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Due to a unique immune substrate consisting of abundant lymphocytic infiltration, high programmed death–ligand 1 (PD-L1) expression, and the presence of several immune targets (CD40, CD70, CD80, and CD86), there is a strong biological rationale for incorporating immunotherapy in the

The UK has detected its first human case of a new strain of influenza, A(H1N2)v, in a person who experienced mild respiratory illness but has now recovered, the UK Health Security Agency (UKHSA) has reported.The agency said that, based on

NHS and care leaders have called for the government to abandon plans to restrict the number of family members overseas health and social care workers can bring with them to the UK, which they say will be “ruinous” for services.The

Why are you shouting?It’s good news! Scientists at the University of California, Davis, think they’ve found why some people develop a headache after drinking red wine.But I only had one glassIt doesn’t matter: they say that a typical “red wine

The Global Commission on Drug Policy’s latest report, published ahead of World AIDS Day on Dec 1, describes decriminalisation of drug use as an essential precursor to ending HIV and viral hepatitis as public health threats. Since its formation in

Last year I returned to clinical practice in the UK as a paediatric registrar after taking a two year break. I needed a medical refresher, so I attended a compulsory two day course on managing the acutely unwell child. I

Itch exacerbates infection and inflammation-associated skin pathology. In this issue of Cell, Deng et al. identify a V8 protease released by Staphylococcus aureus triggering itch via neuronal protease-activated receptor 1. In so doing, they uncover profound consequences of microbial neurosensory modulation

bmj;383/nov22_11/p2750/FAF1faPhoto credit: Jane AllisonVincent Marks was the star expert witness who helped to secure the conviction of British child killer Beverly Allitt and the acquittal of Claus von Bülow, the playboy lawyer originally convicted of killing his heiress wife by

More than 16 million units of blood are transfused in the US each year. Blood transfusion is a cornerstone of modern medicine and far from a new idea. The first successful human blood transfusion was nearly 250 years ago, now

Behind every data scientist and entrepreneur celebrating the powers and potential of artificial intelligence (AI) to enhance modern healthcare, there is a silent majority who are more circumspect. Of course, big data and disruptive technologies in healthcare are not new.

We thank Zhang for comments regarding our article.1 Urinary tract infections are overdiagnosed among older adults and judicious antimicrobial use to prevent patient harms and antimicrobial resistance is needed.2We would, however, caution against the idea that the negative predictive value

More patients in England could get care directly from community pharmacists, after a government agreement on access to contraception services, blood checks, and some minor conditions.NHS England estimated the scheme could prevent more than 1350 heart attacks and strokes in

For the first time, a Lancet Commission is dedicated to the history of medicine: Nazi medicine. The report, The Lancet Commission on medicine, Nazism, and the Holocaust: historical evidence, implications for today, teaching for tomorrow, launched on Nov 9, is

UK regulators have approved a “world first” gene treatment for treating sickle cell disease and transfusion dependent β thalassaemia.Casgevy (exagamglogene autotemcel) is the first medicine using the gene editing tool CRISPR to be licensed for use in patients. The decision

Patients referred to the NHS’s national diabetes prevention programme in England have seen improvements in key cardiovascular risk factors including reductions in blood glucose levels and body weight, a study1 published in Nature has reported.US researchers said their evaluation of

Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.

Accelerating climate change and loss of biodiversity have created a global health emergency.1The record heatwave in France in 2003 was responsible for over 14 000 excess deaths. France has experienced higher temperatures since then, but its 2004 national heat wave

A weekly injection of semaglutide (Wegovy) resulted in a 20% reduction in the risk of death from major cardiovascular events in people classed as overweight or obese who were not diabetic, according to trial results published in the New England

Gambling is often seen as a bit of harmless fun: a light-hearted flutter on a sporting event or a quick try with a scratch card. But gambling harms physical and mental health and can do wider damage to societies. One

Chickenpox was not a helpful analogueGiving evidence on 8 November,1 Mark Sedwill, the former cabinet secretary and head of the civil service, apologised for proposing in private that a “chickenpox party” approach, to deliberately exposed people to SARS-CoV-2, might be

Elea-Maria Abisamra is an honors undergraduate student and research fellow at Virginia Tech. She is majoring in Cognitive & Behavioral Neuroscience and has passions for STEM, writing, and entrepreneurship. In June 2022, Elea acted on her dream and founded Kids

This is a 12×6 mm soft, pink nodule with a small area of ulceration in the right axilla of a man in his late 60s with a history of basal cell carcinomas (fig 1). The lesion was asymptomatic and had

The World Health Organization has called on governments to ensure that outdoor workers are protected from the sun, as new estimates show that nearly one in every three deaths from non-melanoma skin cancer is caused by exposure to solar ultraviolet

In the Letter to the Editor titled “Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab and Remission Induction in ANCA-Associated Vasculitis,” published in the October 19, 2021, issue of JAMA, incorrect study data were reported. The sentence in the second paragraph

Minerva, 14 OctoberNeeds opening sentence to Minerva RefMinerva reports that more than 10% of people admitted to coronary care units had recently used recreational drugs.1Although traditional recreational drugs such as heroin, cocaine, and amphetamines are still prevalent in the UK,

A GP specialty trainee who claimed nearly £10 000 in sick pay from one NHS trust while doing locum work for another has been suspended from the UK medical register for nine months.Tracy Landu-Landu, 30, admitted lying to a human

The BMA’s GP committee for England (GPC England) has called for an immediate pause in the recruitment of physician associates (PAs) in general practice.In an emergency motion passed on 2 November the committee expressed “concerns over the increasing trend of

The field of human embryology has seen major scientific breakthroughs in the past decade. In 2016, researchers were able to culture human embryos for up to 14 days for the first time, whereas previous techniques could reach only 7 days.

