Abstract Radiotherapy is a cornerstone of modern oncologic care, yet its sequelae can significantly impair survivors’ quality of life. Chronic radiation-induced conditions—including skin fibrosis, bone necrosis, radiation cystitis, and proctitis—pose substantial challenges for both patients and caregivers, particularly in the
Publisher Correction: APOBEC3 mutagenesis drives therapy resistance in breast cancer
Nature Genetics, Published online: 12 December 2025; doi:10.1038/s41588-025-02471-0 Publisher Correction: APOBEC3 mutagenesis drives therapy resistance in breast cancer
IN MEMORIAM: Dr. Victoria E. Johnson
Journal of Neurotrauma, Volume 42, Issue 23-24, Page 2127-2128, December 2025.
When I use a word . . . Defining bias in research
Interpreting the results of an interventional studyConsider three possible outcomes in an interventional study, investigating, say, a novel medicine. The medicine improves the condition, worsens it, or has no effect. How is each of these outcomes to be explained?In all
Beyond the modified Rankin Scale: the unseen burden of stroke in young adults
The global burden of stroke in the young continues to grow, with rising incidence and prevalence placing increasing strain on healthcare systems. While stroke is typically associated with older adults, young stroke survivors—often amid career development, family life and other
Interventional oncology: A primer for clinicians on the role of ablation and embolization for solid tumors
Abstract Interventional radiology (IR) is a rapidly evolving medical field that combines advanced imaging with minimally invasive techniques for both diagnosis and treatment. Interventional oncology (IO), a subspecialty of IR, focuses on the minimally invasive, image-guided intervention for cancer and
Validation concerns regarding modified VTE risk scoring in postpartum-adapted YEARS algorithm (Reply to Letter-to-the-Editor)
Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models
Nature Genetics, Published online: 11 December 2025; doi:10.1038/s41588-025-02419-4 DNA methylation and copy number variant analyses across a large number of genetic mouse models of pediatric brain tumors reveal subtype-specific molecular alterations shared with the corresponding human diseases.
[Editorial] Synthesising evidence for antidepressants
Thinking at different scales is challenging. Translating between scales is difficult, and it can be appealing to focus on one aspect, such as short-term solutions versus longer-term effects, but this can create simplified stories. Antidepressants are an area with particularly
Are ultrasensitive ctDNA assays ready for clinical use in early-stage NSCLC?
Disease recurrence in early-stage non-small cell lung cancer (NSCLC) remains a persistent clinical challenge, underscoring the need for better prognostic biomarkers. In this preview, we highlight the clinical implications of ultrasensitive ctDNA monitoring in lung cancer risk modeling reported by
[Editorial] Universal health coverage: necessary, but not enough
Universal health coverage (UHC) rests on a simple idea: every person, everywhere, should be able to access the health services they need without fear of financial ruin. Across history, societies have recognised that health is a collective responsibility—from paid sick
Association Between Adherence to Guidelines and Patient Outcomes in Severe Pediatric Traumatic Brain Injury: A Scoping Review
Journal of Neurotrauma, Volume 42, Issue 19-20, Page 1663-1670, October 2025.
Ministers seek power to control NHS drug approvals to support US pharma deal
Plans to give ministers more power over the UK drug watchdog risk opening the door to political interference in decisions over new treatments, health economists have warned.The plans, subject to consultation,1 would give ministers the power to change the cost-effectiveness
Premature ventricular complex, atrial fibrillation and stroke: causality or coincidence?
Atrial fibrillation (AF) and premature ventricular complexes (PVCs) are two of the most prevalent arrhythmias in the general population. It is not surprising that their prevalence increases further with longer monitoring durations and among patients with structural heart disease (SHD).
Maintenance therapy after first‐line therapy for ovarian cancer: Quantitative effectiveness
CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.
A call for a global cyberbiosecurity framework in genomics
Nature Genetics, Published online: 10 December 2025; doi:10.1038/s41588-025-02447-0 Amid growing geopolitical tension and scientific advances, fragmented and reactive governance policies could increase the risks of dual-use genomics, undermining international collaboration and data security. This Comment calls on the international genomics
[Editorial] Turning policy into action for brain health
Neurological disorders are among the leading causes of disability worldwide, yet millions of people still lack access to effective care, particularly in low-income and middle-income countries (LMICs). A pivotal step to address these gaps was the adoption of the Intersectoral
Strikes: BMA is urged to drop advice on not giving employers notice of walkouts as flu pressures mount
Medical leaders have urged the BMA to suspend advice stating that doctors do not need to tell their employer if they plan to strike.Ahead of next week’s five day walkout by resident doctors in England, the Academy of Medical Royal
Corrigendum to ‘Expanded noninvasive prenatal screening for dominant single-gene disorders: proof-of-concept, performance, and challenges’ American Journal of Obstetrics & Gynecology (2025) 233/6 [673-674]
The authors regret errors in the originally published 95% confidence intervals for the detection performance of expanded NIPT-SGDs. These have been corrected using the Clopper–Pearson method. The authors also clarify that the comment regarding incomplete diagnostic follow-up in prior research
A twist to rose fragrance
Nature Genetics, Published online: 09 December 2025; doi:10.1038/s41588-025-02458-x A twist to rose fragrance
Remembering David Baltimore (1938–2025)
David Baltimore, one of modern biology’s most influential scientists, passed away at his home in Woods Hole, Massachusetts, on September 6, 2025 at the age of 87, leaving legions of former trainees and the scientific community to contemplate the significance
[Editorial] Diabetes and cancer in the age of multimorbidity
Diabetes and cancer are two of the four major non-communicable diseases identified by WHO. Their relationship is multifaceted and complex, involving shared biological mechanisms and overlapping risk factors. At a health-systems level, there are both barriers and opportunities for targeted
JAMA
Drone strikes kill 114 in Sudan hospital and kindergarten, as Russia hits Ukraine maternity ward
A “senseless” triple drone strike on children and health workers in southern Sudan has killed 114 people and injured 35, the World Health Organization (WHO) has reported.The attack, launched on 5 December in Kalogi in South Kordofan state, first targeted
Predictors for short-term outcome in patients with left-sided infective endocarditis: insight from Invention – HK registry
Objective Identify predictors for mortality and clinical short-term outcomes in patients with left-sided infective endocarditis (IE). Methods This study was a retrospective cohort investigating 376 patients who experienced left-sided IE between 1 January 2013 and 31 December 2022, at the
Exercising through cancer: Physical activity as medicine for cancer care
Exercise holds significant potential as an adjunct therapy in cancer, extending beyond quality-of-life improvements to influencing tumor progression, treatment response, and survival. Its clinical integration remains limited by variability in models, heterogenous interventions, and the absence of predictive biomarkers. As
The Great Debate on sexually transmitted infection reporting: balancing public health, policy implications, and costs (Reply to Letter-to-the-Editor)
Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations
Nature Genetics, Published online: 08 December 2025; doi:10.1038/s41588-025-02431-8 Saturation mutagenesis screening examines 11,520 point mutations in the kinase domains of FGFR1, FGFR2, FGFR3 and FGFR4, identifying their activating and resistance properties to the FGFR inhibitors pemigatinib and futibatinib.
