On July 18, 2016, the final rule of the Department of Health and Human Services (HHS) implementing Section 1557 of the Affordable Care Act regarding gender nondiscrimination went into effect. Advocates were relieved that the law now included protections against
Patient cost-sharing during poly(ADP-ribose) polymerase inhibitor treatment in ovarian cancer
More patients with ovarian cancer are being treated with poly (ADP-ribose) polymerase (PARP) inhibitors as regulatory agencies have granted these drugs new approvals for a variety of treatment indications. However, PARP inhibitors are expensive. When given as a maintenance therapy,
Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women
Genetic testing for cancer susceptibility is an established part of medical practice. Until recently, testing was performed mainly in patients with a strong family history of cancer and involved a limited number of genes known to be associated with a
Linking newly occurring mutations to autism
Nature Reviews Genetics, Published online: 04 February 2021; doi:10.1038/s41576-021-00335-x Three new studies identify different types of de novo and somatic mutations associated with autism spectrum disorder (ASD), with potential insights into underlying molecular mechanisms.
Hunting for a Diagnosis
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows.
Management of Antithrombotic Therapy after Acute Coronary Syndromes
Because of rapidly changing guidelines in response to multiple clinical trials of new therapies, the management of antithrombotic agents for patients after an acute coronary syndrome is becoming increasingly complex. Patients and clinicians must make treatment decisions by weighing the…
Hunting for a Diagnosis
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows.
Vaccine Innovations — Past and Future
Vaccination is a powerful method of disease prevention that is relevant to people of all ages and in all countries, as the Covid-19 pandemic illustrates. Vaccination can improve people’s chances of survival, protect communities from new and reemerging health threats,
Learning about End-of-Life Care from Grandpa
Grandpa married my biologic grandmother when I was 4 years old, after the deaths of their first spouses. A quarter-century later, at the age of 85, he officiated at my wedding after undergoing a nonsectarian ordainment in California. He became
Vaccine Innovations — Past and Future
Vaccination is a powerful method of disease prevention that is relevant to people of all ages and in all countries, as the Covid-19 pandemic illustrates. Vaccination can improve people’s chances of survival, protect communities from new and reemerging health threats,
Microvascular Injury in the Brains of Patients with Covid-19
To the Editor: We conducted postmortem high-resolution magnetic resonance imaging (magnetic resonance microscopy) of the brains of patients with coronavirus disease 2019 (Covid-19) (median age, 50 years) and histopathological examination that focused on microvascular changes in the olfactory bulb…
Race and Genetic Ancestry in Medicine — A Time for Reckoning with Racism
In the United States, race, ancestry, genetics, and medicine are inextricably linked in a complex and fraught history. Medicine is replete with examples of racial injustice inflicted by the use of race and ethnicity as biologic constructs to engender hierarchical
Microvascular Injury in the Brains of Patients with Covid-19
To the Editor: We conducted postmortem high-resolution magnetic resonance imaging (magnetic resonance microscopy) of the brains of patients with coronavirus disease 2019 (Covid-19) (median age, 50 years) and histopathological examination that focused on microvascular changes in the olfactory bulb…
Race and Genetic Ancestry in Medicine — A Time for Reckoning with Racism
In the United States, race, ancestry, genetics, and medicine are inextricably linked in a complex and fraught history. Medicine is replete with examples of racial injustice inflicted by the use of race and ethnicity as biologic constructs to engender hierarchical
Fund Black scientists
Our nationwide network of BME women faculty collectively argue that racial funding disparity by the National Institutes of Health (NIH) remains the most insidious barrier to success of Black faculty in our profession. We thus refocus attention on this critical
[Editorial] Genomic sequencing in pandemics
Advanced genetic sequencing techniques have undoubtedly provided valuable information on the biology and evolution of SARS-CoV-2. Never have the nearly 30 000 nucleotides of a virus been so closely considered by scientists, public health experts, and politicians alike. But the use
Covid-19: Drop the hero narrative and support doctors’ mental health, says charity
The mental health charity Mind has launched guidance for NHS leaders on creating workplace cultures where mental health and wellbeing are prioritised and talked about openly.The guidance, which was…
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Abstract This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million
Benefit with first-line ICIs in mesothelioma
Nature Reviews Clinical Oncology, Published online: 03 February 2021; doi:10.1038/s41571-021-00481-5 Benefit with first-line ICIs in mesothelioma
Genital tuberculosis screening at an academic fertility center in the US: A Reply
The Political Nature of Sex — Transgender in the History of Medicine
On July 18, 2016, the final rule of the Department of Health and Human Services (HHS) implementing Section 1557 of the Affordable Care Act regarding gender nondiscrimination went into effect. Advocates were relieved that the law now included protections against
The Political Nature of Sex — Transgender in the History of Medicine
On July 18, 2016, the final rule of the Department of Health and Human Services (HHS) implementing Section 1557 of the Affordable Care Act regarding gender nondiscrimination went into effect. Advocates were relieved that the law now included protections against
Nausea and the Brain: The Chemoreceptor Trigger Zone Enters the Molecular Age
Area postrema in brainstem has long been known to trigger emesis by detecting blood-borne toxins and pathogens. In this issue, Zhang and colleagues provide a single-cell molecular atlas of this region, opening new possibilities for harnessing its neurons in vivo.
[Editorial] Realising the potential of SARS-CoV-2 vaccines—a long shot?
