Second-line Chemotherapy Prolongs Survival in Real World Patients With Advanced Biliary Tract and Gallbladder Cancers: A Multicenter Retrospective Population-based Cohort Study

Background: Limited evidence is available regarding the survival benefit of second-line therapy in real world patients with advanced biliary tract and gallbladder cancer. Until very recently, there was a lack of randomized clinical trials to address this important question. In

β-Thalassemias

The thalassemias are a group of recessively inherited disorders characterized by reduced or no production of hemoglobin and chronic anemia of varying severity. The evolutionary association between the thalassemia carrier state and resistance to malaria explains its high prevalence in

β-Thalassemias

The thalassemias are a group of recessively inherited disorders characterized by reduced or no production of hemoglobin and chronic anemia of varying severity. The evolutionary association between the thalassemia carrier state and resistance to malaria explains its high prevalence in

Physical Activity after Cardiac EventS (PACES): a group education programme with subsequent text message support designed to increase physical activity in individuals with diagnosed coronary heart disease: a randomised controlled trial

Aim To assess the effectiveness of a low-cost pragmatic intervention (structured education and ongoing text message support) to increase daily physical activity in participants 12–48 months after a coronary heart disease cardiac event (myocardial infarction, angina or acute coronary syndrome)

The NCI Genomic Data Commons

Nature Genetics, Published online: 22 February 2021; doi:10.1038/s41588-021-00791-5 The National Cancer Institute (NCI) Genomic Data Commons (GDC) contains more than 2.9 petabytes of genomic and associated clinical data from more than 60 NCI-funded and other contributed cancer genomics research projects.

Highlights from this issue

From an Editorial perspective, this month’s EMJ makes for very happy reading. The quality and breadth of original and clinically relevant research within this issue is fantastic. From large observational analyses, qualitative research embedded within multicentre clinical trials and original

Grand designs of the nucleus

Nature Reviews Genetics, Published online: 19 February 2021; doi:10.1038/s41576-021-00336-w A recent study in Nature presents a method that integrates data from chromosome imaging, nuclear bodies and chromatin states to build a picture of the nuclear layout at the single-cell level.

Highlights from this issue

Scene – 1953, provincial theatre: final act. Frisson of suspense ripples through audience. Main protagonist: detective inspector. ‘Why haven’t I realised before?’ Injured victim: ‘Why didn’t you just open your eyes’. Adversary-doppelgänger: Placing musket (softly but dramatically) on the floor. ‘So, you’ve finally foiled me. I thought

Still we rise

Olufolakemi “Fola” Olusanya is the winner of the first Rising Black Scientist Award for an undergraduate scholar. For this award, we asked emerging Black scientists to tell us about the experiences that sparked their journey in the life sciences. This

Giant genomes of lungfish

Nature Reviews Genetics, Published online: 17 February 2021; doi:10.1038/s41576-021-00337-9 Two new studies report the assembled genomes of the Australian lungfish (Neoceratodus forsteri) and the African lungfish (Protopterus annectens), which provide insights into the water-to-land transition.

Circadian Mechanisms in Medicine

In addition to the sleep–wake cycle and cognitive functions such as learning and memory, intrinsic clocks determine nearly all circadian cycles in physiology, such as daily variation in blood pressure, heart rate, hormone levels, respiratory and exercise capacity, and coagulation.

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