Tens of thousands of people marched against Brazil’s president Jair Bolsonaro last weekend after the supreme court authorised a criminal investigation into alleged government corruption involving a…
Finding the Goldilocks zone in neoadjuvant radioimmunotherapy
Nature Reviews Clinical Oncology, Published online: 05 July 2021; doi:10.1038/s41571-021-00540-x Advances in cancer immunotherapy have led to clinical trials of immunotherapy-based neoadjuvant treatments for early stage non-small-cell lung cancer. Evidence for priming of the immune system using both preoperative short-course
Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses
Nature Genetics, Published online: 05 July 2021; doi:10.1038/s41588-021-00892-1 Imputation of rare coding variants in the UK Biobank enables association and fine-mapping analyses of rare (minor allele frequency (MAF) = 0.00005) genotypes, identifying 600 new variant–trait associations, including long allelic series in individual
Clinical trials: regulators’ inaction has left EU registry “riddled with inaccurate and missing data”
Nearly 6000 clinical trial results are currently missing from the European trial registry, despite transparency rules requiring countries to upload results within 12 months of trial completion, a…
Endometrial Cancer, BRCA1, and BRCA2 in the UK Biobank Cohort
Objectives: Endometrial cancer (EC) risk in BRCA1/2 mutation carriers has been uncertain. EC risk in women with germline BRCA1 or BRCA2 mutations was recently assessed in a multicenter cohort study. BRCA1/2 mutation carriers had a 2- to 3-fold increased risk
Women’s Preventive Services Initiative: Fertility counseling overlooked
The 2021 Women’s Preventive Services Initiative (WPSI) Well Woman Chart outlines a framework for incorporating preventive health services recommended by the WPSI, U.S. Preventive Services Task Force (USPSTF), and Bright Futures based on age, health status, and risk factors. In
Abstracts from; The 38th Annual; National Neurotrauma Symposium ; July 11–14, 2021; Virtual Conference
Journal of Neurotrauma, Volume 38, Issue 14, Page A-1-A-132, July 15, 2021.
“Dr Isaac Schiff, Professor and Chair of the Vincent Department of Obstetrics and Gynecology at Massachusetts General Hospital/Harvard Medical School reopens the Obstetrical Service closed since the Second World War
Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes
In the spring of 2020, the rapid emergence of multisystem inflammatory syndrome in children (MIS-C) — a presumed postinfectious complication of coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) — necessitated decisions regarding…
Treatment of Multisystem Inflammatory Syndrome in Children
In April 2020, practitioners first noted a temporal association between infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome in children (MIS-C) as a rare but serious complication. Since that time, MIS-C has been reported to
Protecting Olympic Participants from Covid-19 — The Urgent Need for a Risk-Management Approach
In late July, approximately 11,000 athletes and 4000 athletic-support staff from more than 200 countries will gather for more than 2 weeks of competition at the Tokyo Olympics. One month later, another 5000 athletes and additional staff will attend the
Treatment of Multisystem Inflammatory Syndrome in Children
In April 2020, practitioners first noted a temporal association between infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome in children (MIS-C) as a rare but serious complication. Since that time, MIS-C has been reported to
Treatment of Multisystem Inflammatory Syndrome in Children
In April 2020, practitioners first noted a temporal association between infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome in children (MIS-C) as a rare but serious complication. Since that time, MIS-C has been reported to
Treatment of Multisystem Inflammatory Syndrome in Children
In April 2020, practitioners first noted a temporal association between infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome in children (MIS-C) as a rare but serious complication. Since that time, MIS-C has been reported to
Consultants will consider industrial action if government’s 1% pay rise offer is not improved
Senior doctors will be consulted on taking industrial action if the government’s 1% pay rise offer is not improved, though they have vowed not to leave patients “unsupported.”The BMA said on Friday 2…
