Intrapartum Sonography for Difficult Labor
Difficult labor — protracted or arrested dilatation in the first stage, arrest of descent in the second stage, and the decision whether to attempt an assisted vaginal birth — accounts for a large proportion of intrapartum cesarean deliveries and for
SpatialVista as a unified ecosystem for high-performance visualization and exploration of 3D spatial transcriptomics data
Nature Genetics, Published online: 14 August 2026; doi:10.1038/s41588-026-02696-7 SpatialVista as a unified ecosystem for high-performance visualization and exploration of 3D spatial transcriptomics data
Hospitals are dealing with 41{degrees}C indoor temperatures
Hospital staff are dealing with indoor temperatures of more than 41°C as the NHS struggles to provide care during the current heatwave, it has been disclosed.Responses to a freedom of information (FOI) request by the Liberal Democrats found one hospital
Electrical cardioversion for atrial fibrillation: nationwide trends in Denmark, 2010-2022
Background Electrical cardioversion (ECV) is widely used for restoring sinus rhythm in atrial fibrillation (AF). However, population-level trends in use of ECV in individuals with AF remain poorly characterised. Aim We examined nationwide temporal trends in ECV utilisation between 2010
Making sense of azithromycin resistance patterns: what have we learnt and what should we do?
As respiratory paediatricians, we were disappointed to see the negative results reported previously in the AZTEC trial1 as we have found it to be a useful treatment in a range of lung diseases affecting children. Although the effects are modest,
Correlations between causal effect sizes of proximal SNPs vary with functional annotations and implicate stabilizing selection
Nature Genetics, Published online: 13 August 2026; doi:10.1038/s41588-026-02712-w This study generates a method to detect correlation of causal complex trait effect sizes between proximal SNPs, finding variation by functional annotation and support for stabilizing selection, whereby proximal SNPs in positive
Ischaemic heart disease beyond obstructive coronary stenoses: from prevention to treatment
For image description, please refer to the figure legend and surrounding text. For the podcast associated with this article, please visit https://academic.oup.com/eurheartj/pages/Podcasts.
[Editorial] Skin diseases: beyond the visible
Even the very word vitiligo denotes stigma—it probably comes from the Latin vitium, meaning a blemish, a defect, or a flaw. The visibility of depigmented skin, a culture that judges people by how they look, and enduring misconceptions of contagion
Healthcare must be built around patients, not profits
Patients are continually let down by health services that aren’t built around their needs. Inertia or the challenge of delivering change may mean that services are stuck in their old ways. For instance, patients in England face unnecessary risks because
Steroids or immunoglobulin for CIDP first-line treatment: why not both?
In Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), 81% of patients respond well to at least one of the established first-line therapies: corticosteroids, immunoglobulin or plasma exchange (PLEX).1 2 However, studies comparing their efficacy and tolerability are limited. Nobile-Orazio et al showed
Precision oncology needs precision trial design: lessons from FGFR2-rearranged cholangiocarcinoma
Nature Reviews Clinical Oncology, Published online: 12 August 2026; doi:10.1038/s41571-026-01194-3 The phase III FIGHT-302 trial demonstrated that the FGFR inhibitor pemigatinib improves progression-free survival and response rates versus first-line chemotherapy in patients with advanced-stage FGFR2-rearranged cholangiocarcinoma. However, the trial accrued
Development and clinical validation of an objective assessment tool for robotic-assisted and laparoscopic hysterectomy
Hysterectomy is one of most performed gynecological procedures worldwide. Recent decades have witnessed a significant uptake of laparoscopic approaches. While technical proficiency is increasingly recognized as being closely linked to patient outcomes in different surgical specialties, standardization of assessment in
hnRNPK condensates facilitate enhancer–promoter looping and RNA polymerase II recruitment
Nature Genetics, Published online: 12 August 2026; doi:10.1038/s41588-026-02710-y This study shows that hnRNPK binds nascent RNAs transcribed from enhancers and promoters to promote enhancer–promoter looping and transcriptional activation, potentially via recruitment of Pol II through phase separation.
[Editorial] Epilepsy care must look beyond seizure control
More than 50 million people live with active epilepsy worldwide, making it one of the most common neurological conditions across the lifespan. More than 80% of this burden falls on poor regions, where specialist services and treatment are scarce, and
[Editorial] Questions AI cannot answer
The new era of artificial intelligence (AI) in health has arrived. AI tools are being developed and adopted across research and clinical practice. In mental health, generative AI is already being used to facilitate administrative tasks in clinical practice and
India’s heatwaves expose the gendered harms of the climate crisis
Flashbacks of summers spent in the stifling heat of India, watching the women of my household (IS) toiling over open flames in a poorly ventilated kitchen, are strong. They would be drenched in sweat, cooking in the midday heat, dressed
Progression of valvular heart disease: an academic concept or a clinical imperative?
Acquired valvular heart disease (VHD) is common in the 21st century and its prevalence is increasing, mainly due to increasing longevity associated with the progression of age-related degenerative changes as well as the rising prevalence of rheumatic heart disease.1 Cross-sectional
The International Olympic Committee advances a second Consensus Statement on Mental Health in Elite Athletes
The International Olympic Committee (IOC) Consensus Statement on Mental Health in Elite Athletes, published in 2019,1 marked a pivotal shift in how mental health was conceptualised and addressed within elite sport. Importantly, this statement was not merely aspirational; it catalysed
Clinical and histological chorioamnionitis, particularly when associated with funisitis, attenuate intrapartum fetal heart rate responses and increase vulnerability to hypoxic-ischemic brain injury at milder degrees of acidemia
Animal experimental studies and human observational data suggest that fetal inflammatory response to chorioamnionitis is associated with increased risk of neonatal encephalopathy and attenuation of fetal responses to intrapartum hypoxia-ischemia, but the effects of clinical and/or histological chorioamnionitis and fetal
Different lysosomal insults, one microglial fate
Genetic associations point to a connection between lysosomal function and neurodegeneration. In this issue of Immunity, Balak et al. and Tejwani et al. show that genetically distinct lysosomal insults converge on a shared MITF/TFE-driven epigenetic program that underlies disease-associated microglial
Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease
Nature Genetics, Published online: 11 August 2026; doi:10.1038/s41588-026-02716-6 Molecular profiling of myeloid cells from the prefrontal cortex of 1,607 donors with varying degrees of Alzheimer’s disease neuropathology delineates distinct myeloid subtypes and identifies changes associated with aging and disease progression.
