Is clonal hematopoiesis ‘mostly harmless’?

Nature Genetics, Published online: 23 November 2023; doi:10.1038/s41588-023-01556-y Whole-genome sequencing data of individuals from the UK Biobank and Iceland and a somatic mutation barcoding strategy enabled detection of clonal hematopoiesis at scale. This comprehensive study provides insights into the epidemiology,

Staphylococcus scratches its itch

Itch exacerbates infection and inflammation-associated skin pathology. In this issue of Cell, Deng et al. identify a V8 protease released by Staphylococcus aureus triggering itch via neuronal protease-activated receptor 1. In so doing, they uncover profound consequences of microbial neurosensory modulation

At a glance

Risk factors for corneal ulcers: a population-based matched case-control study in Nepal (see page 1771) This population-based matched case-control study in Nepal evaluated risk factors for corneal ulcer. We found that ocular injury, manual labour, and lower education were associated

Combination neoadjuvant therapies are paving the way for bladder preservation to become the standard for selected patients

Nature Reviews Clinical Oncology, Published online: 17 November 2023; doi:10.1038/s41571-023-00841-3 Neoadjuvant cisplatin-based combination chemotherapy followed by radical cystectomy with pelvic lymphadenectomy is the current standard therapy for cisplatin-eligible patients with muscle-invasive bladder cancer (MIBC). A phase II trial testing treatment

Changes in prevalence of Mycoplasma genitalium macrolide and fluoroquinolone resistance: notes from a 13-year retrospective survey in Dalarna County, Sweden

Objective Macrolide and fluoroquinolone resistance in Mycoplasma genitalium (MG) is of emerging global concern. Compared with neighbouring countries such as Denmark, Sweden has had lower rates of macrolide resistance while fluoroquinolone resistance rates are less well documented. This study retrospectively

Gene of the month: GATA3

GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity. During development, GATA3 plays a key role in


The new turquoise A good case could be made for awarding the dynamics of etymology the (centuries overdue) ‘official’ eighth wonder of the world award. I concede this is a more nebulous entity than the already recognised (edificial) jaw-droppers making

New ingredients for old recipes

Nature Genetics, Published online: 16 November 2023; doi:10.1038/s41588-023-01591-9 The pancreas is an essential organ present in all vertebrates, and human pancreatic agenesis is an extremely rare disorder of largely unknown genetic determinants. A study now demonstrates that a primate-specific regulatory

Correspondence on “Safety of vaccination against SARS-CoV-2 in people with rheumatic and musculoskeletal diseases: results from the EULAR Coronavirus Vaccine (COVAX) physician-reported registry” by Machado et al

We read with great interest the article by Machado et al who describe safety of vaccination against SARS-CoV-2 in people with rheumatic and musculoskeletal disease.1 The authors observed that vaccine against SARS-CoV-2 is well tolerated with rare report of I-RMD

Comparative cardiovascular outcomes of novel drugs as an addition to conventional triple therapy for heart failure with reduced ejection fraction (HFrEF): a network meta-analysis of randomised controlled trials

Background Currently, there is no head-to-head comparison of novel pharmacological treatments for heart failure with reduced ejection fraction (HFrEF). A network meta-analysis aimed to compare effects of both conventional and alternative drug combinations on time to develop primary composite outcome

Incorrect Study Data

In the Letter to the Editor titled “Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab and Remission Induction in ANCA-Associated Vasculitis,” published in the October 19, 2021, issue of JAMA, incorrect study data were reported. The sentence in the second paragraph

Corrigendum to ‘A comparison of criteria for defining metabolic acidemia in live born neonates and its effect on predicting serious adverse neonatal outcomes’. [American Journal of Obstetrics and Gynecology 229/4 (2023) 439-440]

The authors regret an error in the manuscript and the long video narration. In the last sentence of the results section of the manuscript, the text should read, “Furthermore, the positive predictive value (PPV) of the ACOG criteria was calculated

Delivery outcomes in the subsequent pregnancy following the conservative management of placenta accreta spectrum disorder: A systematic review and meta-analysis

Cesarean hysterectomy is generally presumed to decrease maternal morbidity and mortality secondary to placenta accreta spectrum disorder (PAS). Recently, uterine-sparing techniques have been introduced in conservative management of PAS to preserve fertility and potentially reduce surgical complications. However, despite often


Though he’d gained a little weight since the height of his legal sparring prowess, he still had an aura, a charisma which few of his high street rivals could even start to muster, let alone match. He pulled some of

Paul Dominic Martin

bmj;383/oct27_10/p2485/FAF1faPaul Dominic Martin was born in Stockport, Greater Manchester. When he was young, his draughtsman father relocated the family as “Ten Pound Poms,” so his secondary education began in Tasmania. After only a couple of years the family returned to

Do mammals have menopause?

Semantics and lack of data have clouded our understanding about menopause in non-human mammals. The traditional definition of menopause based on the last menstrual bleed is limited and hinders cross-species comparison. Here, we redefine it as the permanent cessation of

Shortcomings and Disparities in Contraception Counseling and Use by Hypertensive Individuals at Risk for Unintended Pregnancy: A Comparative Analysis of the National Survey of Family Growth 2015-2019

Hypertension is a leading cause of adverse pregnancy outcomes. These outcomes disproportionately affect Black individuals. Reproductive life planning that includes patient-centered contraception counseling could mitigate the impact of unintended pregnancy.

At a glance

Associations between visual impairment, incident falls and fall frequency among older Asians: longitudinal findings from the Singapore Epidemiology of Eye Diseases Study (see page 1590) Baseline bilateral but not unilateral visual impairment (VI) conferred nearly two-fold higher odds of any


Estimated neonatal survival for very preterm births in the UK Sarah Seaton et al have provided valuable new outcome information about extremely preterm babies born in the UK between 2016 and 2020. These data will be highly valuable in discussions

Associations between antipsychotics and the risk of incident cardiovascular diseases in individuals with schizophrenia: a nested case-control study

Background The association between antipsychotics and cardiovascular diseases (CVDs) remains significant yet unestablished, especially in Chinese populations. Objective To investigate the risk of CVDs associated with antipsychotics among Chinese individuals with schizophrenia. Methods We conducted a nested case–control study on

New kids on the block: FOS and FOSB gene

FOS and FOSB proto-oncogens are involved in a wide variety of tumourigenic processes. FOS and FOSB gene rearrangements are observed in epithelioid haemangioma, pseudomyogenic haemangioendothelioma, osteoid osteoma/osteoblastoma/cementoblastoma and proliferative myositis/fasciitis. In this review, we provide an overview of FOS and

High prevalence and incidence of gonorrhoea and chlamydia in young women eligible for HIV pre-exposure prophylaxis in South Africa and Zimbabwe: results from the HPTN 082 trial

Introduction We investigated the prevalence, incidence and factors associated with sexually transmitted infections (STIs) among young African women seeking HIV pre-exposure prophylaxis (PrEP). Methods HPTN 082 was a prospective, open-label PrEP study enrolling HIV-negative sexually active women aged 16–25 years

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