Wake up call for collegiate athlete sleep: narrative review and consensus recommendations from the NCAA Interassociation Task Force on Sleep and Wellness

Sleep is an important determinant of collegiate athlete health, well-being and performance. However, collegiate athlete social and physical environments are often not conducive to obtaining restorative sleep. Traditionally, sleep has not been a primary focus of collegiate athletic training and

Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity

Chanda et al. used reprogrammed human neurons to model the neurodevelopmental toxicity induced by prenatal exposure to valproic acid, a potent teratogenic compound. By analyzing different phases of neuronal maturation in vitro, the authors identified valproate-mediated cellular mechanisms that selectively impair neuronal

Carrier screening for recessive disorders

Nature Reviews Genetics, Published online: 29 May 2019; doi:10.1038/s41576-019-0134-2 This Review discusses the current status of expanded carrier screening, including existing recommendations and limitations. The author reviews the framework that is needed for successful comprehensive carrier screening programmes for all

Assessing molecular subtypes of gastric cancer: microsatellite unstable and Epstein-Barr virus subtypes. Methods for detection and clinical and pathological implications

Background The molecular classification of gastric cancer recognises two subtypes prone to immune checkpoint blockade: the microsatellite unstable and the Epstein-Barr virus (EBV)-related tumours. We aim to assess the concordance between immunohistochemistry and PCR for microsatellite status evaluation, and explore

Highlights from this issue

Global child healthAntibiotics in non-bloody diarrhoea Managing infectious diarrhoea is essentially uncomplicated. In only a small proportion of children, those with bloody diarrhoea (shigella, cholera amoebiasis) and associated toxicity or sepsis are antibiotics indicated. In other situations, they can prolong

Evolution to the rescue

Nature Reviews Genetics, Published online: 16 May 2019; doi:10.1038/s41576-019-0138-y A study in Science uses experimental and population genomic approaches to examine the molecular underpinnings of evolved pollution resistance in Gulf killifish.

Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection

Upon infection, T cell clones harboring TCRs of distinct antigen affinity undergo differential expansion. Whether NK cells show similar clonal dynamics is not clear. By using retrogenic color-barcoding and single-cell adoptive transfers, Grassmann et al. show that NK cells adapt to cytomegalovirus

Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits

Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits Nature Genetics, Published online: 13 May 2019; doi:10.1038/s41588-019-0409-8 Multi-tissue transcriptome analyses using PrediXcan identify numerous trait-associated genes for schizophrenia, bipolar disorder, attention deficit hyperactivity disorder and broad depression, and highlight potentially

A novel classification of residual disease after interval debulking surgery for advanced-stage ovarian cancer to better distinguish oncologic outcome

Complete surgical resection affords the best prognosis at the time of interval debulking surgery. When complete surgical resection is unachievable, optimal residual disease is considered the next best alternative. Despite contradicting evidence on the survival benefit of interval debulking surgery

Author Correction: Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

Author Correction: Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration Author Correction: Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration, Published online: 08 May 2019; doi:10.1038/s41588-019-0430-y Author Correction: Retinal transcriptome and eQTL

Immune-checkpoint inhibition for metastatic triple-negative breast cancer: safety first?

Immune-checkpoint inhibition for metastatic triple-negative breast cancer: safety first? Immune-checkpoint inhibition for metastatic triple-negative breast cancer: safety first?, Published online: 03 May 2019; doi:10.1038/s41571-019-0216-2 Breast oncologists are intimately familiar with managing treatment-related adverse events of endocrine, cytotoxic and targeted therapies,

Editörden

Değerli Adli Bilimciler, Adli Tıp Bülteni’nin 2019 yılı ilk sayısıyla karşınızdayız. 1919’dan 2019 yılına, 14 Mart’ın 100. yılının tüm sağlık çalışanlarına ve adli bilimler alanında çalışan hepimize başarı ve barış getirmesini diliyoruz. Adli Tıp Bülteni’nin, DOAJ (Directory of Open Access

Türkiye’deki Psikiyatri Hekimlerinin Adli Psikiyatri Bilgi Düzeyi Nedir? “Sizce Adli Psikiyatri Bir Yan Dal Olmalı mıdır?”

Amaç: Adli Psikiyatri pek çok ülkede hali hazırda psikiyatrinin bir yan dalı olarak tanımlanmaktadır. Ancak ülkemizde henüz yapılandırılmış bir eğitimi yoktur. Bu çalışmayla, psikiyatri hekimlerinde, sağlık hukuku temel bakış açısıyla adli psikiyatri alanında biriken bilginin düzeyini ölçmek ve camiada adli

Muğla Adli Tıp Şube Müdürlüğü’ne Başvuran Gençlik Yaş Grubuna Ait Cinsel Saldırı Olgularının Değerlendirilmesi

Amaç:Muğla Adli Tıp Şube Müdürlüğüne başvuran gençlik yaş grubu cinsel saldırı olgularının değerlendirilmesiyle durum tespiti, bölgesel özelliklerin ortaya konması, öneriler geliştirilmesi amaçlanmıştır. Gereç ve Yöntem:Haziran 2012-Aralık 2016 tarihleri arasında cinsel suç nedeniyle muayenesi yapılmış 477 olgu arasından 15-24 yaş grubunda

İnsan İskeletlerinde Travma: Travmaya Bağlı Ölüm Nedeni Üzerine Bir Araştırma

Amaç: Adli Antropoloji’de, insan kemiklerindeki kırıklar, ezikler, kesikler ve delikler analiz edilerek travma çeşidi, ölüm şekli ve buna bağlı muhtemelölüm nedeni tahminleri yapılmaktadır. Bu çalışmanın amacı, ölüm nedeni travmaya bağlı bireylerin kemiklerindeki kırıkları, BT kullanarak perimortem süreçte incelemek, kırıkların ölümle

Elektrik Yaralanması Nedeniyle Başvuran Çocukların Klinik, Demografik Özellikleri ve Klinik Sonucu Etkileyen Faktörler: Tek Merkez Çocuk Acil Kliniği Deneyimi

Giriş ve amaç: Bu çalışmada çocukluk çağı elektrik yaralanmalarının demografik ve klinik özelliklerinin belirlenmesi, klinik sonucu etkileyen faktörlerin saptanması amaçlanmıştır. Gereç ve yöntem: Ocak 2008- Aralık 2015 tarihleri arasında elektrik yaralanması nedeniyle acil servise başvuran 112 hastanın dosya verileri geriye

Advancing cancer genomics

Advancing cancer genomics Advancing cancer genomics, Published online: 01 May 2019; doi:10.1038/s41588-019-0419-6 The field of cancer genomics is currently in an exciting and fast-paced era. With advances in sequencing technologies, computational approaches and tumor models, understanding of cancer processes is

VIP Interneurons Contribute to Avoidance Behavior by Regulating Information Flow across Hippocampal-Prefrontal Networks

How VIP interneurons modulate network-level activity to regulate behavior is not understood. Lee et al. show that in the elevated plus maze, prefrontal VIP neurons promote open arm avoidance by disinhibiting theta-frequency communication that transmits anxiety-related information across hippocampal-prefrontal networks.

WhatsApp WhatsApp'tan Bize Yazın