Socioeconomic variation in the relationship between cardiac rehabilitation participation and clinical outcomes: a systematic review
Aim To systematically evaluate whether relationships between cardiac rehabilitation participation and clinical outcomes, return to work, or knowledge about cardiovascular disease vary across socioeconomic indicators. Methods A systematic review was conducted using CENTRAL, CINAHL, Embase and Medline up to 1
Patients in England are left in limbo by GP “referral black holes,” watchdog warns
One in seven patients end up in a “referral black hole” as their GP referral for tests or treatment is either delayed, lost, rejected, or not sent, a report from Healthwatch England warns.1While this is an improvement on the watchdog’s
The growing role of imaging in diagnosis and risk stratification
Infection in older adults: underresearched and often undermanaged
Medical science has been remarkably successful over the past two centuries at preventing and curing what were once common infectious diseases in children and young adults in the UK. Vaccination has prevented diseases such as polio, smallpox, tetanus, and diphtheria.
The global epidemiology of acute myeloid leukaemia
Nature Reviews Clinical Oncology, Published online: 05 December 2025; doi:10.1038/s41571-025-01099-7 Despite the availability of various novel therapies, the global incidence of acute myeloid leukaemia (AML) has continued to increase. Owing to a combination of population ageing and more effective diagnosis,
Human papillomavirus self‐collection: The long road from scientific evaluation to implementation in screening programs
CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.
Patients prioritize choice for postpartum contraception (Reply to Letter-to-the-Editor)
Distinct gene expression mechanisms in classical and basal PDAC subtypes
Pancreatic ductal adenocarcinoma (PDAC) represents approximately 90% of all malignant tumours in the pancreas, and it is one of the deadliest human diseases. It has a 5-year survival rate of less than 10%, primarily due to the lack of early
UpFront
Welcome to the January 2026 issue of Frontline Gastroenterology (FG) and Happy New Year 2026! I am pleased to report it has been a busy few weeks for the journal and it has been promoted both on a national and
When the heart calls for help: Clusterin reprograms immunity to enable regeneration
Adult mammalian hearts exhibit limited regenerative capacity. Fan et al. report that neonatal cardiomyocyte-derived clusterin competes for macrophage Toll-like receptor 4 to suppress inflammation and induces reparative polarization. This cardio-immune dialogue activates BMP2 signaling to stimulate cardiomyocyte proliferation, reframing inflammation
Global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2022
ABSTRACT Cancers of the lip, oral cavity, and pharynx (LOCP) represent a substantial public health challenge worldwide. Using GLOBOCAN national estimates of incidence, detailed cancer registry data from Cancer Incidence in Five Continents, and population statistics from the United Nations,
Clarifying Absolute Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease in Women: The Importance of Competing Risks and Timing of Hormone Replacement Therapy
Impact of the 23andMe bankruptcy on preserving the public benefit of scientific data
Nature Genetics, Published online: 04 December 2025; doi:10.1038/s41588-025-02423-8 The bankruptcy of 23andMe was an inflection point for the direct-to-consumer genetics market. Although the privacy of consumer data has been highlighted by many as a concern, we discuss another key tension
[Editorial] Ultra-processed foods: time to put health before profit
The rise of ultra-processed foods (UPFs) in human diets is damaging public health, fuelling chronic diseases worldwide, and deepening health inequalities. Addressing this challenge requires a unified global response that confronts corporate power and transforms food systems to promote healthier,
The contribution of a multidimensional assessment and iterative measurements of postoperative recovery variables (Reply to Letter-to-the-Editor)
ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity
Nature Genetics, Published online: 03 December 2025; doi:10.1038/s41588-025-02430-9 The authors show that only a small subset of cytosolic double-stranded RNAs (dsRNAs) requires ADAR1-mediated RNA editing to evade an MDA5-dependent immune response. These immunogenic dsRNAs are enriched in mRNAs and overlap
Ancient DNA insights into diverse pathogens and their hosts
Nature Reviews Genetics, Published online: 03 December 2025; doi:10.1038/s41576-025-00912-4 Ancient DNA techniques are being applied to study increasingly diverse pathogens of the past. The authors review the latest insights into pathogen–host coevolution, zoonotic events and the spread of pathogens, all
[Editorial] Accelerating MASH trials: from biopsy to biomarkers
After years of near stasis, efforts to develop medical therapies for metabolic dysfunction-associated steatohepatitis (MASH) seem to have passed a genuine inflection point. Two drugs—resmetirom and semaglutide—have received accelerated approval from the US Food and Drug Administration (FDA) for treating
Bi-directional communication between regulatory T cells and microglia promotes recovery from spinal cord injury
In this issue of Neuron, Qin et al. demonstrate that regulatory T cells (Tregs) are essential for tissue preservation and functional recovery after spinal cord injury, highlighting bilateral communication between Tregs and microglia as a key mechanism underlying Treg-mediated protection.
Transoral endoscopic thyroidectomy using the vestibular approach in pediatric patients: 5-year experience in a single center in Vietnam
Objective To evaluate the clinical and oncological outcomes of transoral endoscopic thyroidectomy via the vestibular approach (TOETVA) in the management of pediatric patients with benign and malignant thyroid lesions in Vietnam. Methods A cross-sectional study was performed on pediatric patients
Road to FAIR: where are all the female, woman and girl athletes?
Female, woman and girl sport has never been more visible,1 with full gender parity reached for the first time at the Paris 2024 Olympic Games, and record attendances set at the 2025’s European football championships and Rugby World Cup. Participation
Occupational risk assessment: lessons from the MSHA Silica Rule
The healthy worker survivor effect (HWSE) arises in occupational epidemiology when less healthy workers leave work, resulting in a survivor population of healthier, more heavily exposed workers. Ignoring this selection process can lead to underestimation of lifetime risk in cohort
Intimacy and Empowerment in Urogynecology: A Qualitative Exploration of Vibrator Use
To explore and describe the views and experiences of urogynecology patients with sexual dysfunction and pelvic floor disorders with scheduled vibrator use.
