Association between implanted cardioverter-defibrillators and mortality for patients with left ventricular ejection fraction between 30% and 35%

Background Consensus guidelines support the use of implanted cardioverter-defibrillators (ICD) for primary prevention of sudden cardiac death in patients with either non-ischaemic or ischaemic cardiomyopathy with left ventricular ejection fraction (LVEF) ≤35%. However, evidence from trials for efficacy specifically for

Illustration Error

In the Review article “Common Hand Conditions,” published in the June 28, 2022, issue of JAMA, Figure 3 incorrectly showed the muscle insertions of the extensor pollicis brevis and the abductor pollicus longus in the lateral view of the hand.

At a glance

Specific location of ocular adnexal lymphoma and mortality: an international multicentre retrospective study (see page 1231) A comparison of 1168 patients with ocular adnexal lymphoma found eyelid location had significantly higher disease-specific mortality than other ocular adnexal locations in both

Emerging therapeutics and evolving assessment criteria for intracranial metastases in patients with oncogene-driven non-small-cell lung cancer

Nature Reviews Clinical Oncology, Published online: 17 August 2023; doi:10.1038/s41571-023-00808-4 Despite improved outcomes owing to advances in systemic targeted therapies, patients with brain metastases from oncogene-driven non-small-cell lung cancer continue to have a poor prognosis. This situation largely reflects the

Fantoms

Two-year outcomes following a randomised platelet-transfusion trial in preterm infants It is great to see the 2 year outcomes of the PlaNeT-2/MATISSE (Platelets for Neonatal Transfusion-2/Management of Thrombocytopenia in Special Subgroup) study in the journal. This randomised-controlled trial examined the

Unravelling the USP6 gene: an update

Ubiquitin-specific protease 6 (USP6) rearrangements have been identified in aneurysmal bone cyst, nodular fasciitis, myositis ossificans, fibro-osseous pseudotumour of digits and cellular fibroma of tendon sheath. These entities show clinical as well as histological overlap, suggesting they are all clonal

Atoms

TimingPnomh Penh 22.10 After a protracted delivery and some unexpected hesitancy after the cord is deftly cut by the obstetrician, Achariya draws her first breath under the glare of the maternity theatre lamp. Lusaka 17.10 Had her parents delayed leaving

Colchicine in patients with heart failure and preserved left ventricular ejection fraction: rationale and design of a prospective, randomised, open-label, crossover clinical trial

Introduction Systemic low-grade inflammation is a fundamental pathophysiological mechanism of heart failure with preserved left ventricular ejection fraction (HFpEF). The efficacy of anti-inflammatory therapy in HFpEF is largely understudied. The aim of the study is to assess the anti-inflammatory effect

Explaining the male bias in cancers

Nature Reviews Genetics, Published online: 14 August 2023; doi:10.1038/s41576-023-00650-5 Two studies published in Nature investigate the genetic mechanisms of sex bias in cancers and implicate Y chromosome genes in contributing to the aggressiveness of bladder cancer and colorectal cancer in

Expert consensus recommendations for the provision of infective endocarditis services: updated guidance from the Joint British Societies

Infective endocarditis (IE) remains a difficult condition to diagnose and treat and is an infection of high consequence for patients, causing long hospital stays, life-changing complications and high mortality. A new multidisciplinary, multiprofessional, British Society for Antimicrobial Chemotherapy (BSAC)-ledWorking Party

Not all co-repressors are equal

Nature Reviews Genetics, Published online: 09 August 2023; doi:10.1038/s41576-023-00647-0 Jacobs et al. report in Science that different co-repressors repress the transcriptional activity of different subsets of enhancers associated with genes of different function.

UpFront

How to manage alcohol-related liver disease: a case-based review Alcohol related liver disease is a major cause of morbidity and mortality. Management can be challenging particularly in the later stages. In this issue James Maurice and colleagues take us through

Toward imaging of alpha-synuclein with PET

Development of radiopharmaceuticals for in vivo positron emission tomography imaging of alpha-synuclein aggregates has the potential to revolutionize Lewy body disease diagnosis and treatment. Reporting in this issue of Cell, Xiang et al. developed a high-affinity positron emission tomography tracer for alpha-synuclein.

WhatsApp WhatsApp'tan Bize Yazın