancet, a Comment by Zoe Schaedel and Janice Ryder highlights many of the misconceptions around, and barriers to, menopause care. Stigma, embarrassment, a lack of public awareness, and miscommunication mean that for many women,
[Editorial] Shifting paradigms
Some messages have to be repeated again and again, especially when they are calling for a meaningful shift in view. As Thomas Kuhn argued in 1962, when problems arise in an explanatory framework or system, they initially pass beneath our
Monkeypox: WHO to rename disease to prevent stigma
World Health Organization officials are working on a new name for the virus and disease commonly known as monkeypox in order to reduce racism and stigma.The UN health body announced on Monday that it…
Temporal trends of aortic stenosis and comorbid chronic kidney disease in the province of Quebec, Canada
Objective To investigate temporal trends of chronic kidney disease (CKD) among patients with incident aortic stenosis (AS) and to compare these trends with that of a matched control population. Methods Using the Quebec Integrated Chronic Disease Surveillance System, we performed
Correction: 402 Lateral-heel release-settings for special ski-bindings
Howell R. 402 Lateral-heel release-settings for special ski-bindings. Br J Sports Med 2021;55:A153. Important data was missing from the table in this abstract. The correct table should be: Torsional-TibiaRelease-Torque(daNm)Test sole Length4 (cm)Skier-WeightLength4(cm)Type-2(daN)MalesTotal abduction Transition-PointFemalesLever-Arm(cm)MalesLateral-Heel force SettingFemalesRelease-(daN)Males3.028.0473549.046.012184.029.8544851.050.520245.031.4676153.554.525
Another win for mimetic peptides in stroke: Disruption of TRPM2-NMDAR signaling
Glutamate excitotoxicity during ischemia triggers an intracellular signaling avalanche leading to cell death, yet blocking NMDA receptors directly in human stroke trials failed. In this issue of Neuron, Zong et al. (2022) disrupt downstream NMDAR-TRPM2 coupling to improve stroke outcomes, supporting
[Editorial] Epilepsy syndromes: an essential piece of the puzzle
Epilepsy syndromes have long been recognised as distinct conditions with typical seizure types, characteristic clusters of clinical and EEG features, and often age-dependent hallmarks, such as age at onset, seizure triggers, diurnal variation, and specific comorbidities. However, no formally accepted
[Editorial] Tackling childhood cancer in sub-Saharan Africa
Sub-Saharan Africa is facing an under-recognised burden of cancer and substantial failures in its oncology care systems. Deficiencies in care are pronounced for children with cancer, partly due to low prioritisation, with foundational issues exacerbated by the COVID-19 pandemic. In
NHS to rollout two new drugs to tackle superbugs
The NHS has negotiated a new arrangement with two pharmaceutical companies to oversee the prescription and supply of two antimicrobial drugs for patients with drug resistant “superbugs.”Under the…
Highlights from this issue
At the end of June, the Triumvirate comes to the end of a 7 year stint as editors in chief of Thorax. We will hand over to a new Triumvirate of Cecilia O’Kane, Mark Griffiths and Jenni Quint. As we
Antibody-mediated neutralization of SARS-CoV-2
Neutralizing antibodies play a critical role to protect from SARS-CoV-2 infection and can be effectively used to prevent and treat COVID-19. In this review, Klein et al. summarize key findings on the development and mechanisms of SARS-CoV-2-neutralizing antibodies and discuss advances
Publisher Correction: UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
Nature Genetics, Published online: 14 June 2022; doi:10.1038/s41588-022-01060-9 Publisher Correction: UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
Maternal RSV Vaccine Could Protect Infants, Interim Analysis Suggests
An investigational protein-based maternal vaccine for respiratory syncytial virus (RSV) elicited neutralizing antibodies among pregnant women, and these antibodies were transferred to their infants before birth, according to a planned interim analysis of an ongoing phase 2b randomized trial reported
A lonely planet: time to tackle loneliness as a public health issue
Meaningful social relationships lie at the core of social wellbeing. Loneliness, defined as the discrepancy between one’s desired and actual social relationships, has been linked to a range of health…
Pollutants: a candidate as a new risk factor for osteoarthritis–results from a systematic literature review
Background Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review (SLR) was performed to summarise existing knowledge on associations between OA and pollutants. Methods PubMed was used to identify studies reporting data on OA and pollutants in
Occupation and COVID-19 mortality in England: a national linked data study of 14.3 million adults
Objectives To estimate occupational differences in COVID-19 mortality and test whether these are confounded by factors such as regional differences, ethnicity and education or due to non-workplace factors, such as deprivation or prepandemic health. Methods Using a cohort study of
Cancer vaccines
Given the renewed interest in vaccine development sparked by the COVID-19 pandemic, we are revisiting the current state of vaccine development for cancer prevention and treatment. Experts discuss different vaccine types, their antigens and modes of action, and where we
Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms
Nature Genetics, Published online: 13 June 2022; doi:10.1038/s41588-022-01075-2 Allelic imbalance analysis applied to ATAC-Seq data from 23 cancer types identifies 7,262 allele-specific accessibility quantitative trait loci, which are enriched for cancer risk heritability and altered transcription factor binding motifs.