Genetics and genomics of hybridization
Nature Reviews Genetics, Published online: 11 August 2026; doi:10.1038/s41576-026-00995-7 Hybridization, the exchange of genes between divergent lineages, is now recognized as widespread across eukaryotes and essential to understanding genome evolution. In this Review, Schumer and Rieseberg overview methodological advances facilitating
[Editorial] Soaring GLP-1 receptor agonist use
According to a new analysis by Gallup, 11% of adults in the USA are currently using injectable GLP-1 or dual GIP–GLP-1 receptor agonists (eg, semaglutide, liraglutide, and tirzepatide) for weight loss—nearly a four-fold increase in just 2 years. The analysis
JAMA
GLP-1s: New daily weight loss pill Foundayo approved by UK regulator
A new daily GLP-1 pill, orforglipron (marketed as Foundayo), has been approved by the UK’s drug regulator for weight management and type 2 diabetes.The UK is the first country in Europe to approve this glucagon-like peptide-1 receptor agonist developed by
Impact of a durable left ventricular assist device on inflammation and cardiac remodelling in subjects with advanced heart failure
Background This study aimed to explore the association of long-term left ventricular assist device (LVAD) support with changes in inflammation and cardiac remodelling in subjects with advanced heart failure (HF). Methods A single-centre prospective observational trial was conducted in 16
The proteome comes of age, but precision oncology needs functional maps
Nature Reviews Clinical Oncology, Published online: 10 August 2026; doi:10.1038/s41571-026-01196-1 Yue and colleagues present a landmark anatomical atlas of human protein abundance across non-malignant tissues and cancers. We argue that precision oncology needs functional proteomic maps that add signalling activity,
Beyond BCL-2: What drives venetoclax resistance in acute myeloid leukemia?
The BCL-2 inhibitor venetoclax has transformed outcomes for older or frail patients with acute myeloid leukemia (AML), and its resistance mechanisms are becoming better defined, including compensatory and lineage-associated switches toward MCL-1 or BCL-xL dependence, oncogenic signaling activation, blast phenotype,
Maternal Gestational Diabetes and the Risk of Polyendocrine Metabolic Ovarian and Metabolic Syndromes in their Daughters: A Sibling Controlled Cohort Study
Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer
Nature Genetics, Published online: 10 August 2026; doi:10.1038/s41588-026-02692-x Integrative analyses of whole-genome and transcriptome sequencing on Japanese colorectal cancer along with whole-genome metagenomic sequencing on fecal samples characterize host–microbiome interactions and colibactin-associated mutational signatures.
Temporal trends in sports and exercise participation: a study in a population-representative sample of 96 948 European Union adults
Objectives The aim of this study was to determine temporal trends in sports and exercise participation frequency among European Union adults. Methods We analysed Eurobarometer survey data collected among 96 948 adults from 26 European Union countries in 2009, 2013,
Nestorone, a potent progestin, exhibits anti-inflammatory activity and prevents preterm birth in murine models
Preterm birth remains a leading cause of neonatal morbidity and mortality worldwide. Vaginal progesterone reduces the rate of preterm birth by approximately 45% in women with a singleton gestation and a sonographically short cervix, but it is not effective in
Retatrutide: Obesity drug opens to “compassionate use” in US after speculation Trump took it
A next generation glucagon-like peptide-1 (GLP-1) drug for obesity, retatrutide, will now be available to some patients before it is approved by the US Food and Drug Administration (FDA) through an expanded access programme (also known as compassionate use).The announcement,
HCT–ASCT confirmed as standard-of-care consolidation therapy for PCNSL
Nature Reviews Clinical Oncology, Published online: 07 August 2026; doi:10.1038/s41571-026-01197-0 HCT–ASCT confirmed as standard-of-care consolidation therapy for PCNSL
What does uterine artery Doppler reflect in late pregnancy? Insights from angiogenic, hemodynamic, and vascular markers in preeclampsia
: Preeclampsia is a complex disorder arising from abnormal placentation and maternal vascular maladaptation. Uterine artery Doppler is widely used to assess placental perfusion in early pregnancy. However, in late pregnancy its role remains unclear.
Universal cell embedding for single-cell biology
Nature Genetics, Published online: 07 August 2026; doi:10.1038/s41588-026-02718-4 Universal cell embedding for single-cell biology
The genetics of complex gene expression phenotypes illuminated
Nature Reviews Genetics, Published online: 07 August 2026; doi:10.1038/s41576-026-00999-3 Christian Landry reflects on a 2002 study by Brem, Yvert and colleagues, which combined yeast genetics and genome-wide expression profiling to reveal the genetic architecture underlying gene expression and transformed our
“Heart-in-the-dish” models identify mechanisms of diastolic dysfunction
Modeling of cardiac pathologies in tissue-engineered models is coming of age. Two independent studies by Reid et al.1 and Tani et al.2 present in-depth multi-phenomics data from a human cardiac organoid (hCO) model and explore hCOs and engineered heart tissues
A preclinical inflammatory phase in amniotic fluid embolism: evidence from circulating cytokines
Transcatheter aortic valve implantation vs surgical aortic valve replacement for aortic stenosis: the saga continues
For image description, please refer to the figure legend and surrounding text.
Filling the holes in whole genomes: A vision for personalized genomics from telomere to telomere
Two decades after the Human Genome Project, we finally have the ability to read the complete genome of any human and (nearly) any species. These sequences provide the ideal foundation for training predictive models of the genome that will accelerate
[Editorial] Wildfires: a health emergency
Europe is burning. Wildfires in France and Spain have engulfed hundreds of square miles of land, destroying homes and forcing the evacuation of 330 000 people as the threat now moves east to Greece, Italy, and central Europe. The fires have
New look on oats in coeliac disease
The suitability and tolerability of oats has been a long-standing controversy in the management of coeliac disease (CD). In Europe and the USA, pure oats are recommended for their nutritional benefits, palatability and desire by the patients with CD, whereas
UpFront
Welcome to the September 2026 issue of Frontline Gastroenterology (FG). Following what was a great British Society of Gastroenterology (BSG) Annual Meeting in recent years, hosted in Liverpool between 22 and 25 June 2026, it is a pleasure to introduce
Benefit from perioperative enfortumab vedotin–pembrolizumab in cisplatin-eligible MIBC
Nature Reviews Clinical Oncology, Published online: 04 August 2026; doi:10.1038/s41571-026-01195-2 Benefit from perioperative enfortumab vedotin–pembrolizumab in cisplatin-eligible MIBC
[Editorial] A decade in gastroenterology and hepatology
This issue of the journal marks our 10th anniversary, a milestone that offers an opportunity to reflect on the progress made in gastroenterology and hepatology since we last took stock, 5 years ago. In addition, although not exhaustive, the issue
When less is more and when it isn’t: Microglial Spi1 and the limits of what we know
Microglia are key players in Alzheimer’s disease, but the transcriptional control of their phagocytic function remains unclear. Kim et al. show that mouse microglial Spi1 deletion worsens amyloid pathology by impairing Aβ clearance through Syk, Lyn, and Fcgr1, providing new
Ultrasound-guided robotic myomectomy using a drop-in probe
Robot-assisted myomectomy offers the advantages of minimally invasive surgery but lacks tactile feedback, making identification of intramural fibroids dependent on visual assessment. This limitation may be particularly relevant in fertility-preserving surgery and in patients with multiple myomas. Although laparoscopic intraoperative
High-resolution promoter interaction analysis implicates genes involved in activation of type 3 innate lymphoid cells in immune disease risk
Nature Genetics, Published online: 04 August 2026; doi:10.1038/s41588-026-02681-0 High-resolution mapping of promoter-anchored chromosomal contacts in type 3 innate lymphoid cells (ILC3s), coupled with GWAS effector gene prioritization and functional studies, identifies ILC3-linked genes as potential mediators of risk for several
Decoding neural signals to build metabolic therapies
Ongoing research points to neural circuits as the major targets for the incretin-mimetic drugs that are transforming obesity treatment. In this Voices piece, we asked researchers to discuss their work on how central and peripheral pathways influence energy balance and
[Editorial] Moving the needle on child health in the UK
The UK’s Royal College of Paediatrics and Child Health (RCPCH) State of child health 2026 report, published on July 14, comes at an opportune moment as Andy Burnham takes charge as the new Prime Minister. The report’s 12 indicators—alongside insights
JAMA
Concerns About Shortcomings in Retrospective Application of the YEARS Criteria (Reply to Letter-to-the-Editor)
Histone marks are conserved across eukaryotes but chromatin states are diversified
Nature Genetics, Published online: 03 August 2026; doi:10.1038/s41588-026-02683-y Eukaryotes share many ancient histone post-translational modifications, but whether they use them in the same way remains unknown. By profiling some of these modifications across diverse eukaryotic lineages, we find that active
Embracing non-linearity in human ageing
Nature Reviews Genetics, Published online: 03 August 2026; doi:10.1038/s41576-026-00993-9 Ageing has often been conceptualized as a gradual, linear decline, yet growing evidence suggests it unfolds through dynamic, stage-specific transitions. In this Perspective, the authors examine such evidence across molecular and
JAMA Pediatrics
Vision: JAMA Pediatrics will be the most respected source of information for investigators, providers, and policy makers seeking the highest quality evidence to guide decision-making.
