Fantoms

Two-year outcomes following a randomised platelet-transfusion trial in preterm infants It is great to see the 2 year outcomes of the PlaNeT-2/MATISSE (Platelets for Neonatal Transfusion-2/Management of Thrombocytopenia in Special Subgroup) study in the journal. This randomised-controlled trial examined the

Atoms

TimingPnomh Penh 22.10 After a protracted delivery and some unexpected hesitancy after the cord is deftly cut by the obstetrician, Achariya draws her first breath under the glare of the maternity theatre lamp. Lusaka 17.10 Had her parents delayed leaving

Atoms

OK. I’ll come clean. Occasionally, I procrastinate. Both editorially and clinically if an acute situation doesn’t demand an instant response. There it is, I’ve said it now: out in the open for all to see. This, though, can be advantageous,

Atoms

It was only after the trunk was disinterred… Swathed in fluorescent peach reflective stripes, the search party had set off, torches aloft, in the penumbral half-light, eager, zestful and optimistic. Their task, the exhumation and recovery of a box of

Fantoms

When to treat with surfactant? More than 30 years after surfactant treatment came into widespread use for preterm infants there is still a lot of variation in practice. Thresholds for treatment in infants who are stabilised on non-invasive respiratory support

Atoms

The last consumptive History is literally littered with examples of interventions which enjoyed a Warholian 15 min in the limelight. Without these ideas being aired though, there would have been no progression, no evolution of thinking. They should, therefore, be

Fantoms

Surfactant nebulisation in the delivery room In search of what would be truly non-invasive surfactant administration, Vincent Gaertner and colleagues investigated whether surfactant nebulisation in the delivery room immediately after birth would improve initial lung aeration in preterm infants born

Atoms

‘Take 5’ The camera swings smoothly from the penumbral apartment view to a vertiginous angle above the staircase. The sole source of illumination a swaying, flickering lightbulb too intermittent to allow you to determine whether the silhouette near the cellar

Atoms

Sox It’s not as if the clues weren’t there. Once the cache of documents (many calligraphically etched) were disinterred from the mahogany box under cobweb-veiled trapdoor beside the ever-penumbral fork in the forest trail, events moved quickly. The chronology, ultimately

Error in Text

In the Original Investigation titled “Telehealth Treatment of Behavior Problems in Young Children With Developmental Delay: A Randomized Clinical Trial,” published online January 9, 2023, the Results section of the Abstract and article body incorrectly listed children’s age in years

Atoms

Travelling light? Some of us find the process of packing for a trip, tough. I consider myself lucky not to have this gene, but, sympathise with those who need to factor in variables from the medium term weather forecast in

Fantoms

Caffeine for late preterm infants? Elizabeth Oliphant and colleagues report the outcomes of a double-blind placebo controlled randomised dosage trial of caffeine for late preterm infants. Their focus was on finding a suitable dose to prevent intermittent hypoxaemic (IH) events

Atoms

Ovine or ursine? Human behavioural phenotypes are complex and the debate around relative contribution(s) of genetics, epigenetics and environment (however defined) are likely (however loudly each proponent shouts) insoluble. Chacun à son gout. Whatever our whole exome sequence predicts for

Errors in Funding/Support

The Original Investigation titled “Effect of Vitamin C Supplementation for Pregnant Smokers on Offspring Airway Function and Wheeze at Age 5 Years: Follow-up of a Randomized Clinical Trial,” published online November 21, 2022, listed incomplete and inaccurate Funding/Support information regarding

Fantoms

What’s new in the management of neonatal early-onset sepsis? Noa Fleiss and colleagues compare and contrast professional guidelines for the management of early onset neonatal sepsis from the UK and the USA. Although these are evidence based, the limitations of

Atoms

Tell-tale smudges It’s only when you look really closely at the family cartological heirlooms, the yellowing atlases from the early 20th century, that the changes startle. Many of the outlines are familiar (plate tectonics and continental outlines metamorphosing at a

Error in Figure 1

In the Original Investigation titled “Incidence of Kawasaki Disease Before and After the COVID-19 Pandemic in Japan: Results of the 26th Nationwide Survey, 2019 to 2020” published online on October 17, 2022, there was a typographical error in Figure 1.

Atoms

Though deliberately moved back to mid- autumn to avoid the blistering July heat, the Mexico City Olympics could only be described as gold-medal-sultry. Add to this, the altitude, advantageous only for the short sprints where the reduced air resistance gave

Atoms

“But you have to say something“, admonished her jaded crime editor, vexation serving only to enhance both his proptosis and sundowner-crimson cheeks, his long-serving herring-bone jacket and corduroys at breaking point round his girth. These outbursts had become more familiar

Fantoms

Trends in the use of non-invasive respiratory support for term infants Brett Manley and colleagues report data from tertiary NICUs in the Australia and New Zealand Neonatal Network for the years 2010–2018. 14 656 inborn term (>37 weeks gestation) infants

Atoms

Even compared with ‘the sizzler in 36’, this summer would go down in the East Coast annals. It wasn’t just the relentless heat, the unbroken shimmer over the skyscraper backdrop, the drinking water considered too unreliable to be imported as

