Abstract Oral mucositis (OM) is a common, highly symptomatic complication of cancer therapy that affects patients’ function, quality of life, and ability to tolerate treatment. In certain patients with cancer, OM is associated with increased mortality. Research on the management
Abemaciclib crowned in monarchE
Nature Reviews Clinical Oncology, Published online: 29 October 2021; doi:10.1038/s41571-021-00578-x Abemaciclib crowned in monarchE
Sentinel lymph node biopsy for vulvar melanoma: Trends in tumor stage-specific utilization
Rare Skin Reactions after mRNA Vaccination, Similar to Jones–Mote Basophil Responses
To the Editor: In a small group of recipients of messenger RNA (mRNA) vaccines against coronavirus disease 2019 (Covid-19), the occurrence of erythematous and indurated skin reactions has been reported at an average of 8 days after the first or
Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis
As of June 6, 2021, approximately 175 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and 3.8 million deaths from coronavirus disease 2019 (Covid-19) have been reported worldwide. Programs providing unprecedented rapid clinical development of vaccines have been…
Uncomfortable Truths — What Covid-19 Has Revealed about Chronic-Disease Care in America
“Jump off the cliff and figure it out on the way down. People think that improvisation is moving forward,” comedian Keegan-Michael Key has said about improvisational comedy. “What improvisation really is, it’s walking backward.…It’s backing up that gives you discovery.…You
The 2021 Reauthorization of CAPTA — Letting Public Health Lead
The Child Abuse Prevention and Treatment Act (CAPTA), the foundational child-protection legislation in the United States, has been revised more than 20 times since its original passage in 1974. For nearly 30 years, CAPTA didn’t cover infants who had been
Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis
As of June 6, 2021, approximately 175 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and 3.8 million deaths from coronavirus disease 2019 (Covid-19) have been reported worldwide. Programs providing unprecedented rapid clinical development of vaccines have been…
Pediatric Achalasia
Figure 1.
Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis
As of June 6, 2021, approximately 175 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and 3.8 million deaths from coronavirus disease 2019 (Covid-19) have been reported worldwide. Programs providing unprecedented rapid clinical development of vaccines have been…
Alexander Addison
bmj;375/oct29_10/n2604/FAF1faAlexander (known to all as Sandy) Addison was born in Achencoil, Kerala, south India, the son of Lilian and Alexander Addison, a tea plantation manager. Along with his…
FOLFOX–HAIC active in large HCC
Nature Reviews Clinical Oncology, Published online: 28 October 2021; doi:10.1038/s41571-021-00577-y FOLFOX–HAIC active in large HCC
Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis
As of June 6, 2021, approximately 175 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and 3.8 million deaths from coronavirus disease 2019 (Covid-19) have been reported worldwide. Programs providing unprecedented rapid clinical development of vaccines have been…
The 2021 Reauthorization of CAPTA — Letting Public Health Lead
The Child Abuse Prevention and Treatment Act (CAPTA), the foundational child-protection legislation in the United States, has been revised more than 20 times since its original passage in 1974. For nearly 30 years, CAPTA didn’t cover infants who had been
Clinical Translation of Basic Science in Asthma
Basic science has enriched our understanding of the pathophysiology of severe asthma. Clinical translation of these discoveries has resulted in biologic therapies that target key components of asthma-related disease pathways. For example, identification and validation of biomarkers such as elevated…
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
Nature Genetics, Published online: 28 October 2021; doi:10.1038/s41588-021-00945-5 Open Targets Genetics is a community resource that provides systematic fine mapping at human GWAS loci, enabling users to prioritize genes at disease-associated regions and assess their potential as drug targets.
Pediatric Achalasia
Figure 1.
A Therapeutic Relationship
She first came to my resident clinic a few years ago, when it was normal for doctors to touch patients. When I say touch, I really mean palpate the abdomen, press a stethoscope against the chest wall to auscultate the
Disseminated Cryptococcosis
Figure 1.
A Therapeutic Relationship
She first came to my resident clinic a few years ago, when it was normal for doctors to touch patients. When I say touch, I really mean palpate the abdomen, press a stethoscope against the chest wall to auscultate the
The 2021 Reauthorization of CAPTA — Letting Public Health Lead
The Child Abuse Prevention and Treatment Act (CAPTA), the foundational child-protection legislation in the United States, has been revised more than 20 times since its original passage in 1974. For nearly 30 years, CAPTA didn’t cover infants who had been
Emergency drug use in a pandemic: Harsh lessons from COVID-19
The scientific and clinical communities have both experienced several harsh lessons on clinical care management and drug development during the COVID-19 pandemic. Here, we discuss several key lessons learned and describe a framework within which our two communities can work
[Editorial] The climate emergency: a last chance to act?
The annual Lancet Countdown on health and climate change, published today, precedes the global convening of political leaders at the UN Framework Convention on Climate Change 26th Conference of the Parties (COP26) in Glasgow, UK, from Oct 31 to Nov
Case 33-2021: A 68-Year-Old Man with Painful Mouth Ulcers
Presentation of Case. Dr. Ian D. Cooley (Medicine): A 68-year-old man was admitted to this hospital because of painful mouth ulcers and weight loss. The patient had been well until 6 weeks before the current admission, when painful mouth ulcers
NHS gets {pound}5.9bn funding boost in autumn budget to tackle waiting lists in England
The NHS in England will get a £5.9bn (€7bn; $8.1bn) funding boost in the autumn budget to tackle record high waiting lists, the government has announced.1The 2021 budget states that £2.3bn will be…
Prognostic importance of the Controlling Nutritional Status (CONUT) score in patients undergoing cardiac resynchronisation therapy
Aims Malnutrition is common and associated with worse clinical outcomes in patients with heart failure (HF). The Controlling Nutritional Status (CONUT) score is an integrated index for evaluating diverse aspects of the complex mechanism of malnutrition. However, the relationship between
Adjuvant immunotherapy for NSCLC — does treating earlier mean treating better?