The changing landscape of adult congenital heart diseases
For image description, please refer to the figure legend and surrounding text.
More options, more questions in the management of early relapsed and/or refractory multiple myeloma
Nature Reviews Clinical Oncology, Published online: 31 July 2026; doi:10.1038/s41571-026-01191-6 In MonumenTAL-3, the G-protein-coupled receptor class C group 5 memberD-directed bispecific T cell engager talquetamab combined with either daratumumab or daratumumab–pomalidomide conferred significantly longer progression-free survival than daratumumab–pomalidomide–dexamethasone in patients
Correction to “Serious mental illness and cancer: A call to action for equitable care”
CA: A Cancer Journal for Clinicians, Volume 76, Issue 4, July/August 2026.
Shoring Up Shortcomings in Retrospective Application of the YEARS Criteria (Letter-to-the-Editor)
Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency
Nature Genetics, Published online: 31 July 2026; doi:10.1038/s41588-026-02703-x This study uses single-molecule footprinting to quantify chromatin accessibility at enhancers and promoters in mouse embryonic stem cells and to dissect the contributions of transcription factor binding and chromatin context.
Towards quantifying immune diversity through HLA genomics
Nature Reviews Genetics, Published online: 31 July 2026; doi:10.1038/s41576-026-00996-6 Computational metrics such as HLA evolutionary divergence offer new ways to quantify functional variation in antigen presentation. In this Comment, the authors discuss how population-scale genomics can benchmark these approaches and
Genetic ancestry and risk of atrial fibrillation in individuals of Black ethnicity in the UK Biobank
Background Black individuals have a lower incidence of atrial fibrillation (AF) than White individuals, despite a higher burden of traditional risk factors. Prior studies have suggested that European genetic ancestry may contribute to this paradox, but findings have been inconsistent.
Clinical toxicity of ADCs and ICI–ADC combinations: mechanisms, patterns and management
Nature Reviews Clinical Oncology, Published online: 30 July 2026; doi:10.1038/s41571-026-01188-1 With the expanded use of antibody–drug conjugates (ADCs) and immune checkpoint inhibitors (ICIs) in combination, clinicians increasingly face overlapping toxicity profiles with uncertain attribution. The authors of this Review propose
[Editorial] Sex and gender inequality in classical haematology: time to act
Women, girls, and people assigned female at birth still face major shortfalls in health care because of their sex and gender, and classical haematology is no exception. A major disparity between males and females is the much longer time that
Mediators of cell fate decisions in human fetal kidney development identified using spatial transcriptomics
Nature Genetics, Published online: 30 July 2026; doi:10.1038/s41588-026-02679-8 During human development, the human kidney reproducibly generates approximately one million patterned nephrons. Using spatial transcriptomics and functional validation studies, we help identify how ligands and cell–cell interactions coordinate this complex process.
Establishing Normal Blood Loss Thresholds at the Time of Delivery Based on Quantitative Blood Loss
[Editorial] Learning from a decade of progress in amyloidosis
Improving outcomes for people with rare diseases is a major challenge, but it is possible. Amyloidosis is a heterogeneous group of rare disorders in which amyloid (misfolded protein deposits) accumulates in the tissues, causing progressive organ failure. Until recently, it
De-escalation trials in multiple myeloma: past, present and future
Nature Reviews Clinical Oncology, Published online: 29 July 2026; doi:10.1038/s41571-026-01186-3 Current treatment approaches for patients with multiple myeloma are characterized by a ‘more is better’ philosophy aiming for deep and long-term clinical responses. The authors of this Review challenge this
Inflammatory bowel disease and cancer-driving mutations occupy different cellular neighborhoods
Nature Genetics, Published online: 29 July 2026; doi:10.1038/s41588-026-02686-9 With the profound epithelial and stromal remodeling observed in inflammatory bowel disease, why does progression to cancer often take decades? Using a mouse model of early malignant lesions arising from colitis, we
Genomic, epigenomic and transcriptomic regulation of cellular senescence
Nature Reviews Genetics, Published online: 29 July 2026; doi:10.1038/s41576-026-00982-y Senescence — a complex, dynamic and heterogeneous stress-responsive cell state — shapes ageing biology and tissue homeostasis. This Review examines the molecular regulation of senescence initiation, maintenance and propagation, highlighting the
[Editorial] Growing old and well with HIV
For most of the 45 years since HIV-associated illness was first identified, living a long and active life with HIV was not something most people with the virus could imagine. Antiretroviral therapy transformed a prognosis measured in months into a
Electronic cigarettes, smoking and lung cancer risk: some evidence about the continuum of harm
Nature Reviews Clinical Oncology, Published online: 28 July 2026; doi:10.1038/s41571-026-01192-5 Since the introduction of vaping with electronic cigarettes in the late 2000s, controversy has continued to exist regarding the risks and benefits. Many studies indicate that electronic cigarettes are an
Expression of Concern: RE: Is rectal misoprostol really effective in the treatment of third stage of labor? A randomized controlled trial. Am J Obstet Gynecol. 2002 Oct;187(4):1038–1045
Paired mutation calling and spatial transcriptomics identify cellular neighborhoods associated with the neoplastic outcome of mouse colitis
Nature Genetics, Published online: 28 July 2026; doi:10.1038/s41588-026-02673-0 This study uses a mouse model of inflammatory bowel disease to explore how mutations and cellular context combine to drive the transition to malignancy.
