Progress in the understanding of the pathophysiology of immunologic maladaptation related to early-onset preeclampsia and metabolic syndrome related to late-onset preeclampsia

Among mammalian species, human reproduction has 2 outstanding features. The human hemochorial placentation is characterized by a very deep endovascular trophoblast invasion in the spiral arteries, reaching deep into the myometrium. This requires an agonistic direct cell-cell interaction between the

Feasibility and Acceptability of a Toolkit-Based Process to Implement Patient-Centered, Immediate Postpartum Long-Acting Reversible Contraception Services

National guidelines recommend that maternity systems provide patient-centered access to immediate postpartum long-acting reversible contraception (i.e., insertion of an intrauterine device or implant during the delivery hospitalization). Hospitals face significant barriers to offering these services, and efforts to improve peripartum

Catastrophic health expenditures, insurance churn, and non-employment among gynecologic cancer patients in the United States

In recent years, there has been growing recognition of the financial burden of severe illness, including associations with higher rates of non-employment, uninsurance and catastrophic out-of-pocket health spending. Gynecologic cancer patients often require expensive and prolonged treatments, potentially disrupting employment

Towards individualised contraceptive counselling: clinical and reproductive factors associated with self-reported hormonal contraceptive-induced adverse mood symptoms

Objective The study aim was to establish which demographic, clinical, reproductive and psychiatric factors are associated with self-reported hormonal contraceptive (HC)-induced adverse mood symptoms. Study design We compiled baseline data from two Swedish studies: one cross-sectional study on combined oral

Longitudinal effects of adjuvant chemotherapy and lymph node staging on patient-reported outcomes in endometrial cancer survivors: a prospective cohort study

Most endometrial cancer patients with localized disease are effectively treated and survive for a long time. Primary treatment is hysterectomy, to which surgical staging procedures may be added to assess the need for adjuvant therapy. Longitudinal data on patient-reported outcomes

Urologic morbidity associated with placenta accreta spectrum surgeries: single-center experience with a multidisciplinary team

Hysterectomy for placenta accreta spectrum (PAS) may be associated with urologic morbidity including intentional or unintentional cystostomy, ureteral injury and bladder fistula. Although previous retrospective studies have shown association between PAS and urologic morbidities, there is still paucity of literature

Understanding the diverse sexual repertoires of men who have sex with men, trans and gender-diverse groups is important for sexually transmitted infection prevention

The sexual repertoires of men who have sex with men (MSM), transgender (trans) and gender-diverse groups are poorly understood despite their disproportionate rates of sexually transmitted infections (STIs). The interrelated landscapes and syndemics of the social and sexual behaviour of

Cost Effectiveness of Behavioral and Pelvic Floor Muscle Therapy Combined With Midurethral Sling Surgery vs Surgery Alone Among Women With Mixed Urinary Incontinence: Results of the ESTEEM Randomized Trial

Urinary incontinence is prevalent among women, and it has a significant economic impact. Mixed urinary incontinence, with both stress and urgency urinary incontinence, has a greater adverse impact on quality of life and is more complex to treat compared to

Society for Maternal-Fetal Medicine (SMFM) Consult Series #57: Evaluation and Management of Isolated Soft Ultrasound Markers for Aneuploidy in the Second Trimester

Soft markers were originally introduced to prenatal ultrasonography to improve the detection of trisomy 21 over that achievable with age-based and serum screening strategies. As prenatal genetic screening strategies have greatly evolved over the last 2 decades, the relative importance

Subgroups of failure after surgery for pelvic organ prolapse and associations with quality of life outcomes: a longitudinal cluster analysis

Treatment outcomes after pelvic organ prolapse (POP) surgery are often presented as dichotomous ‘success or failure’ based upon anatomic and symptom criteria. However, clinical experience suggests some women with outcome ‘failures’ are asymptomatic and perceive their surgery to be successful,

Anti-Müllerian hormone levels among contraceptive users: evidence from a cross-sectional cohort of 27,125 individuals

Anti-Müllerian Hormone has become the clinical biomarker-based standard to assess ovarian reserve. As anti-Müllerian hormone testing becomes more common, more individuals are seeking to interpret values obtained while using contraceptives. To appropriately counsel women, a better understanding of anti-Müllerian hormone

Experience of 300 cases of prenatal fetoscopic open spina bifida repair: Report of the International Fetoscopic Neural Tube Defect Repair Consortium.

The multicenter randomized control trial Management of Myelomeningocele Study (MOMS) demonstrated that prenatal repair of open spina bifida (OSB) via hysterotomy, compared with postnatal repair, decreases the need for ventriculoperitoneal shunting and increases the chances of independent ambulation. However, the

Prophylactic manual Rotation of Occiput POsterior and transverse Positions to decrease operative Delivery: The PROPOP Randomized Clinical Trial

Persistent occiput posterior and occiput transverse positions are the commonest malpositions of the fetal head during labor and are associated with prolonged second stage of labor, cesarean sections, instrumental deliveries, severe perineal tears, postpartum hemorrhage and chorioamnionitis. Manual rotation is

Prediction of preeclampsia throughout gestation with maternal characteristics and biophysical and biochemical markers: a longitudinal study

The current approach to predict preeclampsia combines maternal risk factors and evidence from biophysical markers (mean arterial pressure, Doppler velocimetry of the uterine arteries) and maternal blood proteins (placental growth factor, soluble vascular endothelial growth factor receptor-1, pregnancy-associated plasma protein

Society for Maternal-Fetal Medicine Special Statement: Maternal-fetal medicine subspecialist survey on abortion training and service provision

Following a collaborative workshop at the 39th Annual Pregnancy Meeting, the Society for Maternal-Fetal Medicine Reproductive Health Advisory Group identified a need to assess attitudes of maternal-fetal medicine subspecialists about abortion services and available resources at the local and regional

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