[Editorial] Food insecurity in the UK: a public health issue left to fester
In May, the Office for National Statistics announced that UK inflation had reached levels not seen since 1982. The 9% overall rise in consumer prices in the 12 months to April, 2022—the highest in the G7—was driven largely by an
Health experts cry foul as food industry targets India’s ripe market
India’s packaged and processed foods will soon have a health star rating (HSR) displayed on the front of packaging after the scheme was approved by the country’s food safety regulator.The front of…
Impact of COVID-19 on patients awaiting ablation for atrial fibrillation
Objective Atrial fibrillation (AF) ablation services were significantly affected by the COVID-19 pandemic. We aimed to evaluate a symptom-based clinician prioritisation scheme for waiting list management compared with patient-completed quality of life (QoL) scores. We also sought to understand factors
Oncologic emergencies and urgencies: A comprehensive review
Abstract Patients with advanced cancer generate 4 million visits annually to emergency departments (EDs) and other dedicated, high-acuity oncology urgent care centers. Because of both the increasing complexity of systemic treatments overall and the higher rates of active therapy in
Metabolomics profile of 5649 users and non-users of hormonal intrauterine devices in Finland
Use of hormonal intrauterine devices has grown during the last decades. Although the hormonal intrauterine devices act mostly via local effects on uterus, measurable concentrations of levonorgestrel are absorbed into the systemic circulation. The possible metabolic changes and large scale
The missing diversity in human epigenomic studies
Nature Genetics, Published online: 09 June 2022; doi:10.1038/s41588-022-01081-4 Recent work has highlighted a lack of diversity in genomic studies. However, less attention has been given to epigenomics. Here, we show that epigenomic studies are lacking in diversity and propose several
Unpacking race and ethnicity in African genomics research
Nature Reviews Genetics, Published online: 10 June 2022; doi:10.1038/s41576-022-00506-4 In this Comment, the authors highlight caveats about using African ethnicities as population categories in genomics research and emphasize the need for an Africa-oriented humanities research agenda to inform genomics research.
Providing care for those fleeing war: challenges and solutions for Polish doctors looking after refugees from Ukraine
The ongoing armed conflict in Ukraine has caused the biggest migration crisis Europe has faced in the 21st century. Over this period, more than seven million people have fled the country, the largest…
High risk of systemic lupus erythematosus development in patients with ITP: antiphospholipid syndrome is also a concern
Zhu et al in their elegant population-based cohort study investigated the development of systemic lupus erythematosus (SLE) in patients with idiopathic (immune) thrombocytopenic purpura (ITP) and demonstrated the significantly higher risk compared with the control population.1 They rightfully used sensitivity
Heartbeat: sex-based discrepancies in survival from sudden cardiac death
Sudden cardiac death (SCD) is a major cause of death worldwide, with a higher prevalence in men compared with women. To further understand sex differences in SCD presentation and outcomes, Skjelbred and colleagues1 looked at data on deaths in Denmark
A human embryo model cracks symmetry breaking
In this issue of Cell Stem Cell, Simunovic et al. (2022) establish embryoids by combining embryonic and extraembryonic components derived from human pluripotent stem cells. The embryoids resemble human embryos cultured to post-implantation stages in vitro with regard to morphology, symmetry breaking,
Society for Maternal-Fetal Medicine Special Statement: Postpartum visit checklists for normal pregnancy and complicated pregnancy
Rising maternal morbidity and mortality rates, widening healthcare disparities, and increasing focus on cardiometabolic risk modification in at-risk patients have together catalyzed a shift in the postpartum care paradigm. What was once a single office visit in the 6 weeks
Context-specific Polycomb mechanisms in development
Nature Reviews Genetics, Published online: 09 June 2022; doi:10.1038/s41576-022-00499-0 In this Review, Kim and Kingston discuss the compositional and mechanistic diversity of Polycomb repressive complexes (PRCs) and how their context-dependent formation may be required for proper epigenetic regulation in development.
Biting into a union of oncology and metabolism through leukemic stem cells
In this issue of Cell Metabolism, Liu et al. demonstrate that Prmt7 can regulate the onset and progression of leukemogenesis by inhibiting self-renewal capacity of leukemic stem cells (LSCs) as modeled in a murine version of chronic myeloid leukemia (CML).