JAMA
[Editorial] ILDs: from scientific discoveries to equitable care
On July 8, 2026, the UK Medicines and Healthcare products Regulatory Agency (MHRA) announced the marketing authorisation for the use of nerandomilast in the treatment of adults with two types of pulmonary fibrosis: idiopathic pulmonary fibrosis (IPF) and progressive pulmonary
[Editorial] Indigenous-led cancer control
Aug 9 marks the UN’s International Day of the World’s Indigenous Peoples. Although Indigenous Peoples represent just 6% of the global population, they make up more than 15% of individuals living in extreme poverty worldwide. Indigenous Peoples have a holistic
Toward generalizable and interpretable AI in regulatory genomics
Nature Genetics, Published online: 27 July 2026; doi:10.1038/s41588-026-02670-3 This Review surveys the current landscape of genomic artificial intelligence through the lens of sequence-to-function models, examining how architectural choices, training data, prediction tasks, model interpretation and evaluation strategies can shape their
Towards liquid biopsy-based analysis of antitumour immunity
Nature Reviews Clinical Oncology, Published online: 24 July 2026; doi:10.1038/s41571-026-01181-8 Advances in multimodal analyses of diverse cell types and cellular products present in the blood have presented opportunities to non-invasively and repeatedly assess systemic immune dynamics, predict and monitor responses
Corrigendum to ‘Sublingual or Oral versus vaginal misoprostol for cervical priming prior to first-trimester surgical abortion: a systematic review and meta-analysis’ [American Journal of Obstetrics and Gynecology 234/4 (2026) 980-1002]
The authors regret that the originally published results text included a typographical error in the description of results for duration of procedure (oral vs vaginal; Figure 8). The correct values are: WMD = 0.20 minutes (95% CI, −0.42 to 0.82;
Nanoparticle-enriched mass spectrometry proteomics in British South Asians identifies links between genetic variants, plasma protein levels and disease risk
Nature Genetics, Published online: 24 July 2026; doi:10.1038/s41588-026-02697-6 This study reports genetic effects on mass spectrophotometry-based plasma proteomics in a cohort of ~1,400 British South Asians, accessing parts of the proteome missed by other proteomics platforms. The resulting protein quantitative
Palantir: NHS England is warned by statistics watchdog over FDP claims
The UK’s statistics watchdog has warned NHS England and the Department of Health and Social Care over their claims about the benefits of Palantir’s federated data platform (FDP).1The Office for Statistical Regulation (OSR) examined how NHSE was using statistics to
Non-specific ECG ST-T abnormalities: cardiac repolarisation memory assessment
In this issue of the journal, Shoji et al showed that isolated non-specific ST-segment and T-wave abnormalities (NSSTTAs) are associated with incident heart failure (HF).1 The authors conducted a large prospective general population cohort study of more than 30 000
Liquid Biopsy Cell-free RNA-based Machine Learning Enables Preoperative Risk-Stratification of Uterine Leiomyosarcoma
Accurate preoperative distinction between uterine leiomyoma (UM) and uterine leiomyosarcoma (UMS) remains a major clinical challenge. Misclassification can lead to inadvertent dissemination of occult malignancy during minimally invasive procedures, while cautious management increases the use of more invasive surgery with
Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants
Nature Genetics, Published online: 23 July 2026; doi:10.1038/s41588-026-02685-w Intrinsically disordered regions impose regulatory restraints on gene-activating demethylases, limiting chromatin engagement and preserving genomic stability. This function is a key determinant of the distinct substrate preferences and regulatory activities of FTO
Human genetics across levels of biological organization
Nature Reviews Genetics, Published online: 23 July 2026; doi:10.1038/s41576-026-00991-x Genetic variation influences biological processes across scales; however, deciphering how effects propagate from molecules to whole organisms remains a key challenge in human genetics. In this Review, Laman Trip and Beltrao
UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins
How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3′UTR of an mRNA co-translationally chaperones the protein it encodes, preventing intrinsically disordered regions from making inappropriate contacts. This functionality, localized to
[Editorial] Who owns cardiometabolic disease?
A person with obesity, type 2 diabetes, chronic kidney disease, metabolic dysfunction-associated steatotic liver disease, and heart failure might receive five different diagnoses, attend five different clinics, and be managed according to five different guidelines. But these conditions are not
Association between liver fibrosis severity and impaired myocardial glucose metabolism in subjects with different degrees of glucose tolerance
Introduction Increasing evidence suggests that liver fibrosis is an independent risk factor for cardiovascular disease. However, the mechanisms underlying this increased risk are still unsettled. The aim of this study was to explore the relationship between myocardial glucose metabolism and
Development and validation of a nomogram predicting all-cause mortality for patients with an implantable cardioverter defibrillator
Background For patients with a high risk of sudden cardiac death, despite the benefits of an implantable cardioverter defibrillator (ICD), some patients are still at high risk of death. Aim The purpose of this study was to develop and validate
Clinical characteristics and prognosis of SDHD pathogenic variant carriers: a systematic review and meta-analysis
Background Germline pathogenic variants (PVs) of succinate dehydrogenase subunit D (SDHD) are major genetic causes of pheochromocytomas and paragangliomas. Existing studies have reported inconsistent findings and lack a comprehensive synthesis regarding penetrance, multifocality and metastatic risk in carriers of SDHD
Mandatory, standardised food labelling should be just one element of a multifaceted campaign against obesity
We agree with Vogel that there is an abundance of unhealthy foods in many settings and that obesogenic environments are contributing to the obesity epidemic.1 The Institute of Health Promotion and Education and others have repeatedly called for a clear
A tetraploid wheat pangenome reveals genomic variation and domestication footprints
Nature Genetics, Published online: 22 July 2026; doi:10.1038/s41588-026-02680-1 We constructed a tetraploid wheat pangenome from 12 genomes covering all 10 recognized subspecies. Combined with graph-based pangenome and population genomic analyses, we investigated untapped beneficial alleles, determined domestication trajectories, revealed convergent
[Editorial] Our twenty-five year journey
This August issue marks the 25th anniversary of The Lancet Infectious Diseases. The journal was created in 2001 by our late Editor-in-Chief John McConnell whose vision for a journal for specialists in infectious diseases that could inform public health decisions
PMOS could quadruple risk of heart disease in women, study suggests
Women with polyendocrine metabolic ovarian syndrome (PMOS) face four times the risk of heart disease compared with women without the condition, a study has found.PMOS is a lifelong condition already associated with several health risks such as type 2 diabetes,
Correction: Work participation and disability pension after work-related PTSD: trajectories and impact of occupation
Persson ML, Willert MV, Kyndi M, et al Work participation and disability pension after work-related PTSD: trajectories and impact of occupation. Occupational and Environmental Medicine 2025;82:589-596. This article was previously published with an error. The percentage of patients with a
At a glance
Current burden and future projections of glaucoma in the United Kingdom (see page 850) The authors estimate that over one million UK adults aged≥40 currently have glaucoma. Despite a 28% population increase by 2060, ageing and demographic shifts may drive
Minute particulars
‘He who would do good to another must do it in Minute Particulars. General Good is the plea of the scoundrel, hypocrite and flatterer; For Art and Science cannot exist but in minutely organized Particulars’.1 The poet William Blake expressed
Depressive Symptoms and Associated Factors Among Obstetrics and Gynecology First-Year Residents
Medical training is a high-stress period, and residents in surgical specialties face elevated risk for depression due to demanding schedules, intensity of training, persistent mistreatment, and long work hours. Obstetrics and gynecology (OBGYN) is the only surgical specialty predominantly composed
SUMOylation fine-tunes DNMT1 to silence viral mimicry transcripts
Nature Genetics, Published online: 21 July 2026; doi:10.1038/s41588-026-02595-x DNMT1 binds unmethylated CpG islands at active genes and, upon catalytic inhibition, redistributes to partially methylated, inaccessible regions, triggering viral mimicry via endogenous retroelements and mega-intergenic RNAs. A SUMOlyated pool of DNMT1
JAMA
How a legacy of mistrust in DRC has led to 17 Ebola outbreaks in 50 years
Seventeen Ebola outbreaks in 50 years. The same country, over and over again.On 17 May, the World Health Organization declared a public health emergency of international concern as Bundibugyo virus disease re-emerged in Democratic Republic of Congo (DRC), spreading to
We have recognised inequalities: now we must act
Emergency departments: the great leveller? As a resident doctor working for an eminent and traditional bow-tied cardiologist, I vividly remember how many patients would attend the outpatient clinic in their Sunday best—suits and skirts, shiny shoes. This was in stark
Percutaneous coronary interventions improve phasic cardiac-coronary interaction in chronic coronary syndromes as assessed by wave intensity analysis
Background Clinical benefit of percutaneous coronary intervention (PCI) in chronic coronary syndromes (CCS) remains controversial. Coronary wave intensity analysis (WIA) provides mechanistic insights into cardiac–coronary coupling. Objectives To assess peri-PCI WIA changes at rest and during hyperaemia, and to identify
Does OptiTROP-Lung05 open a new frontier for first-line ADC–ICI combinations in NSCLC?