Oliver discusses the right comparisons for NHS doctors’ pay.1 There is no “right” comparison. Happiness is relative and a choice. I choose to compare myself to my father, who was a general practitioner in Malaysia who was still working longer

bmj;383/oct31_11/p2526/FAF1faMarianne KellyHealth professionals, including hospital doctors and GPs, took part in a “die in” outside JP Morgan Chase’s London offices on 18 October to highlight the bank’s investment role in fossil fuel extraction, which the protesters say is driving increasing

We amended this feature article by Katharine Lang, published on 25 October 2023 (BMJ 2023;383:p1612, doi:10.1136/bmj.p1612), to correct the author affiliation, which was stated incorrectly as London.

bmj;383/oct27_10/p2485/FAF1faPaul Dominic Martin was born in Stockport, Greater Manchester. When he was young, his draughtsman father relocated the family as “Ten Pound Poms,” so his secondary education began in Tasmania. After only a couple of years the family returned to

Semantics and lack of data have clouded our understanding about menopause in non-human mammals. The traditional definition of menopause based on the last menstrual bleed is limited and hinders cross-species comparison. Here, we redefine it as the permanent cessation of

This year, Sri Lanka marks 75 years of independence from the British as well as the 200th anniversary of the arrival of the Malaiyaha Tamil community, brought from South India to work on colonial plantations. Much is owed to this

bmj;383/oct26_10/p2488/FAF1faUchenna Okoye, a renowned cosmetic dentist, author, and TV personality, who treated complex, restorative cases at St George’s Hospital, Tooting, and was an active spokesperson for the British Dental Association, has died suddenly at the age of 53.Uchenna Okoye was

Contract negotiations between the Welsh government, NHS Wales, and BMA Cymru Wales’s General Practitioners Committee (GPC Wales) have ended without resolution, the BMA has said.A letter sent to GPs in Wales1 by the GPC Wales chair, Gareth Oelmann, said that

The Original Investigation titled “Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial,” published on January 12, 2023, was corrected to fix the description of how the medications

One of the key roles of the general practitioner is to stratify risk and manage multiple undifferentiated, covarying, evolving illnesses. The key objective is not always to arrive at a definitive conclusion or diagnosis, but to act as a gateway

Members of the Royal College of Anaesthetists have voted through six resolutions proposed by grassroots campaigners who have opposed the expansion of anaesthesia associates, in an extraordinary general meeting held last week.In all, 89% of college members at the virtual

As someone who spent his career teaching medical students about uncertainty, I appreciated Launer’s reflection.1Richard Smith, a former editor of The BMJ, gave similar advice 20 years ago.2 He quotes the famous aphorism of Dave Sackett: “Half of what you’ll

Is the USA finally taking the issue of guns more seriously? A new White House Office of Gun Violence Prevention has been formed, overseen by Vice President Kamala Harris. It will help to implement legislation to curb the major harms

Rhythm and reviewsBack in those dark early days of my medical career it seemed that inpatients developed atrial fibrillation on a daily basis, and much time was spent stressing about zigzagging INRs. When a patient’s underlying illness improved, often the

Scarlett McNally, 23 SeptemberMcNally is right, the new strategic framework for major conditions accurately details our current burden of ill health and some of our future major public health challenges.1 We also agree that the solutions in the framework are

Cardiovascular disease (CVD) is the leading cause of death in the US and is responsible for extensive costs to the health care system. Although CVD mortality rates declined over the past several decades in the US, this decline has recently

Abbasi says that the importance of sharing data and code from research is obvious.1 As epidemiologists, our research involves using large routine healthcare databases, for which data sharing is not a legal possibility. Although data sharing may not be possible,

“At the end of the day people won’t remember what you said or did, they will remember how you made them feel”—Maya Angelou.McCartney says that the General Medical Council should not make recommendations related to kindness.1 Kindness in a caring

Pregnant women are being urged to get the covid vaccine after an expert group found that “confused messaging and vaccine hesitancy” may have contributed to the deaths of 27 women during the pandemic in the UK.The women who died from

ADP-ribosylation of proteins and nucleic acids regulates various cellular functions in all kingdoms of life, and its manipulation holds potential for human therapeutics. 60 years after the discovery of ADP-ribosylation, this review provides state-of-the-art insights on structural biology, biochemistry, cell