Getting a grasp on BMIs: Decoding prehension and speech signals
Wandelt et al. (2022) show that different grasps can be decoded from neural activity in the human supramarginal gyrus (SMG), ventral premotor cortex, and somatosensory cortex during motor imagery and speech, highlighting the attractiveness of higher-level areas such as the SMG
Challenges and potential solutions to health disparities in genomic medicine
Significant disparities in the clinical usefulness of genomic information across diverse groups are due to underrepresentation in genetic databases and inequitable access to genetic services. Remedying disparities is immediately needed to ensure that genomic medicine is more equitable but will
[Editorial] Mental health after China’s prolonged lockdowns
On June 1, Shanghai reopened after a 2-month lockdown to curb COVID-19. On June 6, Beijing also eased COVID-19 restrictions by allowing restaurant dining and the gradual reopening of schools from June 13 in most districts. Although many countries instituted
How the US can have guns but fewer gun problems
The US will probably always have lots of guns, so we need to learn to live with them. Currently, we are dying from them. We are also causing many deaths in neighbouring nations, as US guns are…
Effects of exercise-based cardiac rehabilitation delivery modes on exercise capacity and health-related quality of life in heart failure: a systematic review and network meta-analysis
Background This review aimed to compare the relative effectiveness of different exercise-based cardiac rehabilitation (ExCR) delivery modes (centre-based, home-based, hybrid and technology-enabled ExCR) on key heart failure (HF) outcomes: exercise capacity, health-related quality of life (HRQoL), HF-related hospitalisation and HF-related
Reverting to old theories of ageing with new evidence for the role of somatic mutations
Nature Reviews Genetics, Published online: 08 June 2022; doi:10.1038/s41576-022-00513-5 Somatic mutations accumulate with age in the genome of healthy individuals. Franco and Eriksson posit that recent sequencing data indicate a functional role for this increased mutational load in ageing and
A full time job: a year with early-stage breast cancer
Nobody told me that breast cancer is a full time job. In my case—stage 2 invasive ductal carcinoma, a type responsible for 80% of cases—it turned out to be a job that doesn’t care that you have other…
Prognostic impact of follow-up pulmonary vascular resistance in pulmonary arterial hypertension
Objective Pulmonary arterial hypertension (PAH), caused by pulmonary artery remodelling and increased pulmonary vascular resistance (PVR) due to an unknown mechanism, is an intractable disease with a poor prognosis. The recent development of PAH-specific treatment medications may allow for higher
Initiating SGLT2 inhibitor therapy to improve renal outcomes for persons with diabetes eligible for an intensified glucose-lowering regimen: hypothetical intervention using parametric g-formula modeling
Introduction Sodium–glucose cotransporter 2 (SGLT2) inhibitors are now recommended in guidelines for persons with type 2 diabetes mellitus (T2DM) and at risk of advanced kidney disease as part of the glucose-lowering regimen. Research design and methods To explore the optimal
Oncologic emergencies and urgencies: A comprehensive review
Abstract Patients with advanced cancer generate 4 million visits annually to emergency departments (EDs) and other dedicated, high-acuity oncology urgent care centers. Because of both the increasing complexity of systemic treatments overall and the higher rates of active therapy in
Thoughts on a legacy
Nature Reviews Genetics, Published online: 07 June 2022; doi:10.1038/s41576-022-00510-8 In this Editorial, we reflect on the field’s responsibility around the potential uses and abuses of genetics and genomics research.
Abstracts from; The 39th Annual Symposium; of the National Neurotrauma Society,; including the AANS/CNS Joint Section; on Neurotrauma and Critical Care
Journal of Neurotrauma, Volume 39, Issue 11-12, Page A-1-A-128, June 2022.
Correction to Nonauthor Collaborators Supplement
In the Original Investigation titled “Mortality, In-Hospital Morbidity, Care Practices, and 2-Year Outcomes for Extremely Preterm Infants in the US, 2013-2018,” published in the January 18, 2022, issue of JAMA, Supplement 2, which lists the members of the Eunice Kennedy
Death and the bogus contract between doctors and patients
Perhaps medicine is best understood when it confronts death. “That distinguished thing,” as Henry James called it, highlights misunderstandings, confusions, and contradictions.Until the 16th century…
Gut check: can other microbes or communities phenocopy H. pyloris early gastric pathology?