Nature Reviews Clinical Oncology, Published online: 20 July 2026; doi:10.1038/s41571-026-01183-6 Interim data from the phase III OptiTROP-Lung05 trial demonstrate that adding the TROP2-targeted antibody–drug conjugate sacituzumab tirumotecan to pembrolizumab improves progression-free survival in patients with PD-L1-positive advanced-stage non-small-cell lung cancer.
Promoter strength and position govern promoter competition through transcript-dependent insulation
Nature Genetics, Published online: 20 July 2026; doi:10.1038/s41588-026-02691-y By inserting diverse promoters at the mouse Sox2 locus, Koska et al. show that promoter strength, position and transcript length tune promoter competition through transcription-dependent insulation, independent of CTCF/cohesin, while HUSH silencing
The fascinating evolution of vascular biology: novel mechanisms leading to new therapeutic targets
For image description, please refer to the figure legend and surrounding text.
High cholesterol: FDA approves new pill
A new pill for patients whose cholesterol remains high despite treatment has been approved by the US Food and Drug Administration (FDA).Called Lipfendra, the daily pill can be taken alone or in conjunction with statins.When trialled in patients whose low
Reticular pseudodrusen load is associated with an increased risk of stroke
Background/aims Reticular pseudodrusen (RPD) are increasingly recognised as a distinct phenotype in the age-related macular degeneration (AMD) disease spectrum. This study investigates the association between RPD and cardiovascular outcomes, specifically myocardial infarction (MI) and stroke in the UK Biobank (UKBB).
‘From lab to lifesaving: the evolution of a public health campaign to reduce drownings
Worldwide drowning is a leading cause of accidental loss of life and in the UK accounts for more fatalities than fire or cycling. Because 40% of those that die are under the age of 40 years, the annual number of
Accurate data as the foundation of equitable cancer control: Lessons from global cancer statistics 2024 and the complexity of ovarian cancer
CA: A Cancer Journal for Clinicians, Volume 76, Issue 4, July/August 2026.
Tracking Cesarean Scar Morphology by Sonohysterography After Consecutive Cesarean Deliveries with Endometrium-Free Closure
To evaluate the impact of an endometrium-free closure on uterine scar morphology by comparing sonohysterograms in the same women, first after a cesarean with a standard or an endometrium-free closure, and then after a subsequent cesarean with an endometrium-free closure.
Rethinking Placenta Accreta Spectrum: A Topography-Based Framework for Prenatal Imaging and Individualized Surgery
Placenta accreta spectrum represents one of the most challenging scenarios in complex cesarean delivery, in which abnormal placental adherence coexists with a scarred myometrium. It remains a leading cause of severe obstetric hemorrhage, maternal morbidity, and peripartum hysterectomy. Although prenatal
Cyclosporiasis: as “explosive diarrhoea” sweeps US, what’s behind the outbreak and what is Trump’s role?
An unprecedented cyclosporiasis outbreak is sweeping the US.Cases of the disease, which causes explosive diarrhoea, abdominal cramps, nausea, fatigue, low grade fever, anorexia, and weight loss, have so far been reported in 34 states.1As of 14 July, the US Centers
Comparative performance of stroke risk scores in patients with atrial fibrillation with low stroke risk
Background Australian guidelines recommend the CHA2DS2-VA (congestive heart failure, hypertension, age ≥75 years (double weight), diabetes mellitus, previous stroke (double weight), vascular disease, age 65–74 years) score to identify patients with atrial fibrillation (AF) at low stroke risk who should
Atoms
You mean there’s a risk? Probably… You’d hard pushed (at least I would) to name one part of our clinical lives where what we ‘do’ isn’t at some subliminal level determined/dictated by/influenced by an estimation of risk. This happens mostly
Triple-negative breast cancer: a threshold-defined diagnostic category within a biological continuum
Triple-negative breast cancer (TNBC) is defined in routine practice by the absence of oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) expression using fixed immunohistochemical and in situ hybridisation cut-offs. Although this framework ensures
Second-line 177Lu-edotreotide shows promise in GEP NETs
Nature Reviews Clinical Oncology, Published online: 16 July 2026; doi:10.1038/s41571-026-01187-2 Second-line 177Lu-edotreotide shows promise in GEP NETs
Uterine artery perfusion in pregnancies after artificial frozen embryo transfer (Letter-to-the-Editor)
Pioneer transcription factors direct tissue-specific cohesin chromatin entry and three-dimensional genome organization
Nature Genetics, Published online: 16 July 2026; doi:10.1038/s41588-026-02688-7 Analyses in prostate cancer cell lines show that FOXA1 mediates tissue-specific recruitment of NIPBL to chromatin to orchestrate three-dimensional genome organization, acting in concert with ETS1 and other pioneer transcription factors.