Nature Reviews Clinical Oncology, Published online: 27 October 2021; doi:10.1038/s41571-021-00574-1 Efforts are being made to incorporate immune-checkpoint inhibitors into therapy for early stage non-small-cell lung cancer. The IMpower010 trial of adjuvant atezolizumab has recently become the first study to demonstrate
[Editorial] Telehealth and digital equity for older people
October saw welcome attention given to older patients with the 30th UN International Day for Older Persons on Oct 1 and the publication of The Lancet Haematology–The Lancet Healthy Longevity Series on haematological malignancies in older people on Oct 5.
[Editorial] Unmet need for COVID-19 therapies in community settings
There was widespread coverage in the media of Merck and Ridgeback’s interim results of their phase 3 trial of the antiviral molnupiravir. According to a press release from Merck on Oct 1, molnupiravir reduced the risk of hospitalisation or death
Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab
More than 4.8 million persons worldwide have died from coronavirus disease 2019 (Covid-19) during the global pandemic. In the United States alone, an estimated 960,000 to 2.4 million Covid-19–related hospitalizations occurred through the fall of 2020 and, at the peak
Crimes against humanity in Brazil’s covid-19 response—a lesson to us all
After almost six months of investigation, a Brazilian senate inquiry into covid-19 has ended its proceedings by recommending the indictment of federal authorities, government aides, and companies for…
Association of anesthetic and surgical risk factors with outcomes of initial diagnostic biopsies in a current cohort of children with anterior mediastinal masses
Background Diagnostic biopsies of pediatric anterior mediastinal masses (AMMs) are high-risk procedures in which general anesthesia (GA) is traditionally avoided. However, awareness of historically recognized risk factors and corresponding perioperative management have improved over time and may now no longer
Correction: Pregnancy with coarctation appears low risk overall but individual cardiovascular evaluation remains essential
Cordina R, Li W. Pregnancy with coarctation appears low risk overall but individual cardiovascular evaluation remains essential. Heart 2021;107:266–267. doi: 10.1136/heartjnl-2020-318268 This article has been corrected since it was first published. The provenance and peer review statement has been included.
Mature minors and gender dysphoria: a matter for clinicians not courts
Lord Scarman’s judgment about when someone under the age of 16 years should have the right to make their own medical decisions emphasised the decision-making abilities of the particular child. He said: …the parental right to determine whether or not
From Copenhagen to Nyborg 2022: take the Tour de France Route to #WCSPT2022
It is finally time to meet again in person. Danish Society of Sports Physical Therapy (DSSF) is busy organising #Sportskongres2022 in Copenhagen (3 February 2022–5 February 2022) and #WCSPT2022 in Nyborg (26 August 2022–27 August 2022). As the front cover
Unclear Diagnostic Testing Standard
In the US Preventive Services Task Force Recommendation Statement titled “Screening for Prediabetes and Type 2 Diabetes: US Preventive Services Task Force Recommendation Statement,” published in the August 24, 2021, issue of JAMA, a diagnostic testing standard was unclear. In
Low-grade metabolic acidosis as a driver of chronic disease: a 21st century public health crisis
Partha Kar: Making sense of the health multiverse
The world of Marvel movies and comics involves a whole multiverse where it can be hard to make sense of what’s really happening—which Spider-Man exists in which reality, or which main characters are…
MSI-H/dMMR mCRC: ICIs in the first line?
Nature Reviews Clinical Oncology, Published online: 25 October 2021; doi:10.1038/s41571-021-00576-z MSI-H/dMMR mCRC: ICIs in the first line?
A vast potential genome editor toolbox
Nature Reviews Genetics, Published online: 25 October 2021; doi:10.1038/s41576-021-00429-6 Two recent studies demonstrate that putative nucleases encoded by IS200/IS605 family transposons are programmable RNA-guided DNA endonucleases, which could represent a new source of genome-editing enzymes for biotechnological applications.
Covid-19: UK stockpiles two unapproved antiviral drugs for treatment at home
The UK has started stockpiling two antiviral drugs as part of a plan to give people who are staying at home with covid-19 a treatment to reduce symptoms and the spread of the virus.The government has…
Letter to the Editor RE: COVID-19 vaccination during pregnancy: Coverage and Safety
Interpreting COVID-19 Outcomes in Pregnancy Needs Knowledge of Prevalent Conditions in that Time-frame
Point-of-Care Ultrasonography
Point-of-care ultrasonography (POCUS) is defined as the acquisition, interpretation, and immediate clinical integration of ultrasonographic imaging performed by a treating clinician at the patient’s bedside rather than by a radiologist or cardiologist. POCUS is an inclusive term; it is not
Peak Moments — When Kindergarten Is High Risk
Before my son left home on the first day of school, I took his photo — attempting, like generations of parents before me, to hit the “pause” button on life for a few seconds, capturing the start of a new
Peak Moments — When Kindergarten Is High Risk
Before my son left home on the first day of school, I took his photo — attempting, like generations of parents before me, to hit the “pause” button on life for a few seconds, capturing the start of a new
Obesity and Gαs Variants
Mendes de Oliveira and colleagues now report in the Journal that variants in GNAS exons that encode the stimulatory G-protein alpha subunit (Gαs) have a strong genetic association with severe obesity, owing to reduced signaling by the melanocortin 4 receptor
Call for emergency action to limit global temperature increases, restore biodiversity and protect health
Wealthy nations must do much more, much faster. The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis. They will meet again at the
Ambulances queue outside A&Es as 999 calls pile up
Ambulance services in England are struggling to cope with huge numbers of calls, as crowded hospitals are unable to take patients and queues of ambulances waiting outside emergency departments have…
Call for emergency action to limit global temperature increases, restore biodiversity and protect health
Wealthy nations must do much more, much faster. The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis. They will meet again at the
Case 32-2021: A 14-Year-Old Girl with Swelling of the Jaw and Hypercalcemia
Presentation of Case. Dr. Austin Be (Surgery): A 14-year-old girl was admitted to this hospital because of swelling of the left jaw. The patient had been well until 6 weeks before this admission, when she noticed a lump in the
Pelvic organ prolapse following hysterectomy on benign indication: a nationwide, nulliparous cohort study
Hysterectomy is commonly performed and may increase the risk of pelvic organ prolapse (POP). Previous studies in parous women have shown an increased risk of POP surgery after hysterectomy. Parity is a strong risk factor for POP and may confuse