The gastric mucosa is exposed to billions of diverse microorganisms every day. To stymie gastric colonisation as well as to limit passage of potential pathogens to more distal segments of the GI tract, the stomach has several broadly active defence
Highlights from this issue
Serum ammonia use: unnecessary, frequent and costly This is an important topic and an interesting paper to work through. Serum ammonia is important for the diagnosis and management of urea cycle disorders and acute liver failure. Based on the premise
Histone gene editing probes functions of H3K27 modifications in mammals
Nature Genetics, Published online: 06 June 2022; doi:10.1038/s41588-022-01096-x A new study employs CRISPR–Cas9-based base editing for simultaneous mutagenesis of all copies of histone H3 genes in mammals, highlighting the functional importance of H3K27me3 for Polycomb-mediated gene silencing and the dispensability
Prevalence of Children With Medical Complexity and Associated Health Care Needs
This cohort study analyzes data for 1.9 million children to gauge the association of childhood medical complexity with health care service use and in-hospital mortality and assess the algorithms used for predictions.
Every decision about me, without me: the tyranny of the multidisciplinary team meeting in mental healthcare
It’s been 12 years since the UK government set out their vision for patients having greater involvement in their care with the strapline: “No decision about me, without me.”1 The challenges involved…
Oncologic emergencies and urgencies: A comprehensive review
Abstract Patients with advanced cancer generate 4 million visits annually to emergency departments (EDs) and other dedicated, high-acuity oncology urgent care centers. Because of both the increasing complexity of systemic treatments overall and the higher rates of active therapy in
Genomic insights into the recent chromosome reduction of autopolyploid sugarcane Saccharum spontaneum
Nature Genetics, Published online: 02 June 2022; doi:10.1038/s41588-022-01084-1 A high-quality autopolyploid genome of Saccharum spontaneum accession Np-X and resequencing of 102 accessions provide insights into the recent chromosome reduction and polyploidization in Saccharum.
[Editorial] Gun violence in the USA: children’s right to health
An epidemic of preventable violence is killing and harming Americans—especially, children and adolescents. On May 24, an 18-year-old man killed 19 children and two adults in Robb Elementary School in Uvalde, Texas. As the world mourns for the US and
The future of medication abortion in a post-Roe world
Abortion in the United States currently stands at a crossroads. The landmark 1973 Supreme Court decision Roe v Wade will almost certainly be overturned this summer, allowing states to implement…
Effects of diet on the outcomes of rheumatic and musculoskeletal diseases (RMDs): systematic review and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs
Background A EULAR taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). In this paper, the literature on the effect of diet on the progression of RMDs is reviewed. Methods Systematic reviews and meta-analyses
Transcatheter tricuspid valve intervention techniques and procedural steps for the treatment of tricuspid regurgitation: a review of the literature
Severe tricuspid regurgitation (TR) is an undertreated common pathology associated with significant morbidity and mortality. Classically, surgical repair or valve replacement were the only therapeutic options and are associated with up to 10% postprocedural mortality. Transcatheter tricuspid valve interventions are
Improving outcomes demands patient-centred interventions and equitable delivery
Nature Reviews Clinical Oncology, Published online: 01 June 2022; doi:10.1038/s41571-022-00653-x A recent study not only confirms mounting evidence that technology-facilitated symptom monitoring improves care and should be considered for all patients with cancer, but also suggests that patient navigators can
Publisher Correction: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells
Nature Genetics, Published online: 01 June 2022; doi:10.1038/s41588-022-01112-0 Publisher Correction: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells
[Editorial] PEPFAR looks to the future
On May 5, 2022, John Nkengasong was confirmed as US Ambassador-at-Large, Coordinator of the United States Government Activities to Combat HIV/AIDS Globally. The role, which oversees the President’s Emergency Plan for AIDS Relief (PEPFAR), as well as partnerships with the
[Editorial] Tackling tuberculosis: what lies beneath the surface?
World TB Day on March 24, 2022, provided an opportunity to raise awareness of the devastating health, social, and economic impacts of tuberculosis—the world’s second leading infectious killer after COVID-19—and to consider what is needed to strengthen care and control
Resting heart rate and risk of left and right heart failure in 0.5 million Chinese adults
Objectives To compare the shape and strength of the associations of resting heart rate (RHR) with incident heart failure (HF) and pulmonary heart disease (PHD) in Chinese adults. Methods The prospective China Kadoorie Biobank recruited >0.5 million adults from 10
Relationships between self-reflectiveness and clinical symptoms in individuals during pre-morbid and early clinical stages of psychosis
Background Self-reflectiveness, one dimension of cognitive insight, plays a protective role in an individual’s mental state. Both high and low levels of self-reflectiveness have been reported in patients with schizophrenia and individuals at clinical high risk for the illness. Aims
School shootings are preventable, not inevitable
One of the fundamental roles of government is to protect its citizens from undue injury or death; this protection should be even further amplified for those citizens who are most vulnerable,…
New CAPSTONE of SCLC therapy?
Nature Reviews Clinical Oncology, Published online: 31 May 2022; doi:10.1038/s41571-022-00654-w New CAPSTONE of SCLC therapy?
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