Phase I Study of Aurora A Kinase Inhibitor Alisertib (MLN8237) in Combination With Selective VEGFR Inhibitor Pazopanib for Therapy of Advanced Solid Tumors

Objectives: Pazopanib is a multikinase angiogenesis inhibitor. Alisertib is a highly selective inhibitor of mitotic Aurora A kinase. There is preclinical evidence that mitosis-targeting agents exhibit antiangiogenic effects. Thus, the combination of these 2 agents may have a synergistic effect

Keeping score with obesity

Keeping score with obesity Keeping score with obesity, Published online: 25 April 2019; doi:10.1038/s41576-019-0132-4 A new study reports a genome-wide polygenic score (GPS) that is predictive of obesity, thus providing opportunities for early health interventions.

Bug battles end in compromise

Bug battles end in compromise Bug battles end in compromise, Published online: 24 April 2019; doi:10.1038/s41576-019-0133-3 An experimental evolution study published in Science demonstrates that non-additive interactions between pollinators (bumblebees) and herbivores (caterpillars) drive rapid evolution in plants.

Long-range interactions between topologically associating domains shape the four-dimensional genome during differentiation

Long-range interactions between topologically associating domains shape the four-dimensional genome during differentiation Long-range interactions between topologically associating domains shape the four-dimensional genome during differentiation, Published online: 22 April 2019; doi:10.1038/s41588-019-0392-0 The authors identify the formation of dynamic topologically associating domain

High-sensitive cardiac troponin T as a predictor of efficacy and safety after pulmonary vein isolation using focal radiofrequency, multielectrode radiofrequency and cryoballoon ablation catheter

Introduction Myocardial injury markers such as high-sensitive cardiac troponin T (hs-cTnT) and creatine kinase MB (CK-MB) reflects the amount of myocardial injury with ablation. The aim of the study was to identify the value of myocardial injury markers to predict

Highlights from this issue

Milestones Like many words with an implicit sense of drama, ‘milestones’ has become something of an overused term, a ‘millstone’, if you will. There are occasions, though, where it is fully justified and, by chance, this month’s issue describes events

In this issue

Accuracy of a point-of-care test for hCG Point-of-care testing (POCT), performed at or near the site of patient care, is now available for early quantitative measurement of human chorionic gonadotropin (hCG) levels. Could this help exclude ectopic pregnancy at very

Collecting and exploiting data to understand a nations sexual health needs: Implications for the British National Surveys of Sexual Attitudes and Lifestyles (Natsal)

Accurate information about a nation’s sexual health is essential to plan and evaluate services, inform prevention efforts, and contribute to societal discourse on sexuality. In Britain, sexual health data come from a range of sources. There are world-class surveillance data

Spatial transcriptomics coming of age

Spatial transcriptomics coming of age Spatial transcriptomics coming of age, Published online: 12 April 2019; doi:10.1038/s41576-019-0129-z Two new spatial transcriptomics techniques published in Nature and Science bring us an important step closer to the goal of achieving transcriptome-wide data at

Multiplexing of Theta and Alpha Rhythms in the Amygdala-Hippocampal Circuit Supports Pattern Separation of Emotional Information

Zheng et al. demonstrate that successful pattern separation of emotional stimuli is associated with bidirectional amygdala-hippocampal interactions via theta band (3–7 Hz). In contrast, unidirectional influence from the amygdala to the hippocampus via alpha band (7–13 Hz) leads to overgeneralization errors (i.e., failure

Effectiveness and safety of intravitreal aflibercept in patients with wet age-related macular degeneration treated in routine clinical practices across France: 12-month outcomes of the RAINBOW study

Background/aims To monitor treatment-naïve patients with wet age-related macular degeneration (wet AMD) receiving intravitreal aflibercept (IVT-AFL) in France. Methods RAINBOW (Real life use of intravitreal Aflibercept In FraNce – oBservatiOnal study in Wet age-related macular degeneration) is an ongoing, observational,

Exercise-based cardiac rehabilitation for patients following open surgical aortic valve replacement and transcatheter aortic valve implant: a systematic review and meta-analysis

Objectives Exercise-based cardiac rehabilitation (CR) may be beneficial to patients following transcatheter aortic valve implantation (TAVI) and open surgical aortic valve replacement (SAVR). We aimed to undertake a systematic review and meta-analysis to evaluate the efficacy, safety and costs of

When the elite compete

When the elite compete When the elite compete, Published online: 02 April 2019; doi:10.1038/s41576-019-0123-5 A new study in Science reports the existence of a subpopulation of somatic cells from which ‘elite’ clones emerge that outperform other clones to drive reprogramming.

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