Toward the next 20 years of Cell Metabolism
We started our journal’s 20th anniversary celebrations with a series of reflections from authors who have published with us throughout the history of Cell Metabolism. They shared stories of challenges, surprising findings, old questions answered, and new ones asked. As
[Editorial] Ultra-processed food: from first tastes to lifelong habits
Ultra-processed foods (UPFs) are everywhere. Our supermarket aisles, billboards, and offline and online media are filled with brightly coloured packages of sweet and savoury snacks, baked goods, ready meals, and sugar-sweetened beverages. Given their ubiquity and cheap price, it’s unsurprising
JAMA
From adult centric to child specific: the Pediatric Scale for Quality of Recovery (PedSQoR) as a pioneering tool
Do the pharmacokinetics of statins explain psychiatric symptom improvement from adjunctive statin prescribing in severe mental illness? Three target trial emulation studies
Background Evidence regarding the efficacy of adjunct statins to treat severe mental illness (SMI) is mixed. The varying pharmacokinetic properties of statins mean that specific statin-antipsychotic combinations might improve psychiatric symptoms. Objective To test whether some statin-antipsychotic/mood stabiliser combinations result
When ctDNA says ‘maybe’: improving the dynamics of MRD trials
Nature Reviews Clinical Oncology, Published online: 01 December 2025; doi:10.1038/s41571-025-01111-0 Circulating tumour DNA (ctDNA) has emerged as a promising biomarker enabling the detection of minimal residual disease (MRD) in patients with locally advanced colon cancer. The phase II/III DYNAMIC-III trial,
[Editorial] Acute myeloid leukaemia at the extremes
The past decade has seen advances for the treatment of acute myeloid leukaemia (AML), but challenges remain for those at the extremes of the disease, particularly for those older than 65 years, and paediatric patients. Therefore, the announcement on Oct
Error in Table and Figure
The Original Investigation titled “Gonorrhea and Chlamydia Screening for Adolescents and Young Adults in Emergency Departments,” published on September 8, 2025, was corrected to fix the row headings in Table 2 and some of the participant numbers in Figure 1.
Detecting transcription factor binding sites with PADIT-seq
Nature Reviews Genetics, Published online: 01 December 2025; doi:10.1038/s41576-025-00924-0 In this Tools of the Trade article, Shubham Khetan presents PADIT-seq (protein affinity to DNA by in vitro transcription and RNA sequencing), which enables the reliable identification of low-affinity DNA binding
Atherothrombosis: its mechanisms and novel targets
Author Correction: Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Nature Genetics, Published online: 28 November 2025; doi:10.1038/s41588-025-02464-z Author Correction: Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Understanding microbial ecology and evolution with single-cell genomics
Nature Reviews Genetics, Published online: 28 November 2025; doi:10.1038/s41576-025-00918-y Engelberts and Tyson discuss the potential and challenges of microbial single-cell genomics, emphasizing the integration of single-cell omics and meta-omics data as a promising opportunity to reveal the ecological and evolutionary
[Editorial] The Global Fund and the future of global health
There was a strange sense of relief at the eighth replenishment conference for The Global Fund to Fight AIDS, Tuberculosis and Malaria, which took place on Nov 21, in South Africa. The USA is by far the Global Fund’s largest
Development and validation of a 10-year predictive model for cardiovascular and metabolic disease risk: insights from a large-scale health examination cohort
Objective To develop and validate a 10-year predictive model for cardiovascular and metabolic disease (CVMD) risk using comprehensive health examination data from nearly 37 701 individuals. Methods This retrospective cohort study used health examination data, including demographic information, clinical measurements,
Towards biomarker-driven therapies for urothelial carcinoma
Nature Reviews Clinical Oncology, Published online: 27 November 2025; doi:10.1038/s41571-025-01095-x The identification of prognostic and predictive biomarkers for immune checkpoint inhibitors, antibody–drug conjugates and targeted therapies for urothelial carcinoma is currently an active area of research. In this setting, circulating
Single-cell 3D architecture maps the drivers of lung adenocarcinoma
Nature Genetics, Published online: 27 November 2025; doi:10.1038/s41588-025-02414-9 A study using single-cell 3D genome mapping reveals phenotypic convergence during mouse Kras-driven lung adenocarcinoma progression and prioritizes clinically actionable driver genes. This highlights the importance of cell-to-cell variation in chromatin architecture
SUGAR and stents: evaluating long-term percutaneous coronary intervention outcomes in patients with diabetes
Diabetes mellitus is highly prevalent in patients with coronary atherosclerosis. As a result of several factors, including a pro-inflammatory state, dyslipidaemia, hyperglycaemia and insulin resistance, coronary artery disease in patients with diabetes is characterised by diffusely diseased vessels with smaller
Correction: Does surgery reduce knee osteoarthritis, meniscal injury and subsequent complications compared with non-surgery after ACL rupture with at least 10 years follow-up? A systematic review and meta-analysis
Lien-Iversen T, Morgan DB, Jensen C, et al. Does surgery reduce knee osteoarthritis, meniscal injury and subsequent complications compared with non-surgery after ACL rupture with at least 10 years follow-up? A systematic review and meta-analysis. Br J Sports Med 2020;54:592–598.
AI and human expertise in cancer care — striving for synergy
Nature Reviews Clinical Oncology, Published online: 25 November 2025; doi:10.1038/s41571-025-01108-9 Artificial intelligence (AI) excels at rapid data synthesis and pattern recognition, yet the practice of oncology demands nuanced clinical judgement, ethical reasoning and authentic empathy — qualities only humans can
[Editorial] Making prostate cancer screening fit for purpose
Prostate cancer incidence is predicted to double to 2·9 million cases by 2040. Men diagnosed with clinically significant prostate cancer have many effective treatment options, but questions remain regarding the best diagnostic pathway. The value of population-based prostate cancer screening
Fuzuloparib with or without apatinib as maintenance therapy in newly diagnosed, advanced ovarian cancer (FZOCUS‐1): A multicenter, randomized, double‐blind, placebo‐controlled phase 3 trial
Abstract Although poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPis) and bevacizumab were approved as first-line maintenance for advanced ovarian cancer (OC), evidence comparing this combination with PARPi monotherapy, especially in BRCA-mutated/homologous recombination-deficient (HRD) patients, is lacking. This study compared combined fuzuloparib (a
The Impact of conception by IVF on Breastfeeding Initiation and Establishment Amongst Singleton Infants: A Statewide Cohort Study
Breastfeeding has many benefits for mother and child. Previous studies have suggested that breastfeeding is highly desired in pregnancies conceived through IVF, but that early breastfeeding cessation may be more common in this population. We aimed to study the effect
Publisher Correction: Realizing the full potential of Our Future Health through data linkage and trans-biobank efforts
Nature Genetics, Published online: 25 November 2025; doi:10.1038/s41588-025-02452-3 Publisher Correction: Realizing the full potential of Our Future Health through data linkage and trans-biobank efforts
[Editorial] The clock is ticking for UNAIDS
In March, 2025, UN Secretary-General António Guterres launched UN80, an initiative marking the 80th anniversary of the founding of the organisation. Acknowledging changing global priorities and shocks to aid financing, the UN80 initiative is intended to adapt the UN for
Activation-induced cytidine deaminase: The missing piece of many puzzles
Twenty-five years ago, two Cell papers reported the key missing functional piece in three molecular puzzles. The genetic swapping of immunoglobulin constant regions, the mutational fine-tuning of antibody specificity, and a baffling human immunodeficiency were traced to the action of
JAMA
[Editorial] Public trust: the vaccine against vaccine hesitancy
One of the greatest achievements in the history of public health has been protection against infectious diseases by vaccinations which is of considerable importance in controlling respiratory diseases. Vaccinations against influenza, respiratory syncytial virus (RSV), pneumococcal disease, and COVID-19, to
Budget 2025: Government scraps two child benefit cap in major U turn
Hundreds of thousands of children are set to be lifted out of poverty, as the UK government has announced that it will end the limit restricting universal credit support to two children per family.The announcement—part of the autumn budget that
HPV vaccine safe and reduces risk of cervical cancer, anti-misinformation review finds
Human papillomavirus (HPV) vaccination reduces the incidence of cervical cancer by 80% in people vaccinated at or before the age of 16, according to two Cochrane reviews.12 The comprehensive systematic reviews also found vaccination was not associated with an increased
Systematic review of national and international clinical practice guidelines for management of preterm prelabour rupture of membranes
Preterm prelabour rupture of membranes (PPROM) is a common pregnancy complication and a major contributor to preterm birth, but lacks contemporary evidence to guide management. This systematic review aims to highlight the areas of consensus and inconsistency between international guidelines.
