SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus

Hess et al. quantified circulating aldehyde dehydrogenase-expressing (ALDHhi) cell subsets in people with T2DM given either empagliflozin (EMPA) or placebo. EMPA treatment increased circulating pro-angiogenic CD133+ progenitor cells, decreased pro-inflammatory ALDHhi granulocyte precursors, and increased ALDHhi monocytes with M2 polarization. EMPA

Mobile Devices and Health

Mobile health — the application of sensors, mobile apps, social media, and location-tracking technology to obtain data pertinent to wellness and disease diagnosis, prevention, and management — makes it theoretically possible to monitor and intervene whenever and wherever acute and

SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus

Hess et al. quantified circulating aldehyde dehydrogenase-expressing (ALDHhi) cell subsets in people with T2DM given either empagliflozin (EMPA) or placebo. EMPA treatment increased circulating pro-angiogenic CD133+ progenitor cells, decreased pro-inflammatory ALDHhi granulocyte precursors, and increased ALDHhi monocytes with M2 polarization. EMPA

Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer

Bieniasz-Krzywiec et al. demonstrate a triad interaction of podoplanin (PDPN)-expressing tumor-associated macrophages (PoEMs), GAL8-expressing lymphatic vessels, and invading breast cancer cells, which promotes metastasis. PoEMs remodel the extracellular matrix, stimulating lymphangiogenesis, and release previously trapped cancer-promoting factors that facilitate cancer cell

Bad to the Bone

A 52-year-old man presented to the emergency department with nausea, vomiting, and profound lethargy. He had noted mild nausea and fatigue for approximately 5 months. Given acute worsening of his symptoms in the days leading up to presentation, he sought

Plant-derived polyunsaturated fatty acids and markers of glucose metabolism and insulin resistance: a meta-analysis of randomized controlled feeding trials

The objective of this meta-analysis was to investigate the effects of plant-derived polyunsaturated fatty acids (PUFAs) on glucose metabolism and insulin resistance. Scopus and PubMed databases were searched until January 2018. Eligible studies were randomized controlled feeding trials that investigated

A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila

Scopelliti et al. identified a novel intestinal/neuronal/adipose tissue communication network in Drosophila with implications for endocrine-regulated metabolic homeostasis. In response to nutrients, enteroendocrine cells (EE) secrete the neuroendocrine peptide Bursicon α, which binds to its neuronal receptor DLgr2 to regulate organismal

[Comment] Obesity is rarely healthy

Obesity adversely affects almost all the cardiovascular disease risk factors, particularly those related to metabolic syndrome, including blood pressure, lipids (especially increasing triglycerides and reducing high-density lipoprotein cholesterol), and increasing blood glucose levels (eventually leading to type 2 diabetes).1 In

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