Peak Moments — When Kindergarten Is High Risk
Before my son left home on the first day of school, I took his photo — attempting, like generations of parents before me, to hit the “pause” button on life for a few seconds, capturing the start of a new
Esophageal cancer mutational signatures around the world
Nature Genetics, Published online: 21 October 2021; doi:10.1038/s41588-021-00958-0 Mutational signatures can shed light onto mechanisms of carcinogenesis and reveal the mutagenic impact of novel and established environmental risk factors. A new study examines the mutational spectra of esophageal squamous cell
Optogenetics — The Might of Light
Using light to control neuronal activity has been the dream of neuroscientists for decades. Because light does not interfere with normal brain function and can be targeted with exquisite spatial and temporal precision, it has long held the promise of
Disentangling host–microbiota complexity through hologenomics
Nature Reviews Genetics, Published online: 21 October 2021; doi:10.1038/s41576-021-00421-0 Hologenomic studies aim to further our understanding of host–microbiota interactions through the integrated analysis of host genomes and microbiota metagenomes. Here, Alberdi and colleagues discuss key considerations for designing optimal hologenomic
Point-of-Care Ultrasonography
Point-of-care ultrasonography (POCUS) is defined as the acquisition, interpretation, and immediate clinical integration of ultrasonographic imaging performed by a treating clinician at the patient’s bedside rather than by a radiologist or cardiologist. POCUS is an inclusive term; it is not
Obesity and Gαs Variants
Mendes de Oliveira and colleagues now report in the Journal that variants in GNAS exons that encode the stimulatory G-protein alpha subunit (Gαs) have a strong genetic association with severe obesity, owing to reduced signaling by the melanocortin 4 receptor
Nonalcoholic Steatohepatitis — Opportunities and Challenges
Nonalcoholic steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease, has superseded hepatitis C as the main cause of cirrhosis and the main reason for liver transplantation. Contrary to hepatitis C, a liver-specific disorder caused by a single etiologic
Optogenetics — The Might of Light
Using light to control neuronal activity has been the dream of neuroscientists for decades. Because light does not interfere with normal brain function and can be targeted with exquisite spatial and temporal precision, it has long held the promise of
Case 32-2021: A 14-Year-Old Girl with Swelling of the Jaw and Hypercalcemia
Presentation of Case. Dr. Austin Be (Surgery): A 14-year-old girl was admitted to this hospital because of swelling of the left jaw. The patient had been well until 6 weeks before this admission, when she noticed a lump in the
[Editorial] Abortion bans in the USA harm health equity
On Sept 1, the state of Texas enacted Senate Bill 8S (SB8S), banning all abortions once a fetal heartbeat is detected—at as early as 6 weeks of gestation and before most women know they are pregnant—effectively making abortion illegal in
Emphysematous Hepatitis
Figure 1.
[Editorial] A design for life
If the 1990s were the decade of Peter Kramer’s Listening to Prozac, the 2020s are shaping up to be the decade of Kate Pickett and Richard Wilkinson’s The Inner Level. The popularity of both books beyond the usual academic and
Covid-19: Vaccines are highly effective in preventing deaths from delta variant, study indicates
The first countrywide study of deaths caused by the delta variant of covid-19 has found that vaccination is 90% effective in preventing people from dying.The research was carried out in Scotland and…
Mortality and ventricular arrhythmia after acute myocarditis: a nationwide registry-based follow-up study
Objective Incidence and severity of acute myocarditis vary significantly in previous reports and there is a lack of epidemiological studies on the short-term risks of mortality, heart failure and ventricular arrhythmias in patients with acute myocarditis. Therefore, study aims were
Highlights from this issue
Long-term outcome of transcanalicular microdrill dacryoplasty—a minimally invasive alternative to dacryocystorhinostomy (see page 1480) In contrast to dacryocystorhinostomy, transcanalicular microdrill dacryoplasty is an anatomy preserving, microendoscopic lacrimal duct surgery technique, which is suitable for management of nasolacrimal duct obstruction in
Call for emergency action to limit global temperature increases, restore biodiversity and protect health
Wealthy nations must do much more, much faster. The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis. They will meet again at the
Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage
To the Editor: Pregnant women with coronavirus disease 2019 (Covid-19) are at increased risk for adverse outcomes, and Covid-19 vaccination is recommended during pregnancy. However, safety data on Covid-19 vaccination during pregnancy remain limited. We performed a case–control study with
Publisher Correction: Epigenomic contributions to tumor cell heterogeneity and plasticity
Nature Genetics, Published online: 20 October 2021; doi:10.1038/s41588-021-00966-0 Publisher Correction: Epigenomic contributions to tumor cell heterogeneity and plasticity
Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19
To the Editor: Ivermectin is approved by the Food and Drug Administration as an oral treatment for intestinal strongyloidiasis and onchocerciasis and as a topical treatment for pediculosis and rosacea. It is also used as a treatment for parasites in
Closing the Gender Pay Gap in Medicine
The Association of American Medical Colleges (AAMC) has issued a new assessment of salary disparities among U.S. physicians according to gender, race, and their intersection that reaffirms a persistent gender pay gap. Building on decades of research demonstrating that female
Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19
To the Editor: Ivermectin is approved by the Food and Drug Administration as an oral treatment for intestinal strongyloidiasis and onchocerciasis and as a topical treatment for pediculosis and rosacea. It is also used as a treatment for parasites in
[Editorial] Embracing a positive view of mental health
For far too long, mental health has been seen, mistakenly, as synonymous with mental ill health. UNICEF’s report The State of the World’s Children 2021, launched on Oct 5 at the third Ministerial Mental Health Summit, builds on the growing
Shubha Tole
Shubha Tole, Dean of Graduate Studies at the Tata Institute of Fundamental Research in Mumbai, India, shares with Neuron her approach to mentorship during these challenging times, how connecting diverse perspectives across the globe makes us stronger, and her love
[Editorial] Migraine matters
Migraine and other headache disorders are among the most prevalent diseases and one of the main causes of disability worldwide, ranking second among all causes of disease, after low back pain, in terms of years of life lived with disability.
Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19
To the Editor: Ivermectin is approved by the Food and Drug Administration as an oral treatment for intestinal strongyloidiasis and onchocerciasis and as a topical treatment for pediculosis and rosacea. It is also used as a treatment for parasites in
Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19
To the Editor: Ivermectin is approved by the Food and Drug Administration as an oral treatment for intestinal strongyloidiasis and onchocerciasis and as a topical treatment for pediculosis and rosacea. It is also used as a treatment for parasites in
Health inequalities and the elective backlog—understanding the problem and how to resolve it
Even before covid-19 the NHS was struggling to manage rising demand, as waiting lists continued to grow and people faced long waits for vital treatment. The pandemic has exacerbated the issue and…
PRospective Evaluation of natriuretic peptide-based reFERral of patients with chronic heart failure in primary care (PREFER): a real-world study
Objective To assess current management practice of heart failure with reduced ejection fraction (HFrEF) in multinational primary care (PC) and determine whether N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP)-guided referral of HFrEF patients from PC to a cardiologist could improve care, defined as
Correction: NeoBeat offers rapid newborn heart rate assessment
Bush JB, Cooley V, Perlman J, et al. NeoBeat offers rapid newborn heart rate assessment. Arch Dis Child Fetal Neonatal Ed 2021;106:550–2. doi: 10.1136/archdischild-2020-320901. This article has been corrected since it first published. The provenance and peer review statement has
Highlights from this issue
20/20 vision There’s no doubt that trust is ‘won’ immediately in some circumstances and in young children is the default position. Usually, though, it has to be earned: and even when deserved it isn’t always granted. I wonder whether this
Selective Reduction in Complicated Monochorionic Pregnancies: A Systematic Review and Meta-analysis of Different Techniques
This systematic review and meta-analysis aims to compare the perinatal outcomes of complicated monochorionic (MC) pregnancies after selective reduction by radiofrequency ablation (RFA), bipolar cord coagulation (BCC) and interstitial laser (IL).
[Editorial] The digital frontier: bringing one generation to the next
Oct 1 marked the UN International Day of Older Persons, which this year focused on Digital Equity for All Ages. The aim—to amplify the need for meaningful participation in the digital world by older persons—is more relevant and important now
Retinal Artery Thrombosis and Aortic Valve Vegetations
A 42-year-old woman had 30 days of blurry vision in the right eye. Dilated-fundus examination and fluorescein angiography showed retinal artery thrombosis; echocardiography showed pedunculated and mobile aortic valve vegetations, and results of testing for antinuclear antibodies were positive at
Call for emergency action to limit global temperature increases, restore biodiversity and protect health
Wealthy nations must do much more, much faster. The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis. They will meet again at the
Covid-19: Government faces legal challenge over “failure to protect care home residents”
Two women who lost their fathers to covid-19 are legally challenging what they describe as the government’s failure to protect care home residents during the pandemic.Cathy Gardner and Fay Harris…
A pragmatic approach to risk assessment in pulmonary arterial hypertension using the 2015 European Society of Cardiology/European Respiratory Society guidelines
Objective To optimise treatment of patients with pulmonary arterial hypertension (PAH), the 2015 European Society of Cardiology/European Respiratory Society guidelines recommend using risk stratification, with the aim of patients achieving low-risk status. Previous analyses of registries made progress in using
From ENA 2021
Nature Reviews Clinical Oncology, Published online: 18 October 2021; doi:10.1038/s41571-021-00575-0 From ENA 2021
Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia
Nature Genetics, Published online: 18 October 2021; doi:10.1038/s41588-021-00941-9 Automated and single-cell CUT&Tag is used to characterize the effects of KMT2A fusion proteins on chromatin in human primary leukemia samples, identifying oncogenic networks and fusion-specific therapeutic vulnerabilities.
Statins to prevent or treat preeclampsia: sometimes it is too late.
The Great Chlamydia Control Bake Off: the same ingredients (evidence) but different recipes for success
Successful baking requires careful measurement, the precise mixing of ingredients and an attentive eye while the mixture is in the oven. However, the environment may have an impact on the final product. Humidity, quality of ingredients, type of oven used
Covid-19: Valneva’s vaccine produces stronger immune response than AstraZeneca’s, company reports
Valneva’s covid-19 vaccine produces significantly higher concentrations of neutralising antibodies than the Oxford-AstraZeneca vaccine does, preliminary trial results show.The phase III trial…
Correction: Impact of pregnancy and risk factors for ventricular arrhythmias in women with tetralogy of Fallot
What is the most important thing in the world?
He tangata, he tangata, he tangata It is the people, it is the people, it is the people Welcome to the Australasian College of Sport and Exercise Physicians (ACSEP) edition of BJSM. He tangata—it is the people in our lives
Trends in Cardiovascular Disease Related Maternal Mortality in the United States, 1999-2018
A Good Death?
“I’ve lived with this for 10 years. I’m hoping for another 2, to make it to my 85th birthday so I can have a big party.” My patient’s voice was weak, but his goals were clear. He had been transferred
Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion
To the Editor: Pregnant persons are at risk for severe coronavirus disease 2019 (Covid-19), and infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during pregnancy is associated with increased risks of preterm birth and other adverse maternal and neonatal
MeDiGes study: a brief sub-analysis on women diagnosed with GDM since the 24th gestational week.
A Good Death?
“I’ve lived with this for 10 years. I’m hoping for another 2, to make it to my 85th birthday so I can have a big party.” My patient’s voice was weak, but his goals were clear. He had been transferred
A Good Death?
“I’ve lived with this for 10 years. I’m hoping for another 2, to make it to my 85th birthday so I can have a big party.” My patient’s voice was weak, but his goals were clear. He had been transferred
Aspergillus Infections
Aspergillus conidia (spores) are ubiquitous in the environment and thus unavoidable. In soil and on other vegetative or moist material, aspergillus species exist as saprobes, digesting dead or dying organic material. This highly competitive environment requires aspergillus species to survive
Camilla Bosanquet
bmj;375/oct15_10/n2505/FAF1faCamilla Bosanquet, who has died at the age of 100, was a prominent Jungian psychoanalyst who was at one time chair of the Society of Analytical Psychology and was…
A Prospective Analysis of the Relationship Between Sexual Acceptability and Contraceptive Satisfaction Over Time
Contraceptives are used to prevent unwanted pregnancies and treat certain gynecological conditions, but many women report non-use or inconsistent use due to method dissatisfaction. The sexual acceptability of contraception—how birth control methods affect users’ sexual wellbeing—is likely an important component
The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation
Nature Genetics, Published online: 14 October 2021; doi:10.1038/s41588-021-00947-3 A deep-learning framework interprets multiomic data across epidermal differentiation, identifying cooperative DNA sequence rules that regulate gene modules. Massively parallel reporter assay analysis validates temporal dynamics and cis-regulatory logic.