The race to develop safe, effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has produced impressive results. As of Jan 18, 2021, 64 vaccines were in clinical development according to the WHO COVID-19 candidate vaccine database. Phase 3
Covid-19: New data on Oxford AstraZeneca vaccine backs 12 week dosing interval
The UK’s approach of leaving an interval of three months between doses of the Oxford AstraZeneca covid-19 vaccine has been supported by new data, with the Oxford University researchers also saying…
Inclusion of pregnant individuals among priority populations for COVID-19 vaccination for all 50 US States
The American College of Obstetricians and Gyncologists (ACOG)1 recommends that COVID-19 vaccines should not be withheld from pregnant individuals who meet criteria for vaccination based on the Advisory Committee on Immunization Practices (ACIP)-recommended priority groups, which include pregnancy in priority
A new era for the young community of the ESC
The new ESC Board Committee for Young Cardiovascular Professionals was launched in 2020 and is discussed by the inaugural chair Dr Afzal Sohaib
Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation
Atrial fibrillation, the most common cardiac arrhythmia, affects approximately 1 to 2% of the overall population. Without preventive treatment, atrial fibrillation will recur in 90% of patients. Guidelines recommend the use of antiarrhythmic drugs as initial therapy for the maintenance
Low-Calorie Sweeteners with Carbohydrate Do Not Impair Insulin Sensitivity in Humans: Re-analysis Highlighting the Importance of the Comparator
The lack of appropriate comparator can lead to incorrect interpretation of results regarding low-calorie sweeteners. The result of a re-analysis of the study by Dalenberg et al. shows that the impairment of insulin sensitivity by sucralose in combination with carbohydrate may
Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury
Journal of Neurotrauma, Volume 38, Issue 3, Page 301-308, February 2021.
Paying for Telemedicine After the Pandemic
This Viewpoint discusses the importance of value as policy makers consider the role of telemedicine for the remainder of and following the COVID-19 pandemic, and how to calibrate payment for services to that value in a likely expansion of video
China races to contain covid outbreak
bmj;372/feb02_17/n307/FAF1faYang Shiyao/Xinhua News Agency/PAAfter a new outbreak of covid-19 last month, China is constructing a quarantine camp to house around 4000 people.The quarantine centre in…
Ethics and injury risk in World Rugby and England Rugby tackle-height trial
Concussion in rugby Concerns about concussion in contact sport have permeated debate within sports medicine.1–4 Considerable scientific attention has been focussed on the short-term and long-term outcomes of concussions, as well as the strategies to reduce the risk of traumatic
FDA Encourages Greater Trial Diversity [News in Brief]
The FDA has issued a final guidance on strategies for boosting diversity in clinical trials, such as broadening eligibility criteria and offering financial assistance, to encourage enrollment among patients in low-income and minority communities.
A quantitative genomics map of rice provides genetic insights and guides breeding
Nature Genetics, Published online: 01 February 2021; doi:10.1038/s41588-020-00769-9 A comprehensive rice quantitative trait nucleotide map provides new genetic insights and serves as the basis for RiceNavi, a tool to optimize breeding schemes.
[Editorial] Valuing all lives equally: cancer surgery, COVID-19, and the NHS in crisis
As COVID-19 infections continue to increase at an unprecedented rate, and the UK enters the toughest phase of the pandemic so far, the National Health Service (NHS) finds itself under the most pressure seen in its 72-year history. With the
Effect of CD47 Blockade on Vascular Inflammation
To the Editor: Macrophage checkpoint inhibition, an approach in which the phagocytic clearance of cancer cells is reactivated, represents a new paradigm in immuno-oncology. In parallel, a defect in “efferocytosis” (i.e. the removal of inflamed and dying cells by phagocytosis)
Professionally Responsible COVID-19 Vaccination Counseling of Obstetric/Gynecologic Patients
The development of COVID-19 vaccines in current and planned clinical trials is essential for the success of this public health response. This paper focuses on how physicians should implement the results of these clinical trials: counseling patients who are pregnant,
[Editorial] Do not repeat mistakes from HIV in COVID-19 response
40 years since the first cases of HIV were identified, we often reflect in these pages about the enormous advances that have been made to combat the disease. From the vantage point of 2021 there is a lot to celebrate:
Changing Hand Color after Carpal Tunnel Injection
Figure 1.
JAMA Pediatrics
Vision: JAMA Pediatrics will be the most respected source of information for investigators, providers, and policy makers seeking the highest quality evidence to guide decision making.
Covid-19: volunteers cannot be outsourced
A spokesperson from the Department of Health and Social Care said that there were no delays in accrediting volunteers to help with the covid-19 vaccination programme.1 Evidently NHS staff have time…
Workplace violence and health in human service industries: a systematic review of prospective and longitudinal studies
Objectives To provide systematically evaluated evidence of prospective associations between exposure to physical, psychological and gender-based violence and health among healthcare, social care and education workers. Methods The guidelines on Preferred Reporting Items for Systematic Reviews and Meta-Analyses were followed.
Case 3-2021: A 48-Year-Old Man with Transient Vision Loss
Presentation of Case. Dr. Naomi J. Serling-Boyd (Medicine): A 48-year-old man was evaluated at this hospital because of transient vision loss. The patient had been in his usual state of good health until 1 hour before evaluation, when he noticed
Management of ischaemic stroke, prognostic impact of procedural myocardial injury, and antiplatelet treatment: the many facets of interventional cardiology
Case 3-2021: A 48-Year-Old Man with Transient Vision Loss
Presentation of Case. Dr. Naomi J. Serling-Boyd (Medicine): A 48-year-old man was evaluated at this hospital because of transient vision loss. The patient had been in his usual state of good health until 1 hour before evaluation, when he noticed
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