Stomata — guarding the gates against bacterial invasion
Nature Reviews Genetics, Published online: 16 July 2026; doi:10.1038/s41576-026-00994-8 In this Journal Club, Tatsuya Nobori recalls a landmark paper by Melotto et al., who showed that stomata are active components of plant innate immunity rather than passive entry points for
[Editorial] The right medicines for the right reasons
US Secretary of Health and Human Services Robert F Kennedy Jr has suggested that antidepressants are more addictive than heroin and may contribute to school shootings—allegations repeatedly rejected as false. Given this history, the announcement in May, 2026 of a
Spinal muscular atrophy: all babies in England to be screened for rare neuromuscular disease
A national newborn screening programme for spinal muscular atrophy (SMA) will be rolled out throughout England, the government has announced.It comes after campaigners complained that existing plans for a more limited testing programme were unfair.The government announced in April that
Differentiating HFmr/rEF from HFpEF using standard 12-lead ECG measurements: an interpretable machine learning study
Background Differentiating heart failure (HF) with mildly reduced/reduced ejection fraction (HFmr/rEF) from HF with preserved ejection fraction (HFpEF) guides therapy but echocardiography may be delayed or unavailable. We developed and validated machine learning models using routine 12-lead ECG data to
Diffractive optical element (D.O.E) spectacle lenses for myopia prevention and control: a small-scale pilot study among younger Chinese children
Aim To assess the efficacy and safety of diffractive optical element (D.O.E) spectacle lenses in reducing the incidence and progression of myopia compared with currently available myopia control spectacle lenses in younger Chinese children. Methods This randomised, investigator-masked, parallel-controlled, small-scale
Evolving global sexually transmitted infection guidance: translating evidence-based WHO recommendations into clinical practice
Sexually transmitted infections (STIs) remain a major global public health challenge, affecting all regions and disproportionately impacting women, adolescents, key populations and people living in resource-constrained settings. The WHO estimated in 2020 that approximately 374 million new curable infections (chlamydia,
The future of ciltacabtagene autoleucel in multiple myeloma has just begun
Nature Reviews Clinical Oncology, Published online: 14 July 2026; doi:10.1038/s41571-026-01184-5 The future of ciltacabtagene autoleucel in multiple myeloma has just begun
Beyond neurotoxicity: A new face of 6-hydroxydopamine in cancer immunity
In this issue of Neuron, Yu et al. show that 6-hydroxydopamine (6-OHDA) suppresses tumor growth beyond its established sympathetic neurotoxic activity by inducing a macrophage-TH1 immune axis, uncovering an unexpected immunomodulatory role with potential therapeutic implications for breast cancer.
[Editorial] Risk reduction as a crucial part of dementia prevention
Dementia is one of the most pressing health challenges of the 21st century. Around 57 million people were estimated to be living with dementia in 2021, a figure similar to the entire populations of Italy or Kenya; prevalence of dementia
[Editorial] Investing in young people pays dividends
Adolescence and young adulthood can be exciting but vulnerable periods in a person’s life, especially for their mental health. In addition to dealing with complex biopsychosocial changes, young people are confronted by institutions, in educational, health, and justice systems, designed
The beautiful game versus our favourite drug
Politicians in the UK have always been keen to show their footballing credentials and affinity with fans. Keir Starmer, the current UK prime minister, was no different: he was quick to allow English and Welsh pubs to remain open until
Multicentre international audit of IMACS malignancy screening guidelines in idiopathic inflammatory myopathies: insights from the myositis audit and research collaborative group
Background Consensus guidelines for malignancy screening in idiopathic inflammatory myopathy (IIM) were recently published by the International Myositis Assessment and Clinical Studies (IMACS) working group. This international multicentre study audited historical cancer screening practices against IMACS recommendations and examined the
Is it time for the removal of valproate restrictions in men? Further evidence from a new study
In a population-based cohort study by Razaz et al,1 risks of neurodevelopmental disorders in 2051 children of fathers taking valproate monotherapy during spermatogenesis were no different to those taking levetiracetam or lamotrigine. The authors demonstrate how this aligns with several
Resting heart rate and long-term mortality in young adults: a population-based cohort study
Objectives Elevated resting heart rate (RHR) predicts mortality in middle-aged and older adults, primarily through cardiovascular disease (CVD). Whether RHR predicts mortality in young adults, which causes of death are involved and whether the association replicates are unclear. In young
Trends in self-reported current diabetes care use, socioeconomic inequalities, and associated factors in Japan: evidence from the Comprehensive Survey of Living Conditions (1986-2022)
Introduction Long-term trends in diabetes care use and socioeconomic inequalities are not well described in Japan. Research design and methods We analyzed nationally representative data from the Comprehensive Survey of Living Conditions (1986–2022). Diabetes care use was defined as self-reported
Guidelines adherence: from quality indicator to prognostic relevance
The treatment of chronic obstructive pulmonary disease (COPD) has been guided for decades by robust clinical practice guidelines (CPGs), such as NICE1 and GesEPOC,2 as well as international recommendations such as GOLD,3 which provide clinicians with clear recommendations for diagnosis,
From Peril to New Reality: Scientific Advances Transform Pregestational Diabetes in Pregnancy Care and Outcomes
For hundreds of years, pregestational diabetes mellitus was a life-limiting, devastating diagnosis managed by extreme caloric restriction, but with the inevitable outcome of wasting and death within months to a few years. The maternal mortality rate was unacceptably high (over
The need to consider complexity in the future of behavioral genetics
Nature Genetics, Published online: 14 July 2026; doi:10.1038/s41588-026-02668-x Human behavior is often framed around the ‘nature versus nurture’ debate, but a ‘this or that’ dichotomy does not reflect the current research in genetics and hinders meaningful dialogue. We describe a
Philippe Bousso (1971–2026)
In April of this year, our community lost one of its most brilliant and beloved members, Philippe Bousso. With his unique scientific vision, love of technical innovation, and his generous and kind spirit, Philippe touched many of our lives and
[Editorial] Innovation is key to transforming future obesity care
On June 27, 2026, the UK Government announced 12 innovative pilot projects that will be funded by the Obesity Pathway Innovation Programme (OPIP)—an initiative to transform future obesity care in the UK. A partnership between Government and industry, OPIP funded
JAMA
Place based working and devolved decision making could be the right prescription for health and social care
As prime minister in waiting, Andy Burnham’s speech in Manchester in late June offers some clues about his vision for health and social care.1 Burnham’s speech drew on his experience since 2017 as elected mayor of Greater Manchester to make
Correction: Early versus delayed EKOS thrombolysis in intermediate-high risk pulmonary embolism: a retrospective multicentre analysis
10-year anniversary of BMJ Open Ophthalmology
Editors commentary
Medical training historically was an apprenticeship. Trainees would work with a consultant, usually for an extended time, to build competence through collaboration. Oftentimes this was as part of a team (a ‘firm’ in the UK) with other trainees. This provided
Impact of vehicular data on trauma outcomes after motor vehicle crashes
Introduction Field triage guidelines exist to inform first responder personnel on criteria to expedite the transfer of motor vehicle collision (MVC) patients to trauma centers; however, these guidelines are minimally informed by the vehicle characteristics and collision characteristics. Given this,
OpenIO: An open framework for AI-native immunotherapy
We propose Open Immune Oncology (OpenIO), a framework integrating generative AI and omics to advance precision oncology. By leveraging biological scaling laws and foundation models, we aim to transition immunotherapy from empirical screening to rational, AI-native engineering of therapeutic interventions.
Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions
Nature Genetics, Published online: 13 July 2026; doi:10.1038/s41588-026-02674-z This study examines interactions between polygenic scores and pairs of environmental contexts across seven diseases and introduces the proportion needed to benefit as a metric to quantify the expected effectiveness of interventions
Folding a broken genome: the versatile roles of cohesin in genome maintenance
Nature Reviews Genetics, Published online: 13 July 2026; doi:10.1038/s41576-026-00988-6 The protein complex cohesin shapes 3D genome organization through both cohesion and loop extrusion. The authors review the roles of these two mechanistic functions in the cellular response to DNA double-strand
Epidemiological studies impacting clinical practice
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GP practices could close from NHS England’s “list cleansing” drive, doctors warn
An “aggressive” drive by NHS England to remove so called “ghost patients” from GP lists is posing an “existential threat” to practices and could even force closures, family doctors have warned.“Ghost patients” are those who remain on a practice patient
Incidence of post-procedural atrial fibrillation after multivessel percutaneous coronary intervention versus coronary artery bypass grafting: a nationwide observational study
Background Postoperative atrial fibrillation (AF) is a common complication after coronary artery bypass grafting (CABG) but is less well characterised after multivessel percutaneous coronary intervention (MV-PCI). With the increasing use of MV-PCI, we compared the incidence and clinical implications of
Ischemic Placental Disease and Hospitalization for Neurological and Psychiatric Disorders
Ischemic placental disease, a syndrome that comprises preeclampsia, placental abruption, and fetal growth restriction, is characterized by ischemic, endothelial, and microvascular dysfunction. These processes, in turn, may serve as sentinel markers of maternal brain vulnerability, resulting in structural abnormalities, altered
Chloroplast sunscreen enhances rice yield
Nature Genetics, Published online: 10 July 2026; doi:10.1038/s41588-026-02699-4 Chloroplast sunscreen enhances rice yield
Pakistan arrests Afghan doctor during surgery amid visa fallout
Pakistani police have arrested an Afghan resident doctor mid-operation amid rising political tensions in the country.Pakistan recently decided to expel all Afghans in its borders without a valid visa, as a row deepens with the Taliban in Kabul. The move
Associations of academic performance, sports participation, disordered eating and menstrual cycle irregularities in adolescents: a population-based study
Background Regular menstruation is an important indicator of well-being in adolescent females. We aimed to assess risk factors associated with menstrual cycle irregularities in a population-based cohort of high school students. Methods In the fall of 2022, we recruited a
Prevalence, incidence, mortality, and years of life lost to diabetes from 1996 to 2024 in Denmark
Introduction Population-based surveillance is essential for quantifying the burden of diabetes and monitoring temporal changes. In Denmark, nationwide health registers enable long-term surveillance of type 1 diabetes (T1D) and type 2 diabetes (T2D). We aimed to estimate trends in prevalence,
Establishing research priorities in abortion care: the importance of a UK-wide partnership approach
Abortion is a core component of reproductive healthcare and one of the most common clinical experiences of people’s lives.1 In the UK, however, it remains disproportionately under-researched relative to its prevalence and importance. The 2019 National Institute for Health and
Staphylococcus aureus is not a stand-alone indication for cardiac surgery in patients with infective endocarditis
Infective endocarditis (IE) is a complex and severe disease with in-hospital mortality plateauing at ~20% and 1 year mortality up to 40% in most contemporary cohorts. Although 60–70% of patients with IE present theoretical indication(s) for surgery,1 cohort studies report
CRISPR in clinical oncology: translational advances from molecular diagnostics to therapeutics
Nature Reviews Clinical Oncology, Published online: 09 July 2026; doi:10.1038/s41571-026-01179-2 CRISPR–Cas technologies provide a modular, programmable platform for sequence-specific targeting of DNA or RNA and have advanced from experimental molecular biology tools to clinical translation. This Review describes current and
Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries
Abstract This article provides updated global cancer statistics for the year 2024 based on the GLOBOCAN estimates of the International Agency for Research on Cancer. The authors describe national cancer incidence and mortality by world region and the Human Development
Misoprostol administration routes for cervical priming in first-trimester surgical abortion (Reply to Letter-to-the-Editor)
Photosynthetic medicine: Engineering a plant-derived nanofoundry to power mammalian cells
Mammalian eyes receive constant visible light yet lack photosynthesis. Xing et al. engineer an intact thylakoid grana nanoparticle enabling light-driven NADPH production within corneal cells, restoring antioxidant defenses and interrupting inflammatory cycles in dry eye disease. This work positions borrowed
[Editorial] Ending HIV: a reality check
The fifth UN High-Level Meeting on HIV/AIDS (June 22–23) saw the agreement of a new Political Declaration on HIV/AIDS. In it, countries expressed commitments to end AIDS as a public health threat by 2030, mobilise adequate resources, achieve the 95–95–95
Natural birth ideology and the unavoidable challenge of avoidable harms
The startling safety data from two new reviews on maternity services might be expected to trigger immediate measures for improvement. However, the likelihood is that nothing will change quickly. The reasons for this dispiriting conclusion include the simple fact that
Effects of early continuous renal replacement therapy in critically ill patients requiring ECMO treatment: results of a randomised controlled trial
Background Extracorporeal membrane oxygenation (ECMO) is increasingly used to treat patients with severe cardiac and pulmonary failure but the complications of acute kidney injury and fluid overload are common. We aimed to determine whether the early initiation of continuous renal
Acute radiating gluteal pain caused by obturator internus muscle endometriosis
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing
Nature Genetics, Published online: 08 July 2026; doi:10.1038/s41588-026-02675-y This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combination, identifying those essential for
[Editorial] Drugging the undruggable in pancreatic cancer
A new drug for pancreatic cancer set ASCO abuzz this May, uniting the plenary hall in standing ovation—in a phase 3 trial, the RAS inhibitor daraxonrasib nearly doubled overall survival in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC). Pancreatic cancer
Gaza: Imprisoned Palestinian paediatrician’s health deteriorates—“They brought me here to kill me”
The health of Hussam Abu Safiya, a paediatrician who has been held by Israeli authorities for 18 months over unsubstantiated allegations of ties to Hamas, is rapidly deteriorating.In a statement to the media Safiya’s lawyer, Nasser Odeh, said that the
Fantoms
Serial physical examination to reduce unnecessary antibiotic exposure in newborn infants Anlaug Vatne and colleagues report the outcome of a multicentre interventional study from six Norwegian tertiary and secondary level NICUS to assess whether serial physical examination (SPE) in neonatal
Incidence and risk factors for permanent pacemaker implantation following aortic root surgery
Background Permanent pacemaker implantation (PPI) remains a serious complication following aortic root replacement (ARR) and valve-sparing root replacement (VSRR). This is due to the proximity of the atrioventricular node and the bundle of His to the aortic valve annulus and
Correction: Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases
Sullivan KM, Jiang X, Guha P, et al. Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases. Gut 2023;72:325-337. Following publication of this article on additional review of prior data, the following errors were noted
Correction: Fasting and sports: a summary statement of the IOC workshop
Maughan RJ, Al-Kharusi W, Binnett MS, et al. Fasting and sports: a summary statement of the IOC workshop. British Journal of Sports Medicine 2012;46:457. The author, Pamela Venning, name has been corrected online only.