Publisher Correction: The relationship between genome structure and function
Nature Reviews Genetics, Published online: 14 October 2021; doi:10.1038/s41576-021-00425-w Publisher Correction: The relationship between genome structure and function
Empagliflozin in Heart Failure with a Preserved Ejection Fraction
Patients with heart failure present with either a reduced or a preserved ejection fraction. Whereas heart failure with a reduced ejection fraction can be treated with drugs that act to attenuate the overactivation of endogenous neurohormonal systems, therapeutic options for
Data in Crisis — Rethinking Disaster Preparedness in the United States
In 2017, Hurricane Maria’s devastating impact in Puerto Rico exposed significant flaws in the U.S. medical and public health response to natural disasters. The majority of the nearly 3000 excess deaths caused by the hurricane were attributable not to its
Skeletal Fluorosis
Figure 1.
Data in Crisis — Rethinking Disaster Preparedness in the United States
In 2017, Hurricane Maria’s devastating impact in Puerto Rico exposed significant flaws in the U.S. medical and public health response to natural disasters. The majority of the nearly 3000 excess deaths caused by the hurricane were attributable not to its
Empagliflozin and Major Renal Outcomes in Heart Failure
To the Editor: Sodium–glucose cotransporter 2 inhibitors reduce the risk of serious adverse renal outcomes in type 2 diabetes, but the renal effects of these drugs in patients with heart failure remain uncertain. Although empagliflozin and dapagliflozin have been reported
Covid-19 Breakthrough Infections in Vaccinated Health Care Workers
Since its rollout in late 2020 in Israel, the BNT162b2 messenger RNA vaccine (Pfizer–BioNTech) has been highly effective in preventing clinically significant coronavirus disease 2019 (Covid-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The vaccine has also been
The surprise element: A hallmark of creativity in scientists, artists, and comedians
Truly creative works of science and art produce unexpected and surprising results—just like the punch line of a good joke that generates an unfamiliar twist on a familiar idea. Surprise stimulates curiosity, which triggers a search to reveal the mystery
[Editorial] Malaria vaccine approval: a step change for global health
On Oct 6, WHO announced that it will be recommending widespread use of the RTS,S/AS01 (RTS,S) malaria vaccine for children in sub-Saharan Africa and in other regions with moderate-to-high Plasmodium falciparum transmission. Malaria has ravaged people’s lives for centuries; today
Oxytocin for Autism Spectrum Disorder — Down, but Not Out
Autism spectrum disorder, a common neurodevelopmental disorder with onset in infancy, is characterized by deficits in social functioning and by repetitive–restrictive behaviors, such as repeated body movements, circumscribed interests, or resistance to change in routines. Pharmacologic…
Oxytocin for Autism Spectrum Disorder — Down, but Not Out
Autism spectrum disorder, a common neurodevelopmental disorder with onset in infancy, is characterized by deficits in social functioning and by repetitive–restrictive behaviors, such as repeated body movements, circumscribed interests, or resistance to change in routines. Pharmacologic…
Absorb BRS for in-stent restenosis: the final bow before (scaffold) collapse?
Highlights from this issue
“Remember, remember the 5th of November: gunpowder, treason and plot!” As this issue of Thorax drops on your doormat, UK readers are preparing for Guy Fawkes night, when we remember a foiled attempt to blow up parliament and we burn
Call for emergency action to limit global temperature increases, restore biodiversity and protect health
Wealthy nations must do much more, much faster. The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis. They will meet again at the
Managing conflict in a team: awareness and education may help
As we leave our staycations behind and look forward to winter in the NHS, this article is a timely reminder of the need to manage conflict in our teams.1Anecdotally, my colleagues in occupational…
Feasibility and Acceptability of a Toolkit-Based Process to Implement Patient-Centered, Immediate Postpartum Long-Acting Reversible Contraception Services
National guidelines recommend that maternity systems provide patient-centered access to immediate postpartum long-acting reversible contraception (i.e., insertion of an intrauterine device or implant during the delivery hospitalization). Hospitals face significant barriers to offering these services, and efforts to improve peripartum
Decarbonizing the U.S. Health Sector — A Call to Action
Nowhere are the effects of climate change manifesting more clearly than in human health. Although many people consider climate change a looming threat, health problems stemming from it already kill millions of people per year. It is well established that
Picturing a Path Forward for Development of New Therapeutics for Traumatic Central Nervous System Injury Using Visual System Biomarkers
Journal of Neurotrauma, Volume 38, Issue 20, Page 2777-2777, October 15, 2021.
Nationwide prevalence and characteristics of transthyretin amyloid cardiomyopathy in Sweden
Objective Transthyretin amyloid cardiomyopathy (ATTR-CM) is a rare, progressive and fatal condition caused by deposition of transthyretin amyloid fibrils in the heart. This study aims to identify all patients diagnosed with ATTR-CM in Sweden, estimate the prevalence of ATTR-CM, describe
John Studd: a towering figure in gynaecology
bmj;375/oct13_13/n2499/FAF1faPhoto credit: Mark Large/Daily Mail/ShutterstockOne of the most forthright doctors of his age, John Studd fired controversy in both the medical and the political arenas….
The cerebellum in ALS: friend or foe?
A new MRI study suggests that cerebellar degeneration may contribute to motor and non-motor symptoms in amyotrophic lateral sclerosis Bede et al present an intriguing study of cerebellar degeneration in amyotrophic lateral sclerosis (ALS).1 The authors revisit a contentious facet
Tumour burden and efficacy of immune-checkpoint inhibitors
Nature Reviews Clinical Oncology, Published online: 12 October 2021; doi:10.1038/s41571-021-00564-3 A high tumour burden has long been associated with inferior outcomes on traditional cancer therapies and emerging evidence suggests that tumour burden is particularly relevant for patients receiving immune-checkpoint inhibitors.
