The mutational footprints of cancer therapies

Nature Genetics, Published online: 18 November 2019; doi:10.1038/s41588-019-0525-5 Analysis of whole-genome sequences from more than 3,500 metastatic tumors identifies mutational signatures associated with different chemotherapies and provides estimates of the relative contribution of different treatments to tumor mutational burden.

Acute Upper Airway Obstruction

Acute upper airway obstruction is a life-threatening emergency and requires immediate assessment and intervention with little margin for error, making it a constant challenge for clinicians. Substantial advances have been made in preventive medicine, our understanding of the pathophysiology of…

Acute Upper Airway Obstruction

Acute upper airway obstruction is a life-threatening emergency and requires immediate assessment and intervention with little margin for error, making it a constant challenge for clinicians. Substantial advances have been made in preventive medicine, our understanding of the pathophysiology of…

Achieving equal and timely access to innovative anticancer drugs in the European Union (EU): summary of a multidisciplinary CECOG-driven roundtable discussion with a focus on Eastern and South-Eastern EU countries

The Central European Cooperative Oncology Group (CECOG) and ‘ESMO Open—Cancer Horizons’ roundtable discussion brought together stakeholders from several European Union (EU) countries involved in drug development, drug authorisation and reimbursement or otherwise affected by delayed and unequal access to innovative

Acute Severe Hypertension

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage.

Acute Severe Hypertension

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage.

Double Trouble

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows.

Acute Severe Hypertension

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage.

The genetics of human ageing

Nature Reviews Genetics, Published online: 05 November 2019; doi:10.1038/s41576-019-0183-6 Bringing together different strands of genetic research, including results from recent large-scale genome-wide association studies relevant to human ageing, the authors highlight how genetics can further our understanding of the underlying

Schizophrenia

Schizophrenia is a psychiatric syndrome characterized by psychotic symptoms of hallucinations, delusions, and disorganized speech, by negative symptoms such as decreased motivation and diminished expressiveness, and by cognitive deficits involving impaired executive functions, memory, and speed of…

Schizophrenia

Schizophrenia is a psychiatric syndrome characterized by psychotic symptoms of hallucinations, delusions, and disorganized speech, by negative symptoms such as decreased motivation and diminished expressiveness, and by cognitive deficits involving impaired executive functions, memory, and speed of…

Schizophrenia

Schizophrenia is a psychiatric syndrome characterized by psychotic symptoms of hallucinations, delusions, and disorganized speech, by negative symptoms such as decreased motivation and diminished expressiveness, and by cognitive deficits involving impaired executive functions, memory, and speed of…

Schizophrenia

Schizophrenia is a psychiatric syndrome characterized by psychotic symptoms of hallucinations, delusions, and disorganized speech, by negative symptoms such as decreased motivation and diminished expressiveness, and by cognitive deficits involving impaired executive functions, memory, and speed of…

CRISPR screens come into sight

Nature Reviews Genetics, Published online: 28 October 2019; doi:10.1038/s41576-019-0192-5 A new study in Cell reports a mammalian genetic screening strategy that combines CRISPR libraries with in situ sequencing to read out both complex cellular phenotypes and genetic perturbations using microscopy.

Editörden

Değerli Adli Bilimciler, Adli Tıp Bülteni’nin yeni sayısıyla karşınızdayız. Dergimizin ülkemizde Tübitak Ulakbim TR ve DOAJ (Directory of Open Access Journals) tarafından dizinlenen tek adli bilimler dergisi olması ve adli bilimler alanının bilimsel patformuna dönüşmesi yeni hedefleri de zorunlu kılmaktadır.

Sudan Çıkarılmış Cesetlerde Kolloidal Silika Gradyen Santrifüj Metodu Kullanılarak Vücudun Dış Yüzeylerinden ve İç Organlardan Elde Edilen Diatomların Karşılaştırılması

Amaç: Diatom analizi, suda boğulma olgularında ölüm nedeninin ve boğulma ortamının tespitinde kullanılan çok değerli bir araçtır. Diatom analizinin temel prensibi,  boğulma ortamında bulunan diatomların, suyun inhalasyonu yolu ile penetrasyonu ve alveollerden genel kan dolaşımına katılarak karaciğer, beyin, kemik iliği

Sık Hastane Başvurusu Ev içi Şiddetin Habercisi mi?

Amaç:Eş şiddeti toplumun her kesiminde değişik oranlarda görülmektedir ve orta-uzun vadede çok farklı sağlık sorunlarına neden olabilmektedir. Bu çalışmada, Adli Tıp Polikliniğine eşinden/partnerinden şiddet görme nedeniyle başvuran olguların son bir yıl içindeki hastane başvurularını değerlendirerek; şiddet mağdurlarının sağlık sorunlarını ortaya

Profesyonel Araç Sürücülerinde Sürücü Davranışları ve Becerileri ile Alkol, Madde ve İlaç Kullanımının Değerlendirilmesi

Giriş: Sürücü davranışları ve sürücülük becerileri, trafikte kaza riskini oluşturan ana unsurlar arasında yer almaktadır. Alkol ve madde etkisi altında araç kullanma davranışı; ölümlere, maddi hasarlara ve yaralanmalara neden olan önemli bir trafik sorunudur. Bu çalışmada; profesyonel araç sürücülerinde alkol,

Ekstremite Kırığı Olgularında Tedavi Seçeneklerinin ve Meslekte Çalışma Gücü Kaybı ve Engellilik Oranlarının Karşılaştırılması

Amaç: Çalışmamızda; trafik kazası sonucu meydana gelen kemik kırıklarına uygulanan tedavilerin başarıları ile bu tedavi sonucunda kalan sekellere ait meslekte kazanma gücü kaybı ve özürlülük oranlarının hesaplanarak kıyaslanması amaçlanmıştır. Gereç ve Yöntem:01 Şubat 2016 – 01 Şubat 2017 tarihleri arasında

A prime alternative

Nature Reviews Genetics, Published online: 24 October 2019; doi:10.1038/s41576-019-0191-6 A new genome editing strategy called prime editing uses a catalytically impaired Cas9 fused to an engineered reverse transcriptase to write desired genetic sequence information directly into a target locus.

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