Severe maternal morbidity and risk of adverse pregnancy, delivery, and neonatal outcomes in the subsequent delivery
Severe maternal morbidity (SMM) is associated with substantially increased risks of adverse neonatal outcomes. However, few studies have assessed the association between SMM and adverse pregnancy, delivery, and perinatal outcomes in the subsequent delivery.
Ethical detective work in healthcare
There is a certain kind of ethical inquiry about healthcare which we may call ethical detective work—careful, curious and rigorous analysis which uncovers ethical issues that may not be apparent at first glance. Like regular detective work, ethical detective work
Drug industry payments to groups of influential MPs—“the next great parliamentary scandal?”
MPs and peers must act urgently to avert potential scandal from drug industry payments and connections to parliamentary interest groups, researchers have said.A new study of pharmaceutical firms’ dealings with All Party Parliamentary Groups (APPGs) has flagged fresh concerns over
Primary survey: highlights from this issue
As we reach the final issue of 2025, I want to extend my thanks to all our readers, authors, reviewers and the editorial team for another extraordinary year of emergency medicine scholarship. From global collaborations to grassroots innovation, EMJ continues
Development of a functional assay for the characterisation of SMAD4 variants from the French haemorrhagic hereditary telangiectasia cohort
Background Hereditary haemorrhagic telangiectasia (HHT) and juvenile polyposis syndrome (JPS) can be caused by SMAD4 pathogenic variants. SMAD4 is a common transcription factor of the BMP/TGFβ signalling pathway. In this study, we developed a cell-based functional assay to address the
Could a COVID-19 vaccine improve the effectiveness of cancer immunotherapy?
Nature Reviews Clinical Oncology, Published online: 20 November 2025; doi:10.1038/s41571-025-01105-y A recent Nature article reports that mRNA vaccines against SARS-CoV-2 confer improved survival among patients with advanced-stage non-small-cell lung cancer or melanoma receiving immune-checkpoint inhibitors owing to activation of systemic
Sublingual or Oral Versus Vaginal Misoprostol for Cervical Priming Prior to First-Trimester Surgical Abortion: A Systematic Review and Meta-Analysis
To compare the efficacy of oral or sublingual misoprostol versus the vaginal route for cervical preparation prior to first-trimester surgical abortion. This systematic review and meta-analysis assessed baseline cervical dilation, intraoperative blood loss, and operating time to guide clinical decision-making.
Scalable and accurate rare variant meta-analysis with Meta-SAIGE
Nature Genetics, Published online: 20 November 2025; doi:10.1038/s41588-025-02403-y Meta-SAIGE is a computationally efficient method for meta-analysis of rare variant associations across cohorts. It effectively controls type I error rates and has power similar to analyses of pooled individual-level data.
[Editorial] Chronic kidney disease: breaking the silence
The early stages of chronic kidney disease (CKD) are usually asymptomatic, with kidney function progressively and irreversibly declining over months or years. The silent nature of CKD is perhaps one reason it has, until now, received little attention from policy
Hot topics in valvular heart disease and dyslipedaemias
For the podcast associated with this article, please visit https://academic.oup.com/eurheartj/pages/Podcasts.
New online GP access rules already risking patient harm, practices warn
New rules that force general practices in England to accept online queries from patients during core working hours are already risking harm to patients and increasing GPs’ workload and stress, a survey indicates.More than half (55%) of general practices polled
Strategies to avoid a data mining mindset in secondary analysis of public health datasets
Introduction A broad institutional focus on leveraging technology for open data to support health research transparency and efficiency has spurred increased public access to large online health data sources. Information on morbidity and mortality measures for specific diseases and injuries,
At a glance
Risk factors for bleeding and perioperative bleeding complications in oculoplastic surgery: a prospective pilot study (see page 1330) The authors report that standardised questionnaires are useful in assessing bleeding risks in patients with oculoplastic surgery. Acetylsalicylic acid, diabetes mellitus, renal
Comparative analysis of clinical scores in predicting ICU and hospital mortality in nonagenarians and centenarians after in-hospital cardiac arrest: a retrospective observational study using the Australian and New Zealand Intensive Care Society (ANZICS) Adult Patient Database (2010-2024)
Background Nonagenarians and centenarians admitted to intensive care units (ICUs) following in-hospital cardiac arrest (IHCA) represent a growing yet understudied population. Clinicians require accurate prognostic tools to inform early goals of care discussions and resource allocation. This study evaluated the
Executive Summary of the American Radium Society Appropriate Use Criteria for the Use of Esophageal Stents in Patients With Esophageal Cancer: Systematic Review and Guidelines
Objectives: Esophageal cancer (EC) often presents with dysphagia due to tumor obstruction. Esophageal stenting has the potential of palliating dysphagia, improving nutrition, preventing aspiration, and improving quality of life (QoL) but may be associated with risks. The present systematic review
Adenine DNA methylation is an ancestral and widespread mark in eukaryotes
Nature Genetics, Published online: 19 November 2025; doi:10.1038/s41588-025-02422-9 We establish that adenine DNA methylation is widespread among unicellular eukaryotes, in which it marks transcriptionally active genes. This conserved pattern depends on the AMT1 enzyme, an ancestral eukaryotic adenine methyltransferase that
[Editorial] Lenacapavir—time to change the game for everyone
Lenacapavir is a twice-yearly injectable drug produced by Gilead Sciences that is aimed at preventing HIV infection. In 2024, the findings of the PURPOSE 1 and PURPOSE 2 trials testing lenacapavir for HIV prevention showed 100% efficacy in preventing HIV
Metabolic stress, interneuron vulnerability, and cognitive decline
In this issue of Neuron, Landry et al. show how hippocampal cholecystokinin (CCK)-positive neurons respond to reduced glucose availability induced by a short-term high-fat diet and how changes in CCK neurons contribute to deficits in hippocampal-dependent cognitive function.