Fantoms

Outcomes of preterm infants In 2010, the Dutch practice regarding initiation of active treatment in extremely preterm infants was lowered from 25 completed weeks’ to 24 completed weeks’ gestation. The Editor’s choice for this issue is the EPI-DAF study, reported

Atoms

In the ‘old days’, textbooks were the source of information and wisdom. They were solid chunks of black and white knowledge painstakingly written over many years, each chapter compiled by an authority in the field, often one suspects a friend

Error in Author’s Name

In the Original Investigation titled “Childhood Asthma Incidence, Early and Persistent Wheeze, and Neighborhood Socioeconomic Factors in the ECHO/CREW Consortium,” published online May 23, 2022, an author’s name contained errors in the byline and contributions section. The author’s name has

Highlights from this issue

Rumours of the demise of the observational study have been grossly exaggerated So, maybe I’ve taken some artistic licence with Mark Twain’s original version, but this methodological ‘family’ deserved a fair backing. Take the cohort design: this may have had

Highlights from this issue

Taking a second lookWarmia, Poland 1530s An extraordinary polymath called Nicolaus Copernicus is completing his work on heliocentricity, challenging (with support from both academic and theological colleagues) the ‘earth at the centre of the universe’ assumption Soho, London 1850s A

Highlights from this issue

What the brochure says The WHO top ten list of threats to global health feature many directly relevant to children: climate change, pollution; vaccine hesitancy; dengue; COVID-19; influenza; antimicrobial resistance – all ‘deserving members’ of this unenviable top table, though

Highlights from this issue

Optimising therapeutic hypothermia Using the National Neonatal Research Database, Lara Shipley and colleagues studied infants≥36 weeks gestation who were admitted to UK neonatal units with moderate or severe hypoxic ischaemic encephalopathy (HIE). Between 2011 and 2016 there were 5059 infants.

Obesity and Gαs Variants

Mendes de Oliveira and colleagues now report in the Journal that variants in GNAS exons that encode the stimulatory G-protein alpha subunit (Gαs) have a strong genetic association with severe obesity, owing to reduced signaling by the melanocortin 4 receptor

Obesity and Gαs Variants

Mendes de Oliveira and colleagues now report in the Journal that variants in GNAS exons that encode the stimulatory G-protein alpha subunit (Gαs) have a strong genetic association with severe obesity, owing to reduced signaling by the melanocortin 4 receptor

Highlights from this issue

Therapeutic creep in provision of hypothermia for hypoxic ischaemic encephalopathy Three articles relate to the changing practices of UK clinicians in the provision of therapeutic hypothermia for hypoxic ischaemic encephalopathy (HIE). Lori Hage and colleagues report the clinical characteristics of

Pneumococcal Empyema

A 4-year-old girl was brought to the emergency department with a 4-day history of fever, cough, and lethargy. She was up to date with all childhood vaccinations. Three weeks earlier, she had had a presumed viral respiratory tract infection with

Losing Touch

We called it the “cold light.” It looked like a small blue button with a power cord attached to the end of it. At its center was a single round eye that emitted a light, crimson in color and piercing

Highlights from this issue

In deference to the equivocal A common (if not universal) human phenotype is the need for an answer—ideally a definitive, dichotomous one—a yes/no with no shades of grey. I don’t take sides on this nor am I being deliberately Machiavellian—conclusive

Base Editing in Progeria

“How much longer?” is a question all too familiar to parents. This is also a question that scientists ask themselves when trying to find a truly effective treatment for patients with the Hutchinson–Gilford progeria syndrome (HGPS) and other genetic diseases.

Casting a Wide Net

A 16-year-old girl presented to her pediatrician for evaluation of recent weight gain, irritability, weakness, and skin changes. Her mother reported that her daughter’s grades at school had declined and that she had left the cheerleading team owing to fatigue.

Highlights from this issue

Scene – 1953, provincial theatre: final act. Frisson of suspense ripples through audience. Main protagonist: detective inspector. ‘Why haven’t I realised before?’ Injured victim: ‘Why didn’t you just open your eyes’. Adversary-doppelgänger: Placing musket (softly but dramatically) on the floor. ‘So, you’ve finally foiled me. I thought

Involvement of community paediatricians in the care of children and young people with mental health difficulties in the UK: implications for case ascertainment by child and adolescent psychiatric, and paediatric surveillance systems

Objective To ascertain the extent to which community paediatricians are involved in the care of children with mental health conditions in order to determine which difficulties are appropriate for single or joint surveillance by the British Paediatric Surveillance Unit (BPSU)

Ewing’s Sarcoma

In 1920, during a meeting of the New York Pathological Society, James Ewing described an unusual tumor in a 14-year-old girl as a “diffuse endothelioma of bone.” The tumor had initially been diagnosed as an osteosarcoma, but its architecture, the

Examining the effects of pre-pregnancy weight and gestational weight gain on allergic disease development in offspring: a protocol for a population-based study using health administrative databases in Ontario, Canada

Introduction Over the last 20 years, excess maternal pre-pregnancy weight (overweight and obesity) and gestational weight gain have become the most common morbidities in pregnancy. These morbidities may pose a threat to fetal immunological development through associated metabolic dysfunction and

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