Change in cardiovascular risk assessment tool and updated Norwegian guidelines for cardiovascular disease in primary prevention increase the population proportion at risk: the Tromso Study 2015-2016

Aims To compare the population proportion at high risk of cardiovascular disease (CVD) using the Norwegian NORRISK 1 that predicts 10-year risk of CVD mortality and the Norwegian national guidelines from 2009, with the updated NORRISK 2 that predicts 10-year

[Editorial] Readiness is all

Emergency room psychiatry does not often make it into the pages of medical journals. Academic thought—and research money—is mostly directed towards longer-term issues in mental health. Epidemiological studies might track patients over decades. Trial endpoints are often set at weeks,

01 The effects of a leaflet-based intervention, ‘hypos can strike twice, on recurrent hypoglycaemic attendances by ambulance services: a non-randomised stepped wedge study

Background Hypoglycaemia is a common complication of diabetes therapy needing prompt recognition and treatment. It often results in ambulance attendance incurring health services costs and patient morbidity. Patient education is important for maintaining glycaemic control and preventing recurrent hypoglycaemia. We

Highlights from this issue

Therapeutic creep in provision of hypothermia for hypoxic ischaemic encephalopathy Three articles relate to the changing practices of UK clinicians in the provision of therapeutic hypothermia for hypoxic ischaemic encephalopathy (HIE). Lori Hage and colleagues report the clinical characteristics of

Correction: Serum androgen levels and their relation to performance in track and field: mass spectrometry results from 2127 observations in male and female elite athletes

Bermon S, Garnier P-Y. Serum androgen levels and their relation to performance in track and field: mass spectrometry results from 2127 observations in male and female elite athletes. Br J Sports Med 2017;51:1309–14. doi: 10.1136/bjsports-2017-097792 In 2017 and 2018 the

Exploring the macro-level, meso-level and micro-level barriers and facilitators to the provision of good quality early inflammatory arthritis (EIA) care in England and Wales

Background Evidence from a national clinical audit of early inflammatory arthritis (EIA) shows considerable variability between hospitals in performance, unexplained by controlling for case-mix. Objective To explore the macro-level, meso-level and micro-level barriers and facilitators to the provision of good

Longitudinal effects of adjuvant chemotherapy and lymph node staging on patient-reported outcomes in endometrial cancer survivors: a prospective cohort study

Most endometrial cancer patients with localized disease are effectively treated and survive for a long time. Primary treatment is hysterectomy, to which surgical staging procedures may be added to assess the need for adjuvant therapy. Longitudinal data on patient-reported outcomes

Urologic morbidity associated with placenta accreta spectrum surgeries: single-center experience with a multidisciplinary team

Hysterectomy for placenta accreta spectrum (PAS) may be associated with urologic morbidity including intentional or unintentional cystostomy, ureteral injury and bladder fistula. Although previous retrospective studies have shown association between PAS and urologic morbidities, there is still paucity of literature

Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause

Nature Genetics, Published online: 12 August 2021; doi:10.1038/s41588-021-00906-y Sequence analysis identifies gain-of-function somatic mutations in GNA11 or GNAQ in CTNNB1-mutant aldosterone-producing adenomas. Most patients with these mutations presented during puberty, pregnancy or menopause, with elevated LHCGR expression.

Turning Purple with Pain

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows.

Gene drives gaining speed

Nature Reviews Genetics, Published online: 06 August 2021; doi:10.1038/s41576-021-00386-0 In this Review, Ethan Bier discusses how several impactful technical advancements, particularly involving CRISPR-based methods, are providing a diverse toolkit of gene-drive systems for the control of populations such as insect

Correction: Non-nucleatum Fusobacterium species are dominant in the Southern Chinese population with distinctive correlations to host diseases compared with F. nucleatum

He Y, Mujagond P, Tang W, et al. Non-nucleatum Fusobacterium species are dominant in the Southern Chinese population with distinctive correlations to host diseases compared with F. nucleatum. Gut 2021;70:810–12. The correct funding statement should read: This study was supported

International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer

Nature Reviews Clinical Oncology, Published online: 04 August 2021; doi:10.1038/s41571-021-00538-5 Patients with early-stage rectal cancer might potentially benefit from treatment with an organ-sparing approach, which preserves quality of life owing to avoidance of the need for permanent colostomy. Trials conducted

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