Antimicrobial resistance: Private providers are reversing progress by dispensing more drugs, top adviser warns
The rising number of private antibiotic prescriptions is making it increasingly difficult for the UK to tackle the threat of antimicrobial resistance, a top medical adviser has warned.Speaking at the Faculty of Pharmaceutical Medicine’s annual symposium in London on 18
Atoms
‘I guess this was the (sic) time we’d waited for… our time’ It was sometime towards the end of that last set in the last week of the 6 month tour. Yes, that’s right: that heady week playing the venue
Addition of cribriform pattern 4 and intraductal prostatic carcinoma into the CAPRA-S tool improves post-radical prostatectomy patient stratification in a multi-institutional cohort
Aims Pre-surgical risk classification tools for prostate cancer have shown better patient stratification with the addition of cribriform pattern 4 (CC) and intraductal prostatic carcinoma (IDC) identified in biopsies. Here, we analyse the additional prognostic impact of CC/IDC observed in
Disentangling the architectural and non-architectural functions of CTCF and cohesin in gene regulation
Nature Genetics, Published online: 18 November 2025; doi:10.1038/s41588-025-02404-x This study provides insights into the chromatin-looping-dependent and chromatin-looping-independent roles of cohesin and CTCF in controlling gene regulation.
Harnessing evolution to infer protein networks
Nature Reviews Genetics, Published online: 18 November 2025; doi:10.1038/s41576-025-00919-x In this Journal Club, Nozomu Yachie recalls a 1999 paper by Pellegrini, Marcotte and colleagues that demonstrated how functional information, such as protein–protein interactions, could be revealed through patterns of genetic
T-DXd plus pertuzumab effective as first-line therapy
Nature Reviews Clinical Oncology, Published online: 18 November 2025; doi:10.1038/s41571-025-01106-x T-DXd plus pertuzumab effective as first-line therapy
Early prediction of congenital cytomegalovirus infection and symptoms after maternal primary infection: an in vivo study using CMV-PCR in chorionic villi and in amniotic fluid
The long interval between serological diagnosis of maternal primary infection (MPI) at first trimester and prenatal diagnosis of fetal infection by amniocentesis from 17 weeks’ may cause anxiety and distress. CMV-PCR in chorionic villi (CV) sampled by CVS at 14
JAMA
Association Between Adverse Childhood Experiences Score and Traumatic Brain Injury Occurrence: A Systematic Review and Meta-Analysis
Journal of Neurotrauma, Volume 42, Issue 21-22, Page 1907-1917, November 2025.
GP skills cannot be taught at a distance
Salisbury highlights the risk of reduced consulting time for general practitioner (GP) registrars.1 Improved exam performance cannot be a proxy for patient care. Today’s GPs face escalating workloads, rising administrative burden, workforce burnout, and the challenge of caring for an
Sentinel lymph node biopsy improves surgical management of cervical cancer
Nature Reviews Clinical Oncology, Published online: 17 November 2025; doi:10.1038/s41571-025-01107-w Sentinel lymph node biopsy improves surgical management of cervical cancer
Recommendations for penicillin allergy assessment in pregnancy (Letter-to-the-Editor)
African-ancestry-specific variant IKKβ p.Glu502Lys confers high lupus risk
Nature Genetics, Published online: 17 November 2025; doi:10.1038/s41588-025-02398-6 Whole-genome sequencing identifies a rare missense variant in IKBKB associated with high risk of cutaneous and systemic lupus erythematosus among people with African ancestry.
Policies to promote affordability and access across the life cycle of costly new drugs
The affiliation of the first author in this article by Krista Kruja and colleagues (BMJ 2025;391:e086516; doi:10.1136/BMJ-2025-086516) was incorrectly given as WHO Regional Office for Europe. The online version has been corrected.
The Centenary Series – STIs Through the Ages: Healing with guaiacum: a botanical remedy for syphilis in early modern medicine
Introduction The spread of syphilis through Europe at the end of the 15th century is well documented, as is the use of mercury as a treatment. Less commonly discussed are the botanical remedies that were also used in an attempt
Antenatal Corticosteroid Administration in Periviable Twin Pregnancies Between 22 and 25 weeks: A Nationwide-Based Study
Twin pregnancies are markedly increased risk of preterm birth, with a growing proportion delivering at periviable gestational ages. While antenatal corticosteroid (ACS) administration improves neonatal outcomes in singleton pregnancies, evidence specific to twins at the threshold of viability remains limited.
The degree of cervical remodelling predicts surgical morbidity in high-risk placenta accreta spectrum (Reply to Letter-to-the-Editor)
Two-pronged immunosuppression by TGFβ supports colorectal cancer metastasis
Nature Genetics, Published online: 14 November 2025; doi:10.1038/s41588-025-02379-9 Our study reveals how transforming growth factor-β (TGFβ) enables liver metastasis of colorectal cancer (CRC) in two ways: by limiting CD8⁺ T cell recruitment and inducing SPP1⁺ macrophages. Inhibition of TGFβ sensitizes
When I use a word . . . Medical Janus words
Having a goOf the IndoEuropean roots from which so many of our English words derive, one of the simplest was the biliteral EI, which meant to go. The Greek derivative of that was ἰέναι, to go, whose present participle ἰόν,
Improving lung cancer screening: the role and challenges of risk prediction models
Targeted lung cancer screening saves lives by shifting diagnosis to earlier stages, when curative treatment is more likely to succeed. To improve the efficiency of screening and minimise associated harms, tools have been developed to identify individuals at elevated risk.
Cardiac CT in the era of artificial intelligence: precision imaging, treatment guidance and optimised risk stratification for coronary artery disease
Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide, and CT imaging plays a crucial role in its diagnosis and management. However, the clinical use of CT is limited by factors, such as suboptimal image quality,
Uterine closure after cesarean delivery: surgical principles, biological rationale, and clinical implications
Normal uterine function depends on cyclical regeneration and the capacity to sustain pregnancy. A cesarean incision, however, represents an injury to this remarkable organ. Although the uterus possesses exceptional healing potential, cesarean delivery increases the risk of secondary infertility, pain,
Defining the transcriptional landscape in the classical subtype of pancreatic cancer
Nature Genetics, Published online: 13 November 2025; doi:10.1038/s41588-025-02392-y We found that two key transcription factors contribute to disease progression in the classical subtype of pancreatic ductal adenocarcinoma. In the primary tumor context, the nuclear receptor HNF4G is the critical driver,
Heart failure: focus on genes, kidney, and sudden death
Unlocking rejuvenating potential of mesenchymal progenitor cells
Age-dependent exhaustion of endogenous stem cell pools—and the resulting decline in tissue regeneration and homeostatic maintenance—is a hallmark of organismal aging and age-related pathology. In a study published in Cell, Liu and collaborators engineered human ESC-derived mesenchymal progenitor cells to
[Editorial] Europe cannot get sidetracked from basic health-care needs
On Oct 15 this year, the Patriots for Europe Foundation, a right-wing alliance led by the Hungarian Government, hosted the launch of the Make Europe Healthy Again (MEHA) initiative in the European Parliament. Like Make America Healthy Again, the campaign
Resident doctors’ strike: BMA warns hospital leaders over derogation requests ahead of five day walkout
Hospital leaders’ requests to exempt resident doctors from striking will not be granted if trusts do not properly “incentivise” non-striking doctors to provide cover or if non-emergency work is continuing, the BMA has warned.This comes after NHS England said that
Editors commentary
The meaning of ‘prudence’ has evolved. Initially it meant foresight, but this has moved to mean wisdom, and then to wisdom mixed with increasing amounts of caution. It had quite a run in British politics when its meaning included less
Moving past NfL? Multibiomarker models for ALS prognosis and stratification
Over the past two decades, a multistep process has been proposed to explain amyotrophic lateral sclerosis (ALS) pathogenesis, implicating genetic factors, environmental exposures and time.1 These models require validation through robust clinical and biological measures of disease state and progression.