Psychopathological outcomes and defence mechanisms in clinically healed adults with a paediatric cancer history: an exploratory study
Background The incidence of paediatric cancers has increased in recent years; however, with advances in the treatment of paediatric cancer, almost 80% of children and adolescents who receive a diagnosis of cancer become long-term survivors. Given the high stress levels
“Eyeing” corneal stem cell identity, dynamics, and compartmentalization
The mammalian cornea is maintained by the lifelong self-replenishing activity of its stem cells. In this issue of Cell Stem Cell, Altshuler et al. (2021) and Farrelly et al. (2021) identify two stem cell populations with diverse function and genetic signature, one
Case 19-2021: A 54-Year-Old Man with Irritability, Confusion, and Odd Behaviors
Presentation of Case. Dr. David P. Bullis (Behavioral Medicine, Newton–Wellesley Hospital, Newton, MA): A 54-year-old man was evaluated by the neuropsychology service of this hospital because of irritability, confusion, and odd behaviors. The patient had been in his usual state
Neonatal Outcomes of Births in Freestanding Birth Centers and Hospitals in the United States 2016-2019
Genetic drivers of m6A methylation in human brain, lung, heart and muscle
Nature Genetics, Published online: 01 July 2021; doi:10.1038/s41588-021-00890-3 Analysis of 129 N6-methyladenosine (m6A) profiles across 4 tissues (brain, lung, muscle and heart) identifies 8,843 tissue-specific and 469 tissue-shared m6A quantitative trait loci (QTLs). Of these, 184 m6A QTLs colocalize with
Genetics of substance use disorders in the era of big data
Nature Reviews Genetics, Published online: 01 July 2021; doi:10.1038/s41576-021-00377-1 In this Review, Gelernter and Polimanti discuss how recent large-scale studies have provided insights into the genetics and biology of substance use and abuse. By considering a range of addictive substances
Immunotherapy for MIS-C — IVIG, Glucocorticoids, and Biologics
Since the sudden emergence of multisystem inflammatory disease in children (MIS-C) in April 2020 as a novel and severe presentation of coronavirus disease 2019 (Covid-19), nearly 4000 cases of MIS-C and 35 deaths have been reported in the United States
Treatment of Multisystem Inflammatory Syndrome in Children
In April 2020, practitioners first noted a temporal association between infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome in children (MIS-C) as a rare but serious complication. Since that time, MIS-C has been reported to
[Editorial] Germany’s election: transformation versus more of the same
Angela Merkel’s 16-year reign as German chancellor will come to an end this year. This fact is the only certain outcome, among various possible party coalition options, when Germans vote in federal elections on Sept 26. 2021 is a particularly
Lessons from the pandemic: taking a covid-like approach to other diseases
Preparing for the next pandemic is a global public health concern, which is well voiced by Wenham and colleagues.1 But a pertinent question might be: why do we care more about pandemics than other…
The changing role of Sport & Exercise Medicine in the post COVID-19 world
COVID-19 has affected all walks of life and posed challenges that one would never have expected. The British Association of Sport & Exercise Medicine (BASEM), like other organisations, has had to reflect, transform and adapt in response to the global
Sequencing Tool Sheds New Light on Somatic Mutations [News in Brief]
Researchers have developed a highly sensitive single-molecule sequencing technique that could be used to study somatic mutations in a wide range of normal tissues, including those that aren’t actively dividing. The technique, called NanoSeq, has several potential cancer applications, including
Nasopharyngeal carcinoma: an evolving paradigm
Nature Reviews Clinical Oncology, Published online: 30 June 2021; doi:10.1038/s41571-021-00524-x Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated malignancy endemic to southern China, southeast Asia and north Africa. The authors of this Review present a comprehensive overview of advances from
PERINATAL OUTCOMES AFTER BARIATRIC SURGERY
Bariatric surgery is a widespread treatment for obesity that often provides long-term weight control and health benefits. Although a growing number of women are becoming pregnant after bariatric surgery, few population-based studies have assessed its impact on perinatal outcomes.
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