Abortion regulation in Europe in the era of COVID-19: a spectrum of policy responses
Background Unprecedented public health actions restricting movement and non-COVID related health services are likely to have affected abortion care during the pandemic in Europe. In the absence of a common approach to ensure access to this essential health service, we
Navigating COVID-19: Starting a lab during the pandemic
For new principal investigators, the first years are key to getting a laboratory off the ground and running. COVID-19 has changed the world, bringing on unforeseen difficulties and challenges at every level. We asked these investigators to share their experiences
India’s New COVID-19 DNA Vaccine Is a First
In August, the government of India granted Emergency Use Authorization to a COVID-19 DNA vaccine. Pharmaceutical firm Zydus Cadila, in partnership with India’s Department of Biotechnology, developed the 3-dose intradermal vaccine, called ZyCov-D, which is authorized there for use in
Protecting the world from future pandemics: 3/11 is another day to remember
11 September 2001 is a day that will remain in our memory. On that 9/11, the terrorist attack against the US was a turning point in security policy, the way we travel, and the way we conduct…
Transcatheter aortic valve replacement using the iSleeve expandable sheath in small femoral arteries
Background Small femoral arteries have been associated with a higher risk of vascular complications in transfemoral transcatheter aortic valve replacement (TAVR). We investigated the feasibility and safety of TAVR in patients with small femoral arteries. Methods In this observational study,
Comment on ‘Sustained discontinuation of infliximab with a raising-dose strategy after obtaining remission in patients with rheumatoid arthritis: the RRRR study, a randomised controlled trial by Tanaka et al
We have read with interest the paper of Tanaka et al1 and support the need for a more personalised approach in dosing regimens of tumour necrosis factor (TNF) inhibitors.2 They adjusted infliximab dose based on TNF concentrations at baseline, under
B cells and cancer
Tumor-infiltrating B cells complement T cell-mediated antitumor immunity. A panel of experts share their views on the complexity of B cells within the tumor microenvironment, the variety of mechanisms by which these cells control tumor growth, their organization in tertiary lymphoid
Society for Maternal-Fetal Medicine Special Statement: A Quality Metric for Evaluating Timely Treatment of Severe Hypertension
Severe hypertension in pregnancy is a medical emergency. Although expeditious treatment within 30 to 60 minutes is recommended to reduce the risk of maternal death or severe morbidity, treatment is often delayed by more than 1 hour. In this statement,
Renal plasticity revealed through reversal of polycystic kidney disease in mice
Nature Genetics, Published online: 11 October 2021; doi:10.1038/s41588-021-00946-4 Re-expression of Pkd genes in cystic kidneys results in rapid reversal of autosomal dominant polycystic kidney disease phenotypes in mice, revealing an unexpected capacity for renal plasticity under the control of Pkd
Interleukin 6 trans-signalling and the risk of future cardiovascular events in men and women
Objective Pro-inflammatory interleukin 6 (IL6) trans-signalling is associated with increased risk of cardiovascular events (CVEs). Whether this association exists for both sexes is, however, uncertain. Hence, we analysed the risk of CVE associated with IL6 trans-signalling in men and women
Covid-19: Antibody levels fall after second Pfizer dose, but protection against severe disease remains, studies indicate
Six months after the second dose of the Pfizer-BioNTech covid-19 vaccine, antibody concentrations in healthcare workers had decreased substantially, especially among older men and immunosuppressed…
Heartbeat: sex-related inequities versus differences in management and outcomes of patients with cardiovascular disease
Sex differences in clinical management and outcomes of patients with cardiovascular disease sometimes are due to healthcare inequities (which should be eliminated) but also might be due to sex-related differences in aetiology and pathophysiology. For example, the optimal medical dose
Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults
Nearly all patients with hip fracture undergo surgery, most commonly with spinal anesthesia or general anesthesia. Observational studies have suggested that spinal anesthesia may be associated with lower risks of death, delirium, and major medical complications and with shorter lengths
Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults
Nearly all patients with hip fracture undergo surgery, most commonly with spinal anesthesia or general anesthesia. Observational studies have suggested that spinal anesthesia may be associated with lower risks of death, delirium, and major medical complications and with shorter lengths
Tebentafusp for uveal melanoma
Nature Reviews Clinical Oncology, Published online: 08 October 2021; doi:10.1038/s41571-021-00572-3 Tebentafusp for uveal melanoma
A new index for obstetrics safety and quality of care: integrating cesarean delivery rates with maternal and neonatal outcomes
Cesarean rates have been used as obstetrical quality indicators. However, these approaches do not take into consideration the accompanying maternal and neonatal morbidity. A challenge in the field of obstetrics has been to establish a valid outcomes quality measure that
Autoimmune Hemolytic Anemias
Autoimmune hemolytic anemia (AIHA) is defined as increased destruction of red cells through autoimmune mechanisms, usually mediated by autoantibodies against erythrocyte surface antigens. During the past decade, important new findings have emerged regarding the cause, pathogenesis, diagnosis, and…
Intracardiac Cement Embolism
Figure 1.
Drainage for Infected Pancreatic Necrosis — Is the Waiting the Hardest Part?
Acute necrotizing pancreatitis, which occurs in up to 30% of episodes of acute pancreatitis, can be a devastating, life-threatening disease. For many years, acute necrotizing pancreatitis (the cause of clinically severe pancreatitis) was managed with open surgical necrosectomy. Surgeons eventually…
Covid-19: Private hospitals “fell well short” in delivering care during the pandemic, says report
MPs are being urged to examine how UK private hospitals secured potentially billions of pounds to help the NHS during the pandemic but treated very few covid patients and delivered fewer NHS funded…
Discordant moderate aortic stenosis: is it clinically important?
