A new era in functional genomics screens

Nature Reviews Genetics, Published online: 20 September 2021; doi:10.1038/s41576-021-00409-w In this Review, Przybyla and Gilbert describe the latest approaches for CRISPR-based functional genomics screens, including the adoption of single-cell transcriptomic read-outs and applications in characterizing the non-coding genome and mapping

Gene of the month: FH

Fumarate hydratase (FH), encoded by the FH gene, is an enzyme which catalyses the conversion of fumarate to L-malate as part of the tricarboxylic acid cycle. Biallelic germline mutations in FH result in fumaric aciduria, a metabolic disorder resulting in

Epigenome plasticity in plants

Nature Reviews Genetics, Published online: 15 September 2021; doi:10.1038/s41576-021-00407-y The authors review intra-individual and inter-individual plant epigenome variation during development and in response to environmental changes, including stress. They also discuss functions of epigenome plasticity and epigenome editing technologies that

Autoimmune nodopathies: treatable neuropathies beyond traditional classifications

Precise characterisation of the target antigens and autoantibody isotypes improves patient care in inflammatory neuropathies Antibodies targeting all neurofascin isoforms (pan-neurofascin) have been associated with variants of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that include ataxic presentations, cranial nerve involvement, respiratory

CRISPR systems go mini

Nature Reviews Genetics, Published online: 14 September 2021; doi:10.1038/s41576-021-00419-8 Three recent studies report the generation of miniature CRISPR systems based on compact Cas effector proteins, showing high efficiency of genome editing or transcriptional regulation in mammalian cells.

Correction: 61 The inconsistent choices of inotropic and vasopressors at the front door in patients with ischaemic cardiogenic shock and its impact on in-hospital mortality

Shabana A, Dholoo F, Tran P, et al. 61 The inconsistent choices of inotropic and vasopressors at the front door in patients with ischaemic cardiogenic shock and its impact on in-hospital mortality. Heart 2021;107:A51–52. doi:10.1136/heartjnl-2021-BCS.61 This Abstract has been corrected since

Testing the super-enhancer concept

Nature Reviews Genetics, Published online: 03 September 2021; doi:10.1038/s41576-021-00398-w In this Viewpoint, five experts discuss our biological understanding of super-enhancers, how we can responsibly study their functions, and their opinions on whether names for enhancer clusters are an informative reflection

Change in cardiovascular risk assessment tool and updated Norwegian guidelines for cardiovascular disease in primary prevention increase the population proportion at risk: the Tromso Study 2015-2016

Aims To compare the population proportion at high risk of cardiovascular disease (CVD) using the Norwegian NORRISK 1 that predicts 10-year risk of CVD mortality and the Norwegian national guidelines from 2009, with the updated NORRISK 2 that predicts 10-year

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