Regulators of androgen receptor activity revealed by CRISPR interference screens
Nature Genetics, Published online: 12 November 2025; doi:10.1038/s41588-025-02432-7 Most aggressive metastatic prostate cancers are driven by activity of the androgen receptor (AR). This steroid-responsive transcription factor has a complex series of regulatory interactions with ligands, proteins and DNA that are
[Editorial] The importance of partnerships
The 2025 UN High-Level Meeting on the Prevention and Control of Noncommunicable Diseases and the Promotion of Mental Health marked an important turning point for mental health. Never before had the UN General Assembly put forth a political declaration with
[Editorial] Celebrating decades of progress in Lewy bodies research
Three decades ago, in October 1995, an international group of researchers convened in Newcastle upon Tyne (England, UK) for the inaugural meeting of the Dementia with Lewy Bodies Consortium. This landmark event laid the foundation for the Consortium’s work in
Prevalence of obsessive-compulsive disorder and related healthcare utilisation in China: a cross-sectional epidemiological survey
Background Obsessive-compulsive disorder (OCD) is classified by the World Health Organization as 1 of the 10 most disabling conditions. However, nationally representative epidemiological data on OCD are not yet available in China. Aims To investigate the prevalence, comorbidity, role impairment
EXPRESSION OF CONCERN: Prevention of acute myocardial infarction induced heart failure by intracoronary infusion of mesenchymal stem cells: phase 3 randomised clinical trial
What happened after publicationIn this paper by Attar and colleagues (BMJ 2025;391:e083382, doi:10.1136/bmj-2024-083382, published 29 October 2025), The BMJ was alerted to post-publication discussion raising concerns about a variety of issues; some issues were apparent from the data that support
Ending nuclear weapons, before they end us
This May, the World Health Assembly (WHA) will vote on re-establishing a mandate for the WHO to address the health consequences of nuclear weapons and war.1 Health professionals and their associations should urge their governments to support such a mandate
Navigating the landscape of EGFR TKI resistance in EGFR-mutant NSCLC — mechanisms and evolving treatment approaches
Nature Reviews Clinical Oncology, Published online: 11 November 2025; doi:10.1038/s41571-025-01085-z Third-generation EGFR tyrosine kinase inhibitors such as osimertinib have substantially improved clinical outcomes in advanced-stage EGFR-mutant non-small-cell lung cancer, but resistance remains inevitable. In this Review, the authors discuss biomarker-directed
The ADELIN analysis: the presence of ADenomyosis and its effects on matErnal, neonataL, and obstetrIc outcomes: a systematic review and meta-aNalysis
To systematically review and quantify the impact of adenomyosis on maternal, neonatal, and obstetric outcomes.
Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis
Nature Genetics, Published online: 11 November 2025; doi:10.1038/s41588-025-02405-w This study uses somatic mutations as a natural barcoding system to retrospectively and prospectively trace the fate of hematopoietic stem cells across all major blood cell lineages in healthy aged individuals. It
Aging and immunity
Time marches endlessly on … but what does that mean for the immune system? Here, investigators discuss how aging impacts the immune response and how immune cells can shape the aging process, with broader implications for modifying immunity to improve
[Editorial] Diabetes support at work: an unmet need
According to the latest edition of the IDF Diabetes Atlas, 589 million people around the world were living with diabetes in 2024, with 70% being of working age. People with diabetes face many challenges in the workplace and have specific
JAMA
Thrombolysis in non-ST-elevation myocardial infarction: systematic review and meta-analysis of randomised controlled trials
Background Guidelines strongly recommend reperfusion therapy, including thrombolysis and percutaneous coronary intervention, for ST-elevation myocardial infarction but contraindicate its use in most non-ST-elevation acute coronary syndromes (ACS). This practice largely stems from the landmark fibrinolytic therapy trialists (FTT) meta-analysis, which
Doctor who committed lewd act at work party is suspended for a year
A consultant pathologist has been suspended from the UK medical register for 12 months after spilling beer on a junior female colleague’s cleavage at a work party and licking it off her breasts.Mark Johnson also sent derogatory and sexually demeaning
T-DXd shows promise in neoadjuvant therapy for HER2+ breast cancer
Nature Reviews Clinical Oncology, Published online: 10 November 2025; doi:10.1038/s41571-025-01103-0 T-DXd shows promise in neoadjuvant therapy for HER2+ breast cancer
The coming era of nudge drugs for cancer
We propose an emerging strategy for advanced cancer treatment based on progressive, stepwise remodeling of tumor microenvironments (TMEs). TMEs are variable but show conserved archetypes across patients and tissue origins. Deep learning over single-cell atlases collected from perturbed tumors can
Perineal structural changes on 3D endovaginal ultrasound six months after vaginal birth: the Hourglass-Band pattern and how it relates to levator ani avulsion and hiatus size
Current evidence indicates that pelvic organ prolapse development after childbirth is strongly associated with an enlarged hiatus. However, few childbirth-related injuries beyond anal sphincter lacerations and levator ani avulsion—which explain less than a quarter of hiatal enlargement—have been investigated. Other
Benchmarking of multimodal single-cell omics data integration methods
Nature Genetics, Published online: 10 November 2025; doi:10.1038/s41588-025-02437-2 Benchmarking of multimodal single-cell omics data integration methods
Nascent transcription quantification with scFLUENT-seq
Nature Reviews Genetics, Published online: 10 November 2025; doi:10.1038/s41576-025-00913-3 In this Tools of the Trade article, Shaoqian Ma discusses scFLUENT-seq, a method that enables quantitative, genome-wide analysis of nascent transcription in single cells.
Left main percutaneous or surgical revascularisation and subsequent risk of transient and persistent renal dysfunction
Background Acute kidney injury (AKI) often complicates percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG). However, evidence on the incidence and prognostic impact of AKI after revascularisation for left main coronary artery disease (LMCAD) is scant, especially in
Reducing the harms from ever larger cars
Cleo Kenington’s name was misspelt in this editorial by Anthony Laverty and colleagues (BMJ 2025;391:r2162; doi:10.1136/bmj.r2162, 5 Nov 2025). The online version has been corrected.