The eyeball’s connected to the brain ball
How does the human eye develop in concert with the brain to create a functioning visual system? In this issue of Cell Stem Cell, Gabriel et al. (2021) report the development of eye-like structures from forebrain organoids with light sensitivity, signal
Autoimmune Hemolytic Anemias
Autoimmune hemolytic anemia (AIHA) is defined as increased destruction of red cells through autoimmune mechanisms, usually mediated by autoantibodies against erythrocyte surface antigens. During the past decade, important new findings have emerged regarding the cause, pathogenesis, diagnosis, and…
Cesarean Delivery on Maternal Request in the United States from 1999 to 2015
The rate of cesarean delivery has increased in the United States over the last several decades. The rate of cesarean delivery on maternal request (CDMR) however remains uncertain and recent data on CDMR are lacking.
In Gratitude for mRNA Vaccines
Making vaccines has often been described as a thankless task. In the words of Dr. Bill Foege, one of the world’s greatest public health physicians, “Nobody ever thanks you for saving them from the disease they didn’t know they were
Striving for Diversity in Research Studies
Physicians often find it challenging to apply the lessons of large research studies to their clinical practice, especially when the research participants do not reflect the racial identity, ethnicity, age, or sex and gender of the physicians’ patients. Strict eligibility
Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors
The coronavirus disease 2019 (Covid-19) pandemic that started in December 2019 is caused by SARS-CoV-2. SARS-CoV-2 shares an overall genome sequence identity of approximately 80% with SARS-CoV (referred to here as SARS-CoV-1 to avoid confusion). SARS-CoV-1 was responsible for the
Pearly Penile Papules
Figure 1.
Increased risk for COVID‐19 breakthrough infection in fully vaccinated patients with substance use disorders in the United States between December 2020 and August 2021
Individuals with substance use disorders (SUDs) are at increased risk for COVID-19 infection and for adverse outcomes of the infection. Though vaccines are highly effective against COVID-19, their effectiveness in individuals with SUDs might be curtailed by compromised immune status
[Editorial] Sexual abuse and exploitation at WHO: an erosion of trust
The final report of an Independent Commission investigating accusations of sexual exploitation and abuse arising from WHO’s response to the tenth Ebola outbreak in the Democratic Republic of the Congo (DRC) was issued on Sept 28. The report describes dozens
Myocarditis after Covid-19 Vaccination in a Large Health Care Organization
In Israel, a nationwide campaign to administer the BNT162b2 messenger RNA (mRNA) vaccine (Pfizer–BioNTech) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started on December 20, 2020. By May 5, 2021, a total of 58.2% of the Israeli population had
A world on the edge of climate disaster
The world is heating up and so is the urgency for action. Without radical change in the way we live, move, eat, work, and play, rising global temperatures will result in irreversible planetary…
Correction: Risk factors for SARS-CoV-2 infection and course of COVID-19 disease in patients with IBD in the Veterans Affair Healthcare System
Khan N, Mahmud, N, Trivedi C, et al. Risk factors for SARS-CoV-2 infection and course of COVID-19 disease in patients with IBD in the Veterans Affair Healthcare System. Gut 2021;70:1657–64. doi: 10.1136/gutjnl-2021-324356 The title should read: Risk factors for SARS-CoV-2
Highlights from this issue
National census of UK endoscopy services in 2019 This is an important paper reflecting endoscopy practice in the UK in the year prior to the pandemic and will be an invaluable resource in the (ongoing) planning of how best to
Pembrolizumab tunes up chemotherapy in cervical cancer
Nature Reviews Clinical Oncology, Published online: 06 October 2021; doi:10.1038/s41571-021-00570-5 Pembrolizumab tunes up chemotherapy in cervical cancer
Decidualized ovarian endometrioma
Obesity and Gαs Variants
Mendes de Oliveira and colleagues now report in the Journal that variants in GNAS exons that encode the stimulatory G-protein alpha subunit (Gαs) have a strong genetic association with severe obesity, owing to reduced signaling by the melanocortin 4 receptor
Myocarditis after Covid-19 Vaccination in a Large Health Care Organization
In Israel, a nationwide campaign to administer the BNT162b2 messenger RNA (mRNA) vaccine (Pfizer–BioNTech) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started on December 20, 2020. By May 5, 2021, a total of 58.2% of the Israeli population had
Myocarditis after Covid-19 Vaccination in a Large Health Care Organization
In Israel, a nationwide campaign to administer the BNT162b2 messenger RNA (mRNA) vaccine (Pfizer–BioNTech) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started on December 20, 2020. By May 5, 2021, a total of 58.2% of the Israeli population had
[Editorial] Crunching the numbers for viral hepatitis
According to a recent report from the Clinton Health Access Initiative (CHAI), 9·4 million people were treated for hepatitis C virus (HCV) infection in 2019, a substantial increase from the 1 million treated in 2016. Notably, in that same 3-year
Obesity and Gαs Variants
Mendes de Oliveira and colleagues now report in the Journal that variants in GNAS exons that encode the stimulatory G-protein alpha subunit (Gαs) have a strong genetic association with severe obesity, owing to reduced signaling by the melanocortin 4 receptor
Myocarditis after Covid-19 Vaccination in a Large Health Care Organization
In Israel, a nationwide campaign to administer the BNT162b2 messenger RNA (mRNA) vaccine (Pfizer–BioNTech) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started on December 20, 2020. By May 5, 2021, a total of 58.2% of the Israeli population had
Welcome all
Neuron traditionally publishes a themed collection of reviews to coincide with the Society for Neuroscience’s (SfN) annual meeting. When we were brainstorming potential topics in the spring of 2021, with COVID-19 vaccinations rolling out in many parts of the world
Obesity and Gαs Variants
Mendes de Oliveira and colleagues now report in the Journal that variants in GNAS exons that encode the stimulatory G-protein alpha subunit (Gαs) have a strong genetic association with severe obesity, owing to reduced signaling by the melanocortin 4 receptor
Exploring the intensity, barriers and correlates of physical activity In Iranian pregnant women: a cross-sectional study
Objectives To determine the intensity, barriers and correlates of physical activity (PA) in Iranian pregnant women. Methods This cross-sectional study was carried out with 300 eligible pregnant women referred to the Ilam health centres and bases using stratified random sampling
Critical care management of chimeric antigen receptor T‐cell therapy recipients
Abstract Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapeutic treatment concept that is changing the treatment approach to hematologic malignancies. The development of CAR T-cell therapy represents a prime example for the successful bench-to-bedside translation of advances in
Consider prioritising homeless people on waiting lists to improve their health, says NICE
Health and social care services need to work harder to improve the health of homeless people by considering prioritising them on waiting lists, offering them vouchers to engage with services, and not…
T-DXd effective in HER2-mutant NSCLC
Nature Reviews Clinical Oncology, Published online: 05 October 2021; doi:10.1038/s41571-021-00569-y T-DXd effective in HER2-mutant NSCLC
BRD4 orchestrates genome folding to promote neural crest differentiation
Nature Genetics, Published online: 05 October 2021; doi:10.1038/s41588-021-00934-8 Depletion of BRD4 reduces the chromatin occupancy of NIPBL, resulting in aberrant genome folding. Loss of BRD4 impedes neural crest differentiation, which can be rescued by depletion of WAPL.
