“You are leaving?” she asked. “When will you come again?” “Soon,” I said. “I’ll be back soon, Nanima.” In my heart, I knew it wouldn’t be soon. In truth, I could only bear to visit her once every few months

Zoom Family Meeting

As difficult as 2020 was, it also brought some exhilarating moments when care was redesigned on the fly and delivered in better ways. How can we preserve the benefits of these bursts of innovation once the Covid-19 pandemic eases? One

Bone-free ancient DNA

Nature Reviews Genetics, Published online: 28 April 2021; doi:10.1038/s41576-021-00368-2 A new study in Science reports the extraction and analysis of ancient hominid nuclear DNA from Paleolithic sediments. This advance paves the way to a fuller picture of human evolution by

From LD-based mapping to GWAS

Nature Reviews Genetics, Published online: 23 April 2021; doi:10.1038/s41576-021-00366-4 Cisca Wijmenga reflects on a seminal publication by Houwen et al. that set the stage for genome-wide association studies and inspired her to dedicate her lab to complex trait genetics.

Adrenal Incidentaloma

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage.


“You are leaving?” she asked. “When will you come again?” “Soon,” I said. “I’ll be back soon, Nanima.” In my heart, I knew it wouldn’t be soon. In truth, I could only bear to visit her once every few months

Highlights from this issue

In deference to the equivocal A common (if not universal) human phenotype is the need for an answer—ideally a definitive, dichotomous one—a yes/no with no shades of grey. I don’t take sides on this nor am I being deliberately Machiavellian—conclusive

Omitted Decimal Point

In the Review titled “Diagnosis and Treatment of Irritable Bowel Syndrome: A Review,” published in the March 2, 2021, issue of JAMA, a decimal point was omitted in the description of the number of endoscopic procedures reported in a reference

Perils of hidden depths

Clinical question A man in his 60s presented with lower urinary tract symptoms. His serum prostate-specific antigen level was 6 ng/mL. A prostate biopsy was performed (figure 1). What is your diagnosis? Acinar adenocarcinoma. Benign. High-grade prostatic intraepithelial neoplasia. Intraductal

Prediction of preeclampsia throughout gestation with maternal characteristics and biophysical and biochemical markers: a longitudinal study

The current approach to predict preeclampsia combines maternal risk factors and evidence from biophysical markers (mean arterial pressure, Doppler velocimetry of the uterine arteries) and maternal blood proteins (placental growth factor, soluble vascular endothelial growth factor receptor-1, pregnancy-associated plasma protein

Society for Maternal-Fetal Medicine Special Statement: Maternal-fetal medicine subspecialist survey on abortion training and service provision

Following a collaborative workshop at the 39th Annual Pregnancy Meeting, the Society for Maternal-Fetal Medicine Reproductive Health Advisory Group identified a need to assess attitudes of maternal-fetal medicine subspecialists about abortion services and available resources at the local and regional

Guiding authors to Open Access

Nature Genetics, Published online: 08 April 2021; doi:10.1038/s41588-021-00853-8 Guided Open Access is a new publishing option offered at Nature Genetics. Authors can submit once and be simultaneously considered by three journals. Editorial collaboration and a single submission system combine to

Base Editing in Progeria

“How much longer?” is a question all too familiar to parents. This is also a question that scientists ask themselves when trying to find a truly effective treatment for patients with the Hutchinson–Gilford progeria syndrome (HGPS) and other genetic diseases.

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