Early vaginal progesterone versus Placebo in Twin Pregnancies for prevention of spontaneous preterm birth (EVENTS): A randomised double-blind trial

In women with a singleton pregnancy and sonographic short cervix in mid-gestation, vaginal administration of progesterone reduces the risk of early preterm birth and improves neonatal outcomes, without any demonstrable deleterious effects on childhood neurodevelopment. In women with twin pregnancies

Gabapentin as an Adjunct to Paracervical Block for Perioperative Pain Management for First Trimester Uterine Aspiration: A Randomized Controlled Trial

Pain management approaches during uterine aspiration vary, with methods including local anesthetic, oral analgesics, moderate sedation, deep sedation, or a combination of approaches. For local anesthetic approaches specifically, we continue to have suboptimal pain control [1]. Gabapentin as an adjunct

Risk assessment of endometrial cancer and endometrial intraepithelial neoplasia in women with abnormal bleeding and implications for clinical management algorithms

Most endometrial cancer cases are preceded by abnormal uterine bleeding, offering a potential opportunity for early detection and cure of endometrial cancer. While clinical guidelines exist for diagnostic workup of abnormal uterine bleeding, consensus is lacking regarding optimal management for

Endometriosis

Endometriosis is defined as the presence of endometrium-like tissue outside the uterus. However, this definition does not encompass the complex symptomatic, pathobiologic, and multisystemic nature of the disorder (Figure 1). Endometriosis is primarily diagnosed through surgical visualization —…

Post-traumatic stress, anxiety and depression following miscarriage and ectopic pregnancy: a multi-center, prospective, cohort study

Early pregnancy losses are common, but their psychological sequalae are often overlooked. Previous studies have established links between miscarriage and early symptoms of anxiety and depression. However, the incidence of post-traumatic stress symptoms, and the psychological response specifically to ectopic

Achieving clinically meaningful response in endometriosis pain symptoms is associated with improvements in health-related quality of life and work productivity: Analysis of 2 phase III clinical trials

Endometriosis-related pain symptoms negatively impact health-related quality of life (HRQoL) and productivity. In fact, as endometriosis-related symptom severity and the number of symptoms experienced increases, HRQoL decreases. Dysmenorrhea and non-menstrual pelvic pain are prominent symptoms experienced by women with endometriosis

Placental growth factor predicts time to delivery in women with signs or symptoms of early preterm preeclampsia: a prospective multicenter study.

There is a robust association between altered angiogenic factor concentrations, including placental growth factor and clinically recognized preeclampsia. Alterations in concentrations of angiogenic factors precede the clinical onset of preeclampsia by several weeks. The temporal relationship between the measured angiogenic

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