Foreseeing the principles of genome architecture
Nature Reviews Genetics, Published online: 05 October 2021; doi:10.1038/s41576-021-00423-y Tom Misteli highlights a 2006 study by Shopland et al., which used relatively simple methods to visualize characteristics of chromosome organization. Their conclusions foreshadowed key concepts in the field: topologically associating
Metabolism and China
As reflected in the term “Western diet,” obesity and its related chronic metabolic diseases such as type 2 diabetes are health problems that historically have spared China. But with changes in lifestyles as well as food availability and preferences, the
Japanese Medical Mnemonics—Language, Reflection, and Art
This Arts and Medicine feature explains how Japanese language medical mnemonics are constructed and features a 16-panel mixed-media art installation featuring elements of mnemonics for vaccines, relative bradycardia, and subclavian artery anatomy.
US hospitals tighten security as violence against staff surges during pandemic
Hospitals officials in the United States say that their doctors and nurses are seeing more assaults and threats than ever before as the covid pandemic generates new friction points between patients,…
Speckle tracking strain and ECG heterogeneity correlate in transcatheter aortic valve replacement-induced left bundle branch blocks and right ventricular paced rhythms
Objective Transcatheter aortic valve replacement (TAVR) complications include left bundle branch block (LBBB) and right ventricular paced rhythm (RVP). We hypothesised that changes in electrocardiographic heterogeneity would correlate better with speckle tracking strain measures than with left ventricular ejection fraction
Broad Spectrum Antibiotics in Pregnancy: Role if Inflammation in Neonatal Outcomes
Epigenomic contributions to tumor cell heterogeneity and plasticity
Nature Genetics, Published online: 04 October 2021; doi:10.1038/s41588-021-00932-w Heterogeneity in brain tumors has been viewed through many lenses—from microscopes and experimental models to ‘omic’ analysis at the tissue and single-cell levels. Two studies now characterize patterns of DNA methylation and
Interplay between chromatin marks in development and disease
Nature Reviews Genetics, Published online: 04 October 2021; doi:10.1038/s41576-021-00416-x In this Review, Janssen and Lorincz discuss the intricate and multilayered interplay between chromatin marks. Focusing on histone methylation and DNA methylation during mammalian development, they discuss the implications for gene
Detection of Clostridioides difficile in Asymptomatic Children
This systematic review and meta-analysis assesses the prevalence of Clostridioides difficile detection among asymptomatic children.
Complaints about politicians’ use of statistics rise sharply
Statistics experts have questioned politicians’ and civil servants’ use of data dozens of times over the past year as complaints about how statistics are used have almost tripled in 12 months.The UK…
Health-related physical fitness in patients with complaints of hand, wrist, forearm and elbow: an exploratory study
Objectives Little is known about the physical fitness of patients with complaints of hand, wrist, forearm and/or elbow and its possible determinants. Aims were to assess health-related physical fitness (HRPF) in these patients, to compare HRPF with reference values of
Prostate cancer nomenclature at diagnosis can affect treatment decisions
CA: A Cancer Journal for Clinicians, EarlyView.
Variation in Guideline-Based Prenatal Care in a Commercially Insured Population
Despite the importance of prenatal care, quality measurement efforts have focused on the number of prenatal visits, or prenatal care adequacy, rather than the services received. It is unknown whether receiving more prenatal visits is associated with receiving more guideline-based
Design and Methods of the Apple Women’s Health Study: A Digital Longitudinal Cohort Study
Prospective longitudinal cohorts assessing women’s health and gynecologic conditions have been historically limited.
Transplantation Therapy with Clinically Relevant Sources of Cells in Experimental Traumatic Brain Injury
Journal of Neurotrauma, Volume 38, Issue 19, Page 2633-2633, October 1, 2021.
Kayser–Fleischer Rings in Wilson’s Disease
Figure 1.
A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion
Structural birth defects are a cause of substantial morbidity and mortality among infants, observed in 1 in 33 births and accounting for 20.6% of infant deaths. Such defects result from complex interactions among the genome, the epigenome, and the environment.
Response to “Further genetic testing in prenatal cases of nonimmune hydrops fetalis with a normal array: a targeted panel or exome?”
Leukemia Cutis
Figure 1.
Cool Water
This man is dying, I think. That is my assessment. But I know by now that such thoughts are not welcomed here. “Plan,” says the Resident, “plan.” Dutifully, I prattle, “Well, he has some fluid to give, let’s aim for
The Known Unknowns: An Overview of the State of Blood-Based Protein Biomarkers of Mild Traumatic Brain Injury
Journal of Neurotrauma, Volume 38, Issue 19, Page 2652-2666, October 1, 2021.
Building and supporting identity in peer review
Cell’s mission is to catalyze scientific discovery and enable science and scientists—whoever and wherever they are—to be a powerful force for progress, positive change, and impact, for the benefit of society and health. How we act on this mission is
Covid-19: Spreading vaccine “misinformation” puts licence at risk, US boards tell physicians
Three US medical licensing boards have warned doctors that they risk losing their licence if they spread covid vaccine misinformation.Internists, family doctors, and paediatricians received an email…
Injury epidemiology in professional football in South America compared with Europe
Objective To describe the injury epidemiology in professional football in South America and compare it with European professional football. Methods Data about football exposures and injury occurrences were registered in Six teams participating in Copa Libertadores in 2016. These teams’
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