Highlights from this issue

Optical coherence tomography angiography in preclinical Alzheimer’s disease (see page 157) In this study, an increased retinal vessel density was observed in cognitively normal individuals positive for cortical amyloid-beta on positron emission tomography. This suggests that vessel density might be

Exploratory analysis of front-line therapies in REVEL: a randomised phase 3 study of ramucirumab plus docetaxel versus docetaxel for the treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy

Introduction Non-small-cell lung cancer (NSCLC) is a heterogeneous disease. Front-line therapy may affect responses to subsequent treatment regimens, thus influencing second-line therapy decision making. In the randomised phase 3 REVEL study, second-line ramucirumab plus docetaxel (ram+doc) versus docetaxel (doc) improved

Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: the Nordic-Baltic Bifurcation Study IV

Background It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to

Suicide

Throughout the world, approximately 800,000 people die by suicide every year, accounting for 1.5% of all deaths. Suicide is the 10th leading cause of death in North America and the foremost cause of death worldwide among persons 15 to 24

Suicide

Throughout the world, approximately 800,000 people die by suicide every year, accounting for 1.5% of all deaths. Suicide is the 10th leading cause of death in North America and the foremost cause of death worldwide among persons 15 to 24

Familial adenomatosis polyposis-related desmoid tumours treated with low-dose chemotherapy: results from an international, multi-institutional, retrospective analysis

Introduction Desmoid tumour (DT) is a locally aggressive fibroblastic proliferative disease representing the most common extraintestinal manifestation of familial adenomatosis polyposis (FAP). As data on the activity of chemotherapy in these patients are limited, we examined the outcomes of patients

Baroreflex Dysfunction

The autonomic nervous system innervates all body organs, including the cardiovascular system. Smooth muscle in arteries, arterioles, and veins and pericytes in capillaries receive autonomic innervation, which modulates vascular smooth-muscle tone and vessel diameter. Afferent sensory neurons with…

Eva Raik

bmj;368/jan10_10/m91/FAF1faBorn in Prague, Eva Raik graduated from the Medical School of Sydney University in 1959. She completed a postgraduate medical course at Hammersmith Hospital, London, in…

Defeating Schistosomiasis

Schistosomiasis is an ancient, neglected parasitic disease caused by blood flukes (trematode worms) of the genus schistosoma. Affecting an estimated 200 million persons in 78 countries, the disease is intimately associated with poverty and is grossly debilitating, leading to chronic

Nature Genetics, Published online: 07 January 2020; doi:10.1038/s41588-019-0537-1 Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial

Objective To determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment of periodontitis in patients with type 2 diabetes mellitus. Research design and methods In this double-blind, randomized clinical trial, a total of 42

Head and Neck Cancer

Although head and neck cancer is associated with pain, disfiguration, dysfunction, psychosocial distress, and death, recent advances have brought substantial improvements in outcomes. The introduction of immune-checkpoint inhibitors for treatment of recurrent or metastatic head and neck cancer led…

Defeating Schistosomiasis

Schistosomiasis is an ancient, neglected parasitic disease caused by blood flukes (trematode worms) of the genus schistosoma. Affecting an estimated 200 million persons in 78 countries, the disease is intimately associated with poverty and is grossly debilitating, leading to chronic

Defeating Schistosomiasis

Schistosomiasis is an ancient, neglected parasitic disease caused by blood flukes (trematode worms) of the genus schistosoma. Affecting an estimated 200 million persons in 78 countries, the disease is intimately associated with poverty and is grossly debilitating, leading to chronic

Editörden

Değerli Adli Bilimciler, Adli Tıp Bülteni’nin 2019 yılı son sayısıyla karşınızdayız. Her sayımızda 12 makale yayınlama geleneği bu sayıda da sürüyor. Medeni Kanun Kapsamında Çocuk Evlilikleri, Suça Sürüklenen Çocuklar, Mobbing, Postmortem Kalp Okulu, Amerikan Hekimler Birliği (AMA) Kalıcı Özürlülüğün Değerlendirmesi Kılavuzu,

Postmortem Kalp Okulu

Giriş: Ani kardiyak ölümlerde, otopsi kesin ölüm nedenini belirlemede ilk ve tek seçenektir. Avrupa Kardiyovasküler Patoloji Birliği tarafından, ani ölüm/ ani kardiyak ölüm tanımlamaları, otopsi prosedürü ve yapılması gereken laboratuvar tetkiklerinin açıklandığı, ani kardiyak ölümlerin otopsisi için güncellenmiş kılavuz yayınlanmıştır.

Sivas İlinde Suça Sürüklenen Çocuk Olguların Sosyodemografik ve Klinik Özellikleri

Amaç: Bu çalışmada suça sürüklenen çocukların sosyodemografik özelliklerinin, işledikleri suç tiplerinin ve zeka düzeylerinin belirlenmesi ve bu çocukları suça iten nedenlerin saptanması amaçlandı. Gereç ve Yöntem: Adli makamlarca 01.01.2017-01.06.2018 tarihleri arasında adli rapor düzenlenmesi için Cumhuriyet Üniversitesi çocuk ve ergen

Mobbing Mağdurlarının Sosyodemografik Özellikleri, İş Yaşamı ve Ruh Sağlıkları Açısından İncelenmesi: Olgu Serisi

Amaç: Çalışmanın amacı, mobbing yaşantısı ile İstanbul Üniversitesi Tıp Fakültesi Adli Tıp Anabilim Dalı Polikliniği’ne başvuran ve buradaki muayeneleri sonrasında haklarında sosyal inceleme raporu hazırlanması istenen 34 hastanın verilerinin değerlendirilmesidir.  Gereç ve Yöntem: Olgulara ait mobbing süreci, sosyodemografik özellikler ve

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