SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus

Hess et al. quantified circulating aldehyde dehydrogenase-expressing (ALDHhi) cell subsets in people with T2DM given either empagliflozin (EMPA) or placebo. EMPA treatment increased circulating pro-angiogenic CD133+ progenitor cells, decreased pro-inflammatory ALDHhi granulocyte precursors, and increased ALDHhi monocytes with M2 polarization. EMPA

Making Asthma Crystal Clear

Charcot–Leyden crystals have been observed in the airway mucus of patients with allergic airway disease since the 19th century, but their role in the pathogenesis of allergy has been unclear. Charcot–Leyden crystals and lysophospholipase are abundant in eosinophils and basophils,

Validation and modification of the ‘Chiang Mai University Intussusception scoring system used to predict failure of non-surgical treatment in infantile intussusception

Background This study aimed to validate and modify the recently released Chiang Mai University Intussusception (CMUI) scoring system in predicting failure of non-surgical management of infantile intussusception. Methods A retrospective review was conducted in 151 cases of infantile intussusception who

Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer

Bieniasz-Krzywiec et al. demonstrate a triad interaction of podoplanin (PDPN)-expressing tumor-associated macrophages (PoEMs), GAL8-expressing lymphatic vessels, and invading breast cancer cells, which promotes metastasis. PoEMs remodel the extracellular matrix, stimulating lymphangiogenesis, and release previously trapped cancer-promoting factors that facilitate cancer cell

Disentangling the tangled web of Neisseria gonorrhoeae transmission: how important are oropharyngeal infections?

The prevalence of gonorrhoea within populations is sustained by continued transmission from asymptomatically infected persons, particularly core group transmitters within sexual networks associated with high gonococcal transmission frequencies.1 It is believed that core group transmitters typically maintain a longer period

Mike’s Labels

Mike is a homeless chronic alcoholic. I know this because I wrote his label right here on his medical record. The first sentence, variations of which appear hundreds of times in his file, reads, “53-year-old homeless male, chronic alcoholic, presenting

Diversity matters

Nature Reviews Genetics, Published online: 16 August 2019; doi:10.1038/s41576-019-0162-y For genomics to fulfil its potential of improving human health, diversity and inclusion must be recognized as essential catalysts of research success.

The aetiology of death for marathon runner Phidippides?Endurance training and myocardial infarction with non-obstructive coronary artery disease may have been the cause of death of Phidippides, from present day evidence of an athlete who survived, and is discussed

Phidippides was a legendary Greek runner who ran from Marathon to Athens in 490 BC to announce the victory of the Greeks over the Persians. After running about 40 km to the Acropolis in Athens, he promptly collapsed and died.

Defining chronic inflammatory demyelinating polyradiculoneuropathy subtypes

An electrophysiological and biopsy study of 106 patients with chronic inflammatory demyelinating polyradiculoneuropathy identifies differences between disease subtypes Chronic inflammatory neuropathies include multifocal motor neuropathy, which is purely motor and often associated with complement-fixing antibodies to ganglioside GM1, paraproteinaemic demyelinating

Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation

Conventional antidepressants have limited efficacy and many side effects, highlighting the need for fast-acting and specific medications. Holz et al. utilize cell-membrane-permeable TAT-fused peptides, which specifically modulate glutamatergic neurotransmission, as a novel strategy for rapid and effective antidepressant treatment.

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