Design of the Association of Uterine Perforation and Expulsion of IUD (APEX-IUD) Study: A Multisite Retrospective Cohort Study

Intrauterine devices (IUDs) are effective and safe, long-acting reversible contraceptives, but risk of uterine perforation occurs with an estimated incidence of 1-2 per 1,000 insertions. EURAS-IUD, a European prospective observational study that enrolled 61,448 participants (2006-2012), found that women breastfeeding

Breathing for Two

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows.

Breathing for Two

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows.

Society for Maternal-Fetal Medicine (SMFM) Consult Series #55: Counseling women at increased risk of maternal morbidity and mortality

Women deserve to be provided with evidence-based information when considering options for contraception and pregnancy management. When counseling about health conditions and available treatments, healthcare practitioners should employ strategies that encourage the incorporation of informed patient preferences into a shared

Intracranial Cysts

Intracranial cysts are a relatively common finding on ultrasound evaluation of the fetus and appear as anechoic structures of varying size. When not associated with other anomalies, most are benign, remain clinically silent, do not evolve, and regress spontaneously.1,2 Intracranial

Expression of SARS-CoV-2 cell entry genes, ACE2 and TMPRSS2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia

While there is some evidence that SARS-CoV-2 can invade the human placenta, limited data exist on the gestational-age dependent expression profile of the SARS-CoV-2 cell entry mediators, ACE2 and TMPRSS2 at the human maternal-fetal interface. There is also no information

Benefit and burden in the Dutch cytology-based versus high-risk human papillomavirus-based cervical cancer screening program

In 2017, the Dutch cervical cancer screening program has replaced primary cytology-based screening by primary high-risk human papillomavirus based screening, including the opportunity to participate through self-sampling. Evaluation and balancing benefit (detection of high-grade cervical intraepithelial neoplasia) and burden (unnecessary

Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1)

Despite expectant management, preeclampsia remote from term usually results in preterm delivery. Antithrombin displays anti-inflammatory and anticoagulant properties and thus may have a therapeutic role treating preterm preeclampsia, a disorder characterized by endothelial dysfunction, inflammation and activation of the coagulation

Pregnancy outcomes in nulliparous women with positive first-trimester preterm preeclampsia screening test: The Great Obstetrical Syndromes (GOS) cohort study

The Fetal Medicine Foundation (FMF) proposed a competing risks model for early identification of women at high risk of preterm preeclampsia, typically associated with deep placentation disorders. The Great Obstetrical Syndromes include a spectrum of pregnancy complications (preeclampsia, intrauterine growth

Exploratory and confirmatory analysis to investigate the presence of vaginal metabolome expression of microbial invasion of the amniotic cavity in women with preterm labor using high-performance liquid chromatography

While the influence of microbial invasion of the amniotic cavity on the development of spontaneous preterm delivery is unquestionable, the use of an invasive procedure to diagnosis the status of infection limits its clinical translation.

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