Blame

The sliver of light under the door interrupts the dark and marks this room as foreign. The room I share with my sister at home has no doors, just a curtain separating our room from the closet area, and then

Down Syndrome

Down syndrome, also called Down’s syndrome (DS), is the most common chromosomal condition associated with intellectual disability and is characterized by a variety of additional clinical findings. It occurs in approximately 1 of 800 births worldwide. In the United States,

The Game Is Afoot

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows.

Pituitary-Tumor Endocrinopathies

Pituitary adenomas account for approximately 15% of intracranial tumors. Management of these benign tumors requires diagnosis of the specific intrasellar disease and comprehensive, multidisciplinary treatment of local mass effects and peripheral endocrinopathies. Since tumors can produce different…

Milk and Health

Milk products from cows and other nonhuman mammals are major components of traditional Western diets, especially in cold climates. The recommended intake of milk or equivalent portions of cheese, yogurt, or other dairy products in the United States is three

Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial

Objective To determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment of periodontitis in patients with type 2 diabetes mellitus. Research design and methods In this double-blind, randomized clinical trial, a total of 42

SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus

Hess et al. quantified circulating aldehyde dehydrogenase-expressing (ALDHhi) cell subsets in people with T2DM given either empagliflozin (EMPA) or placebo. EMPA treatment increased circulating pro-angiogenic CD133+ progenitor cells, decreased pro-inflammatory ALDHhi granulocyte precursors, and increased ALDHhi monocytes with M2 polarization. EMPA

Mobile Devices and Health

Mobile health — the application of sensors, mobile apps, social media, and location-tracking technology to obtain data pertinent to wellness and disease diagnosis, prevention, and management — makes it theoretically possible to monitor and intervene whenever and wherever acute and

SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus

Hess et al. quantified circulating aldehyde dehydrogenase-expressing (ALDHhi) cell subsets in people with T2DM given either empagliflozin (EMPA) or placebo. EMPA treatment increased circulating pro-angiogenic CD133+ progenitor cells, decreased pro-inflammatory ALDHhi granulocyte precursors, and increased ALDHhi monocytes with M2 polarization. EMPA

Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer

Bieniasz-Krzywiec et al. demonstrate a triad interaction of podoplanin (PDPN)-expressing tumor-associated macrophages (PoEMs), GAL8-expressing lymphatic vessels, and invading breast cancer cells, which promotes metastasis. PoEMs remodel the extracellular matrix, stimulating lymphangiogenesis, and release previously trapped cancer-promoting factors that facilitate cancer cell

Bad to the Bone

A 52-year-old man presented to the emergency department with nausea, vomiting, and profound lethargy. He had noted mild nausea and fatigue for approximately 5 months. Given acute worsening of his symptoms in the days leading up to presentation, he sought

Plant-derived polyunsaturated fatty acids and markers of glucose metabolism and insulin resistance: a meta-analysis of randomized controlled feeding trials

The objective of this meta-analysis was to investigate the effects of plant-derived polyunsaturated fatty acids (PUFAs) on glucose metabolism and insulin resistance. Scopus and PubMed databases were searched until January 2018. Eligible studies were randomized controlled feeding trials that investigated

A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila

Scopelliti et al. identified a novel intestinal/neuronal/adipose tissue communication network in Drosophila with implications for endocrine-regulated metabolic homeostasis. In response to nutrients, enteroendocrine cells (EE) secrete the neuroendocrine peptide Bursicon α, which binds to its neuronal receptor DLgr2 to regulate organismal

[Comment] Obesity is rarely healthy

Obesity adversely affects almost all the cardiovascular disease risk factors, particularly those related to metabolic syndrome, including blood pressure, lipids (especially increasing triglycerides and reducing high-density lipoprotein cholesterol), and increasing blood glucose levels (eventually leading to type 2 diabetes).1 In

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