24-Nor-ursodeoxycholic acid: a novel treatment targeting T-cell-mediated immune dysregulation in primary sclerosing cholangitis and beyond
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterised by progressive inflammation and fibrosis of the bile ducts, leading to biliary cirrhosis and an increased risk of cholangiocarcinoma. PSC is commonly associated with inflammatory bowel disease (IBD). The
Performance of an individualized, subcutaneous, basal-bolus insulin regimen for the management of prednisolone-associated hyperglycemia in hospitalized patients: a proof-of-concept study
Introduction Prednisolone is widely prescribed to hospitalized patients for a range of conditions. Up to 40% of hospitalized patients treated with prednisolone will experience hyperglycemia. Current guidelines recommend management of acute hyperglycemia in hospitalized patients with subcutaneous basal-bolus insulin (BBI),
Prostate cancer statistics, 2025
Abstract Prostate cancer is the most common cancer among men in the United States, and the incidence of advanced disease is increasing rapidly. This article provides an overview of prostate cancer occurrence using population-based incidence and mortality data from the
Characterizing Labor Progression and Duration According to Maternal Body Mass Index
To describe labor progression and duration according to maternal body mass index in patients who achieve vaginal delivery.
Timing and mechanisms of immune evasion in colorectal cancers
Nature Genetics, Published online: 07 November 2025; doi:10.1038/s41588-025-02348-2 Evading elimination by the immune system is a hallmark of cancer, but the exact timing and pathways of immune evasion are still to be explored. Colorectal cancers were found to engage a
Radiomics Quality Score 2.0: what changed from version 1.0 and why it matters
Nature Reviews Clinical Oncology, Published online: 07 November 2025; doi:10.1038/s41571-025-01098-8 Radiomics Quality Score 2.0: what changed from version 1.0 and why it matters
Tackling the challenge of in-utero blood exchange transfusion for fetal anemia at 15 weeks’ gestation
Significant fetal anemia due to parvovirus infection and alpha-thalassemia major can occur during the first trimester. In-utero transfusion before 16 gestational weeks is beneficial but challenging, because the umbilical vein is too narrow to be punctured precisely. Secondly, the fetal
Doctor ȷailed for three years after defrauding NHS of more than {pound}250 000
A former hospital doctor has been jailed for three years after admitting to defrauding the NHS of more than £268 000.Richard Akinrolabu, from Orpington in Kent, worked on-call and night shifts for three trusts while telling his employing trust he
Boosting dopamine: Following the lineage toward Parkinson’s repair
Low yields of dopamine neurons in human stem cell-derived neural grafts limit their potential for treating Parkinson’s disease. Zhang et al. develop a new three-dimensional differentiation method, informed and refined through careful clonal linage tracing of donor cells post-transplantation, to
Genomics of drug target prioritization for complex diseases
Nature Reviews Genetics, Published online: 06 November 2025; doi:10.1038/s41576-025-00904-4 In this Review, Chen et al. discuss how the advancement and integration of large-scale genetic resources, multi-omics data and sophisticated computational tools are improving drug development pipelines.
Trends and risk factors of stroke and mortality after transcatheter aortic valve implantation in the Netherlands
Background Stroke after transcatheter aortic valve implantation (TAVI) is an infrequent but serious complication with important impact on morbidity and mortality. Contemporary real-world evidence on the risk factors of early stroke after TAVI is scarce. We aimed to evaluate the
Focus on trials: primary prevention, ischaemic heart disease, atrial fibrillation, and obstructive sleep apnoea
[Editorial] Understanding the health threats of drone warfare
The use of drones as a weapon of war by both countries and non-state actors has transformed conflict. And as technology develops further—including autonomous unmanned weapon systems—implications for health and safety of both military personnel and civilians are grave.
Placing the Amazon at centre of COP30
The Amazon rainforest is the world’s largest tropical forest and one of its most vital ecosystems for human health and planetary stability. It stores the equivalent of 15-20 years of global carbon emissions and regulates rainfall patterns critical to food
Research and development of emergency contraception over five decades
Emergency contraception (EC) serves as an important backup method used to prevent unplanned pregnancies after episodes of unprotected sexual intercourse (UPSI) as a result of contraceptive omission or failure, or an incident of rape. Here we review some of the
Third-Trimester HIV Testing during Pregnancy in the United States
Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer
Nature Genetics, Published online: 05 November 2025; doi:10.1038/s41588-025-02388-8 Genome-wide CRISPRi screens for modulators of androgen receptor (AR) protein levels using live-cell quantitative endogenous AR fluorescence reporters identify PTGES3 as a new regulator of AR stability and function in prostate cancer.
[Editorial] Bridging the evidence gap in dietary approaches to gut disorders
An estimated one in ten people are living with constipation at any point in time. Chronic constipation has a substantial impact on the quality of life of those affected and is also associated with considerable economic impact, both in terms
Glutamate promotes glioma growth via a non-excitable, receptor tyrosine kinase-mediated mechanism
In this issue, Anastasaki et al. show that glutamate promotes proliferation of pilocytic astrocytoma cells. The authors demonstrate that glutamate receptors activate mitogenic PDGFRα signaling without altering the electrical properties of tumor cells, providing new understanding of how neurotransmitters enhance
RFK Jr urges world to follow US’s lead on mercury in vaccines
The US health secretary, Robert F Kennedy Jr, has called on the world’s health bodies to “follow America’s lead” and remove mercury from all vaccines.In July the US moved to ban the mercury based preservative thiomersal (known in the US
Disparities in diabetes technology utilization in youth with diabetes
Background Diabetes technology can improve glycemic variability and diabetes outcomes, but there are disparities in patient use. Aims Identify racial, ethnic, and socioeconomic disparities in technology utilization and determine provider-, patient-, and parent-identified barriers. Methods Technology (continuous glucose monitors (CGM)
From the ESMO Congress 2025
Nature Reviews Clinical Oncology, Published online: 04 November 2025; doi:10.1038/s41571-025-01101-2 From the ESMO Congress 2025
CA turns 75: Looking at the future but never forgetting the roots
CA: A Cancer Journal for Clinicians, EarlyView.
Multi-ancestry genome-wide association analyses of polycystic ovary syndrome
Nature Genetics, Published online: 04 November 2025; doi:10.1038/s41588-025-02393-x Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.
Convergent evolution of a conserved molecular network underlies parenting and sociality
Nature Reviews Genetics, Published online: 04 November 2025; doi:10.1038/s41576-025-00903-5 Kay et al. review evidence that parental care, and more complex social behaviour based on parental care, evolved in multiple species through the repeated co-option of members of a pleiotropic molecular
The role of the ventromedial hypothalamus in glycemic responses
Mechanisms that preserve glucose homeostasis are highly conserved across species, with the brain playing a central role in regulating these counterregulatory responses. However, the exact neural circuits underlying this regulation remain poorly understood. The previewed papers illuminate how the ventromedial
[Editorial] The example we set: Gen AI, honesty, and authenticity
Artificial intelligence (AI)—algorithm-based technologies solving complex tasks that previously required human thinking—has permeated life for decades in our daily use of search engines, navigation apps, and recommendation algorithms. Yet, generative AI (Gen AI)—a form of AI that generates new and
Sex differences in dual antiplatelet therapy de-Escalation strategies in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis
Abstract Background and aims Strategies of de-escalation of dual antiplatelet therapy (DAPT) improve outcomes after percutaneous coronary intervention compared to standard DAPT. However, the potential impact of sex on the safety and efficacy of these strategies is yet to be
Missing Conflict of Interest Disclosure
In the Editorial titled “Artificial Intelligence in Peer Review,” published in the August 28, 2025, issue of JAMA, a financial disclosure for author Dimitri A. Christakis, MD, MPH, had been missing. This article was corrected online.