Double versus single emergency cervical cerclage combined with vaginal progesterone: a multicenter, non-blinded, randomized controlled trial
Emergency cervical cerclage is used to reduce extreme preterm birth in women with advanced cervical dilatation and exposed fetal membranes. Although double-level cerclage has been proposed to provide greater mechanical support than single-level cerclage, evidence comparing these techniques in emergency
Toward a framework for measuring the impact of ELSI research
Nature Genetics, Published online: 07 July 2026; doi:10.1038/s41588-026-02659-y Despite growing investment in research addressing the ethical, legal and social implications (ELSI) of genomics, the field lacks frameworks for measuring the impact of ELSI on policy, governance and institutional practice. This
FGF21 connects ER stress to sulfide signaling to enhance cellular resilience
Fibroblast growth factor 21 (FGF21) is a stress-induced endocrine hormone that regulates metabolism. Grandl et al. show that FGF21, through its receptor β-klotho (KLB), enhances sulfide signaling and hydrogen sulfide production, strengthening the unfolded protein response and integrated stress response
[Editorial] Children and adolescents in the humanitarian response
World Refugee Day on June 20 is a sobering reminder that 1·4% of the world’s population is forcibly displaced today. According to the UNHCR’s latest Global Trends report, at the end of 2025, there were an estimated 41·6 million refugees
JAMA
Continental heatwave: Fires blaze across Europe
bmj;394/jul07_14/e100214/FAF1faJean-Christophe Milhet / AFP / GettyFrance’s civil security service drops water on a wildfire in the southern department of Pyrénées-Orientales, where 700 firefighters battled a huge blaze on 5 July. More than 10 000 people were evacuated.Wildfires in France, Spain,
Artificial intelligence-based tools to address current gaps in transition to adult care for youth with chronic surgical conditions: a perspective piece
Development and assessment of an assisted diagnosis model using machine learning for identifying adult-onset Stills disease in fever of unknown origin: a retrospective study in China
Background Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disorder lacking a gold-standard diagnostic criterion. Objective To develop and validate a clinically applicable model for identifying AOSD among patients with fever of unknown origin (FUO) who have clinical suspicion for
Standard vs. Lower Pressure Pneumoperitoneum in Laparoscopic Gynecologic Surgery: A Randomized Controlled Trial
Postoperative pain following laparoscopic surgery can delay recovery and increase opioid use. Lower insufflation pressures have been consistently shown to reduce pain in general surgery procedures, but their impact in gynecologic surgery is not well established.
Genetic analysis of imaging-derived phenotypes
Nature Reviews Genetics, Published online: 06 July 2026; doi:10.1038/s41576-026-00989-5 When integrated with genetic data, imaging-derived phenotypes (IDPs) enable large-scale analyses of genotype–phenotype relationships. Bian and Akey review analytical approaches to derive IDPs, key biological insights from genetic studies of imaging
Update on lipoprotein(a): the rising star in residual lipid risk
For image description, please refer to the figure legend and surrounding text. For the podcast associated with this article, please visit https://academic.oup.com/eurheartj/pages/Podcasts.
JAMA Pediatrics
Vision: JAMA Pediatrics will be the most respected source of information for investigators, providers, and policy makers seeking the highest quality evidence to guide decision-making.
The hand surgeon who sailed in the wake of Captain Cook
Claire Edwards’s role as a consultant orthopaedic surgeon at Norfolk and Norwich University Hospitals NHS Foundation Trust gives her “that joy of working with your hands and making a visible and functional difference.”“You see change happen before your eyes. Using
Time to monitor the mental health of esports athletes
The International Olympic Committee’s (IOC) recent announcement of the Olympic Esports Games signals a new era of institutional recognition for esports players and the field. Despite the elevation of esports to Olympic status, the accompanying attention to protecting and enhancing
Serious mental illness and cancer: A call to action for equitable care
Abstract Cancer advances are not distributed equitably among many segments of the population. Specifically, individuals with serious mental illness (SMI) face compounded disparities in cancer detection, treatment, and survival. SMI, characterized by conditions such as schizophrenia, bipolar disorder, and severe
Association of Surgical Approach with Oncologic Outcomes in Low-Risk Cervical Cancer
Recent randomized evidence suggesting that simple hysterectomy is non-inferior to radical hysterectomy in cervical cancer patients with low-risk disease has invigorated questions about the safety of a minimally invasive approach in this population.
Trends in Infertility Treatments by Race, Ethnicity, Socioeconomic Status, and Region in U.S. Birth Certificates from Live Births: 2011–2022
Understanding national trends and disparities in infertility treatment utilization and modalities is crucial for equitable reproductive care. We examined age-standardized rates of infertility treatment utilization and specific treatment modalities among birthing individuals in the U.S. from 2011 to 2022, and
Uganda confirms Marburg case as Ebola outbreak continues
A new case of Marburg disease has been registered in Uganda, the World Health Organization (WHO) has confirmed.Teams are already on the ground to help the East African country stem the spread as it continues to battle Ebola, said WHO.
Dual-stage deep learning framework for neuroblastoma differentiation by integrating cell segmentation and multiscale modeling
Background As the most common extracranial solid tumor in children, accurate and consistent pathological diagnosis of neuroblastoma (NB) is critical for clinical decision-making. However, traditional methods relying on manual interpretation are constrained by tumor heterogeneity and inter-observer variability, necessitating the
Extracellular vesicles exposing complement split products are associated with kidney involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)
Background The complement system is crucial in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) pathogenesis. Extracellular vesicles (EVs) serve as carriers of bioactive substances, influencing the immune system. We aimed to investigate myeloperoxidase-positive EVs (MPO+EVs) exposing complement components (C3a, C4d), terminal complement
Reference equations for peak oxygen uptake during cycle ergometry based on body composition estimates
Objectives To derive sex-specific peak oxygen uptake (VO2peak) reference equations for cycle ergometer cardiopulmonary exercise testing (CPET) that integrate estimations of lean body mass (eLBM) and body fat percentage (eBF) based on sex, age, height and weight. Methods We pooled
From repair to relay: Human retinal organoids re-couple a severed optic nerve
Restoring vision after complete optic nerve transection has long seemed out of reach. In this issue of Cell Stem Cell, Gong et al. now show that human retinal organoids transplanted into the lesion form a chimeric host-graft bridge capable of
[Editorial] Ebola outbreak: why haematology matters
As of June 3, WHO Director-General Tedros Ghebreyesus reported 344 confirmed cases of Ebola virus disease in DR Congo, as well as 15 confirmed cases in Uganda. Encouragingly, suspected cases in the DR Congo have fallen, as efforts continue to
Building up pangenome analysis block by block
Nature Genetics, Published online: 02 July 2026; doi:10.1038/s41588-026-02656-1 Graph-based pangenome representations are computationally and visually challenging. A linear representation of the Brassica ‘A’ genome based on syntenic pan-blocks offers an intuitive framework for tracing the evolutionary history of important crop