New allergy conference criticised over sponsorship links
An upcoming conference for health professionals is under fire for accepting sponsorship by formula milk companies.Clinicians and nutritionists have criticised the Infant Allergy and Paediatrics Conference for taking money from industry and say it is against World Health Organization guidance.The
Intervening on dormancy to prevent breast cancer recurrence
Nature Reviews Clinical Oncology, Published online: 03 November 2025; doi:10.1038/s41571-025-01087-x Dormant tumour cells that survive initial therapy can awaken years later to seed metastases. New data from a phase II trial indicate that intercepting this dormancy by targeting autophagy and
[Editorial] New hope, old challenges in myelodysplastic syndromes
Myelodysplastic syndromes are a complex and heterogenous group of clonal myeloid neoplasms, characterised by ineffective haematopoiesis, diverse cytopenias, and the risk of progression to acute myeloid leukaemia. Since being identified as a distinct disease in the late 1970s, the journey
Doxycycline versus levofloxacin combined with tinidazole for treating chronic endometritis (Reply to Letter-to-the-Editor)
Functional dominance in the central dogma of tumor mitochondrial genetics
Nature Genetics, Published online: 03 November 2025; doi:10.1038/s41588-025-02375-z We have discovered recurrent, somatic mutations in mitochondrial ribosomal RNA genes across all tumor types assessed. In contrast with the established idea that the majority of mitochondrial DNA molecules must be mutated
Microbial genomics for antimicrobial resistance ecology and action
Nature Reviews Genetics, Published online: 03 November 2025; doi:10.1038/s41576-025-00909-z Microbial genomics can improve our understanding of antimicrobial resistance dynamics across ecosystems. In this Comment, Kathryn Holt emphasizes the interconnectedness of human, animal and environmental health and calls for greater integration
JAMA Pediatrics
Vision: JAMA Pediatrics will be the most respected source of information for investigators, providers, and policy makers seeking the highest quality evidence to guide decision-making.
When I use a word . . . Clinical pharmacology—the quintessential generalist specialty
An NHS flow problemRecent media coverage has focused on a think tank called Re:State, formerly known as Reform, which has just published a report titled “Hospital of the future. Ending the patient gridlock.”1 This is the third in a series
Lymph node removal and long-term lymphedema in cervical cancer. (Reply to Letter-to-the-Editor)
How is the mental health of teachers faring? A 10-year follow-up study of depressive symptoms and job dissatisfaction in the CONSTANCES cohort
Objectives Teachers’ mental health, an important asset for society, may be impacted by security or health crises alongside more structural changes. Our primary aim was to assess 2012–2022 trends in depressive symptoms among French teachers compared to similar employees. We
The importance of non-traditional risk factors: poor carbohydrate quality, infections, pre-eclampsia, mental health disorders, belonging to non-heterosexual populations
For the podcast associated with this article, please visit https://academic.oup.com/eurheartj/pages/Podcasts.
Salpingectomy in individuals at high risk for tubo-ovarian cancer – consensus and precaution
Tubo-ovarian carcinoma, particularly high-grade serous carcinoma (HGSC), is one of the most lethal gynecologic malignancies, largely due to its late-stage diagnosis and lack of effective screening strategies. For individuals with hereditary pathogenic variants (PVs) in genes associated with ovarian cancer
Left atrial strain tracks abnormal ventricular mechanics in Fabry disease
Background Fabry disease (FD) is an X linked lysosomal disorder with ventricular myocardial involvement that drives morbidity and mortality. Early diagnosis of cardiac involvement can be difficult. This study explored whether abnormal left atrial (LA) strain by cardiovascular magnetic resonance
Engaging migrants and immigrants in genetics research
Nature Genetics, Published online: 31 October 2025; doi:10.1038/s41588-025-02373-1 This Perspective examines the challenges to equitable participation of migrants and immigrants in genetics research and proposes inclusive, community-driven approaches to advance scientific discovery and overcome health disparities.
Domvanalimab plus zimberelimab shows promise in upper-tract cancers
Nature Reviews Clinical Oncology, Published online: 31 October 2025; doi:10.1038/s41571-025-01097-9 Domvanalimab plus zimberelimab shows promise in upper-tract cancers
Integrating Trauma-Informed Approaches into OBGYN Medical Education: A Framework for Safer Learning and Care
Trauma-Informed Medical Education (TIME) extends the principles of Trauma-Informed Care (TIC) into medical training to foster awareness and sensitivity to trauma, aiming to avoid further harm. TIC is patient-centered, emphasizes shared decision-making, and promotes safety, empowerment, and healing within physician-patient
Doctors’ leaders brand government’s 2.5% proposed pay rise “indefensible”
Doctors’ leaders have reacted strongly to the government’s proposed 2.5% pay rise for clinicians next year, suggesting it’s “neglect dressed up as restraint.”The Department of Health and Social Care (DHSC) submitted its annual evidence1 to the pay review body, the
Comparative study of coronary artery disease prediction: conventional QRISK3 versus enhanced machine learning models combined with particle swarm optimisation algorithm
Background Coronary artery disease (CAD) is one of the biggest causes of mortality worldwide. Risk stratification for early detection is essential for the primary prevention of CAD. QRISK3 is known to overestimate future CAD risk in some populations, resulting in
Risk factors for and outcomes of intraoperative desaturation in neonates undergoing non-cardiac surgery: a retrospective study
Objective The aim of this study was to determine the prevalence, outcomes and risk factors for intraoperative desaturation in neonates undergoing non-cardiac surgery. Methods This retrospective study included neonates who underwent non-cardiac surgery between April 2020 and October 2022. Patients
Assessing Implementation of Research Requirements in Obstetrics and Gynecology Subspecialty Fellowship
Transcription factor switching drives subtype-specific pancreatic cancer
Nature Genetics, Published online: 30 October 2025; doi:10.1038/s41588-025-02389-7 Pancreatic cancer progression is driven by a switch from HNF4G-driven transcriptional activity in primary disease to FOXA1-mediated transcription in the metastatic setting.
From clonality to complexity: a journey through microbial ecology and evolution
Nature Reviews Genetics, Published online: 30 October 2025; doi:10.1038/s41576-025-00910-6 Jaime Martinez-Urtaza reflects on two papers by Smith et al., who found that bacteria exist along a continuum from clonal to recombining populations, and introduced the concept of an ‘epidemic’ microbial